Development of multivalent CAR T cells as dual immunotherapy and conditioning agents

Authors: Bubb, Quenton Rashawn ^{1, 2, 7}, Balood, Mohammad ², Seir, Gabe Eduardo ^{2, 3}, Swartzrock, Leah ^{2, 7}, Haslett, Ethan ^{2, 7}, Ho, Katie ^{2, 7}, Xu, Peng ⁴, Wiltz, Saida G. ^{2, 7}, Sotillo, Elena ⁴, Gruber, Tanja A. ², Richards, Rebecca M. ⁵, Mackall, Crystal L. ^{2, 4, 6}, Czechowicz, Agnieszka ^{2, 7, ∗}

Source: In Molecular Therapy: Oncology 20 March 2025 33(1)

A phase 1 clinical trial of NKTR-255 with CD19-22 CAR T-cell therapy for refractory B-cell acute lymphoblastic leukemia

Authors: Srinagesh, Hrishikesh, Jackson, Clayton, Shiraz, Parveen, Jeyakumar, Nikeshan, Hamilton, Mark, Egeler, Emily, Mavroukakis, Sharon, Kuo, Adam, Cancilla, Juancarlos, Sahaf, Bita, Agarwal, Neha, Kanegai, Alyssa, Kramer, Anne Marijn, Arai, Sally, Bharadwaj, Sushma, Dahiya, Saurabh, Hosoya, Hitomi, Johnston, Laura, Kennedy, Vanessa, Liedtke, Michaela, Lowsky, Robert, Mikkilineni, Lekha, Negrin, Robert, Rezvani, Andrew, Sidana, Surbhi, Shizuru, Judith, Smith, Melody, Weng, Wen-Kai, Feldman, Steven, Frank, Matthew J., Lee, Zachary, Tagliaferri, Mary, Marcondes, A. Mario, Miklos, David, Mackall, Crystal, Muffly, Lori

Source: In Blood 17 October 2024 144(16):1689-1698

The cytokine Meteorin-like inhibits anti-tumor CD8+ T cell responses by disrupting mitochondrial function

Authors: Jackson, Christopher M., Pant, Ayush, Dinalankara, Wikum, Choi, John, Jain, Aanchal, Nitta, Ryan, Yazigi, Eli, Saleh, Laura, Zhao, Liang, Nirschl, Thomas R., Kochel, Christina M., Hwa-Lin Bergsneider, Brandon, Routkevitch, Denis, Patel, Kisha, Cho, Kwang Bog, Tzeng, Stephany, Neshat, Sarah Y., Kim, Young-Hoon, Smith, Barbara J., Ramello, Maria Cecilia, Sotillo, Elena, Wang, Xinnan, Green, Jordan J., Bettegowda, Chetan, Li, Gordon, Brem, Henry, Mackall, Crystal L., Pardoll, Drew M., Drake, Charles G., Marchionni, Luigi, Lim, Michael

Source: In Immunity 13 August 2024 57(8):1864-1877

CD22-directed CAR T-cell therapy for large B-cell lymphomas progressing after CD19-directed CAR T-cell therapy: a dose-finding phase 1 study

Authors: Klysz, Dorota Danuta, Gkitsas-Long, Nikolaos, Bacigalupi, Juliana, Iglesias, Maria, Crawford, Emma, Nichols, Linnea, Cunanan, Kristen, Tamaresis, John, Spiegel, Jay Y., Ehlinger, Zachary, Kuo, Adam, Reynolds, Warren D., Arai, Sally, Johnston, Laura, Lowsky, Robert, Meyer, Everett, Negrin, Robert S., Rezvani, Andrew R., Shiraz, Parveen, Sidana, Surbhi, Weng, Wen Kai, Bharadwaj, Sushma, Dahiya, Saurabh, Smith, Melody, Schultz, Liora M., Ramakrishna, Sneha, Davis, Kara L., Tunuguntla, Ramya, Frank, Matthew J ^{*, *}, Baird, John H ^*, Kramer, Anne Marijn ^*, Srinagesh, Hrishikesh K, Patel, Shabnum, Brown, Annie Kathleen, Oak, Jean S, Younes, Sheren F, Natkunam, Yasodha, Hamilton, Mark P, Su, Yi-Jiun, Agarwal, Neha, Chinnasamy, Harshini, Egeler, Emily, Mavroukakis, Sharon, Feldman, Steven A, Sahaf, Bita, Mackall, Crystal L, Muffly, Lori, Miklos, David B ^**

Source: In The Lancet 27 July-2 August 2024 404(10450):353-363

CAR19 monitoring by peripheral blood immunophenotyping reveals histology-specific expansion and toxicity

