Multiple Myeloma in Italy: An Epidemiological Model by Treatment Line and Refractoriness Status

Authors: Mina, Roberto ¹, Mangiacavalli, Silvia ², Rossini, Bernardo ³, Ghetti, Gianni ^{4, ⁎}, Pellizzaro, Simona ⁵, Iannello, Fabrizio ⁵, Bellucci, Stefania ⁵

Source: In Clinical Lymphoma, Myeloma and Leukemia December 2024

Novel Drug Combinations and Donor Lymphocyte Infusions Allow Prolonged Disease Control in Multiple Myeloma Patients Relapsing after Allogeneic Transplantation

Authors: Nozzoli, Chiara ^{1, ⁎}, Pucillo, Martina ², Giaccone, Luisa ³, Rambaldi, Alessandro ⁴, Stanghellini, Maria Teresa Lupo ⁵, Benedetti, Edoardo ⁶, Russo, Domenico ⁷, Mordini, Nicola ⁸, Mangiacavalli, Silvia ⁹, Bernasconi, Paolo ⁹, Parma, Matteo ¹⁰, Carluccio, Paola ¹¹, Galieni, Piero ¹², Rivela, Paolo ¹³, Martino, Massimo ¹⁴, Chiusolo, Patrizia ¹⁵, Isola, Miriam ¹⁶, De Martino, Maria ¹⁶, Oldani, Elena ⁴, Degrandi, Eliana ¹⁷, Boncompagni, Riccardo ¹, Antonioli, Elisabetta ¹⁸, Carnevale, Fabrizio ¹⁹, Tozzi, Monica ²⁰, Selleri, Carmine ²¹, Fanin, Renato ², Patriarca, Francesca ²

Source: In Transplantation and Cellular Therapy January 2025 31(1):26-26

Adjusted comparison between elotuzumab and carfilzomib in combination with lenalidomide and dexamethasone as salvage therapy for multiple myeloma patients

Authors: Morabito, Fortunato, Zamagni, Elena, Conticello, Concetta, Pavone, Vincenzo, Palmieri, Salvatore, Bringhen, Sara, Galli, Monica, Mangiacavalli, Silvia, Derudas, Daniele, Rossi, Elena, Ria, Roberto, Catalano, Lucio, Tacchetti, Paola, Mele, Giuseppe, Donatella Vincelli, Iolanda, Antonia Martino, Enrica, Vigna, Ernesto, Botta, Cirino, Bruzzese, Antonella, Mele, Anna, Pantani, Lucia, Rocchi, Serena, Garibaldi, Bruno, Cascavilla, Nicola, Ballanti, Stelvio, Tripepi, Giovanni, Frigeri, Ferdinando, Pia Falcone, Antonetta, Cangialosi, Clotilde, Reddiconto, Giovanni, Farina, Giuliana, Barone, Marialucia, Rizzello, Ilaria, Musto, Pellegrino, De Stefano, Valerio, Musso, Maurizio, Teresa Petrucci, Maria, Offidani, Massimo, Neri, Antonino, Di Renzo, Nicola, Di Raimondo, Francesco, Boccadoro, Mario, Cavo, Michele, Gentile, Massimo

Source: European journal of haematology. 108(3):178-189

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140041280.0x000001&indx=1&recIds=ETOCvdc_100140041280.0x000001

Elotuzumab plus lenalidomide and dexamethasone in relapsed/refractory multiple myeloma: Extended 3‐year follow‐up of a multicenter, retrospective clinical experience with 319 cases outside of controlled clinical trials

