Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis

Authors: Rahimi, Kazem ^*, Bidel, Zeinab, Nazarzadeh, Milad, Copland, Emma, Canoy, Dexter, Wamil, Malgorzata, Majert, Jeannette, McManus, Richard, Adler, Amanda, Agodoa, Larry, Algra, Ale, Asselbergs, Folkert W, Beckett, Nigel S, Berge, Eivind, Black, Henry, Boersma, Eric, Brouwers, Frank P J, Brown, Morris, Brugts, Jasper J, Bulpitt, Christopher J, Byington, Robert P, Cushman, William C, Cutler, Jeffrey, Devereaux, Richard B, Dwyer, Jamie P, Estacio, Ray, Fagard, Robert, Fox, Kim, Fukui, Tsuguya, Gupta, Ajay K, Holman, Rury R, Imai, Yutaka, Ishii, Masao, Julius, Stevo, Kanno, Yoshihiko, Kjeldsen, Sverre E, Kostis, John, Kuramoto, Kizuku, Lanke, Jan, Lewis, Edmund, Lewis, Julia B, Lievre, Michel, Lindholm, Lars H, Lueders, Stephan, MacMahon, Stephen, Mancia, Giuseppe, Matsuzaki, Masunori, Mehlum, Maria H, Nissen, Steven, Ogawa, Hiroshi, Ogihara, Toshio, Ohkubo, Takayoshi, Palmer, Christopher R, Patel, Anushka, Pfeffer, Marc Allan, Pitt, Bertram, Poulter, Neil R, Rakugi, Hiromi, Reboldi, Gianpaolo, Reid, Christopher, Remuzzi, Giuseppe, Ruggenenti, Piero, Saruta, Takao, Schrader, Joachim, Schrier, Robert, Sever, Peter, Sleight, Peter, Staessen, Jan A, Suzuki, Hiromichi, Thijs, Lutgarde, Ueshima, Kenji, Umemoto, Seiji, van Gilst, Wiek H, Verdecchia, Paolo, Wachtell, Kristian, Whelton, Paul, Wing, Lindon, Woodward, Mark, Yui, Yoshiki, Yusuf, Salim, Zanchetti, Alberto, Zhang, Zhen-Yu, Anderson, Craig, Baigent, Colin, Brenner, Barry Morton, Collins, Rory, de Zeeuw, Dick, Lubsen, Jacobus, Malacco, Ettore, Neal, Bruce, Perkovic, Vlado, Rodgers, Anthony, Rothwell, Peter, Salimi-Khorshidi, Gholamreza, Sundström, Johan, Turnbull, Fiona, Viberti, Giancarlo, Wang, Jiguang, Chalmers, John, Davis, Barry R, Pepine, Carl J, Teo, Koon K

Source: In The Lancet 18-24 September 2021 398(10305):1053-1064

Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis

Authors: Rahimi, Kazem, Bidel, Zeinab, Nazarzadeh, Milad, Copland, Emma, Canoy, Dexter, Ramakrishnan, Rema, Pinho-Gomes, Ana-Catarina, Woodward, Mark, Adler, Amanda, Agodoa, Larry, Algra, Ale, Asselbergs, Folkert W, Beckett, Nigel S, Berge, Eivind, Black, Henry, Brouwers, Frank P J, Brown, Morris, Bulpitt, Christopher J, Byington, Robert P, Cushman, William C, Cutler, Jeffrey, Devereaux, Richard B, Dwyer, Jamie, Estacio, Ray, Fagard, Robert, Fox, Kim, Fukui, Tsuguya, Gupta, Ajay K, Holman, Rury R, Imai, Yutaka, Ishii, Masao, Julius, Stevo, Kanno, Yoshihiko, Kjeldsen, Sverre E, Kostis, John, Kuramoto, Kizuku, Lanke, Jan, Lewis, Edmund, Lewis, Julia B, Lievre, Michel, Lindholm, Lars H, Lueders, Stephan, MacMahon, Stephen, Mancia, Giuseppe, Matsuzaki, Masunori, Mehlum, Maria H, Nissen, Steven, Ogawa, Hiroshi, Ogihara, Toshio, Ohkubo, Takayoshi, Palmer, Christopher R, Patel, Anushka, Pfeffer, Marc Allan, Pitt, Bertram, Poulter, Neil R, Rakugi, Hiromi, Reboldi, Gianpaolo, Reid, Christopher, Remuzzi, Giuseppe, Ruggenenti, Piero, Saruta, Takao, Schrader, Joachim, Schrier, Robert, Sever, Peter, Sleight, Peter, Staessen, Jan A, Suzuki, Hiromichi, Thijs, Lutgarde, Ueshima, Kenji, Umemoto, Seiji, van Gilst, Wiek H, Verdecchia, Paolo, Wachtell, Kristian, Whelton, Paul, Wing, Lindon, Yui, Yoshiki, Yusuf, Salim, Zanchetti, Alberto, Zhang, Zhen-Yu, Anderson, Craig, Baigent, Colin, Brenner, Barry Morton, Collins, Rory, de Zeeuw, Dick, Lubsen, Jacobus, Malacco, Ettore, Neal, Bruce, Perkovic, Vlado, Rodgers, Anthony, Rothwell, Peter, Salimi-Khorshidi, Gholamreza, Sundström, Johan, Turnbull, Fiona, Viberti, Giancarlo, Wang, Jiguang, Chalmers, John, Teo, Koon K, Pepine, Carl J, Davis, Barry R