Authors: Hamilton, Mark P., Craig, Erin, Gentille Sanchez, Cesar, Mina, Alain, Tamaresis, John, Kirmani, Nadia, Ehlinger, Zachary, Syal, Shriya, Good, Zinaida, Sworder, Brian, Schroers-Martin, Joseph, Lu, Ying, Muffly, Lori, Negrin, Robert S., Arai, Sally, Lowsky, Robert, Meyer, Everett, Rezvani, Andrew R., Shizuru, Judith, Weng, Wen-Kai, Shiraz, Parveen, Sidana, Surbhi, Bharadwaj, Sushma, Smith, Melody, Dahiya, Saurabh, Sahaf, Bita, Kurtz, David M., Mackall, Crystal L., Tibshirani, Robert, Alizadeh, Ash A., Frank, Matthew J., Miklos, David B.

Source: In Blood Advances 25 June 2024 8(12):3314-3326

INSPIRED Symposium Part 5: Expanding the Use of CAR T Cells in Children and Young Adults

Authors: Talleur, Aimee C., Fabrizio, Vanessa A., Aplenc, Richard, Grupp, Stephan A., Mackall, Crystal, Majzner, Robbie, Nguyen, Rosa, Rouce, Rayne, Moskop, Amy, McNerney, Kevin O.

Source: In Transplantation and Cellular Therapy June 2024 30(6):565-579

A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells

Authors: Tieu, Victor, Sotillo, Elena, Bjelajac, Jeremy R., Chen, Crystal, Malipatlolla, Meena, Guerrero, Justin A., Xu, Peng, Quinn, Patrick J., Fisher, Chris, Klysz, Dorota, Mackall, Crystal L., Qi, Lei S.

Source: In Cell 29 February 2024 187(5):1278-1295

Inosine induces stemness features in CAR-T cells and enhances potency

Authors: Klysz, Dorota D., Fowler, Carley, Malipatlolla, Meena, Stuani, Lucille, Freitas, Katherine A., Chen, Yiyun, Meier, Stefanie, Daniel, Bence, Sandor, Katalin, Xu, Peng, Huang, Jing, Labanieh, Louai, Keerthi, Vimal, Leruste, Amaury, Bashti, Malek, Mata-Alcazar, Janette, Gkitsas, Nikolaos, Guerrero, Justin A., Fisher, Chris, Patel, Sunny, Asano, Kyle, Patel, Shabnum, Davis, Kara L., Satpathy, Ansuman T., Feldman, Steven A., Sotillo, Elena, Mackall, Crystal L.

Source: In Cancer Cell 12 February 2024 42(2):266-282

Immune determinants of CAR-T cell expansion in solid tumor patients receiving GD2 CAR-T cell therapy

Authors: Kaczanowska, Sabina, Murty, Tara, Alimadadi, Ahmad, Contreras, Cristina F., Duault, Caroline, Subrahmanyam, Priyanka B., Reynolds, Warren, Gutierrez, Norma A., Baskar, Reema, Wu, Catherine J., Michor, Franziska, Altreuter, Jennifer, Liu, Yang, Jhaveri, Aashna, Duong, Vandon, Anbunathan, Hima, Ong, Claire, Zhang, Hua, Moravec, Radim, Yu, Joyce, Biswas, Roshni, Van Nostrand, Stephen, Lindsay, James, Pichavant, Mina, Sotillo, Elena, Bernstein, Donna, Carbonell, Amanda, Derdak, Joanne, Klicka-Skeels, Jacquelyn, Segal, Julia E., Dombi, Eva, Harmon, Stephanie A., Turkbey, Baris, Sahaf, Bita, Bendall, Sean, Maecker, Holden, Highfill, Steven L., Stroncek, David, Glod, John, Merchant, Melinda, Hedrick, Catherine C., Mackall, Crystal L., Ramakrishna, Sneha, Kaplan, Rosandra N.

Source: In Cancer Cell 8 January 2024 42(1):35-51

The future of CAR T-cell therapy for B-cell acute lymphoblastic leukemia in pediatrics and adolescents

Authors: Schultz, Liora, Mackall, Crystal L

Source: Expert opinion on biological therapy. 23(7):633-640

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187638752.0x000001&indx=1&recIds=ETOCvdc_100187638752.0x000001

Tisagenlecleucel utilisation and outcomes across refractory, first relapse and multiply relapsed B-cell acute lymphoblastic leukemia: a retrospective analysis of real-world patterns

Authors: Barsan, Valentin, Li, Yimei, Prabhu, Snehit, Baggott, Christina, Nguyen, Khanh, Pacenta, Holly, Phillips, Christine L., Rossoff, Jenna, Stefanski, Heather, Talano, Julie-An, Moskop, Amy, Baumeister, Susanne, Verneris, Michael R., Myers, Gary Douglas, Karras, Nicole A., Cooper, Stacy, Qayed, Muna, Hermiston, Michelle, Satwani, Prakash, Krupski, Christa, Keating, Amy, Fabrizio, Vanessa, Chinnabhandar, Vasant, Kunicki, Michael, Curran, Kevin J., Mackall, Crystal L., Laetsch, Theodore W., Schultz, Liora M.

