A genome-wide study of the effect of alcohol consumption on the risk of type 2 diabetes

Authors: Ariane Belzile, Sam Pedro Galilée Ayivi, Géraldine Asselin, Sylvie Provost, Louis-Philippe Lemieux Perreault, Marie-Christyne Cyr, Marie-Pierre Dubé

Source: Clinical Nutrition Open Science, Vol 60, Iss , Pp 78-88 (2025)

Subject Terms: Type 2 diabetes, Alcohol consumption, Genome-wide association study, Sex-specific interaction, UK biobank, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667268525000166; https://doaj.org/toc/2667-2685

Access URL: https://doaj.org/article/066e28f465674c8191790d47c712268d

The role of genetically predicted serum iron levels on neurodegenerative and cardiovascular traits

Authors: Wiame Belbellaj, Frida Lona-Durazo, Cinzia Bodano, David Busseuil, Marie-Christyne Cyr, Edoardo Fiorillo, Antonella Mulas, Sylvie Provost, Maristella Steri, Toshiko Tanaka, Brett Vanderwerff, Jiongming Wang, Ross P. Byrne, Francesco Cucca, Marie-Pierre Dubé, Luigi Ferrucci, Russell L. McLaughlin, Jean-Claude Tardif, Matthew Zawistowski, Sarah A. Gagliano Taliun

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: Serum iron, Genetic correlation, Mendelian randomization (MR), Sex-stratified, Cardiovascular, Neurodegeneration, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/eb3acac4864b47caa4bc49294eff8667

GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study

Authors: Emma F. Magavern, Harshal Deshmukh, Geraldine Asselin, Elizabeth Theusch, Stella Trompet, Xiaohui Li, Raymond Noordam, Y.-D. Ida Chen, Teresa E. Seeman, Kent D. Taylor, Wendy S. Post, Jean-Claude Tardif, Dirk S. Paul, Emelia J. Benjamin, Nancy L. Heard-Costa, Ramachandran S. Vasan, Jerome I. Rotter, Ronald M. Krauss, J.Wouter Jukema, Paul M. Ridker, Patricia B. Munroe, Mark J. Caulfield, Daniel I. Chasman, Marie-Pierre Dubé, Graham A. Hitman, Helen R. Warren

Source: Pharmacological Research, Vol 212, Iss , Pp 107575- (2025)

Subject Terms: Statins, C-Reactive Protein, Pharmacogenetics, GWAS, Treatment Response, Pharmacology, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661824005206; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/2f1a2fa11fa44e9e8688f44ae10f03e9

A dataset of proteomic changes during human heat stress and heat acclimation

Authors: Daniel Gagnon, Hadiatou Barry, Amina Barhdadi, Essaid Oussaid, Ian Mongrain, Louis-Philippe Lemieux Perreault, Marie-Pierre Dubé

Source: Scientific Data, Vol 10, Iss 1, Pp 1-6 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2052-4463

Access URL: https://doaj.org/article/d860e0e7f58b43b5a5e7fa78aefad97a

Females present higher dose‐adjusted drug concentrations of metoprolol and allopurinol/oxypurinol than males

Authors: Jessica Hindi, Marc‐Olivier Pilon, Maxime Meloche, Grégoire Leclair, Essaïd Oussaïd, Isabelle St‐Jean, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean Lucien Rouleau, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus

Source: Clinical and Translational Science, Vol 16, Iss 5, Pp 872-885 (2023)

Subject Terms: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

Access URL: https://doaj.org/article/58f822ad9b2840d0901676770757397e

Impact of amiodarone use on metoprolol concentrations, α‐OH‐metoprolol concentrations, metoprolol dosing and heart rate: A cross‐sectional study

Authors: Sabrina Robert, Marc‐Olivier Pilon, Essaïd Oussaïd, Maxime Meloche, Grégoire Leclair, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus

Source: Pharmacology Research & Perspectives, Vol 11, Iss 5, Pp n/a-n/a (2023)

Subject Terms: amiodarone, cytochrome P‐450 CYP2D6, drug interactions, metoprolol, pharmacogenetics, pharmacokinetics, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2052-1707

Access URL: https://doaj.org/article/0853f8a5071a463ca8c6f9d55b6c7249

Pharmacogenomic study of heart failure and candesartan response from the CHARM programme

