LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice

Authors: Ramachandran Prakasam, Angela Bonadiman, Roberta Andreotti, Emanuela Zuccaro, Davide Dalfovo, Caterina Marchioretti, Debasmita Tripathy, Gianluca Petris, Eric N. Anderson, Alice Migazzi, Laura Tosatto, Anna Cereseto, Elena Battaglioli, Gianni Sorarù, Wooi Fang Lim, Carlo Rinaldi, Fabio Sambataro, Naemeh Pourshafie, Christopher Grunseich, Alessandro Romanel, Udai Bhan Pandey, Andrea Contestabile, Giuseppe Ronzitti, Manuela Basso, Maria Pennuto

Source: Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/9fd52a5a537f405caa90331491bb84a3

Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca2+ accumulation in spinobulbar muscular atrophy skeletal muscle

Authors: Caterina Marchioretti, Giulia Zanetti, Marco Pirazzini, Gaia Gherardi, Leonardo Nogara, Roberta Andreotti, Paolo Martini, Lorenzo Marcucci, Marta Canato, Samir R. Nath, Emanuela Zuccaro, Mathilde Chivet, Cristina Mammucari, Marco Pacifici, Anna Raffaello, Rosario Rizzuto, Andrea Mattarei, Maria A. Desbats, Leonardo Salviati, Aram Megighian, Gianni Sorarù, Elena Pegoraro, Elisa Belluzzi, Assunta Pozzuoli, Carlo Biz, Pietro Ruggieri, Chiara Romualdi, Andrew P. Lieberman, Gopal J. Babu, Marco Sandri, Bert Blaauw, Manuela Basso, Maria Pennuto

Source: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/82a8527dca0543cd91761ed8387c3654

Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis

Authors: Laura Pasetto, Stefano Callegaro, Alessandro Corbelli, Fabio Fiordaliso, Deborah Ferrara, Laura Brunelli, Giovanna Sestito, Roberta Pastorelli, Elisa Bianchi, Marina Cretich, Marcella Chiari, Cristina Potrich, Cristina Moglia, Massimo Corbo, Gianni Sorarù, Christian Lunetta, Andrea Calvo, Adriano Chiò, Gabriele Mora, Maria Pennuto, Alessandro Quattrone, Francesco Rinaldi, Vito Giuseppe D’Agostino, Manuela Basso, Valentina Bonetto

Source: Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-21 (2021)

Subject Terms: Extracellular vesicles, HSP90, PPIA, Phosphorylated TDP-43, Biomarkers, Machine learning, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/c1ded2cb5e844a29a6fd916295a220b1

A case report of late-onset cerebellar ataxia associated with a rare p.R342W TGM6 (SCA35) mutation

Authors: Arianna Manini, Tommaso Bocci, Alice Migazzi, Edoardo Monfrini, Dario Ronchi, Giulia Franco, Anna De Rosa, Ferdinando Sartucci, Alberto Priori, Stefania Corti, Giacomo Pietro Comi, Nereo Bresolin, Manuela Basso, Alessio Di Fonzo

Source: BMC Neurology, Vol 20, Iss 1, Pp 1-7 (2020)

Subject Terms: Spinocerebellar ataxias, SCA35, TGM6, Transglutaminase, Case report, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12883-020-01964-1; https://doaj.org/toc/1471-2377

Access URL: https://doaj.org/article/6a5f6dd8716f4871a5e1487ed447e030

Motor Neuron Diseases and Neuroprotective Peptides: A Closer Look to Neurons

Authors: Emanuela Zuccaro, Diana Piol, Manuela Basso, Maria Pennuto

Source: Frontiers in Aging Neuroscience, Vol 13 (2021)

Subject Terms: motor neuron (MN), IGF-1 (insulin-like growth factor 1), PACAP (pituitary adenylate cyclase-activating polypeptide), motor neuron disease (MND), ALS (Amyotrophic lateral sclerosis), spinobulbar muscular atrophy (SBMA), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnagi.2021.723871/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/140e54cf59e24f8181d10beb6754d262

