In vivo 4D x-ray dark-field lung imaging in mice

Authors: How, Ying Ying, Reyne, Nicole, Croughan, Michelle K., Cmielewski, Patricia, Batey, Daniel, Costello, Lucy F., Smith, Ronan, Ahlers, Jannis N., Cholewa, Marian, Kolodziej, Magdalena, Duerr, Julia, Mall, Marcus A., Kitchen, Marcus J., Asselin-Labat, Marie-Liesse, Paganin, David M., Donnelley, Martin, Morgan, Kaye S.

Subject Terms: Physics - Medical Physics

Access URL: http://arxiv.org/abs/2411.14669

Vanzacaftor–tezacaftor–deutivacaftor versus elexacaftor–tezacaftor–ivacaftor in individuals with cystic fibrosis aged 12 years and older (SKYLINE Trials VX20-121-102 and VX20-121-103): results from two randomised, active-controlled, phase 3 trials

Authors: Krick, Stefanie, McCoy, Karen, Goss, Christopher, Weiner, Daniel, Billings, Joanne, Ren, Clement, Atkinson, Jeffrey, Linnemann, Rachel, Trimble, Aaron, Frederick, Carla, Liou, Theodore, Escobar, Hugo, Wang, Janice, Deschamps, Ashley, Froh, Deborah, Chmiel, James, Wurth, Mark, Yonker, Lael, Jain, Manu, Millard, Susan, Tolle, James, Filbrun, Amy, Taylor-Cousar, Jennifer, Ruiz, Fadel, Brown, Cynthia, Quick, Bryon, Brown, Perry, Kennedy, John, Ruddy, Jennifer, Shkolnik, Boris, Pancham, Krishna, DiMango, Emily, Fiel, Stanley, Mueller, Gary, Livingston, Floyd, Braun, Andrew, O'Sullivan, Brian, Dubin, Patricia, Teneback, Charlotte, Kremer, Ted, Welter, John, Hoppe, Jordana, Jain, Raksha, Calimano, Francisco, Johannes, Jimmy, Daines, Cori, Green, Deanna, Keens, Thomas, Trillo-Alvarez, Cesar, Scher, Herschel, Mermis, Joel, Morrissey, Brian, Wallace, James, Barrios, Christopher, Callison, John, Holliday, Zachary, Klingsberg, Ross, Efrati, Ori, Cohen-Cymberknoh, Malena, Prais, Dario, Azevedo, Pilar, Quintana-Gallego, Esther, Wong, Janice, Mondejar-Lopez, Pedro, Lopez Neyra, Alejandro, Amorim, Adelina, Sivam, Sheila, Asensio de la Cruz, Oscar, Waller, Michael, Forseen, Caralee, Marion, Chad, Dittrich, Anna-Maria, Lysinger, Jerimiah, Casserly, Brian, Luna, Carmen, Brown, Sarah, Singer, Jonathan, Schellhase, Dennis, Roberts, Jon, King, Christopher, Byrnes, Catherine, Ringshausen, Felix, Hebestreit, Helge, Lorenz, Michael, Ruppel, Renate, Drevinek, Pavel, Dillenhofer, Stefanie, Stahl, Mirjam, Gleiber, Wolfgang, Homola, Lukas, Naehrig, Susanne, Stehling, Florian, Sutharsan, Sivagurunathan, Fischer, Rainald, Poplawska, Krystyna, Haworth, Charles, Simmonds, Nicholas, Urquhart, Don, Duckers, Jamie, Carroll, Mary, Barry, Peter, Doe, Simon, Hilliard, Tom, MacGregor, Gordon, Patel, Neil, Withers, Nicholas, Peckham, Daniel, Ledson, Martin, Koser, Usma, Gartner, Silvia, Blitz Castro, Enrique, Sole Jover, Amparo, Cox, Desmond, McKone, Edward, Plant, Barry, Williamson, Michael, Elnazir, Basil, Barbosa, Telma, Cols Roig, Maria, Burr, Lucy, Henderson, Daniel, Middleton, Peter, Kotsimbos, Tom, De Monestrol, Isabelle, Gilljam, Marita, Lindberg, Ulrika, Schwarz, Carsten, Bode, Sebastian, Epton, Michael, Halasz, Adrien, Laki, Istvan, O'Carroll, Mark, Fortner, Christopher, Bilodeau, Lara, Lapey, Allen, Moffett, Kathryn, Jia, Shijing, Uluer, Ahmet, Sears, Edmund, Keating, Claire, Omlor, Gregory, Mehdi, Nighat, Tupayachi Ortiz, Maria Gabriela, Messore, Barbara, Lambert, Allison, Mukadam, Zubin, Egan, Marie, Wilhelm, Andrew, Reyes, Santiago, Schaeffer, David, Szepfalusi, Zsolt, Epaud, Ralph, Leroy, Sylvie, Fischer Biner, Reta, Moeller, Alexander, Salvatore, Donatello, Johnson, Larry, Gohy, Sophie, Gramegna, Andrea, Olesen, Hanne, Tissot, Adrien, Marguet, Christophe, Desai, Maya, Owens, Louisa, Kherani, Tamizan, Sands, Dorota, Bakkeheim, Egil, Tullis, Elizabeth, Chilvers, Mark, Quon, Bradley, Lands, Larry, Parkins, Michael, Tremblay, Francois, Maitra, Anirban, Staples, Heather, Elidemir, Okan, Chatziagorou, Elpis, Tirakitsoontorn, Pornchai, Grenet, Dominique, Linnane, Barry, Nicholson, John Michael, Manika, Katerina, Tatopoulos, Aurelie, Pressler, Tacjana, Bagheri-Potthoff, Azadeh, Legg, Julian, Horsley, Alexander, Lee, Timothy, Houdouin, Veronique, Ramel, Sophie, Fajac, Isabelle, Sermet-Gaudelus, Isabelle, Kamphuis, Lieke, van der Ent, Kors, Vermeulen, Francois, Chiron, Raphael, Reix, Philippe, Van Braeckel, Eva, Knoop, Christiane, Vanderhelst, Eef, Durieu, Isabelle, Bui, Stephanie, Weiss, Laurence, Le Rouzic, Olivier, van der Meer, Renske, Roukema, Jolt, Altenburg, Josje, Robinson, Philip, Wainwright, Claire, Mulrennan, Siobhain, Clements, Barry, Taccetti, Giovanni, Cipolli, Marco, Dacco, Valeria, Fabrizzi, Benedetta, Castellani, Carlo, Eber, Ernst, Appelt, Dorothea, Studnicka, Michael, Sapiejka, Ewa, Mazurek, Henryk, Engan, Mette, Sauty, Alain, Mankikian, Julie, Yonker, Lael M ^b, Vermeulen, François ^c, Linnemann, Rachel W ^e, Braun, Andrew T ⁱ, Ramsey, Bonnie ^l, Mall, Marcus A ^{m, n, o}, Taylor-Cousar, Jennifer L ^p, McKone, Edward F ^q, Floreth, Tim ^s, Michelson, Peter ^s, Sosnay, Patrick R ^s, Nair, Nitin ^s, Zahigian, Rachel ^s, Martin, Hannah ^s, Ahluwalia, Neil ^s, Lam, Anna ^s

