Lack of neuroprotection after systemic administration of the soluble TNF inhibitor XPro1595 in an rAAV6-α-Syn + PFFs-induced rat model for Parkinson's disease

Authors: Filip Fredlund, Claes Fryklund, Olivia Trujeque-Ramos, Hannah A. Staley, Joaquin Pardo, Kelvin C. Luk, Malú G. Tansey, Maria Swanberg

Source: Neurobiology of Disease, Vol 207, Iss , Pp 106841- (2025)

Subject Terms: TNF, Parkinson's disease, Neurodegeneration, Neuroinflammation, α-Synuclein, PFF, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

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Relation: http://www.sciencedirect.com/science/article/pii/S0969996125000579; https://doaj.org/toc/1095-953X

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Poldip2 controls leukocyte infiltration into the ischemic brain by regulating focal adhesion kinase-mediated VCAM-1 induction

Authors: Lori N. Eidson, Qingzeng Gao, Hongyan Qu, Daniel S. Kikuchi, Ana Carolina P. Campos, Elizabeth A. Faidley, Yu-Yo Sun, Chia-Yi Kuan, Rosana L. Pagano, Bernard Lassègue, Malú G. Tansey, Kathy K. Griendling, Marina S. Hernandes

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/ca6d527a5c274240a41e6c574dee592d

Is LRRK2 the missing link between inflammatory bowel disease and Parkinson’s disease?

Authors: Mary K. Herrick, Malú G. Tansey

Source: npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2373-8057

Access URL: https://doaj.org/article/1ab6756093fc4693b67b74f77aaf66a0

Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson’s disease

Authors: Velma T. E. Aho, Madelyn C. Houser, Pedro A. B. Pereira, Jianjun Chang, Knut Rudi, Lars Paulin, Vicki Hertzberg, Petri Auvinen, Malú G. Tansey, Filip Scheperjans

Source: Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-14 (2021)

Subject Terms: Parkinson’s disease, Microbiota, Intestine, Inflammation, Short-chain fatty acids, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/62e11fcfd73d4e62812cf8a1ab31083e

Targeting soluble tumor necrosis factor as a potential intervention to lower risk for late-onset Alzheimer’s disease associated with obesity, metabolic syndrome, and type 2 diabetes

Authors: Maria Elizabeth De Sousa Rodrigues, Madelyn C. Houser, Douglas I. Walker, Dean P. Jones, Jianjun Chang, Christopher J. Barnum, Malú G. Tansey

Source: Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-16 (2019)

Subject Terms: Insulin, Soluble tumor necrosis factor, Metabolic inflammation, Neuroactive metabolites, Lipocalin-2, Purines, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/d435f7fcac8c46ffbf1f8a9ba829ca47

Microglia, inflammation and gut microbiota responses in a progressive monkey model of Parkinson's disease: A case series

Authors: Valerie Joers, Gunasingh Masilamoni, Doty Kempf, Alison R. Weiss, Travis M. Rotterman, Benjamin Murray, Gul Yalcin-Cakmakli, Ronald J. Voll, Mark M. Goodman, Leonard Howell, Jocelyne Bachevalier, Stefan J. Green, Ankur Naqib, Maliha Shaikh, Phillip A. Engen, Ali Keshavarzian, Christopher J. Barnum, Jonathon A. Nye, Yoland Smith, Malú G. Tansey

Source: Neurobiology of Disease, Vol 144, Iss , Pp 105027- (2020)

Subject Terms: Parkinson's disease, MPTP, Tumor necrosis factor, Rhesus monkey, Inflammation, Sex differences, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996120303028; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/43c19177d7114cb980da723d241e3f02

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

Authors: Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell

Source: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-18 (2018)

Subject Terms: Neuroinflammation, Parkinson’s disease, Animal models, Synucleinopathy, Microglia, Major-histocompatibility complex-II, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-018-1171-z; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/78b82214e6ad41e9bc7e34dc3be1cf71

Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease

Authors: Lori N. Eidson, George T. Kannarkat, Christopher J. Barnum, Jianjun Chang, Jaegwon Chung, Chelsea Caspell-Garcia, Peggy Taylor, Brit Mollenhauer, Michael G. Schlossmacher, Larry Ereshefsky, Mark Yen, Catherine Kopil, Mark Frasier, Kenneth Marek, Vicki S. Hertzberg, Malú G. Tansey

Source: Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-16 (2017)

Subject Terms: Parkinson’s disease, Inflammation, Protein biomarkers, Daily rhythm, CSF, Serum, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-017-0935-1; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/4759130fbf4b43dfb829cdfe656a57b3

Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice

Authors: Kathryn P. MacPherson, Pradoldej Sompol, George T. Kannarkat, Jianjun Chang, Lindsey Sniffen, Mary E. Wildner, Christopher M. Norris, Malú G. Tansey

Source: Neurobiology of Disease, Vol 102, Iss , Pp 81-95 (2017)