Source: In eClinicalMedicine November 2023 65

HLH-like toxicities predict poor survival after the use of tisagenlecleucel in children and young adults with B-ALL

Authors: McNerney, Kevin O., Si Lim, Stephanie J., Ishikawa, Kyle, Dreyzin, Alexandra, Vatsayan, Anant, Chen, John J., Baggott, Christina, Prabhu, Snehit, Pacenta, Holly L., Philips, Christine, Rossoff, Jenna, Stefanski, Heather E., Talano, Julie-An, Moskop, Amy, Verneris, Michael, Myers, Doug, Karras, Nicole A., Brown, Patrick, Bonifant, Challice L., Qayed, Muna, Hermiston, Michelle, Satwani, Prakash, Krupski, Christa, Keating, Amy K., Baumeister, Susanne H. C., Fabrizio, Vanessa A., Chinnabhandar, Vasant, Egeler, Emily, Mavroukakis, Sharon, Curran, Kevin J., Mackall, Crystal L., Laetsch, Theodore W., Schultz, Liora M.

Source: In Blood Advances 27 June 2023 7(12):2758-2771

Higher doses of tisagenlecleucel are associated with improved outcomes: a report from the pediatric real-world CAR consortium

Authors: Stefanski, Heather E., Eaton, Anne, Baggott, Christina, Rossoff, Jenna, Verneris, Michael R., Prabhu, Snehit, Pacenta, Holly L., Phillips, Christine L., Talano, Julie-An, Moskop, Amy, Margossian, Steven P., Myers, Gary Douglas, Karras, Nicole A., Brown, Patrick A., Qayed, Muna, Hermiston, Michelle, Satwani, Prakash, Krupski, M. Christa, Keating, Amy K., Wilcox, Rachel, Rabik, Cara A., Fabrizio, Vanessa A., Chinnabhandar, Vasant, Goksenin, A. Yasemin, Curran, Kevin J., Mackall, Crystal L., Laetsch, Theodore W., Schultz, Liora M.

Source: In Blood Advances 28 February 2023 7(4):541-548

Determinants of resistance to engineered T cell therapies targeting CD19 in large B cell lymphomas

Authors: Sworder, Brian J., Kurtz, David M., Alig, Stefan K., Frank, Matthew J., Shukla, Navika, Garofalo, Andrea, Macaulay, Charles W., Shahrokh Esfahani, Mohammad, Olsen, Mari N., Hamilton, James, Hosoya, Hitomi, Hamilton, Mark, Spiegel, Jay Y., Baird, John H., Sugio, Takeshi, Carleton, Mia, Craig, Alexander F.M., Younes, Sheren F., Sahaf, Bita, Sheybani, Natasha D., Schroers-Martin, Joseph G., Liu, Chih Long, Oak, Jean S., Jin, Michael C., Beygi, Sara, Hüttmann, Andreas, Hanoun, Christine, Dührsen, Ulrich, Westin, Jason R., Khodadoust, Michael S., Natkunam, Yasodha, Majzner, Robbie G., Mackall, Crystal L., Diehn, Maximilian, Miklos, David B., Alizadeh, Ash A.

Source: In Cancer Cell 9 January 2023 41(1):210-225

The impact of race, ethnicity, and obesity on CAR T-cell therapy outcomes

Authors: Faruqi, Aiman J., Ligon, John A., Borgman, Paul, Steinberg, Seth M., Foley, Toni, Little, Lauren, Mackall, Crystal L., Lee, Daniel W., Fry, Terry J., Shalabi, Haneen, Brudno, Jennifer, Yates, Bonnie, Mikkilineni, Lekha, Kochenderfer, James, Shah, Nirali N. ^∗

Source: In Blood Advances 13 December 2022 6(23):6040-6050

Dynamic chromatin regulatory landscape of human CAR T cell exhaustion

Authors: Gennert, David G., Lynn, Rachel C., Granja, Jeff M., Weber, Evan W., Mumbach, Maxwell R., Zhao, Yang, Duren, Zhana, Sotillo, Elena, Greenleaf, William J., Wong, Wing H., Satpathy, Ansuman T., Mackall, Crystal L., Chang, Howard Y.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Jul . 118(30), 1-12.

