Mitochondria-Targeted COUPY Photocages: Synthesis and Visible-Light Photoactivation in Living Cells

Authors: López-Corrales, Marta, Rovira, Anna, Gandioso, Albert, Nonell, Santi, Bosch, Manel, Marchán, Vicente

Source: Journal of organic chemistry. 88(11):7128-7140

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A near-infrared light-activatable Ru(ii)-coumarin photosensitizer active under hypoxic conditionsElectronic supplementary information (ESI) available: Additional tables and figures for photophysical and photochemical characterization of the compounds and copies of NMR and MS spectra. See DOI: https://doi.org/10.1039/d3sc01844j

Authors: Ortega-Forte, Enrique, Rovira, Anna, López-Corrales, Marta, Hernández-García, Alba, Ballester, Francisco José, Izquierdo-García, Eduardo, Jordà-Redondo, Mireia, Bosch, Manel, Nonell, Santi, Santana, María Dolores, Ruiz, José, Marchán, Vicente, Gasser, Gilles

Source: Chemical science. 14(26):7170-7184

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186732417.0x000001&indx=1&recIds=ETOCvdc_100186732417.0x000001

Ruthenium(II) Polypyridyl Complexes Containing COUBPY Ligands as Potent Photosensitizers for the Efficient Phototherapy of Hypoxic Tumors.

Authors: Abad-Montero, Diego, Gandioso, Albert, Izquierdo-García, Eduardo, Chumillas, Sergi, Rovira, Anna, Bosch, Manel, Jordà-Redondo, Mireia, Castaño, Davor, Bonelli, Joaquín, Novikov, Valentin V., Deyà, Alba, Hernández, José Luis, Galino, Jorge, Alberto, Marta E., Francés-Monerris, Antonio, Nonell, Santi, Gasser, Gilles, Marchán, Vicente

Source: Journal of the American Chemical Society; 3/5/2025, Vol. 147 Issue 9, p7360-7376, 17p

Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane—Polyurea Hybrid Nanocarrier

Authors: Bonelli, Joaquín, Ortega-Forte, Enrique, Rovira, Anna, Bosch, Manel, Torres, Oriol, Cuscó, Cristina, Rocas, Josep, Ruiz, José, Marchán, Vicente

Source: Biomacromolecules. 23(7):2900-2913

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632324817&indx=1&recIds=ETOCRN632324817

Polyurethane–polyurea hybrid nanocapsules as efficient delivery systems of anticancer Ir(iii) metallodrugsElectronic supplementary information (ESI) available: General methods and analytical techniques. Additional figures for the synthesis and characterization of Ir(iii) complexes (NMR, MS) and of the corresponding Ir(iii)-loaded nanocapsules (IR, DLS, TEM, Z-potential, ICP-MS), and for their biological evaluation (confocal microscopy, antiproliferative activity, morphological analysis of cells, cell membrane integrity test, mitochondrial potential assessment, aerobic respiration and glycolytic rate evaluation and oxidative stress induction). See DOI: 10.1039/d1qi01542g

Authors: Bonelli, Joaquín, Ortega-Forte, Enrique, Vigueras, Gloria, Bosch, Manel, Cutillas, Natalia, Rocas, Josep, Ruiz, José, Marchán, Vicente

Source: Inorganic chemistry frontiers. 9(10):2123-2138

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150901257.0x000001&indx=1&recIds=ETOCvdc_100150901257.0x000001

A Cyclometalated IrIII Complex Conjugated to a Coumarin Derivative Is a Potent Photodynamic Agent against Prostate Differentiated and Tumorigenic Cancer Stem Cells

Authors: Novohradsky, Vojtech, Markova, Lenka, Kostrhunova, Hana, Kasparkova, Jana, Ruiz, José, Marchán, Vicente, Brabec, Viktor

Source: Chemistry. 27(33):8547-8556

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100122584826.0x000001&indx=1&recIds=ETOCvdc_100122584826.0x000001

A versatile click chemistry-based approach for functionalizing biomaterials of diverse nature with bioactive peptidesElectronic supplementary information (ESI) available. See DOI: 10.1039/d0cc07463b

