Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model

Authors: Charlotte Schubert, Kristina Schulz, Jana K. Sonner, Alexandros Hadjilaou, Anna-Lena Seemann, Janine Gierke, Vanessa Vieira, Nina Meurs, Marcel S. Woo, Christian Lohr, Fabio Morellini, Daniela Hirnet, Manuel A. Friese

Source: Journal of Neuroinflammation, Vol 22, Iss 1, Pp 1-21 (2025)

Subject Terms: Multiple sclerosis, Experimental autoimmune encephalomyelitis, Olfactory bulb, Neuroinflammation, Mitral cells, Single-nucleus RNA sequencing, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/c754ef6467534adba2650f2236a81923

Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis

Authors: Mark Walkenhorst, Jana K. Sonner, Nina Meurs, Jan Broder Engler, Simone Bauer, Ingo Winschel, Marcel S. Woo, Lukas Raich, Iris Winkler, Vanessa Vieira, Lisa Unger, Gabriela Salinas, Olivier Lantz, Manuel A. Friese, Anne Willing

Source: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b46535ffb895445790c8443773f73bf9

Frequency, characteristics, and immunological accompaniments of ataxia in anti-NMDAR antibody-associated encephalitis

Authors: Sarah Jesse, Marie Riemann, Hauke Schneider, Marius Ringelstein, Nico Melzer, Niklas Vogel, Lena Kristina Pfeffer, Manuel A. Friese, Kurt-Wolfram Sühs, Dominica Hudasch, Philipp Schwenkenbecher, Albrecht Günther, Christian Geis, Jonathan Wickel, Martin Lesser, Annika Kather, Frank Leypoldt, Justina Dargvainiene, Robert Markewitz, Klaus-Peter Wandinger, Franziska S. Thaler, Joseph Kuchling, Katharina Wurdack, Lidia Sabater, Carsten Finke, Jan Lewerenz

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: NMDAR-encephalitis, ataxia, outcome, cerebellum, multiple sclerosis, MOG antibody, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1500904/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/76e8a5c2cf464bc9bbcf4e92a4798c07

Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity

Authors: Lars Binkle-Ladisch, Andy Pironet, Andrea Zaliani, Chantal Alcouffe, Daniel Mensching, Undine Haferkamp, Anne Willing, Marcel S. Woo, Alexandre Erdmann, Timm Jessen, Stephen D. Hess, Philip Gribbon, Ole Pless, Rudi Vennekens, Manuel A. Friese

Source: iScience, Vol 27, Iss 12, Pp 111425- (2024)

Subject Terms: Molecular biology, Neuroscience, Molecular neuroscience, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224026506; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/7c4743fbba874384a913ff92e62451a3

Generation of two isogenic human iPSC lines (ZIPi013-B-1, ZIPi013-B-2) carrying a CRISPR/Cas9-mediated deletion of TRPM4

Authors: Undine Haferkamp, Narasimha Telugu, Kim Krieg, Wiebe Schaefer, Dennis Lam, Lars Binkle-Ladisch, Manuel A. Friese, Sebastian Diecke, Ole Pless

Source: Stem Cell Research, Vol 81, Iss , Pp 103609- (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506124003076; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/f15cd7cb53b64c50afe05c17fc33c3ae

Identification of late-stage tau accumulation using plasma phospho-tau217Research in context

Authors: Marcel S. Woo, Joseph Therriault, Erin M. Jonaitis, Rachael Wilson, Rebecca E. Langhough, Nesrine Rahmouni, Andrea Lessa Benedet, Nicholas J. Ashton, Cécile Tissot, Juan Lantero-Rodriguez, Arthur C. Macedo, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez Arias, Seyyed Ali Hosseini, Tobey J. Betthauser, Firoza Z. Lussier, Robert Hopewell, Gallen Triana-Baltzer, Hartmuth C. Kolb, Andreas Jeromin, Eliane Kobayashi, Gassan Massarweh, Manuel A. Friese, Jesse Klostranec, Paolo Vilali, Tharick A. Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Sterling C. Johnson, Pedro Rosa-Neto