Subject Terms: Neuroinflammation, Alzheimer's disease, Immune cell trafficking, T cells, Macrophage, MHCII, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996117300396; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/1010916aeda24b02a7611cb0b33b23a5

The gut microbiome and neuroinflammation in amyotrophic lateral sclerosis? Emerging clinical evidence

Authors: Christina N. Fournier, Madelyn Houser, Malú G. Tansey, Jonathan D. Glass, Vicki Stover Hertzberg

Source: Neurobiology of Disease, Vol 135, Iss , Pp 104300- (2020)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996118306879; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/d9cf65e9d19749f0a9bc5bf8565a14cb

Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells

Authors: Souvarish Sarkar, Eric B. Dammer, Emir Malovic, Abby L. Olsen, Syed Ali Raza, Tianwen Gao, Hailian Xiao, Danielle L. Oliver, Duc Duong, Valerie Joers, Nicholas Seyfried, Meixiang Huang, Thomas Kukar, Malú G. Tansey, Anumantha G. Kanthasamy, Srikant Rangaraju

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: synuclein, microglia, neuroinflammation, Parkinson's disease, proteomics, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.00033/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/88a10c77d6fa4f4a901fe44bb0db0cdd

The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?

Authors: Madelyn C. Houser, Malú G. Tansey

Source: npj Parkinson's Disease, Vol 3, Iss 1, Pp 1-9 (2017)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2373-8057

Access URL: https://doaj.org/article/ed0ba2805db348a4801acf12842d3a38

α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson’s Disease Pathogenesis

Authors: Laura M. Butkovich, Madelyn C. Houser, Malú G. Tansey

Source: Frontiers in Neuroscience, Vol 12 (2018)

Subject Terms: α-synuclein, locus coeruleus, Parkinson’s disease, neuroinflammation, norepinephrine, immune cell, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnins.2018.00626/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/fe534e86508241188c61c6860a7f77a1

Microglial Phenotypes and Their Relationship to the Cannabinoid System: Therapeutic Implications for Parkinson’s Disease

Authors: Rachel Kelly, Valerie Joers, Malú G. Tansey, Declan P. McKernan, Eilís Dowd

Source: Molecules, Vol 25, Iss 3, p 453 (2020)

Subject Terms: neuroinflammation, microglia, phenotypes, cannabinoids, neurodegeneration, parkinson’s, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/3/453; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/f7fa885fa0cf49cebaf62ffd8cdb7531

Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120)

Authors: Christopher D. Herzog, Lamar Brown, Brian R. Kruegel, Alistair Wilson, Malú G. Tansey, Fred H. Gage, Eugene M. Johnson, Jr., Raymond T. Bartus

Source: Neurobiology of Disease, Vol 58, Iss , Pp 38-48 (2013)

Subject Terms: Neurotrophic factors, Neurturin, AAV-NRTN, Parkinson's disease, Gene transfer, Axonopathy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996113001253; https://doaj.org/toc/1095-953X

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Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

Authors: Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell

Source: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-1 (2018)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-018-1202-9; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/be17cb9e75054c85be402f41c4ea1d84

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

Authors: Malú G. Tansey, Matthew S. Goldberg

Source: Neurobiology of Disease, Vol 37, Iss 3, Pp 510-518 (2010)

Subject Terms: Microglia, Inflammation, Neuroinflammation, Neurodegeneration, Parkinson's disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S096999610900326X; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/aed675056bca46ce9d396ee741730173

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

Authors: Fiona E. McAlpine, Jae-Kyung Lee, Ashley S. Harms, Kelly A. Ruhn, Mathew Blurton-Jones, John Hong, Pritam Das, Todd E. Golde, Frank M. LaFerla, Salvatore Oddo, Armin Blesch, Malú G. Tansey

Source: Neurobiology of Disease, Vol 34, Iss 1, Pp 163-177 (2009)

Subject Terms: Neuroinflammation, Alzheimer's disease, Tumor necrosis factor, 3xTgAD, Amyloid-β, Amyloid precursor protein, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996109000084; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/7e22b35e528c47e385f58454a8e763ae

Neuroimmunological Processes in Parkinson's Disease and their Relation to α-Synuclein: Microglia as the Referee between Neuronal Processes and Peripheral Immunity

Authors: Vanesa Sanchez-Guajardo, Christopher J. Barnum, Malú G. Tansey, Marina Romero-Ramos

Source: ASN Neuro, Vol 5 (2013)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/1759-0914; https://doaj.org/toc/1759-9091

Access URL: https://doaj.org/article/08e94f07ef1f46c8b31c0ffe8f66b71c

Inflammation in neuropsychiatric disease

Authors: Malú G. Tansey

Source: Neurobiology of Disease, Vol 37, Iss 3, Pp 491-492 (2010)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996109003465; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/3e46211a5d4a4be8a9be3e41565c1e8f