Source: In The Lancet 1-7 May 2021 397(10285):1625-1636

Efficacy of Zofenopril vs. Irbesartan in Combination with a Thiazide Diuretic in Hypertensive Patients with Multiple Risk Factors not Controlled by a Previous Monotherapy: A Review of the Double-Blind, Randomized 'Z' Studies

Authors: Omboni, Stefano, Malacco, Ettore, Napoli, Claudio, Modesti, Pietro, Manolis, Athanasios, Parati, Gianfranco, Agabiti-Rosei, Enrico, Borghi, Claudio

Source: Advances in therapy. 34(4):784-798

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117591466.0x000001&indx=1&recIds=ETOCvdc_100117591466.0x000001

Antihypertensive effect of zofenopril plus hydrochlorothiazide versus zofenopril monotherapy in patients with essential hypertension according to their cardiovascular risk level: A post hoc analysis

Authors: Malacco, Ettore, Omboni, Stefano

Source: In Current Therapeutic Research 2008 69(3):232-242

Efficacy and tolerability of combination therapy with valsartan plus hydrochlorothiazide compared with amlodipine monotherapy in hypertensive patients with other cardiovascular risk factors: The VAST study

Authors: Ruilope, Luis M., Malacco, Ettore, Khder, Yasser, Kandra, Albert, Bönner, Gerd, Heintz, Daniela

Source: In Clinical Therapeutics May 2005 27(5):578-588

Comparison of valsartan 160 mg with lisinopril 20 mg, given as monotherapy or in combination with a diuretic, for the treatment of hypertension: The blood pressure reduction and tolerability of valsartan in comparison with lisinopril (PREVAIL) study

Authors: Malacco, Ettore, Santonastaso, Massimo, Varì, Natale A., Gargiulo, Anna, Spagnuolo, Vitaliano, Bertocchi, Federico, Palatini, Paolo, PREVAIL Study Investigators

Source: In Clinical Therapeutics 2004 26(6):855-865

Blood Pressure Response to Zofenopril or Irbesartan Each Combined with Hydrochlorothiazide in High-Risk Hypertensives Uncontrolled by Monotherapy: A Randomized, Double-Blind, Controlled, Parallel Group, Noninferiority Trial.

Authors: Malacco, Ettore¹ ettore.malacco@tiscali.it, Omboni, Stefano² stefano.omboni@iitelemed.org, Parati, Gianfranco³ gianfranco.parati@unimib.it

Source: International Journal of Hypertension. 8/5/2015, Vol. 2015, p1-12. 12p.

Subject Terms: *CARDIOVASCULAR disease diagnosis, *HYPERTENSION, *CARDIOVASCULAR disease prevention, *CAROTID artery, *MORBID obesity, *OBESITY complications, *AGE distribution, *AMBULATORY blood pressure monitoring, *ACE inhibitors, *BLOOD pressure, *BLOOD pressure measurement, *CARDIOVASCULAR diseases risk factors, *COMBINATION drug therapy, *CHI-squared test, *CONFIDENCE intervals, *DIABETES, *ALCOHOL drinking, *ECHOCARDIOGRAPHY, *HIGH density lipoproteins, *ANTIHYPERTENSIVE agents, *LIPOPROTEINS, *LOW density lipoproteins, *ULTRASONIC imaging, *COMORBIDITY, *DATA analysis, *ALBUMINS, *BODY mass index, *RANDOMIZED controlled trials, *IRBESARTAN, *WAIST circumference, *HYDROCHLOROTHIAZIDE, *DIAGNOSIS, *ANATOMY