Huntingtin-mediated axonal transport requires arginine methylation by PRMT6

Authors: Alice Migazzi, Chiara Scaramuzzino, Eric N. Anderson, Debasmita Tripathy, Ivó H. Hernández, Rogan A. Grant, Michela Roccuzzo, Laura Tosatto, Amandine Virlogeux, Chiara Zuccato, Andrea Caricasole, Tamara Ratovitski, Christopher A. Ross, Udai B. Pandey, José J. Lucas, Frédéric Saudou, Maria Pennuto, Manuela Basso

Source: Cell Reports, Vol 35, Iss 2, Pp 108980- (2021)

Subject Terms: huntingtin, Huntington’s disease, axonal transport, arginine methylation, PRMT6, protein post-translational modification, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124721002941; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/4ec24cea628a418d9972d9f2b7afcdb5

Increased transcription of transglutaminase 1 mediates neuronal death in in vitro models of neuronal stress and Aβ1–42-mediated toxicity

Authors: Debasmita Tripathy, Alice Migazzi, Federica Costa, Alessandro Roncador, Pamela Gatto, Federica Fusco, Lucia Boeri, Diego Albani, J. Leon Juárez-Hernández, Carlo Musio, Laura Colombo, Mario Salmona, M.M. Micha Wilhelmus, Benjamin Drukarch, Maria Pennuto, Manuela Basso

Source: Neurobiology of Disease, Vol 140, Iss , Pp 104849- (2020)

Subject Terms: Transglutaminase 1, Alzheimer's disease, Aβ 1–42 peptides, Neuronal death, Activator protein 1, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996120301248; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/c936871dc947473aa3b05bf9282ee7ec

Skeletal Muscle Pathogenesis in Polyglutamine Diseases

Authors: Caterina Marchioretti, Emanuela Zuccaro, Udai Bhan Pandey, Jessica Rosati, Manuela Basso, Maria Pennuto

Source: Cells, Vol 11, Iss 13, p 2105 (2022)

Subject Terms: Huntington’s disease, spinal and bulbar muscular atrophy, spinocerebellar ataxia, skeletal muscle atrophy, polyglutamine diseases, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/11/13/2105; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/cb251da92dcd44b58b067bfb22c14bbd

Rapid Nickel-based Isolation of Extracellular Vesicles from Different Biological Fluids

Authors: Michela Notarangelo, Deborah Ferrara, Cristina Potrich, Lorenzo Lunelli, Lia Vanzetti, Alessandro Provenzani, Manuela Basso, Alessandro Quattrone, Vito D'Agostino

Source: Bio-Protocol, Vol 10, Iss 3 (2020)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://bio-protocol.org/en/bpdetail?id=3512&type=0; https://doaj.org/toc/2331-8325

Access URL: https://doaj.org/article/7425e1fc87ac450593f587ff6b178e44

Role of Extracellular Vesicles in Amyotrophic Lateral Sclerosis

Authors: Deborah Ferrara, Laura Pasetto, Valentina Bonetto, Manuela Basso

Source: Frontiers in Neuroscience, Vol 12 (2018)

Subject Terms: extracellular vesicles, amyotrophic lateral sclerosis, biomarkers, prion-like behavior, therapy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnins.2018.00574/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/8d825332f0ef4f67979306d7226a11ee

Polyglutamine-Expanded Androgen Receptor Alteration of Skeletal Muscle Homeostasis and Myonuclear Aggregation Are Affected by Sex, Age and Muscle Metabolism

Authors: Mathilde Chivet, Caterina Marchioretti, Marco Pirazzini, Diana Piol, Chiara Scaramuzzino, Maria Josè Polanco, Vanina Romanello, Emanuela Zuccaro, Sara Parodi, Maurizio D’Antonio, Carlo Rinaldi, Fabio Sambataro, Elena Pegoraro, Gianni Soraru, Udai Bhan Pandey, Marco Sandri, Manuela Basso, Maria Pennuto

Source: Cells, Vol 9, Iss 2, p 325 (2020)