Authors: Martin-Gómez, Helena, Oliver-Cervelló, Lluís, Sánchez-Campillo, Iván, Marchán, Vicente, Ginebra, Maria-Pau, Mas-Moruno, Carlos

Source: Chemical communications. 57(8):982-985

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116470984.0x000001&indx=1&recIds=ETOCvdc_100116470984.0x000001

Transformation of COUPY Fluorophores into a Novel Class of Visible‐Light‐Cleavable Photolabile Protecting Groups

Authors: López‐Corrales, Marta, Rovira, Anna, Gandioso, Albert, Bosch, Manel, Nonell, Santi, Marchán, Vicente

Source: Chemistry. 26(69):16222-16227

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115392793.0x000001&indx=1&recIds=ETOCvdc_100115392793.0x000001

Unexpected photoactivation pathways in a folate-receptor-targeted trans-diazido Pt(iv) anticancer pro-drugElectronic supplementary information (ESI) available. See DOI: 10.1039/d0dt02577a

Authors: Gandioso, Albert, Rovira, Anna, Shi, Huayun, Sadler, Peter J., Marchán, Vicente

Source: Dalton transactions. 49(34):11828-11834

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108597315.0x000001&indx=1&recIds=ETOCvdc_100108597315.0x000001

A simple method for the synthesis of N-difluoromethylated pyridines and 4-pyridones/quinolones by using BrCF2COOEt as the difluoromethylation reagentElectronic supplementary information (ESI) available: Experimental procedures and characterization data of all compounds. See DOI: 10.1039/d0ra06322c

Authors: Gandioso, Albert, El Fakiri, Mohamed, Rovira, Anna, Marchán, Vicente

Source: RSC advances. 10(50):29829-29834

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185815240.0x000001&indx=1&recIds=ETOCvdc_100185815240.0x000001

Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated IrIII Complex Conjugated to a Far‐Red Emitting Coumarin

Authors: Novohradsky, Vojtech, Rovira, Anna, Hally, Cormac, Galindo, Alex, Vigueras, Gloria, Gandioso, Albert, Svitelova, Marie, Bresolí‐Obach, Roger, Kostrhunova, Hana, Markova, Lenka, Kasparkova, Jana, Nonell, Santi, Ruiz, José, Brabec, Viktor, Marchán, Vicente

Source: Angewandte Chemie. 131(19):6377-6381

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094116681.0x000001&indx=1&recIds=ETOCvdc_100094116681.0x000001

A Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer Agent.

Authors: Bonelli, Joaquín, Ortega-Forte, Enrique, Vigueras, Gloria, Follana-Berná, Jorge, Ashoo, Pezhman, Abad-Montero, Diego, Isidro, Neus, López-Corrales, Marta, Hernández, Adrián, Ortiz, Javier, Izquierdo-García, Eduardo, Bosch, Manel, Rocas, Josep, Sastre-Santos, Ángela, Ruiz, José, Marchán, Vicente

Source: ACS Applied Materials & Interfaces; 7/31/2024, Vol. 16 Issue 30, p38916-38930, 15p

Exploring Structural–Photophysical Property Relationships in Mitochondria-Targeted Deep-Red/NIR-Emitting Coumarins.

Authors: Izquierdo-García, Eduardo, Rovira, Anna, Forcadell, Joan, Bosch, Manel, Marchán, Vicente

Source: International Journal of Molecular Sciences; Dec2023, Vol. 24 Issue 24, p17427, 15p

Subject Terms: COUMARINS, NEAR infrared radiation, CONFOCAL microscopy, ELECTROMAGNETIC spectrum, CYANO group, HELA cells, PHOTOTHERMAL effect, TISSUES

Ru(II)‐Cyanine Complexes as Promising Photodynamic Photosensitizers for the Treatment of Hypoxic Tumours with Highly Penetrating 770 nm Near‐Infrared Light.