Source: EBioMedicine, Vol 109, Iss , Pp 105413- (2024)

Subject Terms: Alzheimer's disease, p-tau217, Prognosis, Blood biomarker, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424004493; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/fb10423af32b4438978a55cda015eda3

Ferroptosis in health and disease

Authors: Carsten Berndt, Hamed Alborzinia, Vera Skafar Amen, Scott Ayton, Uladzimir Barayeu, Alexander Bartelt, Hülya Bayir, Christina M. Bebber, Kivanc Birsoy, Jan P. Böttcher, Simone Brabletz, Thomas Brabletz, Ashley R. Brown, Bernhard Brüne, Giorgia Bulli, Alix Bruneau, Quan Chen, Gina M. DeNicola, Tobias P. Dick, Ayelén Distéfano, Scott J. Dixon, Jan B. Engler, Julia Esser-von Bieren, Maria Fedorova, José Pedro Friedmann Angeli, Manuel A. Friese, Dominic C. Fuhrmann, Ana J. García-Sáez, Karolina Garbowicz, Magdalena Götz, Wei Gu, Linda Hammerich, Behrouz Hassannia, Xuejun Jiang, Aicha Jeridi, Yun Pyo Kang, Valerian E. Kagan, David B. Konrad, Stefan Kotschi, Peng Lei, Marlène Le Tertre, Sima Lev, Deguang Liang, Andreas Linkermann, Carolin Lohr, Svenja Lorenz, Tom Luedde, Axel Methner, Bernhard Michalke, Anna V. Milton, Junxia Min, Eikan Mishima, Sebastian Müller, Hozumi Motohashi, Martina U. Muckenthaler, Shohei Murakami, James A. Olzmann, Gabriela Pagnussat, Zijan Pan, Thales Papagiannakopoulos, Lohans Pedrera Puentes, Derek A. Pratt, Bettina Proneth, Lukas Ramsauer, Raphael Rodriguez, Yoshiro Saito, Felix Schmidt, Carina Schmitt, Almut Schulze, Annemarie Schwab, Anna Schwantes, Mariluz Soula, Benedikt Spitzlberger, Brent R. Stockwell, Leonie Thewes, Oliver Thorn-Seshold, Shinya Toyokuni, Wulf Tonnus, Andreas Trumpp, Peter Vandenabeele, Tom Vanden Berghe, Vivek Venkataramani, Felix C.E. Vogel, Silvia von Karstedt, Fudi Wang, Frank Westermann, Chantal Wientjens, Christoph Wilhelm, Michele Wölk, Katherine Wu, Xin Yang, Fan Yu, Yilong Zou, Marcus Conrad

Source: Redox Biology, Vol 75, Iss , Pp 103211- (2024)

Subject Terms: Cell death, Lipid peroxidation, Iron, Ischemia/reperfusion, Cancer, Neurodegeneration, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231724001897; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/704bf377a6004407992c3cd92011cf30

Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis

Authors: Ingo Winschel, Anne Willing, Jan Broder Engler, Mark Walkenhorst, Nina Meurs, Lars Binkle-Ladisch, Marcel S. Woo, Lena Kristina Pfeffer, Jana K. Sonner, Uwe Borgmeyer, Sven Hendrik Hagen, Benjamin Grünhagel, Janna M. Claussen, Marcus Altfeld, Manuel A. Friese

Source: Biology of Sex Differences, Vol 15, Iss 1, Pp 1-20 (2024)

Subject Terms: Neuroinflammation, Sex dimorphism, T cell costimulation, Experimental autoimmune encephalomyelitis, Testosterone, X and Y chromosome, Medicine, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2042-6410

