Suppression of microtubule acetylation mediates the anti-leukemic effect of CDK9 inhibition.

Authors: Xie, Xi¹ (AUTHOR), Zhang, Baoyuan¹ (AUTHOR), Li, Donghe¹ (AUTHOR), Gao, Jiaming¹ (AUTHOR), Li, Jiaoyang¹ (AUTHOR), Liu, Chenxuan¹ (AUTHOR), Dan, Yuqing¹ (AUTHOR), Xu, Pengfei¹ (AUTHOR), Yan, Lei¹ (AUTHOR), Huang, Xu¹ (AUTHOR), Zhang, Rui¹ (AUTHOR), Yao, Yunying¹ (AUTHOR), Huang, Wei¹ (AUTHOR), Nie, Jiawei¹ (AUTHOR), Wang, Xinru¹ (AUTHOR), Jiao, Bo¹ (AUTHOR), Ren, Ruibao^1,2 (AUTHOR) rbren@sjtu.edu.cn, Liu, Ping¹ (AUTHOR) liuping@shsmu.edu.cn

Source: Cancer Cell International. 12/5/2024, Vol. 24 Issue 1, p1-13. 13p.

Subject Terms: *TREATMENT effectiveness, *MICROTUBULES, *HEMATOLOGIC malignancies, *ACETYLATION, *ANTINEOPLASTIC agents

Blocking microtubule deacetylation inhibits anaphase chromosome movements in crane-fly spermatocytes.

Authors: Janan, Maral¹ (AUTHOR) mjanan@yorku.ca, MacPherson, Jess¹ (AUTHOR), Forer, Arthur¹ (AUTHOR)

Source: PLoS ONE. 12/2/2024, Vol. 19 Issue 12, p1-16. 16p.

Subject Terms: *CELL motility, *MICROTUBULES, *CELL division, *HISTONE deacetylase, *ANAPHASE, *TUBULINS

Centrosomal Protein 55 Regulates Chromosomal Instability in Cancer Cells by Controlling Microtubule Dynamics.

Authors: Muhs, Stefanie¹ (AUTHOR) s.muhs@uke.de, Paraschiakos, Themistoklis¹ (AUTHOR) themistoklis.paraschiakos@gmail.com, Schäfer, Paula¹ (AUTHOR) p.schaefer@uke.de, Joosse, Simon A.^2,3 (AUTHOR) s.joosse@uke.de, Windhorst, Sabine¹ (AUTHOR) s.windhorst@uke.de

Source: Cells (2073-4409). Aug2024, Vol. 13 Issue 16, p1382. 20p.

Subject Terms: *MICROTUBULES, *CANCER cells, *OVARIAN cancer, *BREAST cancer, *CELL lines

A novel role for microtubule affinity‐regulating kinases in neuropathic pain.

Authors: Shi, Yao‐Qin¹ (AUTHOR), Sun, Zhi‐Hong¹ (AUTHOR), Wang, Zhe‐Zhe¹ (AUTHOR), Su, Chun‐Yu¹ (AUTHOR), Zhang, Wei¹ (AUTHOR), Yu, Lin‐Yao¹ (AUTHOR), Xu, Yang¹ (AUTHOR), Gao, Yong‐Lin² (AUTHOR), Wang, Hong‐Bo¹ (AUTHOR), Tian, Jing‐Wei¹ (AUTHOR) gylbill@163.com, Li, Chun‐Mei¹ (AUTHOR) lichunmei@luye.com

Source: British Journal of Pharmacology. Jul2024, Vol. 181 Issue 13, p2012-2032. 21p.

Subject Terms: *NEURALGIA, *MICROTUBULES, *KINASES, *MOTOR ability, *SPINAL nerves, *TUBULINS, *GABA receptors, *MOTOR learning

BUB1 Inhibition Sensitizes TNBC Cell Lines to Chemotherapy and Radiotherapy.