Authors: Gandioso, Albert¹, albert.gandioso@chimieparistech.psl.eu, Izquierdo‐García, Eduardo^1,2,3, Mesdom, Pierre¹, Arnoux, Philippe⁴, Demeubayeva, Nurikamal⁴, Burckel, Pierre⁵, Saubaméa, Bruno⁶, Bosch, Manel⁷, Frochot, Céline⁴, Marchán, Vicente^2,3, vmarchan@ub.edu, Gasser, Gilles¹, gilles.gasser@chimieparistech.psl.eu

Source: Chemistry - A European Journal; 11/2/2023, Vol. 29 Issue 61, p1-12, 12p

Frontispiece: Transformation of COUPY Fluorophores into a Novel Class of Visible‐Light‐Cleavable Photolabile Protecting Groups

Authors: López‐Corrales, Marta, Rovira, Anna, Gandioso, Albert, Bosch, Manel, Nonell, Santi, Marchán, Vicente

Source: Chemistry. 26(69)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115394047.0x000001&indx=1&recIds=ETOCvdc_100115394047.0x000001

Exploring the HIV-1 Rev Recognition Element (RRE)–Rev Inhibitory Capacity and Antiretroviral Action of Benfluron Analogs.

Authors: Chumillas, Sergi, Loharch, Saurabh, Beltrán, Manuela, Szewczyk, Mateusz P., Bernal, Silvia, Puertas, Maria C., Martinez-Picado, Javier, Alcamí, José, Bedoya, Luis M., Marchán, Vicente, Gallego, José

Source: Molecules; Oct2023, Vol. 28 Issue 20, p7031, 13p

Subject Terms: ANTI-HIV agents, HIV, GLOBAL burden of disease, RNA viruses, BENZOPYRENE, TENOFOVIR, ANTIRETROVIRAL agents, DRUG discovery, ANTIVIRAL agents

Exploring Structure–Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates.

Authors: Rovira, Anna, Ortega-Forte, Enrique, Hally, Cormac, Jordà-Redondo, Mireia, Abad-Montero, Diego, Vigueras, Gloria, Martínez, Jesús I., Bosch, Manel, Nonell, Santi, Ruiz, José, Marchán, Vicente

Source: Journal of Medicinal Chemistry; 6/22/2023, Vol. 66 Issue 12, p7849-7867, 19p

Novel Tumor-Targeted Self-Nanostructured and Compartmentalized Water-in-Oil-in-Water Polyurethane-Polyurea Nanocapsules for Cancer Theragnosis.

Authors: Bonelli, Joaquín, Velasco-de Andrés, María, Isidro, Neus, Bayó, Cristina, Chumillas, Sergi, Carrillo-Serradell, Laura, Casadó-Llombart, Sergi, Mok, Cheryl, Benítez-Ribas, Daniel, Lozano, Francisco, Rocas, Josep, Marchán, Vicente

Source: Pharmaceutics; Jan2023, Vol. 15 Issue 1, p58, 15p

Subject Terms: NANOCAPSULES, INDOCYANINE green, FLUORESCENT probes, HYDROPHILIC compounds, DENDRITIC cells, PREPOLYMERS, NANOMEDICINE

Fluorescently Labeled Ceramides and 1‑Deoxyceramides: Synthesis, Characterization, and Cellular Distribution Studies.

Authors: Izquierdo, Eduardo, López-Corrales, Marta, Abad-Montero, Diego, Rovira, Anna, Fabriàs, Gemma, Bosch, Manel, Abad, José Luís, Marchán, Vicente

Source: Journal of Organic Chemistry; 12/16/2022, Vol. 87 Issue 24, p16351-16367, 17p

SARS-CoV-2 Inhibitors Identified by Phenotypic Analysis of a Collection of Viral RNA-Binding Molecules.

Authors: Simba-Lahuasi, Alvaro, Cantero-Camacho, Ángel, Rosales, Romel, McGovern, Briana Lynn, Rodríguez, M. Luis, Marchán, Vicente, White, Kris M., García-Sastre, Adolfo, Gallego, José

Source: Pharmaceuticals (14248247); Dec2022, Vol. 15 Issue 12, p1448, 16p

Subject Terms: SARS-CoV-2, COVID-19 pandemic, PHENOTYPES, HAIRPIN (Genetics), INFECTION control