A randomized, double-blind, active-controlled, parallel-group comparison of valsartan and amlodipine in the treatment of isolated systolic hypertension in elderly patients: The Val-Syst study

Authors: Malacco, Ettore, Vari, Natale, Capuano, Vincenzo, Spagnuolo, Vitaliano, Borgnino, Carlo, Palatini, Paolo, Val-Syst Investigators

Source: In Clinical Therapeutics 2003 25(11):2765-2780

Erratum to: Efficacy of Zofenopril vs. Irbesartan in Combination with a Thiazide Diuretic in Hypertensive Patients with Multiple Risk Factors not Controlled by a Previous Monotherapy: A Review of the Double-Blind, Randomized 'Z' Studies

Authors: Omboni, Stefano, Malacco, Ettore, Napoli, Claudio, Modesti, Pietro, Manolis, Athanasios, Parati, Gianfranco, Agabiti-Rosei, Enrico, Borghi, Claudio

Source: Advances in therapy. 34(6):1498-1499

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133559305.0x000001&indx=1&recIds=ETOCvdc_100133559305.0x000001

Olmesartan vs. Ramipril in Elderly Hypertensive Patients: Review of Data from Two Published Randomized, Double-Blind Studies.

Authors: Omboni, Stefano¹ stefano.omboni@iitelemed.org, Malacco, Ettore², Mallion, Jean-Michel³, Fabrizzi, Paolo⁴, Volpe, Massimo⁵

Source: High Blood Pressure & Cardiovascular Prevention. Mar2014, Vol. 21 Issue 1, p1-19. 19p.

Subject Terms: *ACE inhibitors, *CONFIDENCE intervals, *DATABASES, *HYPERTENSION, *ANTIHYPERTENSIVE agents, *META-analysis, *HEALTH outcome assessment, *RESEARCH funding, *SAFETY, *STATISTICS, *SYSTEMATIC reviews, *RAMIPRIL, *DATA analysis, *RANDOMIZED controlled trials, *TREATMENT effectiveness, *BLIND experiment, *OLD age

Comparison of valsartan and irbesartan in the treatment of mild to moderate hypertension: a randomized, open-label, crossover study

Authors: Malacco, Ettore, Piazza, Simona, Meroni, Rachele, Milanesi, Anna

Source: In Current Therapeutic Research 2000 61(11):789-797

Antihypertensive Efficacy of Olmesartan Medoxomil and Ramipril in Elderly Patients with Mild to Moderate Hypertension Grouped According to Renal Function Status.

Authors: Malacco, Ettore¹ ettore.malacco@tiscali.it, Omboni, Stefano², Mallion, Jean-Michel³, Volpe, Massimo

Source: High Blood Pressure & Cardiovascular Prevention. 2012, Vol. 19 Issue 4, p213-222. 10p.

Subject Terms: *ANTIHYPERTENSIVE agents, *DIURETICS, *RAMIPRIL, *ANALYSIS of variance, *CHI-squared test, *COMPARATIVE studies, *CONFIDENCE intervals, *HYPERTENSION, *KIDNEY function tests, *MEDICAL cooperation, *RESEARCH, *RESEARCH funding, *SAFETY, *STATISTICS, *DATA analysis, *RANDOMIZED controlled trials, *SEVERITY of illness index, *DESCRIPTIVE statistics, *OLD age, *THERAPEUTICS

Geographic Terms: EUROPE, ITALY

Zofenopril Plus Hydrochlorothiazide Fixed Combination in the Treatment of Hypertension and Associated Clinical Conditions.

Authors: Omboni, Stefano¹ info@iitelemed.org, Malacco, Ettore², Parati, Gianfranco³

Source: Cardiovascular Therapeutics. Dec2009, Vol. 27 Issue 4, p275-288. 14p.

Subject Terms: *ANGIOTENSIN converting enzyme, *DRUG lipophilicity, *HYPERTENSION, *MYOCARDIAL infarction, *ANTIHYPERTENSIVE agents

Nebivolol/Hydrochlorothiazide.

Authors: Malacco, Ettore¹ ettore.malacco@tiscali.it

Source: High Blood Pressure & Cardiovascular Prevention. May2008, Vol. 15 Issue 2, p75-84. 10p. 3 Charts, 1 Graph.

