Surface pTα expression predicts LCK activation and preclinical synergy of LCK and JAK coinhibition in adult T-ALL

Authors: Courtois, Lucien ^{1, 2}, Pinton, Antoine ¹, Cabannes-Hamy, Aurélie ³, Simonin, Mathieu ^{1, 2, 4}, Andrieu, Guillaume ¹, Queri, Mélodie ², Smith, Charlotte ¹, Charbonnier, Guillaume ¹, Dourthe, Marie-Emilie ^{1, 5}, Courgeon, Marianne ^{1, 2}, Huré, Grégoire ¹, Gaidot, Nicolas ¹, Macintyre, Elizabeth ^{1, 2}, Dombret, Hervé ^{6, 7}, Baruchel, André ⁵, Boissel, Nicolas ^{6, 8}, Touzart, Aurore ^{1, 2}, Lhermitte, Ludovic ^{1, 2}, Rousselot, Philippe ³, Asnafi, Vahid ^{1, 2, ∗}

Source: In Blood January 2025

ATP citrate lyase is an essential player in the metabolic rewiring induced by PTEN loss during T-ALL development

Authors: Andrieu, Guillaume P. ^{1, 2}, Hypolite, Guillaume ^{1, 2}, Latiri, Mehdi ^{1, 2, 3}, Balducci, Estelle ^{1, 2, 3}, Costa, Caroline ^{4, 5, 6, 7}, Verhoeyen, Els ⁸, Courgeon, Marianne ^{1, 2, 3}, Allatif, Omran ⁹, Nemazanyy, Ivan ^{10, 11}, Panasyuk, Ganna ^{12, 13}, Wellen, Kathryn ¹⁴, Herranz, Daniel ¹⁵, Genestier, Laurent ^{5, 16, 17}, Macintyre, Elizabeth ^{1, 2, 3}, Asnafi, Vahid ^{1, 2, 3, ∗}, Tesio, Melania ^{1, 5, 16, 17, ∗∗}

Source: In Blood Advances October 2024

NGS-based stratification refines the risk stratification in T-ALL and identifies a very-high-risk subgroup of patients

Authors: Simonin, Mathieu ^{1, 2, 3}, Vasseur, Loïc ^{4, 5}, Lengliné, Etienne ^{6, 7}, Lhermitte, Ludovic ^{1, 2}, Cabannes-Hamy, Aurélie ⁸, Balsat, Marie ⁹, Schmidt, Aline ^{10, 11}, Dourthe, Marie-Emilie ^{1, 2, 12}, Touzart, Aurore ^{1, 2}, Graux, Carlos ¹³, Grardel, Nathalie ¹⁴, Cayuela, Jean-Michel ^{6, 15}, Arnoux, Isabelle ¹⁶, Gandemer, Virginie ¹⁷, Huguet, Françoise ¹⁸, Ducassou, Stéphane ¹⁹, Lhéritier, Véronique ²⁰, Chalandon, Yves ^{21, 22}, Ifrah, Norbert ^{10, 11}, Dombret, Hervé ^{6, 7}, Macintyre, Elizabeth ^{1, 2}, Petit, Arnaud ³, Rousselot, Philippe ⁸, Lambert, Jérôme ^{4, 23}, Baruchel, André ¹², Boissel, Nicolas ^{5, 6, ∗∗}, Asnafi, Vahid ^{1, 2, ∗}

Source: In Blood 10 October 2024 144(15):1570-1580

Genomic imbalance analysis provides new insight into prognostic factors in adult and pediatric T-ALL

Authors: Balducci, Estelle, Simonin, Mathieu, Duployez, Nicolas, Steimlé, Thomas, Dourthe, Marie-Emilie, Villarese, Patrick, Ducassou, Stéphane, Arnoux, Isabelle, Cayuela, Jean-Michel, Balsat, Marie, Courtois, Lucien, Andrieu, Guillaume, Touzart, Aurore, Huguet, Françoise, Petit, Arnaud, Ifrah, Norbert, Dombret, Hervé, Baruchel, André, Macintyre, Elizabeth, Preudhomme, Claude, Boissel, Nicolas, Asnafi, Vahid