Authors: Sriramulu, Sushmitha¹ (AUTHOR), Thoidingjam, Shivani¹ (AUTHOR), Siddiqui, Farzan^1,2,3 (AUTHOR), Brown, Stephen L.^1,2,3 (AUTHOR), Movsas, Benjamin^1,2,3 (AUTHOR), Walker, Eleanor^1,2,3 (AUTHOR), Nyati, Shyam^1,2,3 (AUTHOR) snyati1@hfhs.org

Source: Biomolecules (2218-273X). Jun2024, Vol. 14 Issue 6, p625. 14p.

Subject Terms: *MICROTUBULES, *TRIPLE-negative breast cancer, *CELL lines, *CANCER chemotherapy, *BREAST cancer, *DRUG target, *BREAST

A novel conductive microtubule hydrogel for electrical stimulation of chronic wounds based on biological electrical wires.

Authors: Fan, Weijing¹ (AUTHOR), Yang, Xiao¹ (AUTHOR) yxyx-2010@163.com, Hu, Xiaoming¹ (AUTHOR), Huang, Renyan¹ (AUTHOR), Shi, Hongshuo¹ (AUTHOR) jf17510413109@163.com, Liu, Guobin¹ (AUTHOR) 15800885533@163.com

Source: Journal of Nanobiotechnology. 5/16/2024, Vol. 22 Issue 1, p1-19. 19p.

Subject Terms: *WOUND healing, *MICROTUBULES, *CHRONIC wounds & injuries, *ELECTRIC stimulation, *NERVOUS system regeneration, *HYDROGELS, *MORPHOLOGY, *BIOLOGICAL networks

FgPfn participates in vegetative growth, sexual reproduction, pathogenicity, and fungicides sensitivity via affecting both microtubules and actin in the filamentous fungus Fusarium graminearum.

Authors: Yuan, Zhili¹ (AUTHOR), Li, Pengfei¹ (AUTHOR), Yang, Xin¹ (AUTHOR), Cai, Xiaowei¹ (AUTHOR), Wu, Luoyu¹ (AUTHOR), Zhao, Feifei¹ (AUTHOR), Wen, Weidong¹ (AUTHOR), Zhou, Mingguo¹ (AUTHOR), Hou, Yiping¹ (AUTHOR) houyiping@njau.edu.cn

Source: PLoS Pathogens. 5/3/2024, Vol. 20 Issue 5, p1-28. 28p.

Subject Terms: *TUBULINS, *MICROTUBULES, *FUNGICIDES, *ACTIN, *MICROFILAMENT proteins, *FILAMENTOUS fungi, *CYTOSKELETON

Cooperation of Various Cytoskeletal Components Orchestrates Intercellular Spread of Mitochondria between B-Lymphoma Cells through Tunnelling Nanotubes.

Authors: Halász, Henriett¹ (AUTHOR), Tárnai, Viktória¹ (AUTHOR), Matkó, János² (AUTHOR), Nyitrai, Miklós¹ (AUTHOR), Szabó-Meleg, Edina¹ (AUTHOR) edina.meleg@aok.pte.hu

Source: Cells (2073-4409). Apr2024, Vol. 13 Issue 7, p607. 23p.

Subject Terms: *MOLECULAR motor proteins, *MICROTUBULES, *BIOLOGICAL transport, *CYTOSKELETAL proteins, *MITOCHONDRIA, *NANOTUBES, *CELL communication

Organization of two kinesins in a two-dimensional microtubule network.

Authors: Bergues, Jesús M.¹ (AUTHOR), Falo, Fernando^2,3 (AUTHOR) fff@unizar.es

Source: PLoS ONE. 3/13/2024, Vol. 19 Issue 3, p1-17. 17p.

Subject Terms: *MICROTUBULES, *ACTIVE biological transport, *MOLECULAR motor proteins, *COLLECTIVE behavior, *COLLECTIVE action

Neuronal ageing is promoted by the decay of the microtubule cytoskeleton.