Source: In The Lancet Respiratory Medicine March 2025 13(3):256-271

Vanzacaftor–tezacaftor–deutivacaftor for children aged 6–11 years with cystic fibrosis (RIDGELINE Trial VX21-121-105): an analysis from a single-arm, phase 3 trial

Authors: McPhail, Gary, McCoy, Karen, Roesch, Erica, Weiner, Daniel, Milla, Carlos, Pittman, Jessica, Linnemann, Rachel, Stone, Anne, Escobar, Hugo, Chmiel, James, Ruiz, Fadel, Gaffin, Jonathan, Levy, Hara, Lahiri, Thomas, Hoppe, Jordana, Moore, Brooke, Davies, Gwyneth, Moeller, Alexander, Dittrich, Anna-Maria, Latzin, Philipp, Tirakitsoontorn, Pornchai, Dowell, Maria, Thia, Lena, Stahl, Mirjam, Stehling, Florian, DeCelie-Germana, Joan, Sermet-Gaudelus, Isabelle, Janssens, Hettie, Reix, Philippe, Robinson, Philip, Wainwright, Claire, Tai, Andrew, Svedberg, Marcus, Hoppe, Jordana E ^a, Kasi, Ajay S ^b, Pittman, Jessica E ^c, Jensen, Renee ^d, Thia, Lena P ^e, Ramsey, Bonnie ^j, Mall, Marcus A ^{k, l, m}, Taylor-Cousar, Jennifer L ⁿ, McKone, Edward F ^o, Tullis, Elizabeth ^p, Salinas, Danieli B ^q, Zhu, Jiaqiang ^q, Chen, Yih-Chieh ^q, Rodriguez-Romero, Violeta ^q, Sosnay, Patrick R ^q