Source: In Blood 29 August 2024 144(9):988-1000

Obinutuzumab vs rituximab for transplant-eligible patients with mantle cell lymphoma

Authors: Sarkozy, Clémentine, Callanan, Mary, Thieblemont, Catherine, Obéric, Lucie, Burroni, Barbara, Bouabdallah, Krimo, Damaj, Gandhi, Tessoulin, Benoit, Ribrag, Vincent, Houot, Roch, Morschhauser, Franck, Griolet, Samuel, Joubert, Clémentine, Cacheux, Victoria, Delwail, Vincent, Safar, Violaine, Gressin, Remy, Cheminant, Morgane, Delfau-Larue, Marie-Hélène, Hermine, Olivier, Macintyre, Elizabeth, Le Gouill, Steven

Source: In Blood 18 July 2024 144(3):262-271

Mutational and transcriptional landscape of pediatric B-cell precursor lymphoblastic lymphoma

Authors: Kroeze, Emma, Iaccarino, Ingram, Kleisman, Michelle M., Mondal, Mayukh, Beder, Thomas, Khouja, Mouhamad, Höppner, Marc P., Scheijde-Vermeulen, Marijn A., Kester, Lennart A., Brüggemann, Monika, Baldus, Claudia D., Cario, Gunnar, Bladergroen, Reno S., Garnier, Nathalie, Attarbaschi, Andishe, Verdu-Amorós, Jaime, Sutton, Rosemary, Macintyre, Elizabeth, Scholten, Kenneth, Arias Padilla, Laura, Burkhardt, Birgit, Beishuizen, Auke, den Boer, Monique L., Kuiper, Roland P., Loeffen, Jan L. C., Boer, Judith M., Klapper, Wolfram

Source: In Blood 4 July 2024 144(1):74-83

Human kidney-derived hematopoietic stem cells can support long-term multilineage hematopoiesis

Authors: Sobrino, Steicy, Abdo, Chrystelle, Neven, Bénédicte, Denis, Adeline, Gouge-Biebuyck, Nathalie, Clave, Emmanuel, Charbonnier, Soëli, Blein, Tifanie, Kergaravat, Camille, Alcantara, Marion, Villarese, Patrick, Berthaud, Romain, Dehoux, Laurène, Albinni, Souha, Karkeni, Esma, Lagresle-Peyrou, Chantal, Cavazzana, Marina, Salomon, Rémi, André, Isabelle, Toubert, Antoine, Asnafi, Vahid, Picard, Capucine, Blanche, Stéphane, Macintyre, Elizabeth, Boyer, Olivia, Six, Emmanuelle, Zuber, Julien

Source: Kidney international. 103(1):70-76

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190055102.0x000001&indx=1&recIds=ETOCvdc_100190055102.0x000001

Multimodal cartography of human lymphopoiesis reveals B and T/NK/ILC lineages are subjected to differential regulation

Authors: Alhaj Hussen, Kutaiba, Chabaane, Emna, Nelson, Elisabeth, Lekiashvili, Shalva, Diop, Samuel, Keita, Seydou, Evrard, Bertrand, Lardenois, Aurélie, Delord, Marc, Verhoeyen, Els, Cornils, Kerstin, Kasraian, Zeinab, Macintyre, Elizabeth A., Cumano, Ana, Garrick, David, Goodhardt, Michele, Andrieu, Guillaume P., Asnafi, Vahid, Chalmel, Frederic, Canque, Bruno

Source: In iScience 20 October 2023 26(10)

Distinct subsets of multi-lymphoid progenitors support ontogeny-related changes in human lymphopoiesis

