Synthesis and biological assessment of BUB1B inhibitors for the treatment of clear cell renal cell carcinoma

Authors: El Hafi, Mohamed ^{a, b, 1}, Bouzian, Younos ^{a, 1}, Parvizi, Negar ^{a, 1}, Kim, Woonghee ^{c, 1}, Subaşioğlu, Mine ^a, Ozcan, Mehmet ^d, Turkez, Hasan ^e, Mardinoglu, Adil ^{c, f, ⁎}

Source: In European Journal of Medicinal Chemistry 5 March 2025 285

Integrative proteo-transcriptomic characterization of advanced fibrosis in chronic liver disease across etiologies

Authors: Yang, Hong ^{1, 12}, Atak, Dila ^{2, 12}, Yuan, Meng ¹, Li, Mengzhen ¹, Altay, Ozlem ¹, Demirtas, Elif ³, Peltek, Ibrahim Batuhan ³, Ulukan, Burge ², Yigit, Buket ², Sipahioglu, Tarik ², Álvez, María Bueno ¹, Meng, Lingqi ¹, Yüksel, Bayram ⁴, Turkez, Hasan ⁵, Kirimlioglu, Hale ⁶, Saka, Burcu ⁷, Yurdaydin, Cihan ², Akyildiz, Murat ², Dayangac, Murat ⁹, Uhlen, Mathias ¹, Boren, Jan ⁸, Zhang, Cheng ¹, Mardinoglu, Adil ^{1, 10, ∗}, Zeybel, Mujdat ^{2, 11, 13, ∗∗}

Source: In Cell Reports Medicine 18 February 2025 6(2)

The Human Pathology Atlas for deciphering the prognostic features of human cancers

Authors: Yuan, Meng ^a, Zhang, Cheng ^a, Von Feilitzen, Kalle ^a, Zwahlen, Martin ^a, Shi, Mengnan ^a, Li, Xiangyu ^b, Yang, Hong ^a, Song, Xiya ^a, Turkez, Hasan ^c, Uhlén, Mathias ^a, Mardinoglu, Adil ^{a, d, ∗}

Source: In eBioMedicine January 2025 111

The multifaceted role of post-translational modifications of LSD1 in cellular processes and disease pathogenesis

Authors: Li, Yinrui ^{b, c, 1}, Wang, Bo ^{b, c, 1}, Zheng, Yichao ^{b, c}, Kang, Huiqin ^{b, c}, He, Ang ^{b, c}, Zhao, Lijuan ^d, Guo, Ningjie ^{b, c}, Liu, Hongmin ^{b, c}, Mardinoglu, Adil ^{e, f}, Mamun, M.A.A. ^{b, c}, Gao, Ya ^{b, c, ⁎}, Chen, Xiaobing ^{a, ⁎⁎}

Source: In Genes & Diseases May 2025 12(3)

Synthesis of novel tetrahydrobenzo[b]thiophene-3-carbonitrile (THBTC)-based heterocycles: Structural insights, reactivity profiles, and in-silico bioactivity studies

Authors: Sebhaoui, Jihad ^{a, b, 1}, Ashraf, Sajda ^{a, 1}, Iqbal, Shazia ^a, Hajji, Melek ^{c, ⁎⁎}, Belmen, Burcu ^a, Yeşilyurt, Güldeniz ^a, Hanashalshahaby, Essam ^a, Zhang, Cheng ^d, Uhlen, Mathias ^d, Boren, Jan ^e, Turkez, Hasan ^f, Mardinoglu, Adil ^{d, g, ⁎}

Source: In Journal of Molecular Structure 5 April 2025 1326

Oral-gut microbiome interactions in advanced cirrhosis: characterisation of pathogenic enterotypes and salivatypes, virulence factors and antimicrobial resistance

