TRF2 as novel marker of tumor response to taxane-based therapy: from mechanistic insight to clinical implication

Authors: Sara Iachettini, Irene Terrenato, Manuela Porru, Serena Di Vito, Angela Rizzo, Carmen D’Angelo, Eleonora Petti, Roberto Dinami, Carmen Maresca, Anna Di Benedetto, Aldo Palange, Antonino Mulè, Angela Santoro, Antonella Palazzo, Paola Fuso, Antonella Stoppacciaro, Patrizia Vici, Lorena Filomeno, Francesca Sofia Di Lisa, Teresa Arcuri, Eriseld Krasniqi, Alessandra Fabi, Annamaria Biroccio, Pasquale Zizza

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)

Subject Terms: TRF2, Autophagy, Taxanes, Drug sensitivity, TNBC, Predictive marker, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/b5288dd001e444b193813380b0f2304e

Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer

Authors: Valeria Pecci, Fabiola Troisi, Aurora Aiello, Sara De Martino, Angela Carlino, Vincenzo Fiorentino, Cristian Ripoli, Dante Rotili, Francesco Pierconti, Maurizio Martini, Manuela Porru, Francesco Pinto, Antonello Mai, Pier Francesco Bassi, Claudio Grassi, Carlo Gaetano, Alfredo Pontecorvi, Lidia Strigari, Antonella Farsetti, Simona Nanni

Source: Cancer Cell International, Vol 24, Iss 1, Pp 1-17 (2024)

Subject Terms: lncRNA, Metastasis, Lysine demethylase, Preclinical models, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/2ef6b3a5976845e2bc6148989f39a138

Fluorescent nanodiamonds as innovative delivery systems for MiR-34a replacement in breast cancer

Authors: Marianna Abate, Angela Lombardi, Amalia Luce, Manuela Porru, Carlo Leonetti, Marco Bocchetti, Virginia Campani, Giuseppe De Rosa, Sossio Fabio Graziano, Valeria Nele, Francesco Cardile, Federica Zito Marino, Renato Franco, Andrea Ronchi, Marianna Scrima, Rossella Sperlongano, Roberto Alfano, Gabriella Misso, Evzen Amler, Michele Caraglia, Silvia Zappavigna

Source: Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 127-141 (2023)

Subject Terms: MT: Delivery Strategies, nanodiamonds, MicroRNA, breast cancer, gene delivery, nanomedicine, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253123001622; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/c25edbbf2a774f64bb6dcb2905b5ccfc

DARPP-32 and t-DARPP in the development of resistance to anti-HER2 agents. Pre-clinical evidence from the STEP study

Authors: Giulia Bon, Eriseld Krasniqi, Manuela Porru, Lorenzo D'Ambrosio, Stefano Scalera, Marcello Maugeri-Saccà, Francesca Sofia Di Lisa, Lorena Filomeno, Teresa Arcuri, Andrea Botticelli, Daniele Santini, Maria Agnese Fabbri, Giuliana D'Auria, Claudio Pulito, Giovanni Blandino, Caterina Marchiò, Maddalena Barba, Gennaro Ciliberto, Patrizia Vici, Laura Pizzuti

Source: Neoplasia: An International Journal for Oncology Research, Vol 45, Iss , Pp 100937- (2023)

Subject Terms: HER2 positive metastatic breast cancer, Pertuzumab pretreated, Real-world evidence, PPP1R1B, DARPP-32 and t-DARPP, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558623000611; https://doaj.org/toc/1476-5586

Access URL: https://doaj.org/article/f29fae04ef374dc0bbefa7906732c0e1

Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours

Authors: Florian J Groelly, Manuela Porru, Jutta Zimmer, Hugo Benainous, Yanti De Visser, Anastasiya A Kosova, Serena Di Vito, Violeta Serra, Anderson Ryan, Carlo Leonetti, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas

Source: EMBO Molecular Medicine, Vol 14, Iss 3, Pp 1-22 (2022)

Subject Terms: BRCA1, BRCA2, DNA damage responses, G‐quadruplex ligands, pyridostatin, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/02c619b0acf544c3b51f32c37322ca42

Correction to: Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Authors: Ilaria Romito, Manuela Porru, Maria Rita Braghini, Luca Pompili, Nadia Panera, Annalisa Crudele, Daniela Gnani, Cristiano De Stefanis, Marco Scarsella, Silvia Pomella, Stefano Levi Mortera, Emmanuel de Billy, Adrian Libenzio Conti, Valeria Marzano, Lorenza Putignani, Manlio Vinciguerra, Clara Balsano, Anna Pastore, Rossella Rota, Marco Tartaglia, Carlo Leonetti, Anna Alisi

