Long‐Term Minocycline Treatment Exhibits Enhanced Therapeutic Effects on Ischemic Stroke by Suppressing Inflammatory Phenotype of Microglia Through the EMB/MCT4/STING Pathway.

Authors: Cheng, Bo^1,2 (AUTHOR), Liu, Shangqi^3,4 (AUTHOR), Gao, Ling⁵ (AUTHOR), Xin, Ning³ (AUTHOR), Shang, Zhenying³ (AUTHOR), Zhu, Ziwen¹ (AUTHOR), Yang, Yang⁵ (AUTHOR), Ma, Rui² (AUTHOR), Xu, Zixiang⁶ (AUTHOR), Liu, Jing⁷ (AUTHOR) liujing860131@163.com, Wang, Dunjing³ (AUTHOR) wangdunjing@163.com

Source: CNS Neuroscience & Therapeutics. Mar2025, Vol. 31 Issue 3, p1-14. 14p.

Subject Terms: *ISCHEMIC stroke, *MICROGLIA, *MINOCYCLINE, *CELL communication, *ANTI-inflammatory agents, *GLYCOLYSIS, *NEUROINFLAMMATION, *TREATMENT effectiveness

CCL17/CCR4 Axis Promotes Hematoma Clearance via ERK/AP1/SRA‐Mediated Microglial Polarization After Intracerebral Hemorrhage.

Authors: Chen, Xianglan¹ (AUTHOR), Wang, Yao¹ (AUTHOR), Jin, Junjie¹ (AUTHOR), Jin, Peng² (AUTHOR) doctor_jpeng@163.com, Deng, Shuixiang¹ (AUTHOR) shuixiang2@126.com

Source: CNS Neuroscience & Therapeutics. Feb2025, Vol. 31 Issue 2, p1-14. 14p.

Subject Terms: *MICROGLIA, *HEMATOMA, *DRUG target, *CEREBRAL hemorrhage, *CHEMOKINE receptors, *NEUROINFLAMMATION, *EXTRACELLULAR signal-regulated kinases

H4K12 Lactylation Activated‐Spp1 in Reprogrammed Microglia Improves Functional Recovery After Spinal Cord Injury.

Authors: Wang, Xiaokun¹ (AUTHOR), Zhou, Geliang² (AUTHOR), Xiong, Junjun¹ (AUTHOR), Ye, Wu¹ (AUTHOR), Gao, Yu¹ (AUTHOR), Wang, Haofan¹ (AUTHOR), Pan, Dishui¹ (AUTHOR), Luo, Yongjun³ (AUTHOR) lyjnjmu@163.com, Zhou, Zheng⁴ (AUTHOR) zhouzheng@njmu.edu.cn

Source: CNS Neuroscience & Therapeutics. Feb2025, Vol. 31 Issue 2, p1-15. 15p.

Subject Terms: *SPINAL cord injuries, *MICROGLIA, *REHABILITATION, *HISTONES, *NEURONAL differentiation, *MITOCHONDRIA, *DRUG target, *CELLULAR signal transduction

Examining the Impact of Microglia on Ischemic Stroke With an Emphasis on the Metabolism of Immune Cells.

Authors: Lv, Jing^1,2 (AUTHOR), Jiao, Yang^3,4 (AUTHOR), Zhao, Xinya^1,2 (AUTHOR), Kong, Xin^1,4 (AUTHOR), Chen, Yanwei¹ (AUTHOR), Li, Lu¹ (AUTHOR), Chen, Xuyang¹ (AUTHOR), Tao, Xufeng¹ (AUTHOR) taoxufeng.2008@163.com, Dong, Deshi¹ (AUTHOR) dongdeshi@dmu.edu.cn

Source: CNS Neuroscience & Therapeutics. Feb2025, Vol. 31 Issue 2, p1-11. 11p.

Subject Terms: *ISCHEMIC stroke, *MICROGLIA, *CEREBRAL ischemia, *ENERGY metabolism, *IMMUNOLOGY, *INFLAMMATION, *NEUROLOGICAL disorders, *NEUROINFLAMMATION

Single‐Cell Insights Into Cellular Response in Abdominal Aortic Occlusion‐Induced Hippocampal Injury.

Authors: Ren, Changhong¹ (AUTHOR), Kui, Ling² (AUTHOR), Xu, Jun¹ (AUTHOR), Tong, Fang¹ (AUTHOR), Wang, Xiaojie³ (AUTHOR), Ma, Jianping³ (AUTHOR), Tian, Xiaomei⁴ (AUTHOR), Wang, Guoyun² (AUTHOR), Liu, Feng‐Yong⁴ (AUTHOR), Li, Sijie¹ (AUTHOR) lisijie@xwh.ccmu.edu.cn, Ji, Xunming¹ (AUTHOR) jixm@ccmu.edu.cn

Source: CNS Neuroscience & Therapeutics. Jan2025, Vol. 31 Issue 1, p1-20. 20p.

Subject Terms: *ASTROCYTES, *MICROGLIA, *NEUROGLIA, *REPERFUSION injury, *MYOCARDIAL reperfusion, *HIPPOCAMPUS diseases, *RNA sequencing, *CELL separation

Lipid Droplets Accumulation in the Brain of HIV Transgenic Rat: Implication in the Accelerated Aging of HIV Infected Individuals.

Authors: Ming-Lei Guo^1,2 GuoM@evms.edu, Yan Cheng¹, Pineda, Damian Martinez¹, Dempsey, Rachael E.¹, Lifang Yang³

Source: Aging & Disease. Jan2025, Vol. 16 Issue 1, p454-468. 15p.

Subject Terms: *MICROGLIA, *HIV infections, *AGING

IL‐17A Mediates Depressive‐Like Symptoms by Inducing Microglia Activation in Psoriasiform Dermatitis Mice.

