Brain endothelial permeability, transport, and flow assessed over 10 orders of magnitude using the in situ brain perfusion technique.

Authors: Smith, Quentin R.^1,2 (AUTHOR) quentin.smith@ttuhsc.edu, Mandula, Haritha¹ (AUTHOR) haritha.mandula@gmail.com, Parepally, Jagan Mohan R.¹ (AUTHOR) Jagan.parepally@gmail.com, Oki, Jun^1,2 (AUTHOR) junoki@zf6.so-net.ne.jp, Thomas, Fancy¹ (AUTHOR) thomasfancy@gmail.com, Thorsheim, Helen R.¹ (AUTHOR) helen.thorsheim@ttuhsc.edu, Al-Ahmad, Abraham J.¹ (AUTHOR) abraham.al-ahmad@ttuhsc.edu, Abbruscato, Thomas J.¹ (AUTHOR) thomas.abbruscato@ttuhsc.edu, Ask, Per³ (AUTHOR) per.ask@liu.se, Hage, David S.⁴ (AUTHOR) dhage1@unl.edu, Robinson, Peter J.² (AUTHOR) nosniborp@yahoo.com

Source: Fluids & Barriers of the CNS. 12/17/2024, Vol. 21 Issue 1, p1-41. 41p.

Subject Terms: *CELL permeability, *CEREBRAL circulation, *ACTIVE biological transport, *BLOOD proteins, *SERUM albumin

PBBM Considerations for Base Models, Model Validation, and Application Steps: Workshop Summary Report

Authors: Heimbach, Tycho, Musuamba Tshinanu, Flora, Raines, Kimberly, Borges, Luiza, Kijima, Shinichi, Malamatari, Maria, Moody, Rebecca, Veerasingham, Shereeni, Seo, Paul, Turner, David, Fang, Lanyan, Stillhart, Cordula, Bransford, Philip, Ren, Xiaojun, Patel, Nikunjkumar, Sperry, David, Chen, Hansong, Rostami-Hodjegan, Amin, Lukacova, Viera, Sun, Duxin, Nguefack, Jean-Flaubert, Carducci, Tessa, Grimstein, Manuela, Pepin, Xavier, Jamei, Masoud, Stamatopoulos, Konstantinos, Li, Min, Sanghavi, Maitri, Tannergren, Christer, Mandula, Haritha, Zhao, Zhuojun, Ju, Tzuchi Rob, Wagner, Christian, Arora, Sumit, Wang, Michael, Rullo, Gregory, Mitra, Amitava, Kollipara, Sivacharan, Chirumamilla, Siri Kalyan, Polli, James E., Mackie, Claire

Source: Molecular Pharmaceutics; November 2024, Vol. 21 Issue: 11 p5353-5372, 20p

Applications of Physiologically Based Biopharmaceutics Modeling (PBBM) to Support Drug Product Quality: A Workshop Summary Report

Authors: Mitra, Amitava, Suarez-Sharp, Sandra, Pepin, Xavier J.H., Flanagan, Talia, Zhao, Yang, Kotzagiorgis, Evangelos, Parrott, Neil, Sharan, Satish, Tistaert, Christophe, Heimbach, Tycho, Zolnik, Banu, Sjögren, Erik, Wu, Fang, Anand, Om, Kakar, Shefali, Li, Min, Veerasingham, Shereeni, Kijima, Shinichi, Lima Santos, Gustavo Mendes, Ning, Baoming, Raines, Kimberly, Rullo, Greg, Mandula, Haritha, Delvadia, Poonam, Dressman, Jennifer, Dickinson, Paul A., Babiskin, Andrew

Source: In Journal of Pharmaceutical Sciences February 2021 110(2):594-609

Applications of Clinically Relevant Dissolution Testing: Workshop Summary Report

Authors: Suarez-Sharp, Sandra, Cohen, Michael, Kesisoglou, Filippos, Abend, Andreas, Marroum, Patrick, Delvadia, Poonam, Kotzagiorgis, Evangelos, Li, Min, Nordmark, Anna, Bandi, Nagesh, Sjögren, Erik, Babiskin, Andrew, Heimbach, Tycho, Kijima, Shinichi, Mandula, Haritha, Raines, Kimberly, Seo, Paul, Zhang, Xinyuan

Source: AAPS journal. 20(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128525095.0x000001&indx=1&recIds=ETOCvdc_100128525095.0x000001

Role of Site-Specific Binding to Plasma Albumin in Drug Availability to Brain

Authors: Mandula, Haritha, Parepally, Jagan Mohan R., Feng, Rose, Smith, Quentin R. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics May 2006 317(2):667-675

Current Approaches for Dissolution Similarity Assessment, Requirements, and Global Expectations.

Authors: Abend, Andreas M., Zhang, Limin, Fredro-Kumbaradzi, Emilija, Hoffelder, Thomas, Cohen, Michael J., Anand, Om, Delvadia, Poonam, Mandula, Haritha, Zhang, Zhen, Kotzagiorgis, Evangelos, Lum, Susan, Pereira, Victor Gomes, Barker, Amy, Lavrich, David, Kraemer, Johannes, Sharp-Suarez, Sandra

Source: AAPS Journal; May2022, Vol. 24 Issue 3, p1-11, 11p

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Chapter 197 - Amino Acid Transport Across the Blood—Brain Barrier

Authors: Smith, Quentin R., Mandula, Haritha, Parepally, Jagen M.R.

Source: In Handbook of Biologically Active Peptides 2006:1415-1422

Brain Uptake of Nonsteroidal Anti-Inflammatory Drugs: Ibuprofen, Flurbiprofen, and Indomethacin

Authors: Parepally, Jagan, Mandula, Haritha, Smith, Quentin

Source: Pharmaceutical Research; May 2006, Vol. 23 Issue: 5 p873-881, 9p