FT-4202, a selective pyruvate kinase R activator for sickle cell disease

Authors: Ericsson, Anna ^a, Richard, David J. ^a, Wilker, Erik ^a, Lancia, David R., Jr. ^a, Fessler, Shawn ^a, Troccolo, Paul ^a, Zheng, Xiaozhang ^a, Toms, Angela ^a, Dinsmore, Christopher ^a, Yao, Lili ^a, Kuypers, Frans A. ^b, Larkin, Sandra ^b, Marcotte, Douglas ^a, Fulzele, Keertik ^a, Ribadeneira, Maria ^a, Guichard, Sylvie M. ^{c, ⁎}, Marshall, Gary ^a

Source: In Experimental Hematology January 2025 141

Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model

Authors: Vandeveer, George H., Arduini, Robert M., Baker, Darren P., Barry, Kevin, Bohnert, Tonika, Bowden-Verhoek, Jon K., Conlon, Patrick, Cullen, Patrick F., Guan, Bing, Jenkins, Tracy J., Liao, Shu-Yu, Lin, Lin, Liu, Yu-Ting, Marcotte, Douglas, Mertsching, Elisabeth, Metrick, Claire M., Negrou, Ella, Powell, Noel, Scott, Daniel, Silvian, Laura F., Hopkins, Brian T.

Source: Bioorganic & medicinal chemistry letters. 80

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179026268.0x000001&indx=1&recIds=ETOCvdc_100179026268.0x000001

Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens

Authors: Hopkins, Brian T., Bame, Eris, Bell, Noah, Bohnert, Tonika, Bowden-Verhoek, Jon K., Bui, Minna, Cancilla, Mark T., Conlon, Patrick, Cullen, Patrick, Erlanson, Daniel A., Fan, Junfa, Fuchs-Knotts, Tarra, Hansen, Stig, Heumann, Stacey, Jenkins, Tracy J., Marcotte, Douglas, McDowell, Bob, Mertsching, Elisabeth, Negrou, Ella, Otipoby, Kevin L., Poreci, Urjana, Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Yang, Wenjin, Zhong, Min

Source: In Bioorganic & Medicinal Chemistry 1 July 2019 27(13):2905-2913

The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small‐molecule inhibitor

Authors: Marcotte, Douglas J., Spilker, Kerri A., Wen, Dingyi, Hesson, Thomas, Patterson, Thomas A., Kumar, P. Rajesh, Chodaparambil, Jayanth V.

Source: Acta crystallographica.Section F.Structural biology communications. 76(3):103-108

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103162541.0x000001&indx=1&recIds=ETOCvdc_100103162541.0x000001

Discovery of Potent Isoindolinone Inhibitors that Target an Active Conformation of PARP1 Using DNA‐Encoded Libraries.

Authors: McCarthy, Kelly A., Marcotte, Douglas J., Parelkar, Sangram, McKinnon, Crystal L., Trammell, Lindsay E., Stangeland, Eric L., Jetson, Rachael R.

Source: ChemMedChem; 6/3/2024, Vol. 19 Issue 11, p1-4, 4p

Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity

Authors: May-Dracka, Tricia L., Arduini, Robert, Bertolotti-Ciarlet, Andrea, Bhisetti, Govinda, Brickelmaier, Margot, Cahir-McFarland, Ellen, Enyedy, Istvan, Fontenot, Jason D., Hesson, Thomas, Little, Kevin, Lyssikatos, Joe, Marcotte, Douglas, McKee, Timothy, Murugan, Paramasivam, Patterson, Thomas, Peng, Hairuo, Rushe, Mia, Silvian, Laura, Spilker, Kerri, Wu, Ping, Xin, Zhili, Burkly, Linda C.