Authors: Okenve-Ramos, Pilar¹ (AUTHOR), Gosling, Rory¹ (AUTHOR), Chojnowska-Monga, Monika¹ (AUTHOR), Gupta, Kriti¹ (AUTHOR), Shields, Samuel¹ (AUTHOR), Alhadyian, Haifa¹ (AUTHOR), Collie, Ceryce¹ (AUTHOR), Gregory, Emilia¹ (AUTHOR), Sanchez-Soriano, Natalia¹ (AUTHOR) natalia1@liverpool.ac.uk

Source: PLoS Biology. 3/13/2024, Vol. 22 Issue 3, p1-33. 33p.

Subject Terms: *CYTOSKELETON, *MICROTUBULES, *ALZHEIMER'S disease, *PARKINSON'S disease, *MATERNAL age, *NEURODEGENERATION

Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice.

Authors: Simerly, Calvin¹ (AUTHOR), Robertson, Emily¹ (AUTHOR), Harrison, Caleb¹ (AUTHOR), Ward, Sydney¹ (AUTHOR), George, Charlize¹ (AUTHOR), Deleon, Jasmine¹ (AUTHOR), Hartnett, Carrie¹ (AUTHOR), Schatten, Gerald¹ (AUTHOR) gschatten@pdc.magee.edu

Source: Scientific Reports. 2/27/2024, Vol. 14 Issue 1, p1-19. 19p.

Subject Terms: *SPINDLE apparatus, *MICROTUBULES, *COLON tumors, *AURORA kinases, *KINETOCHORE, *CYTOSKELETON

PAK1-Dependent Regulation of Microtubule Organization and Spindle Migration Is Essential for the Metaphase I–Metaphase II Transition in Porcine Oocytes.

Authors: Peng, Lei¹ (AUTHOR) pengleinjau@163.com, He, Yijing¹ (AUTHOR) 2022207021@stu.njau.edu.cn, Wang, Weihan¹ (AUTHOR) wwang@njau.edu.cn, Dai, Jianjun² (AUTHOR) blackman0520@126.com, Li, Qiao¹ (AUTHOR) liqiao@njau.edu.cn, Ju, Shiqiang¹ (AUTHOR) liqiao@njau.edu.cn

Source: Biomolecules (2218-273X). Feb2024, Vol. 14 Issue 2, p237. 13p.

Subject Terms: *OVUM, *MICROTUBULES, *SLEEP spindles, *CELL migration, *CELL membranes, *CELL proliferation

siRNA-Mediated BmAurora B Depletion Impedes the Formation of Holocentric Square Spindles in Silkworm Metaphase BmN4 Cells.

Authors: Zhang, Bing¹ (AUTHOR) 13261537726@163.com, Ayra-Pardo, Camilo² (AUTHOR) cayrapardo73@163.com, Liu, Xiaoning¹ (AUTHOR) meiting2839@163.com, Song, Meiting¹ (AUTHOR) lidannytc@126.com, Li, Dandan¹ (AUTHOR), Kan, Yunchao^1,3 (AUTHOR) 15236029833@163.com

Source: Insects (2075-4450). Jan2024, Vol. 15 Issue 1, p72. 12p.

Subject Terms: *TUBULINS, *MICROTUBULES, *SILKWORMS, *CHROMOSOME segregation, *CELL anatomy, *SPINDLE apparatus, *GAMETOGENESIS, *NUCLEAR membranes

Centromeric chromatin clearings demarcate the site of kinetochore formation.

Authors: Kixmoeller, Kathryn^1,2,3,4,5, Tarasovetc, Ekaterina V.^1,3,4,5, Mer, Elie^1,2,3,4,5, Chang, Yi-Wei^1,2,3, ywc@pennmedicine.upenn.edu, Black, Ben E.^1,2,3,4,5, blackbe@pennmedicine.upenn.edu

Source: Cell; Mar2025, Vol. 188 Issue 5, p1280-12129, 10850p

Mechanistic basis of temperature adaptation in microtubule dynamics across frog species.

