Generation of four distinct isogenic cell lines with truncating variants in I-band or A-band titin

Authors: Hanne M. Boen, Bert Vandendriessche, Jolien Schippers, Laura Rabaut, Aleksandra Nijak-Paeske, Peter Ponsaerts, Emeline M. Van Craenenbroeck, Bart Loeys, Maaike Alaerts

Source: Stem Cell Research, Vol 81, Iss , Pp 103536- (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506124002344; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/c3299bc2be0e424f95b05a7926882f59

Variants in structural cardiac genes in patients with cancer therapy-related cardiac dysfunction after anthracycline chemotherapy: a case control study

Authors: Hanne M. Boen, Maaike Alaerts, Inge Goovaerts, Johan B. Saenen, Constantijn Franssen, Anne Vorlat, Tom Vermeulen, Hein Heidbuchel, Lut Van Laer, Bart Loeys, Emeline M. Van Craenenbroeck

Source: Cardio-Oncology, Vol 10, Iss 1, Pp 1-12 (2024)

Subject Terms: Cardio-oncology, Cancer therapy-related cardiac dysfunction, Anthracyclines, Cardiogenetics, Risk stratification, Diseases of the circulatory (Cardiovascular) system, RC666-701, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2057-3804

Access URL: https://doaj.org/article/d722bd93cc5b4cb3bf0e63ce250ce1f0

Phenotypic spectrum of the first Belgian MYBPC3 founder: a large multi-exon deletion with a varying phenotype

Authors: Hanne M. Boen, Maaike Alaerts, Lut Van Laer, Johan B. Saenen, Inge Goovaerts, Jarl Bastianen, Pieter Koopman, Philippe Vanduynhoven, Elke De Vuyst, Michael Rosseel, Hein Heidbuchel, Emeline M. Van Craenenbroeck, Bart Loeys

Source: Frontiers in Genetics, Vol 15 (2024)

Subject Terms: MYBPC3, founder variant, cardiogenetic, phenotyping, hypertrophic cardiomyopathy, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2024.1392527/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/ff57bde99f3543aea920e69875af395f

Invasiveness potential of pneumococcal serotypes in children after introduction of PCV13 in Blantyre, Malawi

Authors: Amir Kirolos, Todd D. Swarthout, Andrew A. Mataya, Farouck Bonomali, Comfort Brown, Jacquline Msefula, Naor Bar-Zeev, Pui-Ying Iroh Tam, Maaike Alaerts, Sithembile Bilima, Robert S. Heyderman, Neil French

Source: BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-7 (2023)

Subject Terms: Pneumococcus, Invasive Pneumococcal Disease, Acute Respiratory Infection, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2334

Access URL: https://doaj.org/article/63167f6b39844ccaba2eed1a4eeaad19

Improved selection of zebrafish CRISPR editing by early next-generation sequencing based genotyping

Authors: Ewa Sieliwonczyk, Bert Vandendriessche, Charlotte Claes, Evy Mayeur, Maaike Alaerts, Philip Holmgren, Tycho Canter Cremers, Dirk Snyders, Bart Loeys, Dorien Schepers

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/a80db3a6daa9481ea82d1423965402c5

Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population

Authors: Ewa Sieliwonczyk, Maaike Alaerts, Eline Simons, Dirk Snyders, Aleksandra Nijak, Bert Vandendriessche, Dorien Schepers, Dogan Akdeniz, Emeline Van Craenenbroeck, Katleen Knaepen, Laura Rabaut, Hein Heidbuchel, Lut Van Laer, Johan Saenen, Alain J. Labro, Bart Loeys

Source: Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-12 (2023)

Subject Terms: KCNQ1, LQTS, Jervell-Lange-Nielsen, Recurrent mutation, iPSC-CMs, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/ec0bef1929b34672b754c194513f25b6

Generation and validation of an iPSC line (BBANTWi008-A) from a Loeys-Dietz Syndrome type 3 patient