Authors: Dou, Yue¹ (AUTHOR), You, Jingjing^1,2 (AUTHOR), Wang, Jing¹ (AUTHOR), Li, Xinxin¹ (AUTHOR), Lin, Yawen¹ (AUTHOR), Liu, Bin^1,2 (AUTHOR) liubin3714@136.com, Ma, Lei¹ (AUTHOR) doctor_malei@hotmail.com

Source: Immunity, Inflammation & Disease. Dec2024, Vol. 12 Issue 12, p1-13. 13p.

Subject Terms: *GENE expression, *MICROGLIA, *NEUROINFLAMMATION, *HIPPOCAMPUS (Brain), *NEURONS

Subretinal microglia support donor photoreceptor survival in rd1 mice.

Authors: Ren, Qinjia¹ (AUTHOR), Lu, Fang¹ (AUTHOR), Hao, Ruwa¹ (AUTHOR), Chen, Yingying¹ (AUTHOR), Liang, Chen¹ (AUTHOR) liangchen@scu.edu.cn

Source: Stem Cell Research & Therapy. 11/19/2024, Vol. 15 Issue 1, p1-10. 10p.

Subject Terms: *MICROGLIA, *RETINAL degeneration, *CONFOCAL microscopy, *PHOTORECEPTORS, *GENE expression

Promotion of 14-3-3ζ/Heme Oxygenase-1 Axis on Endotoxin-Induced Uveitis and Microglia Ferroptosis in Mice.

Authors: Li, Mohan¹ (AUTHOR), Gao, Sijia¹ (AUTHOR), Wen, Yu¹ (AUTHOR), Yong, Liang² (AUTHOR), Tao, Liming¹ (AUTHOR) taoliming@ahmu.edu.cn

Source: Ocular Immunology & Inflammation. Nov2024, Vol. 32 Issue 9, p2114-2120. 7p.

Subject Terms: *UVEITIS, *MICROGLIA, *LABORATORY mice, *HEME, *CELL lines, *OCULAR injuries

Microglia cannibalism during neurodevelopment results in necroptotic cell death.

Authors: Bennett, F. Chris^1,2 (AUTHOR) frederick.bennett@pennmedicine.upenn.edu, Bennett, Mariko L.^2,3 (AUTHOR)

Source: PLoS Biology. 10/31/2024, Vol. 22 Issue 10, p1-4. 4p.

Subject Terms: *CELL death, *MICROGLIA, *NEURAL circuitry, *NEURAL development, *NEURONS

Microglia cannibalism and efferocytosis leads to shorter lifespans of developmental microglia.

Authors: Gordon, Hannah^1,2 (AUTHOR), Schafer, Zachary T.¹ (AUTHOR), Smith, Cody J.^1,2 (AUTHOR) csmith67@nd.edu

Source: PLoS Biology. 10/30/2024, Vol. 22 Issue 10, p1-20. 20p.

Subject Terms: *NEURAL development, *MICROGLIA, *CANNIBALISM, *BRACHYDANIO, *OVERPRODUCTION

Ganglion cell-derived LysoPS induces retinal neovascularisation by activating the microglial GPR34-PI3K-AKT-NINJ1 axis.

Authors: Chen, Lushu^1,2 (AUTHOR), Zhang, HuiYing^1,2 (AUTHOR), Zhang, Ying^1,2 (AUTHOR), Li, Xiumiao¹ (AUTHOR), Wang, MeiHuan¹ (AUTHOR), Shen, Yaming¹ (AUTHOR), Cao, Yuan² (AUTHOR), Xu, Yong^1,2 (AUTHOR) yxu4696@njmu.edu.cn, Yao, Jin^1,2 (AUTHOR) dryaojin@126.com

Source: Journal of Neuroinflammation. 10/28/2024, Vol. 21 Issue 1, p1-16. 16p.

Subject Terms: *VASCULAR endothelial cells, *MICROGLIA, *INFLAMMATION, *GANGLIA, *INTERLEUKIN-6

A Morphological Study of HLA-DR-Immunopositive Cells in Multiple Sclerosis Lesions and Their Implications for Pathogenesis.

Authors: Alturkustani, Murad^1,2 (AUTHOR) alturkustani.murad@gmail.com, Ang, Lee-Cyn^2,3 (AUTHOR)

Source: Diagnostics (2075-4418). Oct2024, Vol. 14 Issue 19, p2240. 13p.

Subject Terms: *WHITE matter (Nerve tissue), *MICROGLIA, *MACROPHAGES, *MULTIPLE sclerosis, *AGE groups

Microglial process convergence onto injured axonal swellings, a human postmortem brain tissue study.

Authors: Logan-Wesley, Amanda L.¹, Gorse, Karen M.¹, Lafrenaye, Audrey D.¹ Audrey.Lafrenaye@vcuhealth.org

Source: Scientific Reports. 9/12/2024, Vol. 14 Issue 1, p1-11. 11p.

Subject Terms: *MICROGLIA, *BRAIN injuries, *EDEMA, *TISSUES

Human brain organoids containing microglia that have arisen innately adapt to a β-amyloid challenge better than those in which microglia are integrated by co-culture.

Authors: Wenzel, Tyler J.¹ (AUTHOR) tyler.wenzel@usask.ca, Desjarlais, Joseph D.¹ (AUTHOR), Mousseau, Darrell D.¹ (AUTHOR)

Source: Stem Cell Research & Therapy. 8/13/2024, Vol. 15 Issue 1, p1-15. 15p.

Subject Terms: *ALZHEIMER'S disease, *MICROGLIA, *TWO-way analysis of variance, *PEPTIDES, *AGE of onset

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