Authors: Lee, Sunjae ^{1, 2, †}, Arefaine, Bethlehem ^{3, †}, Begum, Neelu ¹, Stamouli, Marilena ³, Witherden, Elizabeth ¹, Mohamad, Merianne ³, Harzandi, Azadeh ¹, Zamalloa, Ane ⁴, Cai, Haizhuang ¹, Williams, Roger ^{3, #}, Curtis, Michael A. ^{1, 5}, Edwards, Lindsey A. ¹, Chokshi, Shilpa ³, Mardinoglu, Adil ^{1, 6}, Proctor, Gordon ^{1, 5}, Moyes, David L. ¹, McPhail, Mark J. ^{3, 4}, Shawcross, Debbie L. ^{3, 4}, Uhlen, Mathias ⁶, Shoaie, Saeed ^{1, 6, ⁎, ‡}, Patel, Vishal C. ^{3, 4, ⁎, ‡}

Source: In Journal of Hepatology April 2025 82(4):622-633

Targeting Alzheimer's disease with novel dual-function 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carbothioamide derivatives

Authors: Katsogiannou, Aikaterini, Karta, Danai, Di Stefano, Antonio, Oner, Sena, Arslan, Mehmet Enes, Mardinoglu, Adil, Turkez, Hasan, Vassiliou, Stamatia, Cacciatore, Ivana

Source: In European Journal of Medicinal Chemistry Reports December 2024 12

A cocktail of histidine, carnosine, cysteine and serine reduces adiposity and improves metabolic health and adipose tissue immunometabolic function in ovariectomized rats

Authors: Baudin, Julio, Hernandez-Baixauli, Julia, Romero-Giménez, Jordi, Yang, Hong, Mulero, Francisca, Puiggròs, Francesc, Mardinoglu, Adil, Arola, Lluís, Caimari, Antoni

Source: In Biomedicine & Pharmacotherapy October 2024 179

Design and evaluation of novel inhibitors for the treatment of clear cell renal cell carcinoma

Authors: Bouzian, Younos, El Hafi, Mohamed, Parvizi, Negar, Kim, Woonghee, Subaşioğlu, Mine, Ozcan, Mehmet, Turkez, Hasan, Mardinoglu, Adil

Source: In Bioorganic Chemistry October 2024 151

Synthesis, spectroscopic characterization, DFT and molecular docking of N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl) naphthalene-1-sulfonamide derivatives

Authors: Ashraf, Sajda, Iqbal, Shazia, Sebhaoui, Jihad, Ozcan, Mehmet, Kim, Woonghee, Belmen, Burcu, Yeşilyurt, Güldeniz, Hanashalshahaby, Essam, Zhang, Cheng, Uhlen, Mathias, Boren, Jan, Turkez, Hasan, Mardinoglu, Adil

Source: In Journal of Molecular Structure 15 September 2024 1312 Part 2

Unveiling structural features, chemical reactivity, and bioactivity of a newly synthesized purine derivative through crystallography and computational approaches

Authors: Abad, Nadeem, Buhlak, Shafeek, Hajji, Melek, Saffour, Sana, Akachar, Jihane, Kesgun, Yunus, Al-Ghulikah, Hanan, Hanashalshahaby, Essam, Turkez, Hasan, Mardinoglu, Adil

Source: In Journal of Molecular Structure 5 September 2024 1311

Genome-wide expression analysis in a Fabry disease human podocyte cell line

Authors: Snanoudj, Sarah ^a, Derambure, Céline ^b, Zhang, Cheng ^c, Hai Yen, Nguyen Thi ^a, Lesueur, Céline ^a, Coutant, Sophie ^b, Abily-Donval, Lénaïg ^d, Marret, Stéphane ^d, Yang, Hong ^c, Mardinoglu, Adil ^{c, e}, Bekri, Soumeya ^a, Tebani, Abdellah ^{a, ⁎}

Source: In Heliyon 30 July 2024 10(14)

Novel drug targets and molecular mechanisms for sarcopenia based on systems biology

