The impact of analytical treatment interruptions and trial interventions on time to viral re‐suppression in people living with HIV restarting ART in cure‐related clinical studies: a systematic review and meta‐analysis

Authors: Ming Jie Lee, Miles Eason, Antonella Castagna, Galli Laura, Marie‐Angelique De Scheerder, James Riley, Pablo Tebas, Jesper Gunst, Ole Søgaard, Eric Florence, Eugene Kroon, Mark De Souza, Beatriz Mothe, Marina Caskey, Sarah Fidler

Source: Journal of the International AIDS Society, Vol 27, Iss 8, Pp n/a-n/a (2024)

Subject Terms: antiretroviral therapy, ATI, HIV, HIV cure, treatment interruption, viral suppression, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1758-2652

Access URL: https://doaj.org/article/248624d98f04464b807c1ffc49fa3d38

Safety, Efficacy, and Pharmacokinetics of Combination SARS-CoV-2 Neutralizing Monoclonal Antibodies BMS-986414 (C135-LS) and BMS-986413 (C144-LS) Administered Subcutaneously in Non-Hospitalized Persons with COVID-19 in a Phase 2 Trial

Authors: Katya Corado, Kara Chew, Mark Giganti, Ying Mu, Courtney Fletcher, Judith Currier, Eric Daar, David Wohl, Jonathan Li, Carlee Moser, Justin Ritz, Arzhang Javan, Gene Neytman, Marina Caskey, Michael Hughes, Davey Smith, Joseph Eron, ACTIV-2/A5401 Study Team

Source: Pathogens and Immunity, Vol 9, Iss 1 (2024)

Subject Terms: COVID-19, SARS-CoV-2, monoclonal antibodies, outpatient treatment, subcutaneous, Pathology, RB1-214, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.paijournal.com/index.php/paijournal/article/view/660; https://doaj.org/toc/2469-2964

Access URL: https://doaj.org/article/ac470b99dab5435b9837e2685a00d534

SARS-CoV-2 spike glycosylation affects function and neutralization sensitivity

Authors: Fengwen Zhang, Fabian Schmidt, Frauke Muecksch, Zijun Wang, Anna Gazumyan, Michel C. Nussenzweig, Christian Gaebler, Marina Caskey, Theodora Hatziioannou, Paul D. Bieniasz

Source: mBio, Vol 15, Iss 2 (2024)

Subject Terms: SARS-CoV-2, antibody function, neutralization, glycosylation, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/d4d51df98c9c47238de71504346cf0f1

Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape

Authors: Leander Witte, Viren A. Baharani, Fabian Schmidt, Zijun Wang, Alice Cho, Raphael Raspe, Camila Guzman-Cardozo, Frauke Muecksch, Marie Canis, Debby J. Park, Christian Gaebler, Marina Caskey, Michel C. Nussenzweig, Theodora Hatziioannou, Paul D. Bieniasz

Source: Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/99e97881ad1544aba687686826fd535e

Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV

Authors: Bryan T. Mayer, Lily Zhang, Allan C. deCamp, Chenchen Yu, Alicia Sato, Heather Angier, Kelly E. Seaton, Nicole Yates, Julie E. Ledgerwood, Kenneth Mayer, Marina Caskey, Michel Nussenzweig, Kathryn Stephenson, Boris Julg, Dan H. Barouch, Magdalena E. Sobieszczyk, Srilatha Edupuganti, Colleen F. Kelley, M. Juliana McElrath, Huub C. Gelderblom, Michael Pensiero, Adrian McDermott, Lucio Gama, Richard A. Koup, Peter B. Gilbert, Myron S. Cohen, Lawrence Corey, Ollivier Hyrien, Georgia D. Tomaras, Yunda Huang

Source: Pharmaceutics, Vol 16, Iss 5, p 594 (2024)