Authors: Bruzzese, Antonella, Derudas, Daniele, Galli, Monica, Martino, Enrica Antonia, Rocco, Stefano, Conticello, Concetta, Califano, Catello, Giuliani, Nicola, Mangiacavalli, Silvia, Farina, Giuliana, Lombardo, Alessandra, Brunori, Marino, Rossi, Elena, Antonioli, Elisabetta, Ria, Roberto, Zambello, Renato, Di Renzo, Nicola, Mele, Giuseppe, Marcacci, Gianpaolo, Pietrantuono, Giuseppe, Palumbo, Gaetano, Cascavilla, Nicola, Cerchione, Claudio, Belotti, Angelo, Criscuolo, Clelia, Uccello, Giuseppina, Curci, Paola, Vigna, Ernesto, Mendicino, Francesco, Iaccino, Enrico, Mimmi, Selena, Botta, Cirino, Vincelli, Donatella, Sgherza, Nicola, Bonalumi, Angela, Cupelli, Luca, Stocchi, Raffaella, Martino, Massimo, Ballanti, Stelvio, Gangemi, Dominella, Gagliardi, Alfredo, Gamberi, Barbara, Pompa, Alessandra, Tripepi, Giovanni, Frigeri, Ferdinando, Consoli, Ugo, Bringhen, Sara, Zamagni, Elena, Patriarca, Francesca, Stefano, Valerio, Di Raimondo, Francesco, Palmieri, Salvatore, Petrucci, Maria Teresa, Offidani, Massimo, Musto, Pellegrino, Boccadoro, Mario, Cavo, Michele, Neri, Antonino, Morabito, Fortunato, Gentile, Massimo

Source: Hematological oncology. 40(4):704-715

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194610175.0x000001&indx=1&recIds=ETOCvdc_100194610175.0x000001

Feasibility of a Biomarker‐Based Screening for Pre‐Symptomatic AL Amyloidosis in Patients With Intermediate/High‐Risk MGUS.

Authors: Mangiacavalli, Silvia, Milani, Paolo, Cartia, Claudio Salvatore, Varettoni, Marzia, Palumbo, Michele, Basset, Marco, Masoni, Valeria, Nuvolone, Mario, Foli, Andrea, Ferretti, Virginia Valeria, Merlini, Giampaolo, Arcaini, Luca, Palladini, Giovanni

Source: American Journal of Hematology; Feb2025, Vol. 100 Issue 2, p342-345, 4p

Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): a randomised, open-label, phase 3 trial

Authors: Abildgaard, Niels, Adler, Howard, Altuntas, Fevzi, Akay, Olga Meltem, Amin, Bipinkumar, Anagnostopoulos, Achilleas, Anderson, Larry, Anttila, Pekka, Araujo, Carla, Arce-Lara, Carlos, Aydin, Yildiz, Basu, Supratik, Battini, Ramakrishna, Beeker, Thaddeus, Benboubker, Lotfi, Ben-Yehuda, Dina, Bladé, Joan, Blau, Igor Wolfgang, Boccia, Ralph, Burke, Lillian, Byeff, Peter, Cascavilla, Nicola, Cavo, Michele, Chantry, Andrew, Charles, Yen, Chaudhry, Arvind, Corso, Alessandro, Coyne, Mark, De Arriba, Felipe, Delimpasi, Sosana, Desjardins, Pierre, Dhakal, Binod, Di Bartolomeo, Paolo, Di Raimondo, Francesco, Dürig, Jan, Engelhardt, Monika, Escoffre-Barbe, Martine, Esteves, Graca, Flogegard, Max, Gabrail, Nashat, Gamberi, Barbara, Garrison, Mitchell, Gay, Julie, Gisslinger, Heinz, Goldschmidt, Hartmut, Goncalves, Cristina, Gressot, Laurent, Grosicki, Sebastian, Hanna, Wahid, Hayden, Patrick, Henriques Bernardo, Maria Manuela, Hermann, Robert, Holden, Viran, Honkalehto, Kirsti, Huben, Marianne, Huffman, John, Hunter, Hannah, Hus, Marek, Jagasia, Madan, Jagganath, Sundar, Janakiram, Murali, Jaiyesimi, Ishmael, Jenner, Matthew, João, Cristina, Johnson, Peter, Jurcyszyn, Artur, Kalayoğlu Beşişik, Sevgi, Kambhampati, Suman, Kanate, Abraham, Karadoğan, Ihsan, Khojasteh, Ali, Kirkel, Dean, Komarnicki, Mieczyslaw, Krauth, Maria-Theresa, Kuriakose, Phillip, Larocca, Alessandra, Lauri, Birgitta, Leleu, Xavier, Lucio, Paulo, Luppi, Mario, Mangiacavalli, Silvia, Mariette, Clara, Matsue, Kosei, Mellqvist, Ulf-Henri, Mendeleeva, Larisa, Meshad, Michael, Miller, Carole, Mohrbacher, Ann, Moreau, Philippe, Morelli, Anna Maria, Müldür, Ercan, Naassan, Anthony, Nahi, Hareth, Nair, Rajesh, O'Dwyer, Mike, Öngören Aydin, Seniz, Openshaw, Thomas, O'Rourke, Timothy, Osswald, Michael, Overton, Lindsay, Pati, Asmin, Pavic, Michel, Pegourie, Brigitte, Pehlivan, Mustafa, Pierola, Ana Alfonso, Plesner, Torben, Pluta, Andrzej, Rabin, Neil, Ramasamy, Karthik, Rambaldi, Alessandro, Rodriguez, Paula, Röllig, Christoph, Rosenblatt, Jacalyn, Rosenbluth, Jonathan, Salomo, Morten, Samoylova, Olga, Sastre Moral, Jose, Sati, Hamdi, Selleri, Carmine, Shafeek, Salim, Shinagawa, Atsushi, Sleckman, Bethany, Smith, Clay, Sonmez, Mehmet, Stone, Chester, Streetly, Matthew, Suzuki, Kenshi, Taetle, Raymond, Tafuri, Agostino, Takezako, Naoki, Teke, Hava Üsküdar, Vapaatalo, Mirja, Vassilopoulos, George, Verma, Amit, Vidito, Sarah, Viterbo, Luisa, Vural, Filiz, Wang, Xiang Sean, Yağci, Munci, Yee, Andrew, Richardson, Paul G, Oriol, Albert, Beksac, Meral, Liberati, Anna Marina, Galli, Monica, Schjesvold, Fredrik, Lindsay, Jindriska, Weisel, Katja, White, Darrell, Facon, Thierry, San Miguel, Jesus, Sunami, Kazutaka, O'Gorman, Peter, Sonneveld, Pieter, Robak, Pawel, Semochkin, Sergey, Schey, Steve, Yu, Xin, Doerr, Thomas, Bensmaine, Amine, Biyukov, Tsvetan, Peluso, Teresa, Zaki, Mohamed, Anderson, Kenneth, Dimopoulos, Meletios