Authors: Ceyhan, Atakan Burak, Ozcan, Mehmet, Kim, Woonghee, Li, Xiangyu, Altay, Ozlem, Zhang, Cheng, Mardinoglu, Adil

Source: In Biomedicine & Pharmacotherapy July 2024 176

Design and synthesis of novel JNK inhibitors targeting liver pyruvate kinase for the treatment of non-alcoholic fatty liver disease and hepatocellular carcinoma

Authors: Iqbal, Shazia, Sebhaoui, Jihad, Ashraf, Sajda, Ozcan, Mehmet, Kim, Woonghee, Belmen, Burcu, Yeşilyurt, Güldeniz, Hanashalshahaby, Essam, Zhang, Cheng, Uhlen, Mathias, Boren, Jan, Turkez, Hasan, Mardinoglu, Adil

Source: In Bioorganic Chemistry June 2024 147

Sulfone-based human liver pyruvate kinase inhibitors – Design, synthesis and in vitro bioactivity

Authors: Matić, Josipa, Akladios, Fady, Battisti, Umberto Maria, Håversen, Liliana, Nain-Perez, Amalyn, Füchtbauer, Anders Foller, Kim, Woonghee, Monjas, Leticia, Rivero, Alexandra Rodriguez, Borén, Jan, Mardinoglu, Adil, Uhlen, Mathias, Grøtli, Morten

Source: In European Journal of Medicinal Chemistry 5 April 2024 269

A comparison between different human hepatocyte models reveals profound differences in net glucose production, lipid composition and metabolism in vitro

Authors: Bonanini, Flavio, Singh, Madhulika, Yang, Hong, Kurek, Dorota, Harms, Amy C., Mardinoglu, Adil, Hankemeier, Thomas

Source: In Experimental Cell Research 1 April 2024 437(1)

Remodeling of the human skeletal muscle proteome found after long-term endurance training but not after strength training

Authors: Emanuelsson, Eric B. ¹, Arif, Muhammad ², Reitzner, Stefan M. ^{1, 3}, Perez, Sean ⁴, Lindholm, Maléne E. ^{1, 5}, Mardinoglu, Adil ^{2, 6}, Daub, Carsten ^{7, 8}, Sundberg, Carl Johan ^{1, 9, 10}, Chapman, Mark A. ^{1, 11, 12, ∗}

Source: In iScience 19 January 2024 27(1)

Molecular profiling of high-level athlete skeletal muscle after acute endurance or resistance exercise – A systems biology approach

Authors: Reitzner, Stefan M., Emanuelsson, Eric B., Arif, Muhammad, Kaczkowski, Bogumil, Kwon, Andrew TJ., Mardinoglu, Adil, Arner, Erik, Chapman, Mark A., Sundberg, Carl Johan

Source: In Molecular Metabolism January 2024 79

Tuning of CHO secretional machinery improve activity of secreted therapeutic sulfatase 150-fold

Authors: Thalén, Niklas Berndt, Barzadd, Mona Moradi, Lundqvist, Magnus, Rodhe, Johanna, Andersson, Monica, Bidkhori, Gholamreza, Possner, Dominik, Su, Chao, Nilsson, Joakim, Eisenhut, Peter, Malm, Magdalena, Karlsson, Alice, Vestin, Jeanette, Forsberg, Johan, Nordling, Erik, Mardinoglu, Adil, Volk, Anna-Luisa, Sandegren, Anna, Rockberg, Johan

Source: In Metabolic Engineering January 2024 81:157-166

Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators

Authors: Yang, Hong, Li, Xiangyu, Jin, Han, Turkez, Hasan, Ozturk, Gurkan, Doganay, Hamdi Levent, Zhang, Cheng, Nielsen, Jens, Uhlén, Mathias, Borén, Jan, Mardinoglu, Adil

Source: Free radical biology and medicine. 204:347-358

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