Interleukin-12 decorated nanosized semiflexible Immunofilaments enable directed targeting and augmented IFNγ responses of natural killer cells

Authors: Weiss, Lea, Schluck, Marjolein, Classens, René, de Jonge, Paul K.J.D., van der Waart, Anniek, Nguyen, Khue G., Nguyen, Tam T., Zaharoff, David A., Malmberg, Karl-Johan, Dolstra, Harry, Figdor, Carl G., Sohlberg, Ebba, Hammink, Roel

Source: In Acta Biomaterialia 1 January 2025 191:386-397

MetaGate: Interactive analysis of high-dimensional cytometry data with metadata integration

Authors: Ask, Eivind Heggernes, Tschan-Plessl, Astrid, Hoel, Hanna Julie, Kolstad, Arne, Holte, Harald, Malmberg, Karl-Johan

Source: In Patterns 12 July 2024 5(7)

A temporal developmental map separates human NK cells from noncytotoxic ILCs through clonal and single-cell analysis

Authors: Vo, Dang Nghiem, Yuan, Ouyang, Kanaya, Minoru, Telliam-Dushime, Gladys, Li, Hongzhe, Kotova, Olga, Caglar, Emel, Honnens de Lichtenberg, Kristian, Rahman, Shamim Herbert, Soneji, Shamit, Scheding, Stefan, Bryder, David, Malmberg, Karl-Johan, Sitnicka, Ewa

Source: In Blood Advances 11 June 2024 8(11):2933-2951

Systematic evaluation of donor-KIR/recipient-HLA interactions in HLA-matched hematopoietic cell transplantation for AML

Authors: Fein, Joshua A., Shouval, Roni, Krieger, Elizabeth, Spellman, Stephen R., Wang, Tao, Baldauf, Henning, Fleischhauer, Katharina, Kröger, Nicolaus, Horowitz, Mary, Maiers, Martin, Miller, Jeffrey S, Mohty, Mohamad, Nagler, Arnon, Weisdorf, Daniel, Malmberg, Karl-Johan, Toor, Amir A., Schetelig, Johannes, Romee, Rizwan, Koreth, John

Source: In Blood Advances 13 February 2024 8(3):581-590

Mapping the chemotactic landscape in NK cells reveals subset-specific synergistic migratory responses to dual chemokine receptor ligation

Authors: Lachota, Mieszko, Zielniok, Katarzyna, Palacios, Daniel, Kanaya, Minoru, Penna, Leena, Hoel, Hanna Julie, Wiiger, Merete Thune, Kveberg, Lise, Hautz, Wojciech, Zagożdżon, Radosław, Malmberg, Karl-Johan

Source: In eBioMedicine October 2023 96

Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires

Authors: Philippon, Camille, Tao, Sudan, Clement, Dennis, Haroun-Izquierdo, Alvaro, Kichula, Katherine M., Netskar, Herman, Brandt, Ludwig, Oei, Vincent Sheng, Kanaya, Minoru, Lanuza, Pilar Maria, Schaffer, Marie, Goodridge, Jodie P., Horowitz, Amir, Zhu, Faming, Hammer, Quirin, Sohlberg, Ebba, Majhi, Rakesh Kumar, Kveberg, Lise, Önfelt, Björn, Norman, Paul J., Malmberg, Karl-Johan

Source: In Blood Advances 22 August 2023 7(16):4492-4504

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19

Authors: Karolinska KI/K COVID-19 Study Group, Lourda, Magda, Dzidic, Majda, Hertwig, Laura, Bergsten, Helena, Medina, Laura M. Palma, Sinha, Indranil, Kvedaraite, Egle, Chen, Puran, Muvva, Jagadeeswara R., Gorin, Jean-Baptiste, Cornillet, Martin, Emgård, Johanna, Moll, Kirsten, García, Marina, Maleki, Kimia T., Klingström, Jonas, Michaëlsson, Jakob, Flodström-Tullberg, Malin, Brighenti, Susanna, Buggert, Marcus, Mjösberg, Jenny, Malmberg, Karl-Johan, Sandberg, Johan K., Henter, Jan-Inge, Folkesson, Elin, Gredmark-Russ, Sara, Sönnerborg, Anders, Eriksson, Lars I., Rooyackers, Olav, Aleman, Soo, Strålin, Kristoffer, Ljunggren, Hans-Gustaf, Björkström, Niklas K., Svensson, Mattias, Ponzetta, Andrea, Norrby-Teglund, Anna, Chambers, Benedict J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Oct 01. 118(40), 1-12.