Authors: Marie‐Pierre Dubé, Olympe Chazara, Audrey Lemaçon, Géraldine Asselin, Sylvie Provost, Amina Barhdadi, Louis‐Philippe Lemieux Perreault, Ian Mongrain, Quanli Wang, Keren Carss, Dirk S. Paul, Jonathan W. Cunningham, Jean Rouleau, Scott D. Solomon, John J.V. McMurray, Salim Yusuf, Chris B. Granger, Carolina Haefliger, Simon deDenus, Jean‐Claude Tardif

Source: ESC Heart Failure, Vol 9, Iss 5, Pp 2997-3008 (2022)

Subject Terms: Pharmacogenomics, Candesartan, CHARM, Heart failure, Preserved ejection fraction, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2055-5822

Access URL: https://doaj.org/article/dc7585ebfd504c5a9e9d0d9c346c92fa

An association study of ABCG2 rs2231142 on the concentrations of allopurinol and its metabolites

Authors: Marc‐Olivier Pilon, Grégoire Leclair, Essaïd Oussaïd, Isabelle St‐Jean, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean Lucien Rouleau, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus

Source: Clinical and Translational Science, Vol 15, Iss 8, Pp 2024-2034 (2022)

Subject Terms: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

Access URL: https://doaj.org/article/f9425dbf0f014bcc896fcaa842b04bf7

Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease

Authors: Gemma Cadby, Corey Giles, Phillip E. Melton, Kevin Huynh, Natalie A. Mellett, Thy Duong, Anh Nguyen, Michelle Cinel, Alex Smith, Gavriel Olshansky, Tingting Wang, Marta Brozynska, Mike Inouye, Nina S. McCarthy, Amir Ariff, Joseph Hung, Jennie Hui, John Beilby, Marie-Pierre Dubé, Gerald F. Watts, Sonia Shah, Naomi R. Wray, Wei Ling Florence Lim, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Tenielle Porter, Michael Vacher, Ashley I. Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Kevin Taddei, Matthias Arnold, Gabi Kastenmüller, Kwangsik Nho, Andrew J. Saykin, Xianlin Han, Rima Kaddurah-Daouk, Ralph N. Martins, John Blangero, Peter J. Meikle, Eric K. Moses

Source: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1160229aa3d04cc8a6b15b682b0f47a7

Leveraging large observational studies to discover genetic determinants of drug concentrations: A proof‐of‐concept study

Authors: Maxime Meloche, Grégoire Leclair, Martin Jutras, Essaïd Oussaïd, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus

Source: Clinical and Translational Science, Vol 15, Iss 4, Pp 1063-1073 (2022)

Subject Terms: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

Access URL: https://doaj.org/article/81b54697e31d490090a5d831aea25000

Predictive risk factors for hospitalization and response to colchicine in patients with COVID-19

Authors: Jean-Claude Tardif, Mariève Cossette, Marie-Claude Guertin, Nadia Bouabdallaoui, Marie-Pierre Dubé, Guy Boivin

Source: International Journal of Infectious Diseases, Vol 116, Iss , Pp 387-390 (2022)

Subject Terms: COVID-19, colchicine, hospitalization, risk factors, sex, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1201971222000212; https://doaj.org/toc/1201-9712

Access URL: https://doaj.org/article/af97e0c857eb44cd8ee33d9194db5ad6

Construction of a femininity score in the UK Biobank and its association with angina diagnosis prior to myocardial infarction

Authors: Anna Levinsson, Simon de Denus, Johanna Sandoval, Louis-Philippe Lemieux Perreault, Joëlle Rouleau, Jean-Claude Tardif, Julie Hussin, Marie-Pierre Dubé

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/5ec3b8e589484f5a82d6a621193c99b3