Subject Terms: polyglutamine diseases, androgen receptor, skeletal muscle, 2% sds-resistant aggregates, inclusion bodies, muscle metabolism, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/2/325; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/7511012dd5ea4998bf29bae7fce0d28c

Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration

Authors: Manuela Basso, Saravanan S.Karuppagounder, Jürgen Rohr, Rajiv R. Ratan, Jill Berlin, Sama F. Sleiman

Source: Pharmaceuticals, Vol 4, Iss 8, Pp 1183-1195 (2011)

Subject Terms: mithramycin A, HDAC inhibition, Myc, neurons, oxidative stress, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: http://www.mdpi.com/1424-8247/4/8/1183/; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/8fdd87b81373429db72e30b63f5d9533

Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis.

Authors: Manuela Basso, Giuseppina Samengo, Giovanni Nardo, Tania Massignan, Giuseppina D'Alessandro, Silvia Tartari, Lavinia Cantoni, Marianna Marino, Cristina Cheroni, Silvia De Biasi, Maria Teresa Giordana, Michael J Strong, Alvaro G Estevez, Mario Salmona, Caterina Bendotti, Valentina Bonetto

Source: PLoS ONE, Vol 4, Iss 12, p e8130 (2009)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2780298?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/3c2c108b06e54b4694839cae0d95622e

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Killer whale predation on an Antarctic minke whale in the northern Antarctic Peninsula

Authors: ELISA SEYBOTH, MANUELA BASSOI, RENAN C. DE LIMA, JONATAS HENRIQUE F. DO PRADO

Source: Anais da Academia Brasileira de Ciências, Vol 96, Iss suppl 2 (2024)

Subject Terms: Balaenoptera bonaerensis, Orcinus orca, Predator, Southern Ocean, Type A killer whale diet, Science

File Description: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652024000401301&lng=en&tlng=en; http://www.scielo.br/pdf/aabc/v96s2/0001-3765-aabc-96-s2-e20230731.pdf; https://doaj.org/toc/1678-2690

Access URL: https://doaj.org/article/6beab7a7dab546bc915241c5ce73664a

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HIF Prolyl Hydroxylase Inhibitors Prevent Neuronal Death Induced by Mitochondrial Toxins: Therapeutic Implications for Huntington's Disease and Alzheimer's Disease.

Authors: Zoya Niatsetskaya, Manuela Basso, Rachel E. Speer, Stephen J. McConoughey, Giovanni Coppola, Thong C. Ma, Rajiv R. Ratan

Source: Antioxidants & Redox Signaling. Feb2010, Vol. 12 Issue 4, p435-443. 9p.

Subject Terms: *OXYGENASES, *ENZYME inhibitors, *CELL death, *NEURONS, *MITOCHONDRIAL pathology, *NEURODEGENERATION, *HUNTINGTON'S chorea treatment, *ALZHEIMER'S disease treatment, *PREVENTION

Nitroproteomics of Peripheral Blood Mononuclear Cells from Patients and a Rat Model of ALS.

Authors: Giovanni Nardo, Silvia Pozzi, Stefania Mantovani, Silvia Garbelli, Kalliopi Marinou, Manuela Basso, Gabriele Mora, Caterina Bendotti, Valentina Bonetto

Source: Antioxidants & Redox Signaling; Jul2009, Vol. 11 Issue 7, p1559-1567, 9p

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Insoluble Mutant SOD1 Is Partly Oligoubiquitinated in Amyotrophic Lateral Sclerosis Mice*.

Authors: Manuela Basso^1,2, Massignan, Tania^1,2, Samengo, Giuseppina^1,2, Cheroni, Cristina³, Biasi, Silvia De⁴, Saimona, Mario², Bendotti, Caterina³, Bonetto, Valentina^1,2 bonetto@marionegri.it.

Source: Journal of Biological Chemistry. 11/3/2006, Vol. 281 Issue 44, p33325-33335. 11p. 1 Diagram, 1 Chart, 7 Graphs.

Subject Terms: *AMYOTROPHIC lateral sclerosis, *SUPEROXIDE dismutase, *GENETIC mutation, *IMMUNOHISTOCHEMISTRY, *ELECTRON microscopy, *MICE