Authors: Joe Davis Velchev, Aline Verstraeten, Josephina Meester, Peter Ponsaerts, Julie Richer, Maaike Alaerts, Bart Loeys

Source: Stem Cell Research, Vol 64, Iss , Pp 102932- (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506122002811; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/703b49f9f6ef45e5b994ba6d6da347e9

Optical Mapping in hiPSC-CM and Zebrafish to Resolve Cardiac Arrhythmias

Authors: Bert Vandendriessche, Ewa Sieliwonczyk, Maaike Alaerts, Bart L. Loeys, Dirk Snyders, Dorien Schepers

Source: Hearts, Vol 1, Iss 3, Pp 181-199 (2020)

Subject Terms: optical mapping, hiPSC-CM, zebrafish, arrhythmia, channelopathies, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2673-3846/1/3/18; https://doaj.org/toc/2673-3846

Access URL: https://doaj.org/article/ac8a49636556499f988e55bd186300be

Generation of two induced pluripotent stem cell (iPSC) lines (BBANTWi006-A, BBANTWi007-A) from Brugada syndrome patients carrying an SCN5A mutation

Authors: Eline Simons, Aleksandra Nijak, Bart Loeys, Maaike Alaerts

Source: Stem Cell Research, Vol 60, Iss , Pp 102719- (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S187350612200068X; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/750ceb2bc53a4910b4fc4be6bd8fbd9e

Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes

Authors: Aleksandra Nijak, Eline Simons, Bert Vandendriessche, Dieter Van de Sande, Erik Fransen, Ewa Sieliwończyk, Ilse Van Gucht, Emeline Van Craenenbroeck, Johan Saenen, Hein Heidbuchel, Peter Ponsaerts, Alain J. Labro, Dirk Snyders, Winnok De Vos, Dorien Schepers, Maaike Alaerts, Bart L. Loeys

Source: Biology Open, Vol 11, Iss 2 (2022)

Subject Terms: ipsc-cms, cardiomyocyte differentiation, arrhythmia modelling, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://bio.biologists.org/content/11/2/bio059016; https://doaj.org/toc/2046-6390

Access URL: https://doaj.org/article/d433d6b4ecc94dee8781298307b06178

iPSC-Derived Cardiomyocytes in Inherited Cardiac Arrhythmias: Pathomechanistic Discovery and Drug Development

Authors: Eline Simons, Bart Loeys, Maaike Alaerts

Source: Biomedicines, Vol 11, Iss 2, p 334 (2023)

Subject Terms: iPSC, cardiac arrhythmia, iPSC-derived cardiomyocytes, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/11/2/334; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/841bd9fa392245869d53d77df9458bb0

Two novel presentations of KCNMA1‐related pathology––Expanding the clinical phenotype of a rare channelopathy

Authors: Jotte Rodrigues Bento, Candice Feben, Marlies Kempers, Maartje vanRij, Mallory Woiski, Koenraad Devriendt, Luc De Catte, Marcella Baldewijns, Maaike Alaerts, Josephina Meester, Aline Verstraeten, Willy Hendson, Bart Loeys

Source: Molecular Genetics & Genomic Medicine, Vol 9, Iss 10, Pp n/a-n/a (2021)

Subject Terms: channelopathy, KCNMA1 loss‐of‐function, Liang‐Wang syndrome, thoracic aortic aneurysm, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/2324-9269

Access URL: https://doaj.org/article/0ca074ff445a4ee0bbde97fd27f87418

Impact and effectiveness of 13-valent pneumococcal conjugate vaccine on population incidence of vaccine and non-vaccine serotype invasive pneumococcal disease in Blantyre, Malawi, 2006–18: prospective observational time-series and case-control studies