Authors: Keita, Seydou, Diop, Samuel, Lekiashvili, Shalva, Chabaane, Emna, Nelson, Elisabeth, Strullu, Marion, Arfeuille, Chloé, Guimiot, Fabien, Domet, Thomas, Duchez, Sophie, Evrard, Bertrand, Darde, Thomas, Larghero, Jerome, Verhoeyen, Els, Cumano, Ana, Macintyre, Elizabeth A., Kasraian, Zeinab, Jouen, François, Goodhardt, Michele, Garrick, David, Chalmel, Frederic, Alhaj Hussen, Kutaiba, Canque, Bruno

Source: In Cell Reports 27 June 2023 42(6)

Improving outcomes of childhood and young adult non-Hodgkin lymphoma: 25 years of research and collaboration within the framework of the European Intergroup for Childhood Non-Hodgkin Lymphoma

Authors: Beishuizen, Auke ^†, Mellgren, Karin ^†, Andrés, Mara, Auperin, Anne, Bacon, Chris M, Bomken, Simon, Burke, G A Amos, Burkhardt, Birgit, Brugieres, Laurence, Chiang, Alan K S, Damm-Welk, Christine, d'Amore, Emanuele, Horibe, Keizo, Kabickova, Edita, Khanam, Tasneem, Kontny, Udo, Klapper, Wolfram, Lamant, Laurence, Le Deley, Marie-Cecile, Loeffen, Jan, Macintyre, Elizabeth, Mann, Georg, Meyer-Wentrup, Friederike, Michgehl, Ulf, Minard-Colin, Veronique, Mussolin, Lara, Oschlies, Ilske, Patte, Catherine, Pillon, Marta, Reiter, Alfred, Rigaud, Charlotte, Ronceray, Leila, Salaverria, Itziar, Simonitsch-Klupp, Ingrid, Uyttebroeck, Anne, Verdu-Amoros, Jaime, Williams, Denise, Woessmann, Wilhelm, Wotherspoon, Andrew, Wrobel, Grazyna, Zimmermann, Martin, Attarbaschi, Andishe ^†, Turner, Suzanne D ^{†, *}

Source: In The Lancet Haematology March 2023 10(3):e213-e224

Prognostic value of Oncogenetic mutations in pediatric T Acute Lymphoblastic Leukemia: a comparison of UKALL2003 and FRALLE2000T protocols

Authors: Taj, Mary M., Moorman, Anthony V., Hamadeh, Lina, Petit, Arnaud, Asnafi, Vahid, Alby-Laurent, Fanny, Vora, Ajay, Mansour, Marc R., Gale, Rosemary, Chevret, Sylvie, Moppett, John, Baruchel, André, Macintyre, Elizabeth

Source: Leukemia. 36(1):263-266

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193142860.0x000001&indx=1&recIds=ETOCvdc_100193142860.0x000001

The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee

Authors: Campo, Elias, Jaffe, Elaine S., Cook, James R., Quintanilla-Martinez, Leticia, Swerdlow, Steven H., Anderson, Kenneth C., Brousset, Pierre, Cerroni, Lorenzo, de Leval, Laurence, Dirnhofer, Stefan, Dogan, Ahmet, Feldman, Andrew L., Fend, Falko, Friedberg, Jonathan W., Gaulard, Philippe, Ghia, Paolo, Horwitz, Steven M., King, Rebecca L., Salles, Gilles, San-Miguel, Jesus, Seymour, John F., Treon, Steven P., Vose, Julie M., Zucca, Emanuele, Advani, Ranjana, Ansell, Stephen, Au, Wing-Yan, Barrionuevo, Carlos, Bergsagel, Leif, Chan, Wing C., Cohen, Jeffrey I., d'Amore, Francesco, Davies, Andrew, Falini, Brunangelo, Ghobrial, Irene M., Goodlad, John R., Gribben, John G., Hsi, Eric D., Kahl, Brad S., Kim, Won-Seog, Kumar, Shaji, LaCasce, Ann S., Laurent, Camille, Lenz, Georg, Leonard, John P., Link, Michael P., Lopez-Guillermo, Armando, Mateos, Maria Victoria, Macintyre, Elizabeth, Melnick, Ari M., Morschhauser, Franck, Nakamura, Shigeo, Narbaitz, Marina, Pavlovsky, Astrid, Pileri, Stefano A., Piris, Miguel, Pro, Barbara, Rajkumar, Vincent, Rosen, Steven T., Sander, Birgitta, Sehn, Laurie, Shipp, Margaret A., Smith, Sonali M., Staudt, Louis M., Thieblemont, Catherine, Tousseyn, Thomas, Wilson, Wyndham H., Yoshino, Tadashi, Zinzani, Pier-Luigi, Dreyling, Martin, Scott, David W., Winter, Jane N., Zelenetz, Andrew D.