Source: Bioorganic & medicinal chemistry letters. 28(10):1964-1971

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116328553.0x000001&indx=1&recIds=ETOCvdc_100116328553.0x000001

Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction

Authors: Lin, Edward, Silvian, Laura, Marcotte, Douglas, Banos, Charles, Jow, Flora, Chan, Timothy, Arduini, Robert, Qian, Fang, Baker, Darren, Bergeron, Chris, Hession, Catherine, Huganir, Richard, Borenstein, Cassandra, Enyedy, Istvan, Zou, Jinming, Rohde, Ellen, Wittmann, Marion, Kumaravel, Gnanasambandam, Rhodes, Kenneth, Scannevin, Robert, Dunah, Anthone, Guckian, Kevin

Source: Scientific reports. 8(1):1-10

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181165969.0x000001&indx=1&recIds=ETOCvdc_100181165969.0x000001

Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors

Authors: Hopkins, Brian T., Bame, Eris, Bell, Noah, Bohnert, Tonika, Bowden-Verhoek, Jon K., Bui, Minna, Cancilla, Mark T., Conlon, Patrick, Cullen, Patrick, Erlanson, Daniel A., Fan, Junfa, Fuchs-Knotts, Tarra, Hansen, Stig, Heumann, Stacey, Jenkins, Tracy J., Gua, Chuck, Liu, Ying, Liu, YuTing, Lulla, Mukush, Marcotte, Douglas, Marx, Isaac, McDowell, Bob, Mertsching, Elisabeth, Negrou, Ella, Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Yang, Wenjin, Zhong, Min

Source: Bioorganic & medicinal chemistry. 44

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144215683.0x000001&indx=1&recIds=ETOCvdc_100144215683.0x000001

Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol

Alternate Title: Covalent Jak3 Inhibitor (English)

Authors: Goedken, Eric R., Argiriadi, Maria A., Banach, David L., Fiamengo, Bryan A., Foley, Sage E., Frank, Kristine E., George, Jonathan S., Harris, Christopher M., Hobson, Adrian D., Ihle, David C., Marcotte, Douglas, Merta, Philip J., Michalak, Mark E., Murdock, Sara E., Tomlinson, Medha J., Voss, Jeffrey W.

Source: In Journal of Biological Chemistry 20 February 2015 290(8):4573-4589

Discovery of biaryls as RORγ inverse agonists by using structure-based design

Authors: Enyedy, Istvan J., Powell, Noel A., Caravella, Justin, van Vloten, Kurt, Chao, Jianhua, Banerjee, Daliya, Marcotte, Douglas, Silvian, Laura, McKenzie, Andres, Hong, Victor Sukbong, Fontenot, Jason D.

Source: Bioorganic & medicinal chemistry letters. 26(10):2459-2463

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129399080.0x000001&indx=1&recIds=ETOCvdc_100129399080.0x000001

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

Authors: Marcotte, Douglas, Zeng, Weike, Hus, Jean-Christophe, McKenzie, Andres, Hession, Cathy, Jin, Ping, Bergeron, Chris, Lugovskoy, Alexey, Enyedy, Istvan, Cuervo, Hernan, Wang, Deping, Atmanene, Cédric, Roecklin, Dominique, Vecchi, Malgorzata, Vivat, Valérie, Kraemer, Joachim, Winkler, Dirk, Hong, Victor, Chao, Jianhua, Lukashev, Matvey, Silvian, Laura

Source: In Bioorganic & Medicinal Chemistry 15 July 2013 21(14):4011-4019

Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators

Authors: Ma, Bin, Lucas, Brian, Capacci, Andrew, Lin, Edward Yin-Shiang, Jones, John Howard, Dechantsreiter, Michael, Enyedy, Istvan, Marcotte, Douglas, Xiao, Guangqing, Li, Bing, Richter, Karl

Source: Bioorganic & medicinal chemistry letters. 30(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111596539.0x000001&indx=1&recIds=ETOCvdc_100111596539.0x000001

Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors.

Authors: Amaral, Brenda, Capacci, Andrew, Anderson, Trip, Tezer, Ceren, Bajrami, Bekim, Lulla, Mukesh, Lucas, Brian, Chodaparambil, Jayanth V., Marcotte, Douglas, Kumar, P. Rajesh, Murugan, Paramasivam, Spilker, Kerri, Cullivan, Mike, Wang, Ti, Peterson, Anton C., Enyedy, Istvan, Ma, Bin, Chen, TeYu, Yousaf, Zain, Calhoun, Michael

Source: ACS Chemical Neuroscience; 3/15/2023, Vol. 14 Issue 6, p1080-1094, 15p

Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand.