Subject Terms: monoclonal antibodies, LS mutation, two-compartment model, population pharmacokinetics modeling, HIV prevention, targeted maximum likelihood estimation (TMLE), Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/5/594; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/34ca5d472d9b40e7a742cd8a83e9c15b

Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity

Authors: Miriam Rosás-Umbert, Jesper D. Gunst, Marie H. Pahus, Rikke Olesen, Mariane Schleimann, Paul W. Denton, Victor Ramos, Adam Ward, Natalie N. Kinloch, Dennis C. Copertino, Tuixent Escribà, Anuska Llano, Zabrina L. Brumme, R. Brad Jones, Beatriz Mothe, Christian Brander, Julie Fox, Michel C. Nussenzweig, Sarah Fidler, Marina Caskey, Martin Tolstrup, Ole S. Søgaard

Source: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ef639b4a891643dcb296cca780fd13c0

SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells

Authors: Eva M. Stevenson, Sandra Terry, Dennis Copertino, Louise Leyre, Ali Danesh, Jared Weiler, Adam R. Ward, Pragya Khadka, Evan McNeil, Kevin Bernard, Itzayana G. Miller, Grant B. Ellsworth, Carrie D. Johnston, Eli J. Finkelsztein, Paul Zumbo, Doron Betel, Friederike Dündar, Maggie C. Duncan, Hope R. Lapointe, Sarah Speckmaier, Nadia Moran-Garcia, Michelle Premazzi Papa, Samuel Nicholes, Carissa J. Stover, Rebecca M. Lynch, Marina Caskey, Christian Gaebler, Tae-Wook Chun, Alberto Bosque, Timothy J. Wilkin, Guinevere Q. Lee, Zabrina L. Brumme, R. Brad Jones

Source: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d9cd2a88e3f64b5bb298b5bf37dbca63

The RIO trial: rationale, design, and the role of community involvement in a randomised placebo-controlled trial of antiretroviral therapy plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) in participants diagnosed with recent HIV infection—study protocol for a two-stage randomised phase II trial

Authors: Ming Jie Lee, Simon Collins, Daphne Babalis, Nicholas Johnson, Emanuela Falaschetti, A. Toby Prevost, Ambreen Ashraf, Milaana Jacob, Tom Cole, Lisa Hurley, Matthew Pace, Ane Ogbe, Maryam Khan, Panagiota Zacharopoulou, Helen Brown, Euan Sutherland, Hanna Box, Julie Fox, Steven Deeks, Jill Horowitz, Michel C. Nussenzweig, Marina Caskey, John Frater, Sarah Fidler

Source: Trials, Vol 23, Iss 1, Pp 1-26 (2022)

Subject Terms: HIV, Primary infection, Broadly neutralising antibodies, Antiretroviral therapy, Virological remission, T cell Immunity, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/ae528c9319bd40e5b259a15cbdb04027

Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York

Authors: Anthony P. West, Joel O. Wertheim, Jade C. Wang, Tetyana I. Vasylyeva, Jennifer L. Havens, Moinuddin A. Chowdhury, Edimarlyn Gonzalez, Courtney E. Fang, Steve S. Di Lonardo, Scott Hughes, Jennifer L. Rakeman, Henry H. Lee, Christopher O. Barnes, Priyanthi N. P. Gnanapragasam, Zhi Yang, Christian Gaebler, Marina Caskey, Michel C. Nussenzweig, Jennifer R. Keeffe, Pamela J. Bjorkman

Source: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6617c4ad1147439fafe26eec5e36b019

Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies

Authors: Allison J. Greaney, Tyler N. Starr, Christopher O. Barnes, Yiska Weisblum, Fabian Schmidt, Marina Caskey, Christian Gaebler, Alice Cho, Marianna Agudelo, Shlomo Finkin, Zijun Wang, Daniel Poston, Frauke Muecksch, Theodora Hatziioannou, Paul D. Bieniasz, Davide F. Robbiani, Michel C. Nussenzweig, Pamela J. Bjorkman, Jesse D. Bloom

