Activation of Apoptosis in vivo by a Hydrocarbon-Stapled BH3 Helix

Authors: Walensky, Loren D., Kung, Andrew L., Escher, Iris, Malia, Thomas J., Barbuto, Scott, Wright, Renee D., Wagner, Gerhard, Verdine, Gregory L., Korsmeyer, Stanley J.

Source: Science, 2004 Sep 01. 305(5689), 1466-1470.

Access URL: https://www.jstor.org/stable/3837827

Crystal structure of tissue factor in complex with antibody 10H10 reveals the signaling epitope

Authors: Teplyakov, Alexey, Obmolova, Galina, Malia, Thomas J., Wu, Bingyuan, Zhao, Yonghong, Taudte, Susann, Anderson, G. Mark, Gilliland, Gary L.

Source: In Cellular Signalling August 2017 36:139-144

Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography

Authors: Obmolova, Galina, Teplyakov, Alexey, Malia, Thomas J., Wunderler, Nicole, Kwok, Deborah, Barone, Linda, Sweet, Raymond, Ort, Tatiana, Scully, Michael, Gilliland, Gary L.

Source: In Molecular Immunology March 2017 83:92-99

Structural insights into humanization of anti-tissue factor antibody 10H10

Authors: Teplyakov, Alexey, Obmolova, Galina, Malia, Thomas J., Raghunathan, Gopalan, Martinez, Christian, Fransson, Johan, Edwards, Wilson, Connor, Judith, Husovsky, Matthew, Beck, Heena, Chi, Ellen, Fenton, Sandra, Zhou, Hong, Almagro, Juan Carlos, Gilliland, Gary L.

Source: MAbs. 10(2):269-277

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100063115650.0x000001&indx=1&recIds=ETOCvdc_100063115650.0x000001

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations

Authors: Vafa, Omid, Gilliland, Gary L., Brezski, Randall J., Strake, Brandy, Wilkinson, Teresa, Lacy, Eilyn R., Scallon, Bernard, Teplyakov, Alexey, Malia, Thomas J., Strohl, William R.

Source: In Methods 1 January 2014 65(1):114-126

Structural diversity in a human antibody germline library

Authors: Teplyakov, Alexey, Obmolova, Galina, Malia, Thomas J., Luo, Jinquan, Muzammil, Salman, Sweet, Raymond, Almagro, Juan Carlos, Gilliland, Gary L.

Source: MAbs. 8(6):1045-1063

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100033824555.0x000001&indx=1&recIds=ETOCvdc_100033824555.0x000001

IgG2 Fc structure and the dynamic features of the IgG CH2–CH3 interface

Authors: Teplyakov, Alexey, Zhao, Yonghong, Malia, Thomas J., Obmolova, Galina, Gilliland, Gary L.

Source: In Molecular Immunology November 2013 56(1-2):131-139

Lateral Clustering of TLR3:dsRNA Signaling Units Revealed by TLR3ecd:3Fabs Quaternary Structure

Authors: Luo, Jinquan, Obmolova, Galina, Malia, Thomas J., Wu, Sheng-Jiun, Duffy, Karen E., Marion, James D., Bell, Jessica K., Ge, Peng, Zhou, Z. Hong, Teplyakov, Alexey, Zhao, Yonghong, Lamb, Roberta J., Jordan, Jarrat L., San Mateo, Lani R., Sweet, Raymond W., Gilliland, Gary L.

Source: In Journal of Molecular Biology 3 August 2012 421(1):112-124

Structural basis for high selectivity of anti-CCL2 neutralizing antibody CNTO 888

Authors: Obmolova, Galina, Teplyakov, Alexey, Malia, Thomas J., Grygiel, Tami L.R., Sweet, Raymond, Snyder, Linda A., Gilliland, Gary L.

Source: In Molecular Immunology June 2012 51(2):227-233

Solution Structure of the Integral Human Membrane Protein VDAC-1 in Detergent Micelles

Authors: Hiller, Sebastian, Garces, Robert G., Malia, Thomas J., Orekhov, Vladislav Y., Colombini, Marco, Wagner, Gerhard

Source: Science, 2008 Aug . 321(5893), 1206-1210.

Access URL: https://www.jstor.org/stable/20144703

Expression, refolding and purification of a human interleukin-17A variant

Authors: Wu, Bingyuan, Nemeth, Jennifer F., Janecki, Dariusz J., Jones, Brian, Obmolova, Galina, Malia, Thomas J., Baker, Audrey, Bethea, Deidra, Elloso, M. Merle, Naso, Michael, Taudte, Susann

Source: In Cytokine January 2011 53(1):107-114

Human Framework Adaptation of a Mouse Anti-Human IL-13 Antibody

Authors: Fransson, Johan ^†, Teplyakov, Alexey ^†, Raghunathan, Gopalan ^†, Chi, Ellen, Cordier, Wendy, Dinh, Thai, Feng, Yiqing, Giles-Komar, Jill, Gilliland, Gary, Lollo, Bridget, Malia, Thomas J., Nishioka, Walter, Obmolova, Galina, Zhao, Shanrong, Zhao, Yonghong, Swanson, Ronald V., Almagro, Juan C.

Source: In Journal of Molecular Biology 2010 398(2):214-231

NMR Structural Investigation of the Mitochondrial Outer Membrane Protein VDAC and Its Interaction with Antiapoptotic Bcl-xL.

Authors: Malia, Thomas J., Wagner, Gerhard

Source: Biochemistry; January 16 2007, Vol. 46 Issue 2, p514-525, 12p

Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody.

Authors: Van Kolen, Kristof¹ (AUTHOR) kvkolen@its.jnj.com, Malia, Thomas J.² (AUTHOR), Theunis, Clara¹ (AUTHOR), Nanjunda, Rupesh² (AUTHOR), Teplyakov, Alexey² (AUTHOR), Ernst, Robin² (AUTHOR), Wu, Sheng-Jiun² (AUTHOR), Luo, Jinquan² (AUTHOR), Borgers, Marianne¹ (AUTHOR), Vandermeeren, Marc¹ (AUTHOR), Bottelbergs, Astrid¹ (AUTHOR), Wintmolders, Cindy¹ (AUTHOR), Lacy, Eilyn² (AUTHOR), Maurin, Hervé¹ (AUTHOR), Larsen, Peter¹ (AUTHOR), Willems, Roland¹ (AUTHOR), Van De Casteele, Tom³ (AUTHOR), Triana-Baltzer, Gallen⁴ (AUTHOR), Slemmon, Randy⁴ (AUTHOR), Galpern, Wendy⁵ (AUTHOR)

Source: Journal of Alzheimer's Disease. 2020, Vol. 77 Issue 4, p1397-1416. 20p.

Subject Terms: *MONOCLONAL antibodies, *SURFACE plasmon resonance, *CELL analysis, *ALZHEIMER'S disease, *POSTMORTEM changes, *IMMUNOSTAINING, *PROTEINS, *RESEARCH, *NERVE tissue proteins, *ANIMAL experimentation, *RESEARCH methodology, *MEDICAL cooperation, *EVALUATION research, *COMPARATIVE studies, *RESEARCH funding, *DRUG development, *PHOSPHORYLATION, *MICE

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Crystal structure of human germline antibody 3-23/B3

Authors: Malia, Thomas J., Obmolova, Galina, Almagro, Juan Carlos, Gilliland, Gary L., Teplyakov, Alexey

Source: In Molecular Immunology 2011 48(12):1586-1588

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