Loss of Mfn1 but not Mfn2 enhances adipogenesis.

Authors: Mann, Jake P.¹ (AUTHOR), Tábara, Luis Carlos² (AUTHOR), Patel, Satish¹ (AUTHOR), Pushpa, Pushpa¹ (AUTHOR), Alvarez-Guaita, Anna¹ (AUTHOR), Dong, Liang¹ (AUTHOR), Haider, Afreen¹ (AUTHOR), Lim, Koini¹ (AUTHOR), Tandon, Panna³ (AUTHOR), Scurria, Fabio¹ (AUTHOR), Minchin, James E. N.³ (AUTHOR), O'Rahilly S., Stephen¹ (AUTHOR), Fazakerley, Daniel J.¹ (AUTHOR), Prudent, Julien² (AUTHOR), Semple, Robert K.^3,4 (AUTHOR), Savage, David B.¹ (AUTHOR) dbs23@cam.ac.uk

Source: PLoS ONE. 12/31/2024, Vol. 19 Issue 12, p1-24. 24p.

Subject Terms: *MITOFUSIN 2, *MITOCHONDRIAL dynamics, *MISSENSE mutation, *FAT cells, *RNA sequencing, *ADIPOGENESIS

Common mechanisms in pediatric acute liver failure

Authors: Mann, Jake P., Lenz, Dominic, Stamataki, Zania, Kelly, Deirdre

Source: Trends in molecular medicine. 29(3):228-240

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Comparison of the Lipidomic Signature of Fatty Liver in Children and Adults: A Cross-Sectional Study

Authors: Mann, Jake P., Jenkins, Benjamin, Furse, Samuel, Snowden, Stuart G., Alisi, Anna, Draijer, Laura G., Karnebeek, Kylie, Kelly, Deirdre A., Koot, Bart G., Mosca, Antonella, Salvestrini, Camilla, van Mourik, Indra, Vreugdenhil, Anita, Zilbauer, Matthias, Koulman, Albert

Source: Journal of pediatric gastroenterology and nutrition. 74(6):734-741

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155534654.0x000001&indx=1&recIds=ETOCvdc_100155534654.0x000001

A minority of somatically mutated genes in pre‐existing fatty liver disease have prognostic importance in the development of NAFLD

Authors: Mann, Jake P., Hoare, Matthew

Source: Liver international. 42(8):1823-1835

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Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement

Authors: Eslam, Mohammed ^*, Alkhouri, Naim, Vajro, Pietro, Baumann, Ulrich, Weiss, Ram, Socha, Piotr, Marcus, Claude, Lee, Way Seah, Kelly, Deirdre, Porta, Gilda, El-Guindi, Mohamed A, Alisi, Anna, Mann, Jake P, Mouane, Nezha, Baur, Louise A, Dhawan, Anil, George, Jacob