Access URL: https://www.jstor.org/stable/27075972

Perturbed NK-cell homeostasis associated with disease severity in chronic neutropenia

Authors: Sohlberg, Ebba, Pfefferle, Aline, Heggernes Ask, Eivind, Tschan-Plessl, Astrid, Jacobs, Benedikt, Netskar, Herman, Lorenz, Susanne, Kanaya, Minoru, Kosugi-Kanaya, Mizuha, Meinke, Stephan, Mörtberg, Anette, Höglund, Petter, Sundin, Mikael, Carlsson, Göran, Palmblad, Jan, Malmberg, Karl-Johan

Source: Blood. 139(5):704-716

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183249558.0x000001&indx=1&recIds=ETOCvdc_100183249558.0x000001

An optimized platform for efficient siRNA delivery into human NK cells

Authors: Palacios, Daniel, Momayyezi, Pouria, Huhn, Oisín, Ask, Eivind Heggernes, Dunst, Josefine, Malmberg, Karl‐Johan, Hammer, Quirin

Source: European journal of immunology. 52(7):1190-1193

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168270498.0x000001&indx=1&recIds=ETOCvdc_100168270498.0x000001

Advances in immune therapies in hematological malignancies

Authors: Mazzarella, Luca, Enblad, Gunilla, Olweus, Johanna, Malmberg, Karl‐Johan, Jerkeman, Mats

Source: Journal of internal medicine. 292(2):205-220

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157099606.0x000001&indx=1&recIds=ETOCvdc_100157099606.0x000001

NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer

Authors: Salomé, Bérengère, Sfakianos, John P., Ranti, Daniel, Daza, Jorge, Bieber, Christine, Charap, Andrew, Hammer, Christian, Banchereau, Romain, Farkas, Adam M., Ruan, Dan Fu, Izadmehr, Sudeh, Geanon, Daniel, Kelly, Geoffrey, de Real, Ronaldo M., Lee, Brian, Beaumont, Kristin G., Shroff, Sanjana, Wang, Yuanshuo A., Wang, Ying-chih, Thin, Tin Htwe, Garcia-Barros, Monica, Hegewisch-Solloa, Everardo, Mace, Emily M., Wang, Li, O’Donnell, Timothy, Chowell, Diego, Fernandez-Rodriguez, Ruben, Skobe, Mihaela, Taylor, Nicole, Kim-Schulze, Seunghee, Sebra, Robert P., Palmer, Doug, Clancy-Thompson, Eleanor, Hammond, Scott, Kamphorst, Alice O., Malmberg, Karl-Johan, Marcenaro, Emanuela, Romero, Pedro, Brody, Rachel, Viard, Mathias, Yuki, Yuko, Martin, Maureen, Carrington, Mary, Mehrazin, Reza, Wiklund, Peter, Mellman, Ira, Mariathasan, Sanjeev, Zhu, Jun, Galsky, Matthew D., Bhardwaj, Nina, Horowitz, Amir

Source: In Cancer Cell 12 September 2022 40(9):1027-1043

SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells

Authors: Hammer, Quirin, Dunst, Josefine, Christ, Wanda, Picarazzi, Francesca, Wendorff, Mareike, Momayyezi, Pouria, Huhn, Oisín, Netskar, Herman K., Maleki, Kimia T., García, Marina, Sekine, Takuya, Sohlberg, Ebba, Azzimato, Valerio, Aouadi, Myriam, Degenhardt, Frauke, Franke, Andre, Spallotta, Francesco, Mori, Mattia, Michaëlsson, Jakob, Björkström, Niklas K., Rückert, Timo, Romagnani, Chiara, Horowitz, Amir, Klingström, Jonas, Ljunggren, Hans-Gustaf, Malmberg, Karl-Johan

Source: In Cell Reports 8 March 2022 38(10)

Anti-NKG2C/IL-15/anti-CD33 killer engager directs primary and iPSC-derived NKG2C+ NK cells to target myeloid leukemia

Authors: Chiu, Emily, Felices, Martin, Cichocki, Frank, Davis, Zachary, Wang, Hongbo, Tuninga, Katie, Vallera, Daniel A., Lee, Tom, Bjordahl, Ryan, Malmberg, Karl Johan, Valamehr, Bahram, Miller, Jeffrey S.

Source: In Molecular Therapy 1 December 2021 29(12):3410-3421

Cellular immunotherapy with multiple infusions of in vitro-expanded haploidentical natural killer cells after autologous transplantation for patients with plasma cell myeloma

Authors: Tschan-Plessl, Astrid, Kalberer, Christian P., Wieboldt, Ronja, Stern, Martin, Siegler, Uwe, Wodnar-Filipowicz, Aleksandra, Gerull, Sabine, Halter, Jörg, Heim, Dominik, Tichelli, André, Tsakiris, Dimitrios A., Malmberg, Karl-Johan, Passweg, Jakob R., Bottos, Alessia

Source: In Cytotherapy April 2021 23(4):329-338

A Systemic Protein Deviation Score Linked to PD-1+ CD8+ T Cell Expansion That Predicts Overall Survival in Diffuse Large B Cell Lymphoma