Authors: Marcotte, Douglas J.¹ doug.marcotte@biogenidec.com, YuTing Liu¹, Little, Kevin¹, Jones, John H.¹, Powell, Noel A.², Wildes, Craig P.³, Silvian, Laura F.¹, Chodaparambil, Jayanth V.¹

Source: BMC Structural Biology. 6/1/2016, Vol. 16, p1-9. 9p. 6 Diagrams, 1 Chart, 1 Graph.

Subject Terms: *NUCLEAR receptors (Biochemistry), *BENZOXAZINONES, *LIGAND binding (Biochemistry), *GENETIC transcription, *AUTOIMMUNE diseases, *INTERLEUKIN-17, *PROTEIN-protein interactions

Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo.

Authors: Jones, J. Howard, Zhili Xin, Himmelbauer, Martin, Dechantsreiter, Michael, Enyedy, Istvan, Hedde, Joseph, Fang, Terry, Coomaraswamy, Janaky, King, Kristopher W., Murugan, Paramasivam, Santoro, Joseph C., Hesson, Thomas, Walther, Dirk M., Ru Wei, Fengmei Zheng, Marcotte, Douglas J., Spilker, Kerri, Kumar, P. Rajesh, Ying Liu, Gilfillan, Rab

Source: Journal of Medicinal Chemistry; 10/28/2021, Vol. 64 Issue 20, p15402-15419, 18p

Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.

Authors: Bao, Channa, Bajrami, Bekim, Marcotte, Douglas J., Chodaparambil, Jayanth V., Kerns, Hannah M., Henderson, Jaclyn, Wei, Ru, Gao, Benbo, Dillon, Gregory M.

Source: Cellular & Molecular Neurobiology; May2021, Vol. 41 Issue 4, p669-685, 17p

Subject Terms: TAU proteins, SPINOCEREBELLAR ataxia, ALZHEIMER'S disease, FRONTOTEMPORAL dementia, PHOSPHORYLATION, CATALYTIC domains

Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.

Authors: Ma, Bin, Bohnert, Tonika, Otipoby, Kevin L., Tien, Eric, Arefayene, Million, Bai, Judy, Bajrami, Bekim, Bame, Eris, Chan, Timothy R., Humora, Michael, MacPhee, J. Michael, Marcotte, Douglas, Mehta, Devangi, Metrick, Claire M., Moniz, George, Polack, Evelyne, Poreci, Urjana, Prefontaine, Annick, Sheikh, Sarah, Schroeder, Patricia

Source: Journal of Medicinal Chemistry; 11/12/2020, Vol. 63 Issue 21, p12526-12541, 16p

Discovery of novel pyrazole-containing benzamides as potent RORγ inverse agonists

Authors: Wang, Tao, Banerjee, Daliya, Bohnert, Tonika, Chao, Jianhua, Enyedy, Istvan, Fontenot, Jason, Guertin, Kevin, Jones, Howard, Lin, Edward Y., Marcotte, Douglas, Talreja, Tina, Van Vloten, Kurt

Source: In Bioorganic & Medicinal Chemistry Letters 1 August 2015 25(15):2985-2990

Discovery of biaryl carboxylamides as potent RORγ inverse agonists

Authors: Chao, Jianhua, Enyedy, Istvan, Van Vloten, Kurt, Marcotte, Douglas, Guertin, Kevin, Hutchings, Richard, Powell, Noel, Jones, Howard, Bohnert, Tonika, Peng, Chi-Chi, Silvian, Laura, Hong, Victor Sukbong, Little, Kevin, Banerjee, Daliya, Peng, Liaomin, Taveras, Arthur, Viney, Joanne L., Fontenot, Jason

Source: In Bioorganic & Medicinal Chemistry Letters 1 August 2015 25(15):2991-2997

This result is not displayed to guests.
Login for full access.