Source: In The Lancet Gastroenterology & Hepatology October 2021 6(10):864-873

rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis

Authors: Vreugdenhil, Anita, Alisi, Anna, Socha, Piotr, Jańczyk, Wojciech, Baumann, Ulrich, Rajwal, Sanjay, van Mourik, Indra, Lacaille, Florence, Dabbas, Myriam, Kelly, Deirdre A., Nobili, Valerio, Eiriksdottir, Gudny, Garcia, Melissa E., Gudnason, Vilmundur, Harris, Tamara B., Kim, Lauren J., Launer, Lenore J., Nalls, Michael A., Smith, Albert V., Clark, Jeanne M., Hernaez, Ruben, Kao, W.H. Linda, Mitchell, Braxton D., Shuldiner, Alan R., Yerges-Armstrong, Laura M., Borecki, Ingrid B., Carr, J. Jeffrey, Feitosa, Mary F., Wu, Jun, Butler, Johannah L., Fox, Caroline S., Hirschhorn, Joel N., Hoffmann, Udo, Hwang, Shih-Jen, Massaro, Joseph M., O'Donnell, Christopher J., Palmer, Cameron D., Sahani, Dushyant V., Speliotes, Elizabeth K., Teo, Kevin, Abeysekera, Kushala W.M., Adams, Leon, Aigner, Elmar, Anstee, Quentin M., Banales, Jesus M., Banerjee, Rajarshi, Basu, Priyadarshi, Berg, Thomas, Bhatnagar, Pallav, Buch, Stephan, Canbay, Ali, Caprio, Sonia, Chatterjee, Ankita, Ida Chen, Yii-Der, Chowdhury, Abhijit, Daly, Ann K., Datz, Christian, de Gracia Hahn, Dana, DiStefano, Johanna K., Dong, Jiawen, Duret, Amedine, Emdin, Connor, Fairey, Madison, Gerhard, Glenn S., Guo, Xiuqing, Hampe, Jochen, Hickman, Matthew, Heintz, Lena, Hudert, Christian, Hunter, Harriet, Kelly, Matt, Kozlitina, Julia, Krawczyk, Marcin, Lammert, Frank, Langenberg, Claudia, Lavine, Joel, Li, Lin, Lim, Hong Kai, Loomba, Rohit, Luukkonen, Panu K., Melton, Phillip E., Mori, Trevor A., Palmer, Nicholette D., Parisinos, Constantinos A., Pillai, Sreekumar G., Qayyum, Faiza, Reichert, Matthias C., Romeo, Stefano, Rotter, Jerome I., Im, Yu Ri, Santoro, Nicola, Schafmayer, Clemens, Stender, Stefan, Stickel, Felix, Still, Christopher D., Strnad, Pavel, Taylor, Kent D., Tybjærg-Hansen, Anne, Umano, Giuseppina Rosaria, Utukuri, Mrudula, Valenti, Luca, Wagenknecht, Lynne E., Wareham, Nicholas J., Watanabe, Richard M., Wattacheril, Julia, Yaghootkar, Hanieh, Yki-Järvinen, Hannele, Young, Kendra A., Mann, Jake P.

Source: In Journal of Hepatology January 2021 74(1):20-30

A Systematic Review of Animal Models of NAFLD Finds High‐Fat, High‐Fructose Diets Most Closely Resemble Human NAFLD

Authors: Im, Yu Ri, Hunter, Harriet, Gracia Hahn, Dana, Duret, Amedine, Cheah, Qinrong, Dong, Jiawen, Fairey, Madison, Hjalmarsson, Clarissa, Li, Alice, Lim, Hong Kai, McKeown, Lorcán, Mitrofan, Claudia‐Gabriela, Rao, Raunak, Utukuri, Mrudula, Rowe, Ian A., Mann, Jake P.

Source: Hepatology. 74(4):1884-1901

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131459254.0x000001&indx=1&recIds=ETOCvdc_100131459254.0x000001

Rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis

Authors: Teo, Kevin, Abeysekera, Kushala W.M., Adams, Leon, Aigner, Elmar, Anstee, Quentin M., Banales, Jesus M., Banerjee, Rajarshi, Basu, Priyadarshi, Berg, Thomas, Bhatnagar, Pallav, Buch, Stephan, Canbay, Ali, Caprio, Sonia, Chatterjee, Ankita, Ida Chen, Yii-Der, Chowdhury, Abhijit, Daly, Ann K., Datz, Christian, de Gracia Hahn, Dana, DiStefano, Johanna K., Dong, Jiawen, Duret, Amedine, Emdin, Connor, Fairey, Madison, Gerhard, Glenn S., Guo, Xiuqing, Hampe, Jochen, Hickman, Matthew, Heintz, Lena, Hudert, Christian, Hunter, Harriet, Kelly, Matt, Kozlitina, Julia, Krawczyk, Marcin, Lammert, Frank, Langenberg, Claudia, Lavine, Joel, Li, Lin, Lim, Hong Kai, Loomba, Rohit, Luukkonen, Panu K., Melton, Phillip E., Mori, Trevor A., Palmer, Nicholette D., Parisinos, Constantinos A., Pillai, Sreekumar G., Qayyum, Faiza, Reichert, Matthias C., Romeo, Stefano, Rotter, Jerome I., Im, Yu Ri, Santoro, Nicola, Schafmayer, Clemens, Speliotes, Elizabeth K., Stender, Stefan, Stickel, Felix, Still, Christopher D., Strnad, Pavel, Taylor, Kent D., Tybjærg-Hansen, Anne, Umano, Giuseppina Rosaria, Utukuri, Mrudula, Valenti, Luca, Wagenknecht, Lynne E., Wareham, Nicholas J., Watanabe, Richard M., Wattacheril, Julia, Yaghootkar, Hanieh, Yki-Järvinen, Hannele, Young, Kendra A., Mann, Jake P.