Source: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ed99a3d89b4343beb0ebcb8680884099

Effect of 3BNC117 and romidepsin on the HIV-1 reservoir in people taking suppressive antiretroviral therapy (ROADMAP): a randomised, open-label, phase 2A trial

Authors: Henning Gruell, MD, Jesper D Gunst, MD, Yehuda Z Cohen, MD, Marie H Pahus, Jakob J Malin, MD, Martin Platten, MD, Katrina G Millard, RN, Martin Tolstrup, PhD, R Brad Jones, PhD, Winnifer D Conce Alberto, Julio C C Lorenzi, PhD, Thiago Y Oliveira, PhD, Tim Kümmerle, MD, Isabelle Suárez, MD, Cecilia Unson-O'Brien, PhD, Lilian Nogueira, PhD, Rikke Olesen, PhD, Lars Østergaard, ProfMD, Henrik Nielsen, ProfMD, Clara Lehmann, MD, Michel C Nussenzweig, ProfMD, Gerd Fätkenheuer, ProfMD, Florian Klein, ProfMD, Marina Caskey, ProfMD, Ole S Søgaard, ProfMD

Source: The Lancet Microbe, Vol 3, Iss 3, Pp e203-e214 (2022)

Subject Terms: Medicine (General), R5-920, Microbiology, QR1-502

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666524721002391; https://doaj.org/toc/2666-5247

Access URL: https://doaj.org/article/b572a4bc81f74c27b4e7e697acac132e

A clinical trial of non-invasive imaging with an anti-HIV antibody labelled with copper-64 in people living with HIV and uninfected controls

Authors: James H. McMahon, Jennifer M. Zerbato, Jillian S.Y. Lau, Jaclyn L. Lange, Michael Roche, Carolin Tumpach, Ashanti Dantanarayana, Ajantha Rhodes, Judy Chang, Thomas A. Rasmussen, Charlene A. Mackenzie, Karen Alt, Michelle Hagenauer, Janine Roney, Jessica O‘Bryan, Alexandra Carey, Richard McIntyre, Paul Beech, Graeme J. O'Keefe, Christian W. Wichmann, Fiona E. Scott, Nancy Guo, Sze-Ting Lee, Zhanqi Liu, Marina Caskey, Michel C. Nussenzweig, Paul S. Donnelly, Gary Egan, Christoph E. Hagemeyer, Andrew M. Scott, Sharon R. Lewin

Source: EBioMedicine, Vol 65, Iss , Pp 103252- (2021)

Subject Terms: HIV, Imaging, Clinical trial, PET scan, Broadly neutralising antibodies, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396421000451; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/9173e8bdd9024f4b8554f76616f8c5c7

ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens

Authors: Colin R. Zamecnik, Jayant V. Rajan, Kevin A. Yamauchi, Sabrina A. Mann, Rita P. Loudermilk, Gavin M. Sowa, Kelsey C. Zorn, Bonny D. Alvarenga, Christian Gaebler, Marina Caskey, Mars Stone, Philip J. Norris, Wei Gu, Charles Y. Chiu, Dianna Ng, James R. Byrnes, Xin X. Zhou, James A. Wells, Davide F. Robbiani, Michel C. Nussenzweig, Joseph L. DeRisi, Michael R. Wilson

Source: Cell Reports Medicine, Vol 1, Iss 7, Pp 100123- (2020)

Subject Terms: SARS-CoV-2, serology, phage display, COVID-19, diagnostics, assay development, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666379120301658; https://doaj.org/toc/2666-3791

Access URL: https://doaj.org/article/fb798e3575304cdbbba3b382901cca64

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

Authors: Yiska Weisblum, Fabian Schmidt, Fengwen Zhang, Justin DaSilva, Daniel Poston, Julio CC Lorenzi, Frauke Muecksch, Magdalena Rutkowska, Hans-Heinrich Hoffmann, Eleftherios Michailidis, Christian Gaebler, Marianna Agudelo, Alice Cho, Zijun Wang, Anna Gazumyan, Melissa Cipolla, Larry Luchsinger, Christopher D Hillyer, Marina Caskey, Davide F Robbiani, Charles M Rice, Michel C Nussenzweig, Theodora Hatziioannou, Paul D Bieniasz