Source: Blood. 140(11):1229-1253

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183239606.0x000001&indx=1&recIds=ETOCvdc_100183239606.0x000001

International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data

Authors: Arber, Daniel A., Orazi, Attilio, Hasserjian, Robert P., Borowitz, Michael J., Calvo, Katherine R., Kvasnicka, Hans-Michael, Wang, Sa A., Bagg, Adam, Barbui, Tiziano, Branford, Susan, Bueso-Ramos, Carlos E., Cortes, Jorge E., Dal Cin, Paola, DiNardo, Courtney D., Dombret, Hervé, Duncavage, Eric J., Ebert, Benjamin L., Estey, Elihu H., Facchetti, Fabio, Foucar, Kathryn, Gangat, Naseema, Gianelli, Umberto, Godley, Lucy A., Gökbuget, Nicola, Gotlib, Jason, Hellström-Lindberg, Eva, Hobbs, Gabriela S., Hoffman, Ronald, Jabbour, Elias J., Kiladjian, Jean-Jacques, Larson, Richard A., Le Beau, Michelle M., Loh, Mignon L.-C., Löwenberg, Bob, Macintyre, Elizabeth, Malcovati, Luca, Mullighan, Charles G., Niemeyer, Charlotte, Odenike, Olatoyosi M., Ogawa, Seishi, Orfao, Alberto, Papaemmanuil, Elli, Passamonti, Francesco, Porkka, Kimmo, Pui, Ching-Hon, Radich, Jerald P., Reiter, Andreas, Rozman, Maria, Rudelius, Martina, Savona, Michael R., Schiffer, Charles A., Schmitt-Graeff, Annette, Shimamura, Akiko, Sierra, Jorge, Stock, Wendy A., Stone, Richard M., Tallman, Martin S., Thiele, Jürgen, Tien, Hwei-Fang, Tzankov, Alexandar, Vannucchi, Alessandro M., Vyas, Paresh, Wei, Andrew H., Weinberg, Olga K., Wierzbowska, Agnieszka, Cazzola, Mario, Döhner, Hartmut, Tefferi, Ayalew

Source: Blood. 140(11):1200-1228

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183239603.0x000001&indx=1&recIds=ETOCvdc_100183239603.0x000001

One-Step Next-Generation Sequencing of Immunoglobulin and T-Cell Receptor Gene Recombinations for MRD Marker Identification in Acute Lymphoblastic Leukemia

Authors: Villarese, Patrick, Abdo, Chrystelle, Bertrand, Matthieu, Thonier, Florian, Giraud, Mathieu, Salson, Mikaël, Macintyre, Elizabeth

Source: Methods in molecular biology. 2453:43-60

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629444220&indx=1&recIds=ETOCRN629444220

Immature acute leukaemias: lessons from the haematopoietic roadmap

Authors: Lefeivre, Thomas, Jones, Luke, Trinquand, Amélie, Pinton, Antoine, Macintyre, Elizabeth, Laurenti, Elisa, Bond, Jonathan