Access URL: https://doaj.org/article/567ad8ca738140ac904d3852d72995df

Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology

Authors: Joseph Therriault, Marcel S. Woo, Gemma Salvadó, Johan Gobom, Thomas K. Karikari, Shorena Janelidze, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Arthur C. Macedo, Firoza Z. Lussier, Jenna Stevenson, Paolo Vitali, Manuel A. Friese, Gassan Massarweh, Jean-Paul Soucy, Tharick A. Pascoal, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Serge Gauthier, Henrik Zetterberg, Oskar Hansson, Kaj Blennow, Pedro Rosa-Neto

Source: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-14 (2024)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/b47ea600285b4aea8f46ab3e27b0c3b2

Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease

Authors: Ann-Christin Gnirck, Marie-Sophie Philipp, Alex Waterhölter, Malte Wunderlich, Nikhat Shaikh, Virginia Adamiak, Lena Henneken, Tobias Kautz, Tingting Xiong, Daniela Klaus, Pascal Tomczyk, Mohamad M. Al-Bahra, Dirk Menche, Mark Walkenhorst, Olivier Lantz, Anne Willing, Manuel A. Friese, Tobias B. Huber, Christian F. Krebs, Ulf Panzer, Christian Kurts, Jan-Eric Turner

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ea197fd8a59e40e69a85f91fdcdab807

14-3-3 $$\upzeta /\updelta$$ ζ / δ -reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2

Authors: Marcel S. Woo, Johanna Nilsson, Joseph Therriault, Nesrine Rahmouni, Ann Brinkmalm, Andrea L. Benedet, Nicholas J. Ashton, Arthur C. Macedo, Stijn Servaes, Yi-Ting Wang, Cécile Tissot, Jaime Fernandez Arias, Seyyed Ali Hosseini, Mira Chamoun, Firoza Z. Lussier, Thomas K. Karikari, Jenna Stevenson, Christina Mayer, João Pedro Ferrari-Souza, Eliane Kobayashi, Gassan Massarweh, Manuel A. Friese, Tharick A. Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto

Source: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-12 (2023)

Subject Terms: Alzheimer’s disease, sTREM2, Microglia, Neuroinflammation, Synaptic loss, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/8072bbc5673044c19bd12aa939e0a997

Microglial complex I activity: a crucial factor for smoldering inflammation in the central nervous system

Authors: Jana K. Sonner, Christina Mayer, Manuel A. Friese

Source: Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-2 (2024)

Subject Terms: Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2059-3635

Access URL: https://doaj.org/article/12bb25112cc94061af20fc06e7c1457e

A2A adenosine receptor-driven cAMP signaling in olfactory bulb astrocytes is unaffected in experimental autoimmune encephalomyelitis

Authors: Marina Wendlandt, Alina J. Kürten, Antonia Beiersdorfer, Charlotte Schubert, Kiana Samad-Yazdtchi, Jessica Sauer, M. Carolina Pinto, Kristina Schulz, Manuel A. Friese, Christine E. Gee, Daniela Hirnet, Christian Lohr

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: cyclic adenosine monophosphate, astrocyte, purinergic signaling, adenosine, olfactory bulb, cAMP imaging, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1273837/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4efe47dd39af48f7be496c62d1ac970c

Autologous haematopoietic stem cell transplantation for multiple sclerosis: a position paper and registry outline

Authors: Antonios Bayas, Achim Berthele, Norbert Blank, Peter Dreger, Simon Faissner, Manuel A. Friese, Lisa-Ann Gerdes, Oliver Martin Grauer, Vivien Häussler, Christoph Heesen, Dietlinde Janson, Mirjam Korporal-Kuhnke, Markus Kowarik, Nikolaus Kröger, Jan D. Lünemann, Roland Martin, Uwe Meier, Sven Meuth, Paolo Muraro, Michael Platten, Lucas Schirmer, Klarissa Hanja Stürner, Jan Patrick Stellmann, Christof Scheid, Florian Then Bergh, Clemens Warnke, Brigitte Wildemann, Tjalf Ziemssen

Source: Therapeutic Advances in Neurological Disorders, Vol 16 (2023)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1756-2864