Source: Journal of hepatology. 74(1):20-30

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116620948.0x000001&indx=1&recIds=ETOCvdc_100116620948.0x000001

Lipid droplets as the genetic nexus of fatty liver

Authors: Mann, Jake P., Romeo, Stefano, Valenti, Luca

Source: Liver international. 42(12):2594-2596

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170845500.0x000001&indx=1&recIds=ETOCvdc_100170845500.0x000001

The global prevalence of Wilson disease from next-generation sequencing data

Authors: Gao, Jiali, Brackley, Simon, Mann, Jake P.

Source: In Genetics in Medicine May 2019 21(5):1155-1163

European paediatric non-alcoholic fatty liver disease registry (EU-PNAFLD): Design and rationale

Authors: Mann, Jake P., Vreugdenhil, Anita, Socha, Piotr, Jańczyk, Wojciech, Baumann, Ulrich, Rajwal, Sanjay, Casswall, Thomas, Marcus, Claude, van Mourik, Indra, O'Rahilly, Stephen, Savage, David B., Noble-Jamieson, Gabriele, Lacaille, Florence, Dabbas, Myriam, Dubern, Béatrice, Kelly, Deirdre A., Nobili, Valerio, Anstee, Quentin M.

Source: In Contemporary Clinical Trials December 2018 75:67-71

Unmet needs in pediatric NAFLD research: what do we need to prioritize for the future?

Authors: Hatton, Grace, Alterio, Tommaso, Nobili, Valerio, Mann, Jake P.

Source: Expert review of gastroenterology & hepatology. 12(10):961-967

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103655935.0x000001&indx=1&recIds=ETOCvdc_100103655935.0x000001

Paediatric steatotic liver disease has unique characteristics: A multisociety statement endorsing the new nomenclature

Authors: Baumann, Ulrich, Koot, Bart G. P., Fitzpatrick, Emer, Mann, Jake, Vajro, Pietro, Krag, Aleksander, Newsome, Philip N., Shawcross, Debbie, Francque, Sven, Böttler, Tobias, Gold, Benjamin D., Lightdale, Jenifer R., Mouzaki, Marialena, Rodriguez‐Baez, Norberto, Kohli, Rohit, Ng, Vicky L., D'Agostino, Daniel, Porta, Gilda, Spolidoro, José, Klünder‐Klünder, Miguel, Vázquez‐Frias, Rodrigo, Sibal, Anupam, Ko, Jae Sung, Kim, Kyung Mo, Treepongkaruna, Suporn, Ni, Yen‐Hsuan, El‐Guindi, Mohamed, Mohan, Neelam, Verduci, Elvira, Memon, Iqbal, Bozo, Mahmoud, Godoy, Marcela, Orsi, Marina, Aw, Marion, Bandsma, Robert, Ibrahim, Samar, Xanthakos, Stavra, Treepongkaruna, Suporn, Mitsinikos, Tania

Source: Journal of Pediatric Gastroenterology & Nutrition; May 2024, Vol. 78 Issue: 5 p1190-1196, 7p

Noninvasive scores are poorly predictive of histological fibrosis in paediatric fatty liver disease.