Subject Terms: *COMBINATION drug therapy, *ANTIHYPERTENSIVE agents, *ADRENERGIC beta blockers, *THERAPEUTICS, *HYPERTENSION, *DRUG dosage, *DRUG efficacy

Zofenopril versus Lisinopril in the Treatment of Essential Hypertension in Elderly Patients: A Randomised, Double-Blind, Multicentre Study.

Authors: Malacco, Ettore¹ dzava@lusofarmaco.it, Piazza, Simona¹, Omboni, Stefano¹

Source: Clinical Drug Investigation. 2005, Vol. 25 Issue 3, p175-182. 8p.

Subject Terms: *DRUGS, *HYPERTENSION, *BLOOD, *PHARMACOLOGY, *BLOOD circulation disorders, *ELECTRIC properties of hearts, *ELECTRODIAGNOSIS

Treatment of Isolated Systolic Hypertension: The SHELL Study Results.

Authors: MALACCO, ETTORE, MANCIA, GIUSEPPE, RAPPELLI, ALESSANDRO, MENOTTI, ALESSANDRO, M., STEFANO ZUCCARO, COPPINI, ALESSANDRO

Source: Blood Pressure. May2003, Vol. 12 Issue 3, p160-167. 8p.

Subject Terms: *HYPERTENSION, *THERAPEUTICS, *ANTIHYPERTENSIVE agents, *BLOOD pressure, *DIURETICS

Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis

Authors: Adler, Amanda, Agodoa, Larry, Algra, Ale, Asselbergs, Folkert W, Beckett, Nigel S, Berge, Eivind, Black, Henry, Brouwers, Frank P J, Brown, Morris, Bulpitt, Christopher J, Byington, Robert P, Chalmers, John, Cushman, William C, Cutler, Jeffrey, Davis, Barry R, Devereaux, Richard B, Dwyer, Jamie, Estacio, Ray, Fagard, Robert, Fox, Kim, Fukui, Tsuguya, Gupta, Ajay K, Holman, Rury R, Imai, Yutaka, Ishii, Masao, Julius, Stevo, Kanno, Yoshihiko, Kjeldsen, Sverre E, Kostis, John, Kuramoto, Kizuku, Lanke, Jan, Lewis, Edmund, Lewis, Julia B, Lievre, Michel, Lindholm, Lars H, Lueders, Stephan, MacMahon, Stephen, Mancia, Giuseppe, Matsuzaki, Masunori, Mehlum, Maria H, Nissen, Steven, Ogawa, Hiroshi, Ogihara, Toshio, Ohkubo, Takayoshi, Palmer, Christopher R, Patel, Anushka, Pepine, Carl J, Pfeffer, Marc Allan, Pitt, Bertram, Poulter, Neil R, Rakugi, Hiromi, Reboldi, Giuseppe, Reid, Christopher, Remuzzi, Giuseppe, Ruggenenti, Piero, Saruta, Takao, Schrader, Joachim, Schrier, Robert, Sever, Peter, Sleight, Peter, Staessen, Jan A, Suzuki, Hiromichi, Thijs, Lutgarde, Ueshima, Kenji, Umemoto, Seiji, van Gilst, Wiek H, Verdecchia, Paolo, Wachtell, Kristian, Whelton, Paul, Wing, Lindon, Woodward, Mark, Yui, Yoshiki, Yusuf, Salim, Zanchetti, Alberto, Zhang, Zhen-Yu, Anderson, Craig, Baigent, Colin, Brenner, Barry Morton, Collins, Rory, de Zeeuw, Dick, Lubsen, Jacobus, Malacco, Ettore, Neal, Bruce, Perkovic, Vlado, Rodgers, Anthony, Rothwell, Peter, Salimi-Khorshidi, Gholamreza, Sundström, Johan, Turnbull, Fiona, Viberti, Giancarlo, Wang, Jiguang

Source: The Lancet; May 2021, Vol. 397 Issue: 10285 p1625-1636, 12p

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Olmesartan vs ramipril in the treatment of hypertension and associated clinical conditions in the elderly: a reanalysis of two large doubleblind, randomized studies at the light of the most recent blood pressure targets recommended by guidelines.

Authors: Omboni, Stefano, Malacco, Ettore, Mallion, Jean-Michel, Volpe, Massimo

Source: Clinical Interventions in Aging; Oct2015, Vol. 10, p1575-1586, 12p

Subject Terms: HYPERTENSION, THERAPEUTICS, BLOOD pressure, GUIDELINES

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