Redefining NSP12 activity in SARS-CoV-2 and its regulation by NSP8 and NSP7

Authors: Deepa Singh, Tushar Kushwaha, Rajkumar Kulandaisamy, Vikas Kumar, Kamal Baswal, Saras H. Tiwari, Arkadyuti Ghorai, Manoj Kumar, Saroj Kumar, Soumya De, Aparoy Polamarasetty, Deepak Sehgal, Madhumohan R. Katika, Suresh Gadde, Marceline Côté, Sarala R. Kayampeta, Mohan Babu Appaiahgari, Krishna K. Inampudi

Source: Molecular Therapy: Nucleic Acids, Vol 36, Iss 1, Pp 102452- (2025)

Subject Terms: MT: Oligonucleotides: Therapies and Applications, SARS-CoV-2, replication-transcription complex, RdRp, holoenzyme, NSP12, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S216225312500006X; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/3d9c0632dcb542908910f303cd194fec

Repurposing of FDA Approved Drugs Against SARS-CoV-2 Papain-Like Protease: Computational, Biochemical, and in vitro Studies

Authors: Rajkumar Kulandaisamy, Tushar Kushwaha, Anu Dalal, Vikas Kumar, Deepa Singh, Kamal Baswal, Pratibha Sharma, Kokkula Praneeth, Pankaj Jorwal, Sarala R. Kayampeta, Tamanna Sharma, Srinivas Maddur, Manoj Kumar, Saroj Kumar, Aparoy Polamarasetty, Aekagra Singh, Deepak Sehgal, Shivajirao L. Gholap, Mohan B. Appaiahgari, Madhumohan R. Katika, Krishna K. Inampudi

Source: Frontiers in Microbiology, Vol 13 (2022)

Subject Terms: COVID-19, SCoV-2, Papain-like protease, FDA drug, virtual screening, enzymatic assays, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2022.877813/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/10ea328f02e14b0d805ffbc36c6548d3

PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP-dependent lipid uptake and fatty acid synthesis pathways

Authors: Keerthana Balamurugan, Raghavender Medishetti, Jyothi Kotha, Parameshwar Behera, Kanika Chandra, Vijay Aditya Mavuduru, Manjunath B. Joshi, Ramesh Samineni, Madhumohan R. Katika, Writoban Basu Ball, Manjunatha Thondamal, Anil Challa, Kiranam Chatti, Kishore V.L. Parsa

Source: iScience, Vol 25, Iss 2, Pp 103766- (2022)

Subject Terms: Biological sciences, Lipid, Molecular physiology, Molecular biology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222000360; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/fe4f6b2971f64ef89092d79c791f559d

MS-275, a class 1 histone deacetylase inhibitor augments glucagon-like peptide-1 receptor agonism to improve glycemic control and reduce obesity in diet-induced obese mice

Authors: Shilpak Bele, Shravan Babu Girada, Aramita Ray, Abhishek Gupta, Srinivas Oruganti, Phanithi Prakash Babu, Rahul SR Rayalla, Shashi Vardhan Kalivendi, Ahamed Ibrahim, Vishwajeet Puri, Venkateswar Adalla, Madhumohan R Katika, Richard DiMarchi, Prasenjit Mitra

Source: eLife, Vol 9 (2020)

Subject Terms: glucagon-like peptide-1 receptor, HDAC inhibition, insulin secretion, obesity, energy expenditure, glycemic control, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/52212; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/bc7951a1758043849dd74d907661bb2c