Authors: Kalveram, Laura, Baumann, Ulrich, De Bruyne, Ruth, Draijer, Laura, Janczyk, Wojciech, Kelly, Deirdre, Koot, Bart G., Lacaille, Florence, Lefere, Sander, Lev, Hadar Moran, Lubrecht, Judith, Mann, Jake P., Mosca, Antonella, Rajwal, Sanjay, Socha, Piotr, Vreugdenhil, Anita, Alisi, Anna, Hudert, Christian A.

Source: Journal of Pediatric Gastroenterology & Nutrition; Jan2024, Vol. 78 Issue 1, p27-35, 9p

The pharmacological management of NAFLD in children and adolescents

Authors: Liyanagedera, Savinda, Williams, Robert Patrick, Veraldi, Silvio, Nobili, Valerio, Mann, Jake P.

Source: Expert review of clinical pharmacology. 10(11):1225-1237

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100106474327.0x000001&indx=1&recIds=ETOCvdc_100106474327.0x000001

Clinical implications of understanding the association between oxidative stress and pediatric NAFLD

Authors: Mann, Jake P., Raponi, Massimiliano, Nobili, Valerio

Source: Expert review of gastroenterology & hepatology. 11(4):371-382

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103647122.0x000001&indx=1&recIds=ETOCvdc_100103647122.0x000001

Update on lipid species and paediatric nonalcoholic fatty liver disease

Authors: Mann, Jake P., Feldstein, Ariel E., Nobili, Valerio

Source: Current opinion in clinical nutrition and metabolic care. 20(2):110-116

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100042333349.0x000001&indx=1&recIds=ETOCvdc_100042333349.0x000001

Diagnosis of fatty liver in children should occur in parallel to investigation for other causes of liver disease

Authors: Mann, Jake P, Vreugdenhil, Anita CE, Zellos, Aglaia, Krag, Aleksander, Konidari, Anastasia, Alisi, Anna, Koot, Bart, Kohlmaier, Benno, Hudert, Christian A, Tzivinikos, Christos, Arikan, Cigdem, Pienar, Corina, Kelly, Deirdre, Lurz, Eberhard, Verduci, Elvira, Nicastro, Emanuele, Fitzpatrick, Emer, Indolfi, Giuseppe, Ranucci, Giusy, Antunes, Henedina, Labayen, Idoia, Degrassi, Irene, Melek, Jan, Brecelj, Jernej, Bronsky, Jiri, Lubrecht, Judith, Brook, Kimberley, Fotoulaki, Maria, Rogalidou, Maria, Samyn, Marianne, Zavhorodnia, Natalia, Junge, Norman, Zavhorodnia, Olha, Newsome, Phil, DeBruyne, Ruth, Lefere, Sander, Xavier, Stephenne, Berg, Thomas, Lucian, Tudor, Frings, Virginie, Jańczyk, Wojciech, Baumann, Ulli

Source: In The Lancet Gastroenterology & Hepatology July 2023 8(7):598-600

Hospital admission with non-alcoholic fatty liver disease is associated with increased all-cause mortality independent of cardiovascular risk factors.

Authors: Mann, Jake P.^1,2,3 (AUTHOR) jm2032@cam.ac.uk, Carter, Paul^3,4 (AUTHOR), Armstrong, Matthew J.⁵ (AUTHOR), Abdelaziz, Hesham K.^6,7 (AUTHOR), Uppal, Hardeep³ (AUTHOR), Patel, Billal⁶ (AUTHOR), Chandran, Suresh⁸ (AUTHOR), More, Ranjit⁶ (AUTHOR), Newsome, Philip N.^9,10 (AUTHOR), Potluri, Rahul³ (AUTHOR)

Source: PLoS ONE. 10/27/2020, Vol. 15 Issue 10, p1-14. 14p.

Subject Terms: *FATTY liver, *CARDIOVASCULAR diseases risk factors, *HOSPITAL admission & discharge, *PROPORTIONAL hazards models, *CONGESTIVE heart failure

Reply

Authors: Hudert, Christian A., Mann, Jake P.

Source: Hepatology communications. 6(11):3279-3279

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190647262.0x000001&indx=1&recIds=ETOCvdc_100190647262.0x000001