Source: Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-6 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/7ea489c1d2f64a7ea2dea114313c315d

MiR‐182‐3p targets TRF2 and impairs tumor growth of triple‐negative breast cancer

Authors: Roberto Dinami, Luca Pompili, Eleonora Petti, Manuela Porru, Carmen D'Angelo, Serena Di Vito, Angela Rizzo, Virginia Campani, Giuseppe De Rosa, Alejandra Bruna, Violeta Serra, Miguel Mano, Mauro Giacca, Carlo Leonetti, Gennaro Ciliberto, Madalena Tarsounas, Antonella Stoppacciaro, Stefan Schoeftner, Annamaria Biroccio

Source: EMBO Molecular Medicine, Vol 15, Iss 1, Pp n/a-n/a (2023)

Subject Terms: miR‐182‐3p, target therapy, telomeres, TRF2, triple‐negative breast cancer, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/329d8d14529b400796d6b5c09e60a4e4

Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Authors: Ilaria Romito, Manuela Porru, Maria Rita Braghini, Luca Pompili, Nadia Panera, Annalisa Crudele, Daniela Gnani, Cristiano De Stefanis, Marco Scarsella, Silvia Pomella, Stefano Levi Mortera, Emmanuel de Billy, Adrian Libenzio Conti, Valeria Marzano, Lorenza Putignani, Manlio Vinciguerra, Clara Balsano, Anna Pastore, Rossella Rota, Marco Tartaglia, Carlo Leonetti, Anna Alisi

Source: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-19 (2021)

Subject Terms: HCC, FAK, Sorafenib, Epigenetic, Therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/4895e0e2b1b44fabbe5e18ca066750d0

Loss of HER2 and decreased T-DM1 efficacy in HER2 positive advanced breast cancer treated with dual HER2 blockade: the SePHER Study

Authors: Giulia Bon, Laura Pizzuti, Valentina Laquintana, Rossella Loria, Manuela Porru, Caterina Marchiò, Eriseld Krasniqi, Maddalena Barba, Marcello Maugeri-Saccà, Teresa Gamucci, Rossana Berardi, Lorenzo Livi, Corrado Ficorella, Clara Natoli, Enrico Cortesi, Daniele Generali, Nicla La Verde, Alessandra Cassano, Emilio Bria, Luca Moscetti, Andrea Michelotti, Vincenzo Adamo, Claudio Zamagni, Giuseppe Tonini, Giacomo Barchiesi, Marco Mazzotta, Daniele Marinelli, Silverio Tomao, Paolo Marchetti, Maria Rosaria Valerio, Rosanna Mirabelli, Antonio Russo, Maria Agnese Fabbri, Nicola D’Ostilio, Enzo Veltri, Domenico Corsi, Ornella Garrone, Ida Paris, Giuseppina Sarobba, Francesco Giotta, Carlo Garufi, Marina Cazzaniga, Pietro Del Medico, Mario Roselli, Giuseppe Sanguineti, Isabella Sperduti, Anna Sapino, Ruggero De Maria, Carlo Leonetti, Angelo Di Leo, Gennaro Ciliberto, Rita Falcioni, Patrizia Vici

Source: Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-14 (2020)

Subject Terms: HER2+ breast cancer, Trastuzumab/pertuzumab blockade, T-DM1 efficacy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/4d34ed52da98405db47bb21f0f6da119

TRF2 and VEGF-A: an unknown relationship with prognostic impact on survival of colorectal cancer patients

Authors: Roberto Dinami, Manuela Porru, Carla Azzurra Amoreo, Isabella Sperduti, Marcella Mottolese, Simonetta Buglioni, Daniele Marinelli, Marcello Maugeri-Saccà, Andrea Sacconi, Giovanni Blandino, Carlo Leonetti, Giuliana Di Rocco, Alessandra Verdina, Francesca Spinella, Francesco Fiorentino, Gennaro Ciliberto, Annamaria Biroccio, Pasquale Zizza

Source: Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-13 (2020)

Subject Terms: Colorectal cancer, TRF2, VEGF-A, Prognostic markers, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13046-020-01612-z; https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/767fa99324964b889013aba888fd2d7a

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

Authors: Timo Reisländer, Emilia Puig Lombardi, Florian J. Groelly, Ana Miar, Manuela Porru, Serena Di Vito, Benjamin Wright, Helen Lockstone, Annamaria Biroccio, Adrian Harris, Arturo Londoño-Vallejo, Madalena Tarsounas

Source: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a4c12a795f2a4463a4d0d639093cc868

Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance

Authors: Eliana MC Tacconi, Sophie Badie, Giuliana De Gregoriis, Timo Reisländer, Xianning Lai, Manuela Porru, Cecilia Folio, John Moore, Arnaud Kopp, Júlia Baguña Torres, Deborah Sneddon, Marcus Green, Simon Dedic, Jonathan W Lee, Ankita Sati Batra, Oscar M Rueda, Alejandra Bruna, Carlo Leonetti, Carlos Caldas, Bart Cornelissen, Laurent Brino, Anderson Ryan, Annamaria Biroccio, Madalena Tarsounas

Source: EMBO Molecular Medicine, Vol 11, Iss 7, Pp 1-16 (2019)

Subject Terms: alkylating agents, BRCA1, BRCA2, cisplatin, DNA damage responses, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/60b26d5b1f0d4fb1965e8459d8be9b33

Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities

Authors: Manuela Porru, Luca Pompili, Carla Caruso, Annamaria Biroccio, Carlo Leonetti

Source: Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-10 (2018)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13046-018-0719-1; https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/b8f9da400d3f457e935ec8277579877a

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

Authors: Eliana MC Tacconi, Xianning Lai, Cecilia Folio, Manuela Porru, Gijs Zonderland, Sophie Badie, Johanna Michl, Irene Sechi, Mélanie Rogier, Verónica Matía García, Ankita Sati Batra, Oscar M Rueda, Peter Bouwman, Jos Jonkers, Anderson Ryan, Bernardo Reina‐San‐Martin, Joannie Hui, Nelson Tang, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas

Source: EMBO Molecular Medicine, Vol 9, Iss 10, Pp 1398-1414 (2017)

Subject Terms: BRCA1, BRCA2, disulfiram, acetaldehyde dehydrogenase, DNA damage, replication stress, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/6bb88c58f3cf4cfc896831d828ae3700

Adipose-derived stem cell-mediated paclitaxel delivery inhibits breast cancer growth.

Authors: Maria Giovanna Scioli, Simona Artuso, Carmen D'Angelo, Manuela Porru, Federico D'Amico, Alessandra Bielli, Pietro Gentile, Valerio Cervelli, Carlo Leonetti, Augusto Orlandi

Source: PLoS ONE, Vol 13, Iss 9, p e0203426 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6128546?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/115f1bc36af24782aaf01b7c3d1523e5

Chitosan-Based Polyelectrolyte Complexes for Doxorubicin and Zoledronic Acid Combined Therapy to Overcome Multidrug Resistance

Authors: Simona Giarra, Silvia Zappavigna, Virginia Campani, Marianna Abate, Alessia Maria Cossu, Carlo Leonetti, Manuela Porru, Laura Mayol, Michele Caraglia, Giuseppe De Rosa

Source: Pharmaceutics, Vol 10, Iss 4, p 180 (2018)

Subject Terms: chitosan, polyelectrolyte complexes, doxorubicin, zoledronic acid, multidrug resistance, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: http://www.mdpi.com/1999-4923/10/4/180; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/e0d73bfea5d0491787e3d476479c4fdf

Effect of small molecules modulating androgen receptor (SARMs) in human prostate cancer models.

Authors: Anna Tesei, Carlo Leonetti, Marzia Di Donato, Elisa Gabucci, Manuela Porru, Greta Varchi, Andrea Guerrini, Dino Amadori, Chiara Arienti, Sara Pignatta, Giulia Paganelli, Michele Caraglia, Gabriella Castoria, Wainer Zoli

Source: PLoS ONE, Vol 8, Iss 5, p e62657 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23667504/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/1862085ca7bf4eeca8183e3e7658b889

Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo.

Authors: Lavinia Nardinocchi, Valentina Pantisano, Rosa Puca, Manuela Porru, Aurora Aiello, Annalisa Grasselli, Carlo Leonetti, Michal Safran, Gideon Rechavi, David Givol, Antonella Farsetti, Gabriella D'Orazi

Source: PLoS ONE, Vol 5, Iss 12, p e15048 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21179202/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ab2a4d89211047d4bc42ddf4cf41d1bc

N-Cyclic Bay-Substituted Perylene G-Quadruplex Ligands Have Selective Antiproliferative Effects on Cancer Cells and Induce Telomere Damage.

Authors: Valentina Casagrande, Erica Salvati, Antonello Alvino, Armandodoriano Bianco, Alina Ciammaichella, Carmen D’Angelo, Luca Ginnari-Satriani, Anna Maria Serrilli, Sara Iachettini, Carlo Leonetti, Stephen Neidle, Giancarlo Ortaggi, Manuela Porru, Angela Rizzo, Marco Franceschin, Annamaria Biroccio

Source: Journal of Medicinal Chemistry; Mar2011, Vol. 54 Issue 5, p1140-1156, 17p