Authors: Troman, Luca¹ (AUTHOR), de Gaulejac, Ella^1,2 (AUTHOR), Biswas, Abin^3,4,5 (AUTHOR), Stiens, Jennifer¹ (AUTHOR), Kuropka, Benno⁶ (AUTHOR), Moores, Carolyn A.¹ (AUTHOR) c.moores@bbk.ac.uk, Reber, Simone^1,3,4,7 (AUTHOR) reber@mpiib-berlin.mpg.de

Source: Current Biology. Feb2025, Vol. 35 Issue 3, p612-662. 51p.

Subject Terms: *BODY temperature regulation, *MICROTUBULES, *CYTOSKELETON, *ECOLOGICAL niche, *ACTIVATION energy, *TUBULINS

Structural response of microtubule and actin cytoskeletons to direct intracellular load.

Authors: Ryota Orii¹ n235303f@yokohama-cu.ac.jp, Hirokazu Tanimoto¹ tanimoto@yokohama-cu.ac.jp

Source: Journal of Cell Biology. 2/3/2025, Vol. 224 Issue 2, p1-12. 17p.

Subject Terms: *MICROTUBULES, *ACTIN, *STRUCTURAL mechanics, *EUKARYOTIC cells, *RHEOLOGY, *RHEOLOGY (Biology), *MAGNETIC tweezers

Optimal strategies for correcting merotelic chromosome attachments in anaphase.

Authors: Kliuchnikov, Evgenii¹, Marx, Kenneth A.¹, Barsegov, Valeri¹, Valeri_Barsegov@uml.edu, Mogilner, Alex², mogilner@cims.nyu.edu

Source: Proceedings of the National Academy of Sciences of the United States of America; 2/4/2025, Vol. 122 Issue 5, p1-19, 28p

Cryo-ET suggests tubulin chaperones form a subset of microtubule lumenal particles with a role in maintaining neuronal microtubules.

Authors: Chakraborty, Saikat¹, chakraborty@biochem.mpg.de, Martinez-Sanchez, Antonio^1,2, Beck, Florian^1,3, Toro-Nahuelpan, Mauricio⁴, In-Young Hwang⁵, Kyung-Min Noh⁵, Baumeister, Wolfgang¹, baumeist@biochem.mpg.de, Mahamid, Julia^4,6, julia.mahamid@embl.de

Source: Proceedings of the National Academy of Sciences of the United States of America; 2/4/2025, Vol. 122 Issue 5, p1-37, 48p

Tubulin detyrosination shapes Leishmania cytoskeletal architecture and virulence.

Authors: Milagros Corrales, Rosa¹, Vincent, Jeremy¹, Crobu, Lucien¹, Neish, Rachel², Nepal, Binita^3,4, Espeut, Julien⁵, Pasquier, Grégoire¹, Gillard, Ghislain⁵, Cazevieille, Chantal⁶, Mottram, Jeremy C.², Wetzel, Dawn M.^3,4, Sterkers, Yvon¹, Rogowski, Krzysztof⁵, Lévêque, Maude F.¹ maude.leveque@umontpellier.fr

Source: Proceedings of the National Academy of Sciences of the United States of America. 1/21/2025, Vol. 122 Issue 3, p1-12. 34p.

Subject Terms: *TUBULINS, *MICROTUBULES, *CYTOSKELETON, *LEISHMANIASIS, *FLAGELLA (Microbiology)

Microtubule association of TRIM3 revealed by differential extraction proteomics.

Authors: Glover, Hannah L.¹ clague@liverpool.ac.uk, Mendes, Marta², Gomes-Neto, Joana¹, Rusilowicz-Jones, Emma V.¹, Rigden, Daniel J.¹, Dittmar, Gunnar^2,3, Urbé, Sylvie¹, Clague, Michael J.¹ urbe@liverpool.ac.uk

Source: Journal of Cell Science. Jan2025, Vol. 138 Issue 2, p1-13. 13p.

Subject Terms: *UBIQUITIN ligases, *MICROTUBULES, *PACLITAXEL, *MASS spectrometry, *PROTEOMICS