The genomics of heart failure: design and rationale of the HERMES consortium

Authors: R. Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V. Holmes, Johan Ärnlöv, Per Svensson, Harry Hemingway, Neneh Sallah, Peter Almgren, Krishna G. Aragam, Geraldine Asselin, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Eric Boersma, Jeffrey Brandimarto, Michael R. Brown, Hans‐Peter Brunner‐La Rocca, David J. Carey, Mark D. Chaffin, Daniel I. Chasman, Olympe Chazara, Xing Chen, Xu Chen, Jonathan H. Chung, William Chutkow, John G.F. Cleland, James P. Cook, Simon deDenus, Abbas Dehghan, Graciela E. Delgado, Spiros Denaxas, Alexander S. Doney, Marcus Dörr, Samuel C. Dudley, Gunnar Engström, Tõnu Esko, Ghazaleh Fatemifar, Stephan B. Felix, Chris Finan, Ian Ford, Francoise Fougerousse, René Fouodjio, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S. Gottdiener, Stefan Gross, Daníel F. Guðbjartsson, Hongsheng Gui, Rebecca Gutmann, Christopher M. Haggerty, Pim van derHarst, Åsa K. Hedman, Anna Helgadottir, Hans Hillege, Craig L. Hyde, Jaison Jacob, J. Wouter Jukema, Frederick Kamanu, Isabella Kardys, Maryam Kavousi, Kay‐Tee Khaw, Marcus E. Kleber, Lars Køber, Andrea Koekemoer, Bill Kraus, Karoline Kuchenbaecker, Claudia Langenberg, Lars Lind, Cecilia M. Lindgren, Barry London, Luca A. Lotta, Ruth C. Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Douglas Mann, Kenneth B. Margulies, Nicholas A. Marston, Winfried März, John J.V. McMurray, Olle Melander, Giorgio Melloni, Ify R. Mordi, Michael P. Morley, Andrew D. Morris, Andrew P. Morris, Alanna C. Morrison, Michael W. Nagle, Christopher P. Nelson, Christopher Newton‐Cheh, Alexander Niessner, Teemu Niiranen, Christoph Nowak, Michelle L. O'Donoghue, Anjali T. Owens, Colin N.A. Palmer, Guillaume Paré, Markus Perola, Louis‐Philippe Lemieux Perreault, Eliana Portilla‐Fernandez, Bruce M. Psaty, Kenneth M. Rice, Paul M. Ridker, Simon P.R. Romaine, Carolina Roselli, Jerome I. Rotter, Christian T. Ruff, Marc S. Sabatine, Perttu Salo, Veikko Salomaa, Jessica vanSetten, Alaa A. Shalaby, Diane T. Smelser, Nicholas L. Smith, Kari Stefansson, Steen Stender, David J. Stott, Garðar Sveinbjörnsson, Mari‐Liis Tammesoo, Jean‐Claude Tardif, Kent D. Taylor, Maris Teder‐Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp‐Pedersen, Stella Trompet, Danny Tuckwell, Benoit Tyl, Andre G. Uitterlinden, Felix Vaura, Abirami Veluchamy, Peter M. Visscher, Uwe Völker, Adriaan A. Voors, Xiaosong Wang, Nicholas J. Wareham, Peter E. Weeke, Raul Weiss, Harvey D. White, Kerri L. Wiggins, Heming Xing, Jian Yang, Yifan Yang, Laura M. Yerges‐Armstrong, Bing Yu, Faiez Zannad, Faye Zhao, Regeneron Genetics Center, Jemma B. Wilk, Hilma Holm, Naveed Sattar, Steven A. Lubitz, David E. Lanfear, Svati Shah, Michael E. Dunn, Quinn S. Wells, Folkert W. Asselbergs, Aroon D. Hingorani, Marie‐Pierre Dubé, Nilesh J. Samani, Chim C. Lang, Thomas P. Cappola, Patrick T. Ellinor, Ramachandran S. Vasan, J. Gustav Smith

Source: ESC Heart Failure, Vol 8, Iss 6, Pp 5531-5541 (2021)

Subject Terms: Heart failure, Cardiomyopathy, Genetics, Biomarkers, Association studies, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2055-5822

Access URL: https://doaj.org/article/77600c13420346d3a1c4c66140b2a3c7

Genetics of symptom remission in outpatients with COVID-19

Authors: Marie-Pierre Dubé, Audrey Lemaçon, Amina Barhdadi, Louis-Philippe Lemieux Perreault, Essaïd Oussaïd, Géraldine Asselin, Sylvie Provost, Maxine Sun, Johanna Sandoval, Marc-André Legault, Ian Mongrain, Anick Dubois, Diane Valois, Emma Dedelis, Jennifer Lousky, Julie Choi, Elisabeth Goulet, Christiane Savard, Lea-Mei Chicoine, Mariève Cossette, Malorie Chabot-Blanchet, Marie-Claude Guertin, Simon de Denus, Nadia Bouabdallaoui, Richard Marchand, Zohar Bassevitch, Anna Nozza, Daniel Gaudet, Philippe L. L’Allier, Julie Hussin, Guy Boivin, David Busseuil, Jean-Claude Tardif