Authors: Naor Bar-Zeev, PhD, Todd D Swarthout, MSc, Dean B Everett, ProfPhD, Maaike Alaerts, PhD, Jacquline Msefula, BSc, Comfort Brown, Dipl, Sithembile Bilima, BSc, Jane Mallewa, MD, Carina King, PhD, Anne von Gottberg, ProfPhD, Jennifer R Verani, MD, Cynthia G Whitney, MD, Charles Mwansambo, FRCPCH, Stephen B Gordon, ProfPhD, Nigel A Cunliffe, ProfPhD, Neil French, ProfPhD, Robert S Heyderman, ProfPhD

Source: The Lancet Global Health, Vol 9, Iss 7, Pp e989-e998 (2021)

Subject Terms: Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214109X21001650; https://doaj.org/toc/2214-109X

Access URL: https://doaj.org/article/3257b2810c1b45db97f356b85595ed14

Compound Heterozygous SCN5A Mutations in Severe Sodium Channelopathy With Brugada Syndrome: A Case Report

Authors: Aleksandra Nijak, Alain J. Labro, Hans De Wilde, Wendy Dewals, Steve Peigneur, Jan Tytgat, Dirk Snyders, Ewa Sieliwonczyk, Eline Simons, Emeline Van Craenenbroeck, Dorien Schepers, Lut Van Laer, Johan Saenen, Bart Loeys, Maaike Alaerts

Source: Frontiers in Cardiovascular Medicine, Vol 7 (2020)

Subject Terms: Brugada syndrome, cardiac arrhythmia, SCN5A, case report, compound heterozygosity, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcvm.2020.00117/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/2e12587dc2814f6c8a1ad955c9d53689

FLNA mutations in surviving males presenting with connective tissue findings: two new case reports and review of the literature

Authors: Elyssa Cannaerts, Anju Shukla, Mensuda Hasanhodzic, Maaike Alaerts, Dorien Schepers, Lut Van Laer, Katta M. Girisha, Iva Hojsak, Bart Loeys, Aline Verstraeten

Source: BMC Medical Genetics, Vol 19, Iss 1, Pp 1-13 (2018)

Subject Terms: Periventricular nodular heterotopia, Live-born males, Filaminopathy, Connective tissue disease, Internal medicine, RC31-1245, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12881-018-0655-0; https://doaj.org/toc/1471-2350

Access URL: https://doaj.org/article/d0f83f1afa7b4a4bb15e3385ed6429ce

Cardiogeneticsbank@UZA: A Collection of DNA, Tissues, and Cell Lines as a Translational Tool

Authors: Maaike Alaerts, Gerarda van de Beek, Ilse Luyckx, Josephina Meester, Dorien Schepers, Aline Verstraeten, Johan Saenen, Emeline Van Craenenbroeck, Inge Goovaerts, Inez Rodrigus, Steven Laga, Jeroen Hendriks, Sofie Goethals, Annemieke De Wilde, Elke Smits, Philippe Jorens, Manon Huizing, Lut Van Laer, Bart Loeys

Source: Frontiers in Medicine, Vol 6 (2019)

Subject Terms: cardiogenetics, biobank, sudden cardiac arrest, inherited cardiac arrhythmia, aortic aneurysm, cardiomyopathies, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmed.2019.00198/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/6e956abb0cbe4fcea5275b12f1e4bf38

Corrigendum: Candidate Gene Resequencing in a Large Bicuspid Aortic Valve-Associated Thoracic Aortic Aneurysm Cohort: SMAD6 as an Important Contributor

Authors: Elisabeth Gillis, Ajay A. Kumar, Ilse Luyckx, Christoph Preuss, Elyssa Cannaerts, Gerarda van de Beek, Björn Wieschendorf, Maaike Alaerts, Nikhita Bolar, Geert Vandeweyer, Josephina Meester, Florian Wünnemann, Russell A. Gould, Rustam Zhurayev, Dmytro Zerbino, Salah A. Mohamed, Seema Mital, Luc Mertens, Hanna M. Björck, Anders Franco-Cereceda, Andrew S. McCallion, Lut Van Laer, Judith M. A. Verhagen, Ingrid M. B. H. van de Laar, Marja W. Wessels, Emmanuel Messas, Guillaume Goudot, Michaela Nemcikova, Alice Krebsova, Marlies Kempers, Simone Salemink, Toon Duijnhouwer, Xavier Jeunemaitre, Juliette Albuisson, Per Eriksson, Gregor Andelfinger, Harry C. Dietz, Aline Verstraeten, Bart L. Loeys, Mibava Leducq Consortium