Source: In The Lancet Respiratory Medicine March 2025 13(3):244-255

Elexacaftor/tezacaftor/ivacaftor improves nasal nitric oxide in patients with cystic fibrosis

Authors: Pioch, Charlotte O., Ziegahn, Niklas, Allomba, Christine, Busack, Leonie M., Schnorr, Alexandra N., Tosolini, Apolline, Fuhlrott, Bent R., Zagkla, Styliani, Othmer, Till, Syunyaeva, Zulfiya, Graeber, Simon Y., Yoosefi, Mehrak, Thee, Stephanie, Steinke, Eva, Röhmel, Jobst, Mall, Marcus A., Stahl, Mirjam

Source: In Journal of Cystic Fibrosis September 2024 23(5):863-869

Ileal mucus viscoelastic properties differ in Crohn’s disease

Authors: Kramer, Catharina, Rulff, Hanna, Ziegler, Jörn Felix, Mönch, Paul Wilhelm, Alzain, Nadra, Addante, Annalisa, Kuppe, Aditi, Timm, Sara, Schrade, Petra, Bischoff, Philip, Glauben, Rainer, Dürr, Julia, Ochs, Matthias, Mall, Marcus A., Gradzielski, Michael, Siegmund, Britta

Source: In Mucosal Immunology August 2024 17(4):713-722

Lymphocyte transformation tests predict delayed-type allergy to piperacillin/tazobactam in patients with cystic fibrosis

Authors: Roehmel, Jobst F., Rohrbach, Alexander, Staab, Doris, Mall, Marcus A., Ogese, Monday, Doerfler, Friederike, Naisbitt, Dean

Source: In Journal of Cystic Fibrosis May 2024 23(3):573-578

Elexacaftor/tezacaftor/ivacaftor improves chronic rhinosinusitis detected by magnetic resonance imaging in children with cystic fibrosis on long-term therapy with lumacaftor/ivacaftor

Authors: Wucherpfennig, Lena, Becker, Johanna K.Z., Wuennemann, Felix, Eichinger, Monika, Seitz, Angelika, Baumann, Ingo, Stahl, Mirjam, Graeber, Simon Y., Zhao, Shengkai, Chung, Jaehi, Schenk, Jens-Peter, Alrajab, Abdulsattar, Kauczor, Hans-Ulrich, Mall, Marcus A., Sommerburg, Olaf, Wielpütz, Mark O.

Source: In Journal of Cystic Fibrosis March 2024 23(2):234-241

Nasal lavage microbiome, but not nasal swab microbiome, correlates with sinonasal inflammation in children with cystic fibrosis

Authors: Chung, Jaehi, Boutin, Sébastien, Frey, Dario L., Joachim, Cornelia, Mall, Marcus A., Sommerburg, Olaf

Source: In Journal of Cystic Fibrosis March 2024 23(2):226-233

Characterization of transient and progressive pulmonary fibrosis by spatially correlated phase contrast microCT, classical histopathology and atomic force microscopy

Authors: D’Amico, Lorenzo, Svetlove, Angelika, Longo, Elena, Meyer, Ruth, Senigagliesi, Beatrice, Saccomano, Giulia, Nolte, Philipp, Wagner, Willi L., Wielpütz, Mark O., Leitz, Dominik H.W., Duerr, Julia, Mall, Marcus A., Casalis, Loredana, Köster, Sarah, Alves, Frauke, Tromba, Giuliana, Dullin, Christian

Source: In Computers in Biology and Medicine February 2024 169

Potential systemic effects of acquired CFTR dysfunction in COPD

Authors: Miravitlles, Marc, Criner, Gerard J., Mall, Marcus A., Rowe, Steven M., Vogelmeier, Claus F., Hederer, Bettina, Schoenberger, Matthias, Altman, Pablo

Source: In Respiratory Medicine January 2024 221

Phase 3 Open-Label Clinical Trial of Elexacaftor/Tezacaftor/Ivacaftor in Children Aged 2—5 Years with Cystic Fibrosis and at Least One F508del Allele

Authors: Goralski, Jennifer L., Hoppe, Jordana E., Mall, Marcus A., McColley, Susanna A., McKone, Edward, Ramsey, Bonnie, Rayment, Jonathan H., Robinson, Phil, Stehling, Florian, Taylor-Cousar, Jennifer L.