Access URL: https://www.jstor.org/stable/27052636

CD19/22 CAR T cells in children and young adults with B-ALL: phase 1 results and development of a novel bicistronic CAR

Authors: Shalabi, Haneen, Qin, Haiying, Su, Angela, Yates, Bonnie, Wolters, Pamela L., Steinberg, Seth M., Ligon, John A., Silbert, Sara, DéDé, Kniya, Benzaoui, Mehdi, Goldberg, Sophia, Achar, Sooraj, Schneider, Dina, Shahani, Shilpa A., Little, Lauren, Foley, Toni, Molina, John C., Panch, Sandhya, Mackall, Crystal L., Lee, Daniel W., Chien, Christopher D., Pouzolles, Marie, Ahlman, Mark, Yuan, Constance M., Wang, Hao-Wei, Wang, Yanyu, Inglefield, Jon, Toledo-Tamula, Mary Anne, Martin, Staci, Highfill, Steven L., Altan-Bonnet, Gregoire, Stroncek, David, Fry, Terry J., Taylor, Naomi, Shah, Nirali N.

Source: Blood. 140(5):451-463

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183235785.0x000001&indx=1&recIds=ETOCvdc_100183235785.0x000001

Outcomes After Nonresponse and Relapse Post-Tisagenlecleucel in Children, Adolescents, and Young Adults With B-Cell Acute Lymphoblastic Leukemia

Authors: Schultz, Liora M., Eaton, Anne, Baggott, Christina, Rossoff, Jenna, Prabhu, Snehit, Keating, Amy K., Krupski, Christa, Pacenta, Holly, Philips, Christine L., Talano, Julie-An, Moskop, Amy, Baumeister, Susanne H.C., Myers, Gary Douglas, Karras, Nicole A., Brown, Patrick A., Qayed, Muna, Hermiston, Michelle, Satwani, Prakash, Wilcox, Rachel, Rabik, Cara A., Fabrizio, Vanessa A., Chinnabhandar, Vasant, Kunicki, Michael, Mavroukakis, Sharon, Egeler, Emily, Li, Yimei, Mackall, Crystal L., Curran, Kevin J., Verneris, Michael R., Laetsch, Theodore W., Stefanski, Heather

Source: Journal of clinical oncology. 41(2):354-363

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179829962.0x000001&indx=1&recIds=ETOCvdc_100179829962.0x000001

Neurotoxicity following CD19/CD28ζ CAR T-cells in children and young adults with B-cell malignancies

Authors: Shalabi, Haneen, Martin, Staci, Yates, Bonnie, Wolters, Pamela L, Kaplan, Claire, Smith, Hannah, Sesi, Christopher R, Jess, Jennifer, Toledo-Tamula, Mary Anne, Struemph, Kari, Delbrook, Cindy P, Khan, Omar I, Mackall, Crystal L, Lee, Daniel W, Shah, Nirali N

Source: Neuro-oncology. 24(9):1584-1597

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100159695542.0x000001&indx=1&recIds=ETOCvdc_100159695542.0x000001

Paediatric Strategy Forum for medicinal product development of chimeric antigen receptor T-cells in children and adolescents with cancer

Authors: Pearson, Andrew DJ., Rossig, Claudia, Mackall, Crystal, Shah, Nirali N., Baruchel, Andre, Reaman, Gregory, Ricafort, Rosanna, Heenen, Delphine, Bassan, Abraham, Berntgen, Michael, Bird, Nick, Bleickardt, Eric, Bouchkouj, Najat, Bross, Peter, Brownstein, Carrie, Cohen, Sarah Beaussant, de Rojas, Teresa, Ehrlich, Lori, Fox, Elizabeth, Gottschalk, Stephen, Hanssens, Linda, Hawkins, Douglas S., Horak, Ivan D., Taylor, Danielle H., Johnson, Courtney, Karres, Dominik, Ligas, Franca, Ludwinski, Donna, Mamonkin, Maksim, Marshall, Lynley, Masouleh, Behzad K., Matloub, Yousif, Maude, Shannon, McDonough, Joe, Minard-Colin, Veronique, Norga, Koen, Nysom, Karsten, Pappo, Alberto, Pearce, Laura, Pieters, Rob, Pule, Martin, Quintás-Cardama, Alfonso, Richardson, Nick, Schüßler-Lenz, Martina, Scobie, Nicole, Sersch, Martina A., Smith, Malcolm A., Sterba, Jaroslav, Tasian, Sarah K., Weigel, Brenda, Weiner, Susan L., Zwaan, Christian Michel, Lesa, Giovanni, Vassal, Gilles

Source: European journal of cancer. 160:112-133

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100151123946.0x000001&indx=1&recIds=ETOCvdc_100151123946.0x000001