Phase II trial of vaccination with autologous, irradiated melanoma cells engineered by adenoviral mediated gene transfer to secrete granulocyte-macrophage colony stimulating factor in patients with stage III and IV melanoma

Authors: Tamara A. Sussman, Mariano Severgnini, Anita Giobbie-Hurder, Philip Friedlander, Scott J. Swanson, Michael Jaklitsch, Thomas Clancy, Laura A. Goguen, David Lautz, Richard Swanson, Heather Daley, Jerome Ritz, Glenn Dranoff, F. Stephen Hodi

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: melanoma, vaccine, advanced disease, GM-CSF, stage III, Stage IV, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1395978/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/ba235126d5b84090b4b832fedad15dec

Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy

Authors: Garrett S. Dunlap, Daniel DiToro, Joel Henderson, Sujal I. Shah, Mike Manos, Mariano Severgnini, Astrid Weins, Indira Guleria, Patrick A. Ott, Naoka Murakami, Deepak A. Rao

Source: Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e991277fef0d4954afa3894a6cef86f7

688 Transcriptome analyses in patients with myeloid malignances treated with the IRAK4 inhibitor emavusertib

Authors: Daniel J DeAngelo, Chia-Cheng Li, Amit Verma, Mariano Severgnini, David Nickle, Guillermo Garcia-Manero, Uwe Platzbecker, Reinhard von Roemeling, Klaus H Metzeler, Eric S Winer, Gaurav S Choudhary, Wanying Zhao, Maureen Lane, Alyssa Masciarelli, Dora Ferrari, Cole Gallagher, Samantha Carlisle

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/2e667ab0e236414281a1be5dcc4a281e

Molecular correlates of response to eribulin and pembrolizumab in hormone receptor-positive metastatic breast cancer

Authors: Tanya E. Keenan, Jennifer L. Guerriero, Romualdo Barroso-Sousa, Tianyu Li, Tess O’Meara, Anita Giobbie-Hurder, Nabihah Tayob, Jiani Hu, Mariano Severgnini, Judith Agudo, Ines Vaz-Luis, Leilani Anderson, Victoria Attaya, Jihye Park, Jake Conway, Meng Xiao He, Brendan Reardon, Erin Shannon, Gerburg Wulf, Laura M. Spring, Rinath Jeselsohn, Ian Krop, Nancy U. Lin, Ann Partridge, Eric P. Winer, Elizabeth A. Mittendorf, David Liu, Eliezer M. Van Allen, Sara M. Tolaney

Source: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d25f24d7eb06482f96ec27595b0111bc

Simplified mass cytometry protocol for in-plate staining, barcoding, and cryopreservation of human PBMC samples in clinical trials

Authors: Charlotte Abrecht, Margaret Hallisey, Jenna Dennis, Matthew Nazzaro, Martha Brainard, Emma Hathaway, Abigail N. Schork, F. Stephen Hodi, Mariano Severgnini, Joanna Baginska

Source: STAR Protocols, Vol 3, Iss 2, Pp 101362- (2022)

Subject Terms: Cell Biology, Cell isolation, Cell-based Assays, Clinical Protocol, Flow Cytometry/Mass Cytometry, Immunology, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166722002428; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/71f8a2b5c4e5419b9c5012dd0f42c434

Mass cytometry staining for human bone marrow clinical samples

Authors: Margaret Hallisey, Jenna Dennis, Charlotte Abrecht, Romanos Sklavenitis Pistofidis, Abigail N. Schork, Elizabeth D. Lightbody, Daniel Heilpern-Mallory, Mariano Severgnini, Irene M. Ghobrial, F. Stephen Hodi, Joanna Baginska

Source: STAR Protocols, Vol 3, Iss 1, Pp 101163- (2022)

Subject Terms: Cell Biology, Flow Cytometry/Mass Cytometry, Cell-based Assays, Health Sciences, Immunology, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166722000430; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/742388b8e446429081c2e354f4ece9c6

Phase IB study of ziv-aflibercept plus pembrolizumab in patients with advanced solid tumors

Authors: Howard Streicher, Elad Sharon, Mariano Severgnini, Michael Manos, Anita Giobbie-Hurder, F Stephen Hodi, Andrew S Brohl, Philippe L Bedard, Kevin Tyan, Scott Rodig, Osama E Rahma, Daniel J Renouf, Emma Hathaway, Rachel Cunningham

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/3/e003569.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/97b2590c6c9344189d1570b29cf64695

Combining CTLA-4 and angiopoietin-2 blockade in patients with advanced melanoma: a phase I trial

Authors: Mariano Severgnini, Rizwan Haq, Anita Giobbie-Hurder, Scott J Rodig, Patrick A Ott, Evisa Gjini, Ryan J Sullivan, Donald P Lawrence, Matthew Nazzaro, Kathleen L Pfaff, Jacquelyn O Wolff, Elizabeth I Buchbinder

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 11 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/11/e003318.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/209a1d9fbce1433f83f364f311d116e0

Pneumonitis resulting from radiation and immune checkpoint blockade illustrates characteristic clinical, radiologic and circulating biomarker features

Authors: Jonathan D. Schoenfeld, Mizuki Nishino, Mariano Severgnini, Michael Manos, Raymond H. Mak, F. Stephen Hodi

Source: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-7 (2019)

Subject Terms: Pneumonitis, Radiation., PD-1 inhibition., Biomarkers, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40425-019-0583-3; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/1df37f709046454bb97a314f17915995

