Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probeElectronic supplementary information (ESI) available: Supplementary figures and tables; general synthetic methods; compound synthesis and characterization; molecular docking; in vitro pharmacology; fluorescence spectroscopy; TR-FRET kinetic CB2R binding assay; FACS analysis; time-lapse confocal imaging; in vivo zebrafish imaging; NMR spectra; and N-terminal SNAP-hCB2R sequence. CCDC 1923120. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/d1sc06659e

Authors: Gazzi, Thais, Brennecke, Benjamin, Atz, Kenneth, Korn, Claudia, Sykes, David, Forn-Cuni, Gabriel, Pfaff, Patrick, Sarott, Roman C., Westphal, Matthias V., Mostinski, Yelena, Mach, Leonard, Wasinska-Kalwa, Malgorzata, Weise, Marie, Hoare, Bradley L., Miljuš, Tamara, Mexi, Maira, Roth, Nicolas, Koers, Eline J., Guba, Wolfgang, Alker, André, Rufer, Arne C., Kusznir, Eric A., Huber, Sylwia, Raposo, Catarina, Zirwes, Elisabeth A., Osterwald, Anja, Pavlovic, Anto, Moes, Svenja, Beck, Jennifer, Nettekoven, Matthias, Benito-Cuesta, Irene, Grande, Teresa, Drawnel, Faye, Widmer, Gabriella, Holzer, Daniela, van der Wel, Tom, Mandhair, Harpreet, Honer, Michael, Fingerle, Jürgen, Scheffel, Jörg, Broichhagen, Johannes, Gawrisch, Klaus, Romero, Julián, Hillard, Cecilia J., Varga, Zoltan V., van der Stelt, Mario, Pacher, Pal, Gertsch, Jürg, Ullmer, Christoph, McCormick, Peter J., Oddi, Sergio, Spaink, Herman P., Maccarrone, Mauro, Veprintsev, Dmitry B., Carreira, Erick M., Grether, Uwe, Nazaré, Marc

Source: Chemical science. 13(19):5539-5545

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150048376.0x000001&indx=1&recIds=ETOCvdc_100150048376.0x000001

Patent review of cannabinoid receptor type 2 (CB2R) modulators (2016-present).

Authors: Kosar, Miroslav, Mach, Leonard, Carreira, Erick M., Nazaré, Marc, Pacher, Pal, Grether, Uwe

Source: Expert Opinion on Therapeutic Patents; Aug2024, Vol. 34 Issue 8, p665-700, 36p

Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB1R).

Authors: Mach, Leonard, Omran, Anahid, Bouma, Jara, Radetzki, Silke, Sykes, David A., Guba, Wolfgang, Li, Xiaoting, Höffelmeyer, Calvin, Hentsch, Axel, Gazzi, Thais, Mostinski, Yelena, Wasinska-Kalwa, Malgorzata, de Molnier, Fabio, van der Horst, Cas, von Kries, Jens Peter, Vendrell, Marc, Hua, Tian, Veprintsev, Dmitry B., Heitman, Laura H., Grether, Uwe

Source: Journal of Medicinal Chemistry; 7/25/2024, Vol. 67 Issue 14, p11841-11867, 27p

Patent review of cannabinoid receptor type 2 (CB2R) modulators (2016-present)

Authors: Kosar, Miroslav, Mach, Leonard, Carreira, Erick M., Nazaré, Marc, Pacher, Pal, Grether, Uwe

Source: Expert Opinion on Therapeutic Patents; August 2024, Vol. 34 Issue: 8 p665-700, 36p

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Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB1R)

Authors: Mach, Leonard, Omran, Anahid, Bouma, Jara, Radetzki, Silke, Sykes, David A., Guba, Wolfgang, Li, Xiaoting, Höffelmeyer, Calvin, Hentsch, Axel, Gazzi, Thais, Mostinski, Yelena, Wasinska-Kalwa, Malgorzata, de Molnier, Fabio, van der Horst, Cas, von Kries, Jens Peter, Vendrell, Marc, Hua, Tian, Veprintsev, Dmitry B., Heitman, Laura H., Grether, Uwe, Nazare, Marc

Source: Journal of Medicinal Chemistry; 20240101, Issue: Preprints