Source: FEBS journal. 289(15):4355-4370

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157787891.0x000001&indx=1&recIds=ETOCvdc_100157787891.0x000001

Oncogenetic landscape of T-cell lymphoblastic lymphomas compared to T-cell acute lymphoblastic leukemia

Authors: Bontoux, Christophe, Simonin, Mathieu, Garnier, Nathalie, Lhermitte, Ludovic, Touzart, Aurore, Andrieu, Guillaume, Bruneau, Julie, Lengliné, Etienne, Plesa, Adriana, Boissel, Nicolas, Baruchel, André, Bertrand, Yves, Molina, Thierry Jo, Macintyre, Elizabeth, Asnafi, Vahid

Source: In Modern Pathology September 2022 35(9):1227-1235

Global view of haematolymphoid tumor classifications and their application in low‐ and middle‐income countries.

Authors: Fedoriw, Yuri, Silva, Oscar, Znaor, Ariana, Macintyre, Elizabeth

Source: Histopathology; Jan2025, Vol. 86 Issue 1, p6-16, 11p

Subject Terms: PUBLIC health infrastructure, GENE expression profiling, SUSTAINABLE investing, TUMOR classification, CANCER treatment

Validation of the EuroClonality-NGS DNA capture panel as an integrated genomic tool for lymphoproliferative disorders

Authors: Stewart, James Peter, Gazdova, Jana, Darzentas, Nikos, Wren, Dörte, Proszek, Paula, Fazio, Grazia, Songia, Simona, Alcoceba, Miguel, Sarasquete, Maria Eugenia, Villarese, Patrick, van der Klift, Michèle Y., Heezen, Kim C., McCafferty, Neil, Pal, Karol, Catherwood, Mark, Kim, Chang Sik, Srivastava, Shambhavi, Kroeze, Leonie I., Hodges, Elizabeth, Stamatopoulos, Kostas, Klapper, Wolfram, Genuardi, Elisa, Ferrero, Simone, van den Brand, Michiel, Cazzaniga, Giovanni, Davi, Frederic, Sutton, Lesley-Ann, Garcia-Sanz, Ramon, Groenen, Patricia J.T.A., Macintyre, Elizabeth A., Brüggemann, Monika, Pott, Christiane, Langerak, Anton W. ^{*, **}, Gonzalez, David ^{*, *}

Source: In Blood Advances 24 August 2021 5(16):3188-3198

Transcriptomic and genomic heterogeneity in blastic plasmacytoid dendritic cell neoplasms: from ontogeny to oncogenesis

Authors: Renosi, Florian, Roggy, Anne, Giguelay, Ambre, Soret, Lou, Viailly, Pierre-Julien, Cheok, Meyling, Biichle, Sabeha, Angelot-Delettre, Fanny, Asnafi, Vahid, Macintyre, Elizabeth, Geffroy, Sandrine, Callanan, Mary, Petrella, Tony, Deconinck, Eric, Daguindau, Etienne, Harrivel, Véronique, Bouyer, Sabrina, Salaun, Véronique, Saussoy, Pascale, Feuillard, Jean, Fuseau, Pascal, Saas, Philippe, Adotévi, Olivier, Jardin, Fabrice, Ferrand, Christophe, Preudhomme, Claude, Colinge, Jacques, Roumier, Christophe, Garnache-Ottou, Francine ^*

Source: In Blood Advances 9 March 2021 5(5):1540-1551

Adenylate kinase 2 expression and addiction in T-ALL

Authors: Maslah, Nabih ^*, Latiri, Mehdi ^*, Asnafi, Vahid, Féroul, Mélanie, Bedjaoui, Nawel, Steimlé, Thomas, Six, Emmanuelle, Verhoyen, Els, Macintyre, Elizabeth, Lagresle-Peyrou, Chantal, Lhermitte, Ludovic, Andrieu, Guillaume P. ^*

Source: In Blood Advances 9 February 2021 5(3):700-710