Source: In The Lancet Oncology June 2019 20(6):781-794

Nonlymphoplasmacytic lymphomas associated with light-chain amyloidosis

Authors: Basset, Marco, Defrancesco, Irene, Milani, Paolo, Nuvolone, Mario, Rattotti, Sara, Foli, Andrea, Mangiacavalli, Silvia, Varettoni, Marzia, Benvenuti, Pietro, Cartia, Claudio Salvatore

Source: Blood. 135(4):293-296

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN622748403&indx=1&recIds=ETOCRN622748403

Anti-BCMA CAR-T cell-based therapies and bispecific antibodies in the immunotherapy era: are we ready for this?

Authors: Martino, Massimo, Gamberi, Barbara, Antonioli, Elisabetta, Aquino, Sara, Della Pepa, Roberta, Malerba, Lara, Mangiacavalli, Silvia, Pezzatti, Sara, Bringhen, Sara, Zamagni, Elena

Source: Expert Review of Hematology; Jul2024, Vol. 17 Issue 7, p375-390, 16p

Elotuzumab plus pomalidomide and dexamethasone in relapsed/refractory multiple myeloma: Extended follow‐up of a multicenter, retrospective real‐world experience with 321 cases outside of controlled clinical trials.

Authors: Martino, Enrica Antonia, Palmieri, Salvatore, Galli, Monica, Derudas, Daniele, Mina, Roberto, Della Pepa, Roberta, Zambello, Renato, Vigna, Ernesto, Bruzzese, Antonella, Mangiacavalli, Silvia, Zamagni, Elena, Califano, Catello, Musso, Maurizio, Conticello, Concetta, Cerchione, Claudio, Mele, Giuseppe, Di Renzo, Nicola, Offidani, Massimo, Tarantini, Giuseppe, Casaluci, Gloria Margiotta

Source: Hematological Oncology; Jul2024, Vol. 42 Issue 4, p1-10, 10p

Subject Terms: CLINICAL trials, MULTIPLE myeloma, DEXAMETHASONE, OVERALL survival, PROGRESSION-free survival

A real‐life study of daratumumab combinations in newly diagnosed patients with light chain (AL) amyloidosis.