Source: Frontiers in Physiology, Vol 8 (2017)

Subject Terms: bicuspid aortic valve, thoracic aortic aneurysm, SMAD6, targeted gene panel, variant burden test, Physiology, QP1-981

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fphys.2017.00730/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/00bba679614b4010927e1186b126fa61

Candidate Gene Resequencing in a Large Bicuspid Aortic Valve-Associated Thoracic Aortic Aneurysm Cohort: SMAD6 as an Important Contributor

Authors: Elisabeth Gillis, Ajay A. Kumar, Ilse Luyckx, Christoph Preuss, Elyssa Cannaerts, Gerarda van de Beek, Björn Wieschendorf, Maaike Alaerts, Nikhita Bolar, Geert Vandeweyer, Josephina Meester, Florian Wünnemann, Russell A. Gould, Rustam Zhurayev, Dmytro Zerbino, Salah A. Mohamed, Seema Mital, Luc Mertens, Hanna M. Björck, Anders Franco-Cereceda, Andrew S. McCallion, Lut Van Laer, Judith M. A. Verhagen, Ingrid M. B. H. van de Laar, Marja W. Wessels, Emmanuel Messas, Guillaume Goudot, Michaela Nemcikova, Alice Krebsova, Marlies Kempers, Simone Salemink, Toon Duijnhouwer, Xavier Jeunemaitre, Juliette Albuisson, Per Eriksson, Gregor Andelfinger, Harry C. Dietz, Aline Verstraeten, Bart L. Loeys, Mibava Leducq Consortium

Source: Frontiers in Physiology, Vol 8 (2017)

Subject Terms: bicuspid aortic valve, thoracic aortic aneurysm, SMAD6, targeted gene panel, variant burden test, Physiology, QP1-981

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fphys.2017.00400/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/eaa6fdcd9b7a4bbd9409b17748a5090d

Human Melioidosis, Malawi, 2011

Authors: Thembi Katangwe, Janet Purcell, Naor Bar-Zeev, Brigitte Denis, Jacqui Montgomery, Maaike Alaerts, Robert Simon Heyderman, David A.B. Dance, Neil Kennedy, Nicholas Feasey, Christopher Alan Moxon

Source: Emerging Infectious Diseases, Vol 19, Iss 6, Pp 981-984 (2013)

Subject Terms: Melioidosis, Burkholderia pseudomallei, Africa, osteomyelitis, pediatrics, infant, Medicine, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://wwwnc.cdc.gov/eid/article/19/6/12-0717_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059

Access URL: https://doaj.org/article/e75fe91c99344c30b3184bb91a1ce2c3

Drug Resistance in Salmonella enterica ser. Typhimurium Bloodstream Infection, Malawi

Authors: Nicholas A. Feasey, Amy K. Cain, Chisomo L. Msefula, Derek Pickard, Maaike Alaerts, Martin Aslett, Dean B. Everett, Theresa J. Allain, Gordon Dougan, Melita A. Gordon, Robert S. Heyderman, Robert A. Kingsley

Source: Emerging Infectious Diseases, Vol 20, Iss 11, Pp 1957-1959 (2014)

Subject Terms: Salmonella, serotype Typhimurium, Salmonella enterica, antimicrobial resistance, HIV, Africa, Medicine, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://wwwnc.cdc.gov/eid/article/20/11/14-1175_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059

Access URL: https://doaj.org/article/5a61cb6148f146e98fca19cb81880b31