Lomitapide for the treatment of paediatric patients with homozygous familial hypercholesterolaemia (APH-19): results from the efficacy phase of an open-label, multicentre, phase 3 study

Authors: Masana, Luis ^*, Zambon, Alberto, Schmitt, Claus Peter, Taylan, Christina, Driemeyer, Joenna, Cohen, Hofit, Buonuomo, Paola Sabrina, Alashwal, Abdullah, Al-Dubayee, Mohammed, Kholaif, Naji, Diaz-Diaz, José Luis, Maatouk, Faouzi, Martinez-Hervas, Sergio, Mangal, Brian, Löwe, Sandra, Cunningham, Tracy

Source: In The Lancet Diabetes & Endocrinology December 2024 12(12):880-889

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LOMITAPIDE PHASE-3 STUDY IN PEDIATRIC HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HOFH): APH-19

Authors: Kholaif, Naji, Masana, Luis, Zambon, Alberto, Schmitt, Claus Peter, Taylan, Christina, Driemeyer, Joenna, Cohen, Hofit, Buonuomo, Paola Sabrina, Alashwal, Abdullah, Al-Dubayee, Mohammad, Diaz-Diaz, Jose Luis, Maatouk, Faouzi, Martinez-Hervas, Sergio, Mangal, Brian, Lowe, Sandra, Tamas, Zsuzsanna

Source: In Atherosclerosis December 2024 399 Supplement 1

Lomitapide in paediatric patients with homozygous familial hypercholesterolaemia (HoFH) – analysis of patient-level LDL-C reduction, fat soluble vitamins, lipoproteins and patient maturation from APH-19 study

Authors: Masana, Lluis, Zambon, Alberto, Schmitt, Claus, Taylan, Christina, Dreimeyer, Joenna, Cohen, Hofit, Buonuomo, Paola, Alashwal, Abdullah, Al-Dubayee, Mohammed, Diaz-Diaz, Jose, Maatouk, Faouzi, Martínez-Hervás, Sergio, Mangal, Brian, Kholaif, Naji, Löwe, Sandra, Tamas, Zsuzsanna

Source: In Atherosclerosis August 2024 395 Supplement 1

Statistical considerations when estimating time‐saving treatment effects in Alzheimer's disease clinical trials.

Authors: Wang, Guoqiao, Cutter, Gary, Oxtoby, Neil P., Shan, Guogen, Wang, Whedy, Mangal, Brian, Liao, Yijie, Llibre‐Guerra, Jorge J., Li, Yan, Xiong, Chengjie, McDade, Eric, Delmar, Paul, Bateman, Randall J., Schneider, Lon

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Aug2024, Vol. 20 Issue 8, p5421-5433, 13p

Design of INFRONT-3: A phase 3 randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of latozinemab in participants with FTD-GRN

Authors: Carter, Lawrence, Huang, Julie, Nader, David, Mangal, Brian, Stansley, Branden, Wang, Whedy, Rosenthal, Arnon

Source: In Journal of the Neurological Sciences December 2023 455 Supplement

Detection of unreported alcohol consumption in fatty liver disease

Authors: Staufer, Katharina, Mangal, Brian, Trauner, Michael

Source: In Journal of Hepatology February 2023 78(2):e67-e69

Lomitapide in Pediatric Patients with Homozygous Familial Hypercholesterolemia – Analysis of Secondary and Safety Endpoints from the APH-19 Study

Authors: Schmitt, Claus, Zambon, Alberto, Taylan, Christina, Driemeyer, Joenna, Cohen, Hofit, Buonuomo, Paola, Alashwal, Abdullah, Al-Dubayee, Mohammed, Diaz-Diaz, José, Maatouk, Faouzi, Martinez-Hervas, Sergio, Mangal, Brian, Kholaif, Naji, Löwe, Sandra, Tamas, Zsuzsanna, Masana, Luis

Source: In Journal of Clinical Lipidology July-August 2024 18(4) Supplement:e545-e546

The Effect of Xanthine Oxidase Inhibition Upon Ejection Fraction in Heart Failure Patients: La Plata Study

Authors: Cingolani, Horacio E., Plastino, Juan A., Escudero, Eduardo M., Mangal, Brian, Brown, Joanne, Pérez, Néstor G.

Source: In Journal of Cardiac Failure 2006 12(7):491-498

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Efficacy and Safety Study of Oxypurinol Added to Standard Therapy in Patients with New York Heart Association Class III-IV Congestive Heart Failure (The OPT-CHF Trial)

Authors: Hare, Joshua M., Mangal, Brian, Brown, Joanne, Fisher, Charles, Jr., Freudenberger, Ronald S., Colucci, Wilson S., Mann, Douglas L., Liu, Peter, Givertz, Michael M., Schwarz, Richard P.

Source: In Journal of Cardiac Failure 2006 12(9):764-764

Point-of-Use Mixing of Influenza H5N1 Vaccine and MF59 Adjuvant for Pandemic Vaccination Preparedness: Antibody Responses and Safety. A Phase 1 Clinical Trial.

Authors: Mulligan, Mark J., Bernstein, David I., Frey, Sharon, Winokur, Patricia, Rouphael, Nadine, Dickey, Michelle, Edupuganti, Srilatha, Spearman, Paul, Anderson, Edwin, Graham, Irene, Noah, Diana L., Mangal, Brian, Kim, Sonnie, Hill, Heather

Source: Open Forum Infectious Diseases; Oct2014, Vol. 1 Issue 3, p1-1, 1p

Subject Terms: AVIAN influenza A virus, H5N1 Influenza, VACCINE research, VACCINATION, IMMUNOGLOBULINS

Safety, Reactogenicity, and Immunogenicity of Inactivated Monovalent Influenza A(H5N1) Virus Vaccine Administered With or Without AS03 Adjuvant.

Authors: Chen, Wilbur H., Jackson, Lisa A., Edwards, Kathryn M., Keitel, Wendy A., Hill, Heather, Noah, Diana L., Creech, C. Buddy, Patel, Shital M., Mangal, Brian, Kotloff, Karen L.

Source: Open Forum Infectious Diseases; Oct2014, Vol. 1 Issue 3, p1-1, 1p

Subject Terms: INFLUENZA treatment, INFLUENZA vaccination research, PANDEMICS, IMMUNE response, VACCINE research, HEMAGGLUTINATION tests

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