Authors: Bellofiore, Claudia, Benvenuti, Pietro, Mina, Roberto, Basset, Marco, Foli, Andrea, Nanci, Martina, Nuvolone, Mario, Guida, Gianluigi, Attanasio, Andrea, Mussinelli, Roberta, Mangiacavalli, Silvia, Cartia, Claudio Salvatore, Masoni, Valeria, Palumbo, Michele, Cani, Lorenzo, Oliva, Stefania, Consoli, Ugo, Conticello, Concetta, Di Raimondo, Francesco, Arcaini, Luca

Source: Hematological Oncology; Jul2024, Vol. 42 Issue 4, p1-7, 7p

Subject Terms: DARATUMUMAB, AMYLOIDOSIS, LENALIDOMIDE, MULTIPLE myeloma, BORTEZOMIB

A risk‐stratification model based on the initial concentration of the serum monoclonal protein and MYD88 mutation status identifies a subset of patients with IgM monoclonal gammopathy of undetermined significance at high risk of progression to Waldenström macroglobulinaemia or other lymphoproliferative disorders

Authors: Varettoni, Marzia, Zibellini, Silvia, Boveri, Emanuela, Klersy, Catherine, Candido, Chiara, Rattotti, Sara, Ferretti, Virginia V., Defrancesco, Irene, Mangiacavalli, Silvia, Nizzoli, Maria E., Flospergher, Elena, Zerbi, Caterina, Bergamini, Fabio, Benvenuti, Pietro, Brociner, Marco, Merati, Gabriele, Paulli, Marco, Arcaini, Luca

Source: British journal of haematology. 187(4):441-446

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103065399.0x000001&indx=1&recIds=ETOCvdc_100103065399.0x000001

Smoldering multiple myeloma: the role of different scoring systems in identifying high-risk patients in real-life practice

Authors: Cocito, Federica, Mangiacavalli, Silvia, Ferretti, Virginia Valeria, Cartia, Claudio Salvatore, Ganzetti, Maya, Benveuti, Pietro, Pompa, Alessandra, Catalano, Martina, Fugazza, Elena, Landini, Benedetta, Arcaini, Luca, Corso, Alessandro

Source: Leukemia & lymphoma. 60(12):2968-2974

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097924831.0x000001&indx=1&recIds=ETOCvdc_100097924831.0x000001

The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity

Authors: Oliva, Laura, Orfanelli, Ugo, Resnati, Massimo, Raimondi, Andrea, Orsi, Andrea, Milan, Enrico, Palladini, Giovanni, Milani, Paolo, Cerruti, Fulvia, Cascio, Paolo, Casarini, Simona, Rognoni, Paola, Touvier, Thierry, Marcatti, Magda, Ciceri, Fabio, Mangiacavalli, Silvia, Corso, Alessandro, Merlini, Giampaolo, Cenci, Simone

Source: In Blood 13 April 2017 129(15):2132-2142

A real‐world retrospective–prospective analysis of efficacy and safety of combined ixazomib, lenalidomide, and dexamethasone in relapsed/refractory multiple myeloma: The northern Italy experience.

Authors: Furlan, Anna, Cea, Michele, Pavan, Laura, Galli, Monica, Clissa, Cristina, Mangiacavalli, Silvia, Cafro, Anna Maria, Girlanda, Stefania, Patriarca, Francesca, Minotto, Claudia, Bertoldero, Giovanni, Barilà, Gregorio, Pascarella, Anna, Lico, Albana, Paolini, Rossella, Rabassi, Nicholas, Pescosta, Norbert, Porrazzo, Marika, De Sabbata, Giovanni, Pompa, Alessandra

Source: Cancer Medicine; Apr2024, Vol. 13 Issue 7, p1-14, 14p

Subject Terms: MULTIPLE myeloma, LENALIDOMIDE, DEXAMETHASONE, PERIPHERAL neuropathy, EXANTHEMA

Geographic Terms: NORTHERN Italy, ITALY

Is re-challenge still an option as salvage therapy in multiple myeloma? The case of REal-life BOrtezomib re-Use as secoND treatment for relapsed patients exposed frontline to bortezomib-based therapies (the REBOUND Study)