Access URL: https://doaj.org/article/9ebac6238a0044049f1e01a530d4bd56

Neandertal introgression partitions the genetic landscape of neuropsychiatric disorders and associated behavioral phenotypes

Authors: Michael Dannemann, Yuri Milaneschi, Danat Yermakovich, Victoria Stiglbauer, Hanna Maria Kariis, Kristi Krebs, Manuel A. Friese, Christian Otte, Estonian Biobank Research Team, Kelli Lehto, Brenda W. J. H. Penninx, Janet Kelso, Stefan M. Gold

Source: Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2158-3188

Access URL: https://doaj.org/article/fa483aeffa354e6a92ab5192263f8dd7

A glibenclamide-sensitive TRPM4-mediated component of CA1 excitatory postsynaptic potentials appears in experimental autoimmune encephalomyelitis

Authors: Brenna C. Fearey, Lars Binkle, Daniel Mensching, Christian Schulze, Christian Lohr, Manuel A. Friese, Thomas G. Oertner, Christine E. Gee

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3bd731c3c1254a9889512194675bf219

Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination

Authors: Hannah Kapell, Luca Fazio, Julia Dyckow, Sophia Schwarz, Andrés Cruz-Herranz, Christina Mayer, Joaquin Campos, Elisa D’Este, Wiebke Möbius, Christian Cordano, Anne-Katrin Pröbstel, Marjan Gharagozloo, Amel Zulji, Venu Narayanan Naik, Anna Delank, Manuela Cerina, Thomas Müntefering, Celia Lerma-Martin, Jana K. Sonner, Jung Hyung Sin, Paul Disse, Nicole Rychlik, Khalida Sabeur, Manideep Chavali, Rajneesh Srivastava, Matthias Heidenreich, Kathryn C. Fitzgerald, Guiscard Seebohm, Christine Stadelmann, Bernhard Hemmer, Michael Platten, Thomas J. Jentsch, Maren Engelhardt, Thomas Budde, Klaus-Armin Nave, Peter A. Calabresi, Manuel A. Friese, Ari J. Green, Claudio Acuna, David H. Rowitch, Sven G. Meuth, Lucas Schirmer

Source: The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)

Subject Terms: Inflammation, Neuroscience, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/3d8107c041ee41648aa17c5d82d19237

Case report: JAK inhibition as promising treatment option of fatal RVCLS due to TREX1 mutation (pVAL235Glyfs*6)

Authors: Friederike Ufer, Susanne M. Ziegler, Marcus Altfeld, Manuel A. Friese

Source: Frontiers in Neurology, Vol 14 (2023)

Subject Terms: TREX1, brain vascular disorder, hereditary autoinflammatory diseases, CXCL10, immunosuppression, JAK inhibition, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2023.1118369/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/d09d1580c69d441a9f0008c09c94b4b5

GPR52 regulates cAMP in T cells but is dispensable for encephalitogenic responses

Authors: Paula F. Krieg, Jana K. Sonner, Roberta Kurelic, Jan Broder Engler, Marlena F. Scharenberg, Simone Bauer, Viacheslav O. Nikolaev, Manuel A. Friese

Source: Frontiers in Immunology, Vol 13 (2023)

Subject Terms: cAMP, experimental autoimmune encephalomyelitis, FRET, GPCR, multiple sclerosis, T cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1113348/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/af0a257409994883bba763b26456c0a5

Identification of the factor XII contact activation site enables sensitive coagulation diagnostics

Authors: Marco Heestermans, Clément Naudin, Reiner K. Mailer, Sandra Konrath, Kristin Klaetschke, Anne Jämsä, Maike Frye, Carsten Deppermann, Giordano Pula, Piotr Kuta, Manuel A. Friese, Mathias Gelderblom, Albert Sickmann, Roger J. S. Preston, Jerzy-Roch Nofer, Stefan Rose-John, Lynn M. Butler, Ophira Salomon, Evi X. Stavrou, Thomas Renné

Source: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/23842f92b8124cd4863e0db2254038e6