Authors: Ask, Eivind Heggernes, Tschan-Plessl, Astrid, Gjerdingen, Thea Johanne, Sætersmoen, Michelle Lu, Hoel, Hanna Julie, Wiiger, Merete Thune, Olweus, Johanna, Wahlin, Björn E., Lingjærde, Ole Christian, Horowitz, Amir, Cashen, Amanda F., Watkins, Marcus, Fehniger, Todd A., Holte, Harald, Kolstad, Arne, Malmberg, Karl-Johan

Source: In Med 12 February 2021 2(2):180-195

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

Authors: Akber, Mira, Berglin, Lena, Bergsten, Helena, Brighenti, Susanna, Brownlie, Demi, Butrym, Marta, Chambers, Benedict, Chen, Puran, Jeannin, Martin Cornillet, Grip, Jonathan, Gomez, Angelica Cuapio, Dillner, Lena, Lozano, Isabel Diaz, Dzidic, Majda, Tullberg, Malin Flodström, Färnert, Anna, Glans, Hedvig, Haroun-Izquierdo, Alvaro, Henriksson, Elizabeth, Hertwig, Laura, Kalsum, Sadaf, Kokkinou, Efthymia, Kvedaraite, Egle, Loreti, Marco, Lourda, Magalini, Maleki, Kimia, Malmberg, Karl-Johan, Marquardt, Nicole, Maucourant, Christopher, Michaelsson, Jakob, Mjösberg, Jenny, Moll, Kirsten, Muva, Jagadees, Mårtensson, Johan, Nauclér, Pontus, Norrby-Teglund, Anna, Medina, Laura Palma, Persson, Björn, Radler, Lena, Ringqvist, Emma, Sandberg, John Tyler, Sohlberg, Ebba, Soini, Tea, Svensson, Mattias, Tynell, Janne, Varnaite, Renata, Kries, Andreas Von, Unge, Christian, Sekine, Takuya, Perez-Potti, André, Rivera-Ballesteros, Olga, Strålin, Kristoffer, Gorin, Jean-Baptiste, Olsson, Annika, Llewellyn-Lacey, Sian, Kamal, Habiba, Bogdanovic, Gordana, Muschiol, Sandra, Wullimann, David J., Kammann, Tobias, Emgård, Johanna, Parrot, Tiphaine, Folkesson, Elin, Rooyackers, Olav, Eriksson, Lars I., Henter, Jan-Inge, Sönnerborg, Anders, Allander, Tobias, Albert, Jan, Nielsen, Morten, Klingström, Jonas, Gredmark-Russ, Sara, Björkström, Niklas K., Sandberg, Johan K., Price, David A., Ljunggren, Hans-Gustaf, Aleman, Soo, Buggert, Marcus

Source: In Cell 1 October 2020 183(1):158-168

Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity

Authors: Zhu, Huang, Blum, Robert H., Bernareggi, Davide, Ask, Eivind Heggernes, Wu, Zhengming, Hoel, Hanna Julie, Meng, Zhipeng, Wu, Chengsheng, Guan, Kun-Liang, Malmberg, Karl-Johan, Kaufman, Dan S.

Source: In Cell Stem Cell 6 August 2020 27(2):224-237

Effect of mTOR Inhibition with Sirolimus on Natural Killer Cell Reconstitution in Allogeneic Stem Cell Transplantation

Authors: Haroun-Izquierdo, Alvaro, Lanuza, Pilar M., Pfefferle, Aline, Netskar, Herman, Ask, Eivind H., Törlén, Johan, Björklund, Andreas, Sohlberg, Ebba, Malmberg, Karl-Johan

Source: Transplantation and Cellular Therapy. 29(6):376.e1-376.e11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191074775.0x000001&indx=1&recIds=ETOCvdc_100191074775.0x000001

The NKG2/HLA-E Axis Influence Outcomes of Haploidentical Transplantation

Authors: Torralba-Raga, Lamberto ^{1, 2, 3}, Malmberg, Karl-Johan ^{1, 2, 3}

Source: In Transplantation and Cellular Therapy March 2025 31(3):118-120

Targeting HLA-E-overexpressing cancers with a NKG2A/C switch receptor

Authors: Sætersmoen, Michelle ^{1, 2, 7}, Kotchetkov, Ivan S. ^{3, 4, 7}, Torralba-Raga, Lamberto ^{1, 2, 7}, Mansilla-Soto, Jorge ^{4, 6}, Sohlberg, Ebba ⁵, Krokeide, Silje Zandstra ^{1, 2}, Hammer, Quirin ⁵, Sadelain, Michel ⁴, Malmberg, Karl-Johan ^{1, 2, 8, ∗}

Source: In Med 14 February 2025 6(2)