Microbial infection instigates tau-related pathology in Alzheimer’s disease via activating neuroimmune cGAS-STING pathway

Authors: Yan, Xiaoxu ^{a, 1}, Wang, Erlin ^{c, 1}, Zhao, Meng ^{a, 1}, Ma, Guanqin ^b, Xu, Xiang-Xiong ^b, Zhao, Jie-Bin ^b, Li, Xiaohong ^b, Zeng, Jianxiong ^{b, c, d, ⁎}, Ma, Xueling ^{a, ⁎}

Source: In Neuroscience 19 April 2025 572:122-133

Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice

Authors: Zeng, Jianxiong, Xie, Xiaochun, Feng, Xiao-Li, Xu, Ling, Han, Jian-Bao, Yu, Dandan, Zou, Qing-Cui, Liu, Qianjin, Li, Xiaohong, Ma, Guanqin, Li, Ming-Hua, Yao, Yong-Gang

Source: In eBioMedicine January 2022 75

Keap1 recognizes EIAV early accessory protein Rev to promote antiviral defense.

Authors: Wang, Yan¹ (AUTHOR), Ma, Guanqin¹ (AUTHOR), Wang, Xue-Feng¹ (AUTHOR), Na, Lei¹ (AUTHOR), Guo, Xing¹ (AUTHOR), Zhang, Jiaqi¹ (AUTHOR), Liu, Cong¹ (AUTHOR), Du, Cheng¹ (AUTHOR), Qi, Ting¹ (AUTHOR), Lin, Yuezhi¹ (AUTHOR) linyuezhi@caas.cn, Wang, Xiaojun¹ (AUTHOR) linyuezhi@caas.cn

Source: PLoS Pathogens. 2/9/2022, Vol. 18 Issue 2, p1-25. 25p.

Subject Terms: *LENTIVIRUS diseases, *VIRAL proteins, *PROTEIN synthesis, *VIRAL replication, *PROTEINS

Differential pathogenic and molecular features in neurological infection of SARS‐CoV‐2 Omicron BA.5.2 and BA.2.75 and Delta.

Authors: Wang, Erlin, Yang, Qiao‐Jiang, Xu, Xiang‐Xiong, Zou, Qing‐Cui, Long, Yanghaopeng, Ma, Guanqin, Deng, Zhong‐Hua, Zhao, Jie‐Bin, Li, Ming‐Hua, Zeng, Jianxiong

Source: Journal of Medical Virology; Jan2024, Vol. 96 Issue 1, p1-15, 15p

Subject Terms: SARS-CoV-2, SARS-CoV-2 Omicron variant, SARS-CoV-2 Delta variant, COVID-19, CORONAVIRUS diseases

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SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy.

Authors: Ma, Guanqin, Zhang, Deng-Feng, Zou, Qing-Cui, Xie, Xiaochun, Xu, Ling, Feng, Xiao-Li, Li, Xiaohong, Han, Jian-Bao, Yu, Dandan, Deng, Zhong-Hua, Qu, Wang, Long, Junyi, Li, Ming-Hua, Yao, Yong-Gang, Zeng, Jianxiong

Source: Cell Discovery; 9/30/2022, Vol. 8 Issue 1, p1-5, 5p

Subject Terms: AMYLOID plaque, AMYLOID beta-protein precursor, SARS-CoV-2, SARS-CoV-2 Omicron variant, COVID-19, PRESENILINS, NEUROPATHY

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