Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress

Authors: Gelman, Susan J., Naser, Fuad, Mahieu, Nathaniel G., McKenzie, Lisa D., Dunn, Gavin P., Chheda, Milan G., Patti, Gary J.

Source: In Cell Reports 9 January 2018 22(2):512-522

Trace Phosphate Improves ZIC-pHILIC Peak Shape, Sensitivity, and Coverage for Untargeted Metabolomics

Authors: Spalding, Jonathan L., Naser, Fuad J., Mahieu, Nathaniel G., Johnson, Stephen L., Patti, Gary J.

Source: Journal of proteome research. 17(10):3537-3546

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN617680097&indx=1&recIds=ETOCRN617680097

A roadmap for the XCMS family of software solutions in metabolomics

Authors: Mahieu, Nathaniel G, Genenbacher, Jessica Lloyd, Patti, Gary J

Source: In Current Opinion in Chemical Biology February 2016 30:87-93

Systems-Level Annotation of a Metabolomics Data Set Reduces 25 000 Features to Fewer than 1000 Unique Metabolites

Authors: Mahieu, Nathaniel G., Patti, Gary J.

Source: Analytical chemistry. 89(19):10397-10406

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN613109297&indx=1&recIds=ETOCRN613109297

Two complementary reversed-phase separations for comprehensive coverage of the semipolar and nonpolar metabolome

Authors: Naser, Fuad J., Mahieu, Nathaniel G., Wang, Lingjue, Spalding, Jonathan L., Johnson, Stephen L., Patti, Gary J.

Source: Analytical and bioanalytical chemistry. 410(4):1287-1297

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125587763.0x000001&indx=1&recIds=ETOCvdc_100125587763.0x000001

After the feature presentation: technologies bridging untargeted metabolomics and biology

Authors: Cho, Kevin, Mahieu, Nathaniel G, Johnson, Stephen L, Patti, Gary J

Source: In Current Opinion in Biotechnology August 2014 28:143-148

Defining and Detecting Complex Peak Relationships in Mass Spectral Data: The Mz.unity Algorithm

Authors: Mahieu, Nathaniel G., Spalding, Jonathan L., Gelman, Susan J., Patti, Gary J.

Source: Analytical chemistry. 88(18):9037-9046

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN608155994&indx=1&recIds=ETOCRN608155994

Bar Coding MS^2 Spectra for Metabolite Identification

Authors: Spalding, Jonathan L., Cho, Kevin, Mahieu, Nathaniel G., Nikolskiy, Igor, Llufrio, Elizabeth M., Johnson, Stephen L., Patti, Gary J.

Source: Analytical chemistry. 88(5):2538-2542

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN605295007&indx=1&recIds=ETOCRN605295007

Two complementary reversed-phase separations for comprehensive coverage of the semipolar and nonpolar metabolome.

Authors: Naser, Fuad J.¹, Mahieu, Nathaniel G.¹, Wang, Lingjue¹, Spalding, Jonathan L.², Johnson, Stephen L.², Patti, Gary J.¹ agjpattij@wustl.edu

Source: Analytical & Bioanalytical Chemistry. Feb2018, Vol. 410 Issue 2, p1287-1297. 11p.

Subject Terms: *METABOLOMICS, *REVERSE phase liquid chromatography, *HYDROPHILIC interaction liquid chromatography, *LIQUID chromatography-mass spectrometry, *CARBON metabolism

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Exploiting the Inherent Photophysical Properties of the Major Tirapazamine Metabolite in the Development of Profluorescent Substrates for Enzymes That Catalyze the Bioreductive Activation of Hypoxia-Selective Anticancer Prodrugs.

Authors: Xiulong Shen¹, Laber, Charles H.¹, Sarkar, Ujjal¹, Galazzi, Fabio², Johnson, Kevin M.¹, Mahieu, Nathaniel G.¹, Hillebrand, Roman¹, Fuchs-Knotts, Tarra¹, Barnes, Charles L.¹, Baker, Gary A.¹, Gates, Kent S.^1,3, gatesk@missouri.edu

Source: Journal of Organic Chemistry; 3/16/2018, Vol. 83 Issue 6, p3126-3131, 6p

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Bar Coding MS² Spectra for Metabolite Identification.

Authors: Spalding, Jonathan L.^1,2, Cho, Kevin^1,3, Mahieu, Nathaniel G.^1,3, Nikolskiy, Igor^1,2, Llufrio, Elizabeth M.^1,3, Johnson, Stephen L.², Patti, GaryJ.^1,3, gjpattij@wustl.edu

Source: Analytical Chemistry; 3/1/2016, Vol. 88 Issue 5, p2538-2542, 5p

Evidence that 2-hydroxyglutarate is not readily metabolized in colorectal carcinoma cells.

Authors: Gelman, Susan J., Mahieu, Nathaniel G., Cho, Kevin, Llufrio, Elizabeth M., Wencewicz, Timothy A., Patti, Gary J.

Source: Cancer & Metabolism; 12/1/2015, Vol. 3, p1-10, 10p