Correction: Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1- immunotherapy in colon cancer

Authors: Mark Awad, Mizuki Nishino, Mariano Severgnini, Biagio Ricciuti, Joao V Alessi, Gonzalo Recondo, Marissa Lawrence, Greg Jones, Tim Forshew, Christine Lydon, Michael Cheng

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/3/e001643corr1.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/66aac74d6715476bb41128518795d259

Early plasma circulating tumor DNA (ctDNA) changes predict response to first-line pembrolizumab-based therapy in non-small cell lung cancer (NSCLC)

Authors: Mark Awad, Mizuki Nishino, Mariano Severgnini, Biagio Ricciuti, Joao V Alessi, Gonzalo Recondo, Marissa Lawrence, Greg Jones, Tim Forshew, Christine Lydon, Michael Cheng

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/e6145a4c40b5449aabb45da655be4ef6

808 Exploring resistance mechanism to pembrolizumab and ang-2 inhibitor trebananib (NCT03239145) using high-dimensional single-cell mass cytometry (CyTOF)

Authors: Mariano Severgnini, Michael Manos, Anita Giobbie-Hurder, Osama Rahma, F Stephen Hodi, Kevin Tyan, Joanna Baginska, Martha Brainard, James Cleary, Benjamin Schlechter, Anna Maloney, Rizwan Romee

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/bb13f9b6739d4ca29f20d134aa05013b

Plasma IL-6 changes correlate to PD-1 inhibitor responses in NSCLC

Authors: Mariano Severgnini, Biagio Ricciuti, Alissa Keegan, Padric Garden, Limor Cohen, Reiko Nishihara, Anika Adeni, Cloud Paweletz, Julianna Supplee, Pasi A Jänne, Mark M Awad, David R Walt

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/8/2/e000678.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/97ad95d9e28e4f6882c60ec31ab1624e

High-Throughput Mass Cytometry Staining for Immunophenotyping Clinical Samples

Authors: Emily M. Thrash, Katja Kleinsteuber, Emma S. Hathaway, Matthew Nazzaro, Eric Haas, F. Stephen Hodi, Mariano Severgnini

Source: STAR Protocols, Vol 1, Iss 2, Pp 100055- (2020)

Subject Terms: Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166720300423; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/2f78f90cca67436ca5cc2859d58bed32

Distinct predictive biomarker candidates for response to anti-CTLA-4 and anti-PD-1 immunotherapy in melanoma patients

Authors: Priyanka B. Subrahmanyam, Zhiwan Dong, Daniel Gusenleitner, Anita Giobbie-Hurder, Mariano Severgnini, Jun Zhou, Michael Manos, Lauren M. Eastman, Holden T. Maecker, F. Stephen Hodi

Source: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-14 (2018)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40425-018-0328-8; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/0b4e970d2cb54a8e9cd3f79ea9e5e8c9

Anti-CTLA-4 based therapy elicits humoral immunity to galectin-3 in patients with metastatic melanoma

Authors: Xinqi Wu, Anita Giobbie-Hurder, Erin M. Connolly, Jingjing Li, Xiaoyun Liao, Mariano Severgnini, Jun Zhou, Scott Rodig, F. Stephen Hodi

Source: OncoImmunology, Vol 7, Iss 7 (2018)

Subject Terms: antibody responses to galectin-3, anti-vegf, immune therapy, galectin-3, melanoma, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/34b511e6b6a54a6da2ada79988051e9c

Circulating cytokine associations with clinical outcomes in melanoma patients treated with combination nivolumab plus ipilimumab

Authors: Jiajia Chen, Giuseppe Tarantino, Mariano Severgnini, Joanna Baginska, Anita Giobbie-Hurder, Jason L. Weirather, Michael Manos, Janice D. Russell, Kathleen L. Pfaff, Scott J. Rodig, Amy Y. Huang, Ryan Brennick, Matthew Nazzaro, Emma Hathaway, Marta Holovatska, Claire Manuszak, Srinika Ranasinghe, David Liu, F. Stephen Hodi

Source: OncoImmunology, Vol 14, Iss 1 (2025)

Subject Terms: Checkpoint blockade, biomarkers for immunotherapy, combination immunotherapy, melanoma, translational research, cytokines, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/27fe02581b62416ba2b3b748fe670fd9

Effects of definitive chemoradiation on circulating immunologic angiogenic cytokines in head and neck cancer patients

Authors: F. Stephen Hodi, Jonathan Schoenfeld, Mariano Severgnini, Vishwajith Sridharan, Danielle N. Margalit, Stephanie A. Lynch, Robert I. Haddad, Roy B. Tishler

Source: Journal for ImmunoTherapy of Cancer, Vol 4, Iss 1 (2016)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/4/1/32.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/9885852f7f7f461d93162f27413a47bc

5-HT Induction of c-fos Gene Expression Requires Reactive Oxygen Species and Rac1 and Ras GTPases .

Authors: Amy Simon, Mariano Severgnini, Satoe Takahashi, Liliana Rozo, Bathsheeba Andrahbi, Abena Agyeman, Brent Cochran, Regina Day, Barry Fanburg

Source: Cell Biochemistry & Biophysics; Jun2005, Vol. 42 Issue 3, p263-276, 14p

Subject Terms: GENE expression, SMOOTH muscle, MUSCLE cells, BLOOD plasma