Source: American journal of respiratory and critical care medicine. 208(1):59-67

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633460794&indx=1&recIds=ETOCRN633460794

Safety and efficacy of vanzacaftor–tezacaftor–deutivacaftor in adults with cystic fibrosis: randomised, double-blind, controlled, phase 2 trials

Authors: Uluer, Ahmet Z, MacGregor, Gordon, Azevedo, Pilar, Indihar, Veronica, Keating, Claire, Mall, Marcus A, McKone, Edward F, Ramsey, Bonnie W, Rowe, Steven M, Rubenstein, Ronald C, Taylor-Cousar, Jennifer L, Tullis, Elizabeth, Yonker, Lael M, Chu, Chenghao, Lam, Anna P, Nair, Nitin, Sosnay, Patrick R, Tian, Simon, Van Goor, Fredrick, Viswanathan, Lakshmi, Waltz, David, Wang, Linda T, Xi, Yingmei, Billings, Joanne, Horsley, Alexander

Source: Lancet.Respiratory medicine. 11(6):550-562

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191537580.0x000001&indx=1&recIds=ETOCvdc_100191537580.0x000001

Survival-Adjusted FEV1 and BMI Percentiles for Patients with Cystic Fibrosis before the Era of Triple CFTR Modulator Therapy in Germany

Authors: Dittrich, A. Susanne, Dumke, Markus, Kapl, Ferdinand, Schneider, Philipp, Wege, Sabine, Gräber, Simon, Stahl, Mirjam, Herth, Felix J., Naehrlich, Lutz, Mall, Marcus A., Sommburg, Olaf

Source: Respiration. 102(5):351-360

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185357954.0x000001&indx=1&recIds=ETOCvdc_100185357954.0x000001

Advancing the pipeline of cystic fibrosis clinical trials: a new roadmap with a global trial network perspective

Authors: Mayer-Hamblett, Nicole ^*, Clancy, John Paul, Jain, Raksha, Donaldson, Scott H, Fajac, Isabelle, Goss, Christopher H, Polineni, Deepika, Ratjen, Felix, Quon, Bradley S, Zemanick, Edith T, Bell, Scott C, Davies, Jane C, Jain, Manu, Konstan, Michael W, Kerper, Natanya R, LaRosa, Tré ^*, Mall, Marcus A, McKone, Edward, Pearson, Kelsie, Pilewski, Joseph M, Quittell, Lynne, Rayment, Jonathan H, Rowe, Steven M, Taylor-Cousar, Jennifer L, Retsch-Bogart, George, Downey, Damian G

Source: In The Lancet Respiratory Medicine October 2023 11(10):932-944

The future of cystic fibrosis treatment: from disease mechanisms to novel therapeutic approaches

Authors: Graeber, Simon Y, Mall, Marcus A ^*

Source: In The Lancet 30 September-6 October 2023 402(10408):1185-1198

Safety and efficacy of vanzacaftor–tezacaftor–deutivacaftor in adults with cystic fibrosis: randomised, double-blind, controlled, phase 2 trials

