Eosinophilic esophagitis drives tissue fibroblast regenerative programs toward pathologic dysfunction

Authors: Jumabay, Medet ^{a, b}, Abud, Edsel M. ^{a, b, f, j}, Okamoto, Kevin ^{a, b}, Dutta, Paramita ^g, Chiang, Austin W.T. ^{a, c}, Li, Haining ^{a, f}, Manresa, Mario C. ^{a, b}, Zhu, Yanfang P. ^a, Frederick, Dana ^h, Kurten, Richard ^c, Croker, Ben ^a, Lewis, Nathan E. ^{a, f}, Kennedy, Joshua L. ^h, Dohil, Ranjan ^{a, d, g}, Croft, Michael ^g, Ay, Ferhat ^{a, g}, Wechsler, Joshua B. ⁱ, Aceves, Seema S. ^{a, b, d, e, i, ∗}

Source: In The Journal of Allergy and Clinical Immunology November 2024

Novel fibroblast phenotypes in homeostasis and chronic inflammation: From functions to potential regulators

Authors: Miki, Haruka, Manresa, Mario C.

Source: Journal of physiology. 601(12):2273-2291

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189676568.0x000001&indx=1&recIds=ETOCvdc_100189676568.0x000001

Lymphotoxin beta receptor signaling directly controls airway smooth muscle deregulation and asthmatic lung dysfunction

Authors: Miki, Haruka, Kiosses, William B., Manresa, Mario C., Gupta, Rinkesh K., Sethi, Gurupreet S., Herro, Rana, Da Silva Antunes, Ricardo, Dutta, Paramita, Miller, Marina, Fung, Kai, Chawla, Ashu, Dobaczewska, Katarzyna, Ay, Ferhat, Broide, David H., Tumanov, Alexei V., Croft, Michael

Source: In The Journal of Allergy and Clinical Immunology April 2023 151(4):976-990

A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis

Authors: Manresa, Mario C., Miki, Haruka, Miller, Jacqueline, Okamoto, Kevin, Dobaczewska, Katarzyna, Herro, Rana, Gupta, Rinkesh K., Kurten, Richard, Aceves, Seema S., Croft, Michael

Source: Journal of immunology. 209(12):2341-2351

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630652855&indx=1&recIds=ETOCRN630652855

LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms

Authors: Manresa, Mario C., Wu, Amanda, Nhu, Quan M., Chiang, Austin W.T., Okamoto, Kevin, Miki, Haruka, Kurten, Richard, Pham, Elaine, Duong, Loan D., Lewis, Nathan E., Akuthota, Praveen, Croft, Michael, Aceves, Seema S.

Source: In Mucosal Immunology February 2022 15(2):327-337

Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders

Authors: Chiang, Austin W.T., Duong, Loan D., Shoda, Tetsuo, Nhu, Quan M., Ruffner, Melanie, Hara, Takeo, Aaron, Bailey, Joplin, Erik, Manresa, Mario C., Abonia, J. Pablo, Dellon, Evan S, Hirano, Ikuo, Gonsalves, Nirmala, Gupta, Sandeep K., Furuta, Glenn T., Rothenberg, Marc E., Lewis, Nathan E., Muir, Amanda B., Aceves, Seema S.

Source: Journal of pediatric gastroenterology and nutrition. 72(5):718-722

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121778627.0x000001&indx=1&recIds=ETOCvdc_100121778627.0x000001

Animal Models of Contact Dermatitis: 2, 4-Dinitrofluorobenzene-Induced Contact Hypersensitivity

Authors: Manresa, Mario C.

Source: Methods in molecular biology. 2223:87-100

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN625360089&indx=1&recIds=ETOCRN625360089

Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype

Authors: Manresa, Mario C., Chiang, Austin W.T., Kurten, Richard C., Dohil, Ranjan, Brickner, Howard, Dohil, Lucas, Herro, Rana, Akuthota, Praveen, Lewis, Nathan E., Croft, Michael, Aceves, Seema S.

Source: In Gastroenterology November 2020 159(5):1778-1792

Pharmacologic inhibition of hypoxia‐inducible factor (HIF)‐hydroxylases ameliorates allergic contact dermatitis

Authors: Manresa, Mario C., Smith, Leila, Casals‐Diaz, Laura, Fagundes, Raphael R., Brown, Eric, Radhakrishnan, Praveen, Murphy, Stephen J., Crifo, Bianca, Strowitzki, Moritz J., Halligan, Doug N., van den Bogaard, Ellen H., Niehues, Hanna, Schneider, Martin, Taylor, Cormac T., Steinhoff, Martin

Source: Allergy. 74(4):753-766

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083051922.0x000001&indx=1&recIds=ETOCvdc_100083051922.0x000001

Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier Function

Authors: Manresa, Mario C., Taylor, Cormac T.

Source: In Cellular and Molecular Gastroenterology and Hepatology May 2017 3(3):303-315

Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis

Authors: Tambuwala, Murtaza M., Manresa, Mario C., Cummins, Eoin P., Aversa, Vincenzo, Coulter, Ivan S., Taylor, Cormac T.

Source: In Journal of Controlled Release 10 November 2015 217:221-227

Sa125 DIFFERENTIAL TNFSF14/LIGHT-RECEPTOR-MEDIATED PATHWAYS SHAPE THE BALANCE BETWEEN INFLAMMATORY AND REGENERATIVE FIBROBLASTS IN EOSINOPHILIC ESOPHAGITIS

Authors: Manresa, Mario C., Pham, Elaine, Duong, Loan D., Okamoto, Kevin, Miki, Haruka, Croft, Michael, Aceves, Seema S.

Source: Gastroenterology. 160(6):S-430-S-430

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140850468.0x000001&indx=1&recIds=ETOCvdc_100140850468.0x000001

Regulation of pathologic fibroblast functions in digestive diseases: a role for hypoxia?

Authors: Ohlendieck, Cian M.^1,2 (AUTHOR), Matellan, Carlos^1,3 (AUTHOR), Manresa, Mario C.^1,2 (AUTHOR) mario.manresa@ucd.ie

Source: American Journal of Physiology: Gastrointestinal & Liver Physiology. Mar2025, Vol. 328 Issue 3, pG229-G242. 14p.

Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner

Authors: Fitzpatrick, Susan F., Fábián, Zsolt, Schaible, Bettina, Lenihan, Colin R., Schwarzl, Thomas, Rodriguez, Javier, Zheng, Xingnan, Li, Zongwei, Tambuwala, Murtaza M., Higgins, Desmond G., O'Meara, Yvonne, Slattery, Craig, Manresa, Mario C., Fraisl, Peter, Bruning, Ulrike, Baes, Myriam, Carmeliet, Peter, Doherty, Glen, von Kriegsheim, Alex, Cummins, Eoin P., Taylor, Cormac T.

Source: In Biochemical and Biophysical Research Communications 3 June 2016 474(3):579-586

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Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling.

Authors: Manresa, Mario C., Tambuwala, Murtaza M., Radhakrishnan, Praveen, Harnoss, Jonathan M., Brown, Eric, Cavadas, Miguel A., Keogh, Ciara E., Cheong, Alex, Barrett, Kim E., Cummins, Eoin P., Schneider, Martin, Taylor, Cormac T.

Source: American Journal of Physiology: Gastrointestinal & Liver Physiology; Dec2016, Vol. 311 Issue 6, pG1076-G1090, 15p, 1 Diagram, 2 Charts, 6 Graphs

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