Authors: Musto, Pellegrino, Simeon, Vittorio, Cascavilla, Nicola, Falcone, Antonietta, Petrucci, Maria Teresa, Cesini, Laura, Di Raimondo, Francesco, Conticello, Concetta, Ria, Roberto, Catalano, Lucio, Salvatore, Dalila, Mastrullo, Lucia, Gagliardi, Alfredo, Villani, Oreste, Pietrantuono, Giuseppe, D'Arena, Giovanni, Mansueto, Giovanna, Bringhen, Sara, Genuardi, Mariella, Di Renzo, Nicola, Reddiconto, Giovanni, Fragasso, Alberto, Caravita, Tommaso, Scapicchio, Daniele, Marziano, Gioacchino, Boccadoro, Mario, Mangiacavalli, Silvia, Corso, Alessandro

Source: Annals of hematology. 98(2):361-367

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125400152.0x000001&indx=1&recIds=ETOCvdc_100125400152.0x000001

Impact of the Addition of Daratumumab to the Standard Bortezomib-Thalidomide-Dexamethasone Regimen on Hematopoietic Stem Cell Mobilization and Collection, Post-Transplant Engraftment and Infectious Complications: A Case-Control Multicentre Real-Life Analysis

Authors: Cavallaro, Gianluca, Paris, Laura, Stefanoni, Paola, Pavoni, Chiara, Mangiacavalli, Silvia, Cartia, Claudio Salvatore, Pompa, Alessandra, Cafro, Anna Maria, Luisa Pioltelli, Maria, Pezzatti, Sara, Crippa, Stefano, Rambaldi, Alessandro, Galli, Monica

Source: Mediterranean Journal of Hematology & Infectious Diseases; 2024, Vol. 16 Issue 1, p1-4, 4p

Subject Terms: GRANULOCYTE-colony stimulating factor, PLASMA cells, HEMATOPOIETIC stem cells, REFERENCE values, AUTOGRAFTS, STEM cell transplantation

P-239: Health-related quality of life (HRQoL) in patients with relapsed/refractory multiple myeloma (RRMM) receiving real-life standard of care (SOC) treatments: results from the LocoMMotion study

Authors: Delforge, Michel, Moreau, Philippe, Einsele, Hermann, De Stefano, Valerio, Lindsey-Hill, Joanne, Vincent, Laure, Mangiacavalli, Silvia, Perrot, Aurore, Ocio, Enrique, ten Seldam, Silene, Groen-Damen, Ester in 't, Semerjian, Maria, Strulev, Vadim, Schecter, Jordan, Roccia, Tito, Gries, Katharine, Nesheiwat, Tonia, Wapenaar, Robert, Mateos, María-Victoria, Weisel, Katja

Source: Clinical lymphoma, myeloma & leukemia. 22(S):S166-S167

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169000681.0x000001&indx=1&recIds=ETOCvdc_100169000681.0x000001

Implemented myeloma management with whole-body low-dose CT scan: a real life experience

Authors: Mangiacavalli, Silvia, Pezzatti, Sara, Rossini, Fausto, Doni, Elisa, Cocito, Federica, Bolis, Silvia, Corso, Alessandro

Source: Leukemia & lymphoma. 57(7):1539-1545

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100037326406.0x000001&indx=1&recIds=ETOCvdc_100037326406.0x000001

The advantages of switch to subcutaneous bortezomib in the real life

Authors: Mangiacavalli, Silvia, Cocito, Federica, Ferretti, Virginia Valeria, Ganzetti, Maya, Cartia, Claudio Salvatore, Corso, Alessandro

Source: Leukemia & lymphoma. 59(6):1505-1507

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100101010941.0x000001&indx=1&recIds=ETOCvdc_100101010941.0x000001

Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenström's macroglobulinemia and related lymphoid neoplasms

Authors: Varettoni, Marzia, Arcaini, Luca, Zibellini, Silvia, Boveri, Emanuela, Rattotti, Sara, Riboni, Roberta, Corso, Alessandro, Orlandi, Ester, Bonfichi, Maurizio, Gotti, Manuel, Pascutto, Cristiana, Mangiacavalli, Silvia, Croci, Giorgio, Fiaccadori, Valeria, Morello, Lucia, Guerrera, Maria Luisa, Paulli, Marco, Cazzola, Mario

Source: In Blood 28 March 2013 121(13):2522-2528