Authors: Horsley, Alexander, Nash, Edward F., Bakker, Marleen, van der Meer, Renske, Merkus, Petrus, Majoor, Christof, McCoy, Karen, Billings, Joanne, Pancham, Krishna, Tolle, James, Quick, Bryon, Uluer, Ahmet, DiMango, Emily, Rao, Adupa, Reyes, Santiago, Klingsberg, Ross, Barreto, Celeste, Ortega, Victor, Willey-Courand, Donna, Schwarz, Carsten, Sutharsan, Sivagurunathan, Fischer, Rainald, Davies, Jane, Duckers, Jamie, Doe, Simon, Heijerman, Harry, Solomon, George M., Merlo, Christian, Griffonnet, Jennifer, Pilewski, Joseph, Dunitz, Jordan, Sheikh, Saba, Rubenstein, Ronald C., Rosenbluth, Daniel B., Liou, Theodore, Indihar, Maria, Yonker, Lael, Nasr, Samya, Brown, Cynthia D., Sawicki, Gregory S., Ruddy, Jennifer, Garcia, Bryan, Braun, Andrew, Gifford, Alex H., Mehdi, Nighat, Tupayachi Ortiz, Maria, Jain, Raksha, Calimano, Francisco J., Johannes, Jimmy, Daines, Cori L., Fullmer, Jason, Mermis, Joel, Barrios, Christopher, Ly, Ngoc, Casserly, Brian P., Eisenmann, Stephan, Hebestreit, Helge, Kiefer, Alexander, MacGregor, Gordon, Peckham, Daniel, Ledson, Martin, Van Braeckel, Eva, McElvaney, Noel Gerard, McKone, Edward, Plant, Barry, Burr, Lucy, Smith, Daniel J., Middleton, Peter, Wilson, John, Uluer, Ahmet Z ^*, Azevedo, Pilar, Indihar, Veronica, Keating, Claire, Mall, Marcus A, McKone, Edward F, Ramsey, Bonnie W, Rowe, Steven M, Rubenstein, Ronald C, Taylor-Cousar, Jennifer L, Tullis, Elizabeth, Yonker, Lael M, Chu, Chenghao, Lam, Anna P, Nair, Nitin, Sosnay, Patrick R, Tian, Simon, Van Goor, Fredrick, Viswanathan, Lakshmi, Waltz, David, Wang, Linda T, Xi, Yingmei

Source: In The Lancet Respiratory Medicine June 2023 11(6):550-562

Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease

Authors: Margaroli, Camilla, Horati, Hamed, Garratt, Luke W., Giacalone, Vincent D., Schofield, Craig, Dittrich, A. Susanne, Rosenow, Tim, Dobosh, Brian S., Lim, Hong S., Frey, Dario L., Veltman, Mieke, Silva, George L., Brown, Milton R., Schultz, Carsten, Tiddens, Harm A.W.M., Ranganathan, Sarath, Chandler, Joshua D., Qiu, Peng, Peng, Limin, Scholte, Bob J., Mall, Marcus A., Kicic, Anthony, Guglani, Lokesh, Stick, Stephen M., Janssens, Hettie M., Tirouvanziam, Rabindra

Source: In Journal of Cystic Fibrosis November 2022 21(6):967-976

Magnetic resonance imaging detects improvements of pulmonary and paranasal sinus abnormalities in response to elexacaftor/tezacaftor/ivacaftor therapy in adults with cystic fibrosis

Authors: Wucherpfennig, Lena, Triphan, Simon M.F., Wege, Sabine, Kauczor, Hans-Ulrich, Heussel, Claus P., Schmitt, Niclas, Wuennemann, Felix, Mayer, Victoria L., Sommerburg, Olaf, Mall, Marcus A., Eichinger, Monika, Wielpütz, Mark O.

Source: In Journal of Cystic Fibrosis November 2022 21(6):1053-1060

IL‐37 regulates allergic inflammation by counterbalancing pro‐inflammatory IL‐1 and IL‐33

Authors: Schröder, Alexandra, Lunding, Lars P., Zissler, Ulrich M., Vock, Christina, Webering, Sina, Ehlers, Johanna C., Orinska, Zane, Chaker, Adam, Schmidt‐Weber, Carsten B., Lang, Niklas J., Schiller, Herbert B., Mall, Marcus A., Fehrenbach, Heinz, Dinarello, Charles A., Wegmann, Michael

Source: Allergy. 77(3):856-869

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FEATURED ARTICLE OF THE MONTH. Fibroblast Activation Protein-Specific PET/CT Imaging in Fibrotic Interstitial Lung Diseases and Lung Cancer: A Translational Exploratory Study

Authors: Röhrich, Manuel, Leitz, Dominik, Glatting, Frederik M., Wefers, Annika K., Weinheimer, Oliver, Flechsig, Paul, Kahn, Nicolas, Mall, Marcus A., Giesel, Frederik L., Kratochwil, Clemens

Source: Journal of nuclear medicine. 63(1):127-133

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628482091&indx=1&recIds=ETOCRN628482091