Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex

Authors: Maria Kuzikov, Jeanette Reinshagen, Krzysztof Wycisk, Angela Corona, Francesca Esposito, Paolo Malune, Candida Manelfi, Daniela Iaconis, Andrea Beccari, Enzo Tramontano, Marcin Nowotny, Björn Windshügel, Philip Gribbon, Andrea Zaliani

Source: Virus Research, Vol 343, Iss , Pp 199356- (2024)

Subject Terms: SARS-CoV-2, Helicase, RNA-dependent RNA polymerase, Screening, Drug repurposing, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0168170224000492; https://doaj.org/toc/1872-7492

Access URL: https://doaj.org/article/550094371ce149a49691d7b4b0ad8bf8

Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort

Authors: Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen, Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon, Pieter Leyssen

Source: Scientific Data, Vol 9, Iss 1, Pp 1-11 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2052-4463

Access URL: https://doaj.org/article/d090bc5600084cffb8b7e56ad1250b1a

Corrigendum to 'Machine Learning Based Prediction of COVID-19 Mortality Suggests Repositioning of Anticancer Drug for Treating Severe Cases'[Artificial Intelligence in Life Sciences] 1(2021), 100020

Authors: Thomas Linden, Frank Hanses, Daniel Domingo-Fernández, Lauren Nicole DeLong, Alpha Tom Kodamullil, Jochen Schneider, Maria J.G.T. Vehreschild, Julia Lanznaster, Maria Madeleine Ruethrich, Stefan Borgmann, Martin Hower, Kai Wille, Torsten Feldt, Siegbert Rieg, Bernd Hertenstein, Christoph Wyen, Christoph Roemmele, Jörg Janne Vehreschild, Carolin E.M. Jakob, Melanie Stecher, Maria Kuzikov, Andrea Zaliani, Holger Fröhlich

Source: Artificial Intelligence in the Life Sciences, Vol 2, Iss , Pp 100032- (2022)

Subject Terms: Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667318522000034; https://doaj.org/toc/2667-3185

Access URL: https://doaj.org/article/5a320d6d6a6f48538d8322230d437d85

A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection

Authors: Bernhard Ellinger, Denisa Bojkova, Andrea Zaliani, Jindrich Cinatl, Carsten Claussen, Sandra Westhaus, Oliver Keminer, Jeanette Reinshagen, Maria Kuzikov, Markus Wolf, Gerd Geisslinger, Philip Gribbon, Sandra Ciesek

Source: Scientific Data, Vol 8, Iss 1, Pp 1-10 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2052-4463

Access URL: https://doaj.org/article/bd461bec118c4a32a661a0394ac4282f

DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action

Authors: Daniela Iaconis, Francesca Caccuri, Candida Manelfi, Carmine Talarico, Antonella Bugatti, Federica Filippini, Alberto Zani, Rubina Novelli, Maria Kuzikov, Bernhard Ellinger, Philip Gribbon, Kristoffer Riecken, Francesca Esposito, Angela Corona, Enzo Tramontano, Andrea Rosario Beccari, Arnaldo Caruso, Marcello Allegretti

Source: Viruses, Vol 15, Iss 5, p 1128 (2023)

Subject Terms: COVID-19, drug repurposing, methotrexate, EXSCALATE, virtual screening, molecular docking, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/15/5/1128; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/b7bacb79c72b47389e3aeb9d63d3ca35

Machine Learning Based Prediction of COVID-19 Mortality Suggests Repositioning of Anticancer Drug for Treating Severe Cases

Authors: Thomas Linden, Frank Hanses, Daniel Domingo-Fernández, Lauren Nicole DeLong, Alpha Tom Kodamullil, Jochen Schneider, Maria J.G.T. Vehreschild, Julia Lanznaster, Maria Madeleine Ruethrich, Stefan Borgmann, Martin Hower, Kai Wille, Torsten Feldt, Siegbert Rieg, Bernd Hertenstein, Christoph Wyen, Christoph Roemmele, Jörg Janne Vehreschild, Carolin E.M. Jakob, Melanie Stecher, Maria Kuzikov, Andrea Zaliani, Holger Fröhlich

Source: Artificial Intelligence in the Life Sciences, Vol 1, Iss , Pp 100020- (2021)

Subject Terms: Machine learning, Explainable ai, Precision medicine, Covid19, Drug repositioning, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667318521000209; https://doaj.org/toc/2667-3185

Access URL: https://doaj.org/article/f1ebf07fad2e486282bb8146b1b0d351

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

Authors: Pasquale Linciano, Alice Dawson, Ina Pöhner, David M. Costa, Monica S. Sá, Anabela Cordeiro-da-Silva, Rosaria Luciani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Philip Gribbon, Jeanette Reinshagen, Markus Wolf, Birte Behrens, Véronique Hannaert, Paul A. M. Michels, Erika Nerini, Cecilia Pozzi, Flavio di Pisa, Giacomo Landi, Nuno Santarem, Stefania Ferrari, Puneet Saxena, Sandra Lazzari, Giuseppe Cannazza, Lucio H. Freitas-Junior, Carolina B. Moraes, Bruno S. Pascoalino, Laura M. Alcântara, Claudia P. Bertolacini, Vanessa Fontana, Ulrike Wittig, Wolfgang Müller, Rebecca C. Wade, William N. Hunter, Stefano Mangani, Luca Costantino, Maria P. Costi

Source: ACS Omega, Vol 2, Iss 9, Pp 5666-5683 (2017)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2470-1343

Access URL: https://doaj.org/article/5c64fcc1dcb6440098320d12bd53e394

Design, Synthesis and Antiparasitic Evaluation of Click Phospholipids

Authors: George E. Magoulas, Pantelis Afroudakis, Kalliopi Georgikopoulou, Marina Roussaki, Chiara Borsari, Theano Fotopoulou, Nuno Santarem, Emile Barrias, Paloma Tejera Nevado, Julia Hachenberg, Eugenia Bifeld, Bernhard Ellinger, Maria Kuzikov, Irini Fragiadaki, Effie Scoulica, Joachim Clos, Sheraz Gul, Maria Paola Costi, Wanderley de Souza, Kyriakos C. Prousis, Anabela Cordeiro da Silva, Theodora Calogeropoulou

Source: Molecules, Vol 26, Iss 14, p 4204 (2021)

Subject Terms: ether phospholipids, heterocyclic rings, antiparasitic activity, Leishmania infantum, Leishmania donovani, Trypanosoma brucei, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/14/4204; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/445daea165834b30a0f90e3cf6bb94b0