Source: eLife, Vol 9 (2020)

Subject Terms: COVID19, SARS-CoV-2, VSV, antibody, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/61312; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/79b3d5db1a464b1183d621d965b32b35

Characterization of Co-Formulated High-Concentration Broadly Neutralizing Anti-HIV-1 Monoclonal Antibodies for Subcutaneous Administration

Authors: Vaneet K. Sharma, Bijay Misra, Kevin T. McManus, Sreenivas Avula, Kaliappanadar Nellaiappan, Marina Caskey, Jill Horowitz, Michel C. Nussenzweig, Michael S. Seaman, Indu Javeri, Antu K. Dey

Source: Antibodies, Vol 9, Iss 3, p 36 (2020)

Subject Terms: HIV/AIDS, co-formulation, high concentration, analytical characterization, antibody (s), Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4468/9/3/36; https://doaj.org/toc/2073-4468

Access URL: https://doaj.org/article/dfdf1d2826e045a4ba960b0d2c10ab6c

Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study.

Authors: Yehuda Z Cohen, Allison L Butler, Katrina Millard, Maggi Witmer-Pack, Rebeka Levin, Cecilia Unson-O'Brien, Roshni Patel, Irina Shimeliovich, Julio C C Lorenzi, Jill Horowitz, Stephen R Walsh, Shu Lin, Joshua A Weiner, Anna Tse, Alicia Sato, Chelsey Bennett, Bryan Mayer, Kelly E Seaton, Nicole L Yates, Lindsey R Baden, Allan C deCamp, Margaret E Ackerman, Michael S Seaman, Georgia D Tomaras, Michel C Nussenzweig, Marina Caskey

Source: PLoS ONE, Vol 14, Iss 8, p e0219142 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/b4f6a55fa3004a4ca5d76ce1d1d48b8b

In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers.

Authors: Sandhya Vasan, Arlene Hurley, Sarah J Schlesinger, Drew Hannaman, David F Gardiner, Daniel P Dugin, Mar Boente-Carrera, Roselle Vittorino, Marina Caskey, Johanne Andersen, Yaoxing Huang, Josephine H Cox, Tony Tarragona-Fiol, Dilbinder K Gill, Hannah Cheeseman, Lorna Clark, Len Dally, Carol Smith, Claudia Schmidt, Harriet H Park, Jakub T Kopycinski, Jill Gilmour, Patricia Fast, Robert Bernard, David D Ho

Source: PLoS ONE, Vol 6, Iss 5, p e19252 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3095594?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/54e6c0214ce848db98e3291e78e074a0

Phase 1 safety and immunogenicity evaluation of ADMVA, a multigenic, modified vaccinia Ankara-HIV-1 B'/C candidate vaccine.

Authors: Sandhya Vasan, Sarah J Schlesinger, Zhiwei Chen, Arlene Hurley, Angela Lombardo, Soe Than, Phumla Adesanya, Catherine Bunce, Mark Boaz, Rosanne Boyle, Eddy Sayeed, Lorna Clark, Daniel Dugin, Mar Boente-Carrera, Claudia Schmidt, Qing Fang, LeiBa, Yaoxing Huang, Gerasimos J Zaharatos, David F Gardiner, Marina Caskey, Laura Seamons, Martin Ho, Len Dally, Carol Smith, Josephine Cox, Dilbinder Gill, Jill Gilmour, Michael C Keefer, Patricia Fast, David D Ho

Source: PLoS ONE, Vol 5, Iss 1, p e8816 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2810329?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/25b6bfc4047d47d09e9a293a9d14fcdd