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/22ad144ba1304827b38809d5ea8a9606

Population Pharmacokinetics of Candesartan in Patients with Chronic Heart Failure

Authors: Imad Kassem, Steven Sanche, Jun Li, Guillaume Bonnefois, Marie‐Pierre Dubé, Jean‐Lucien Rouleau, Jean‐Claude Tardif, Michel White, Jacques Turgeon, Fahima Nekka, Simon deDenus

Source: Clinical and Translational Science, Vol 14, Iss 1, Pp 194-203 (2021)

Subject Terms: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

Access URL: https://doaj.org/article/06648dc786d34810be9652d22f425824

The associations of hostility and defensiveness with telomere length are influenced by sex and health status

Authors: Louisia Starnino, Gilles Dupuis, Lambert Busque, Vincent Bourgoin, Marie-Pierre Dubé, David Busseuil, Bianca D’Antono

Source: Biology of Sex Differences, Vol 12, Iss 1, Pp 1-13 (2021)

Subject Terms: Telomere length, Hostility, Defensiveness, Cardiovascular disease, Sex and age, Medicine, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2042-6410

Access URL: https://doaj.org/article/dc3e9e308aa94601bd8f92071f5e3aca

A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy

Authors: Simon deDenus, Fannie Mottet, Sandra Korol, Yassamin Feroz Zada, Sylvie Provost, Ian Mongrain, Géraldine Asselin, Essaïd Oussaïd, David Busseuil, Guillaume Lettre, John Rioux, Normand Racine, Eileen O'Meara, Michel White, Jean Rouleau, Jean Claude Tardif, Marie‐Pierre Dubé

Source: ESC Heart Failure, Vol 7, Iss 6, Pp 4384-4389 (2020)

Subject Terms: Heart failure, Genetics, B‐cell lymphoma 2‐associated anthanogene protein, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2055-5822

Access URL: https://doaj.org/article/3d6e05a5bc794595a3acaeab71ce9ed8

Heritability of 596 lipid species and genetic correlation with cardiovascular traits in the Busselton Family Heart Study[S]

Authors: Gemma Cadby, Phillip E. Melton, Nina S. McCarthy, Corey Giles, Natalie A. Mellett, Kevin Huynh, Joseph Hung, John Beilby, Marie-Pierre Dubé, Gerald F. Watts, John Blangero, Peter J. Meikle, Eric K. Moses

Source: Journal of Lipid Research, Vol 61, Iss 4, Pp 537-545 (2020)

Subject Terms: lipidomics, cardiovascular disease, lipids, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520435035; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/66724ad8474a47388f724ee514c97a7b

Comparative Effectiveness and Safety of Low-Dose Oral Anticoagulants in Patients With Atrial Fibrillation

Authors: Sylvie Perreault, Alice Dragomir, Robert Côté, Aurélie Lenglet, Simon de Denus, Marc Dorais, Brian White-Guay, James Brophy, Mireille E. Schnitzer, Marie-Pierre Dubé, Jean-Claude Tardif

Source: Frontiers in Pharmacology, Vol 12 (2022)

Subject Terms: atrial fibrillation, oral anticoagulant, effectiveness outcomes, safety outcomes, low dose, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.812018/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/4e8f4f329cac4385b69b9b4e951ed5f4

A sex-specific evolutionary interaction between ADCY9 and CETP

Authors: Isabel Gamache, Marc-André Legault, Jean-Christophe Grenier, Rocio Sanchez, Eric Rhéaume, Samira Asgari, Amina Barhdadi, Yassamin Feroz Zada, Holly Trochet, Yang Luo, Leonid Lecca, Megan Murray, Soumya Raychaudhuri, Jean-Claude Tardif, Marie-Pierre Dubé, Julie Hussin

Source: eLife, Vol 10 (2021)

Subject Terms: population genetics, pharmacogenomics, transcriptomics, phenotype associations, cardiovascular disease, linkage disequilibrium, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/69198; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/1eb82435960b4dda9cb9c0f636c44f60