MANF overexpression ameliorates oxidative stress-induced apoptosis of human nucleus pulposus cells by facilitating mitophagy through promoting MFN2 expression

Authors: Liang Ma, Xiangyu Meng, Tuerhongjiang Abudurexiti, Yuntao Liu, Jiang Gao, Weibin Sheng

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-11 (2025)

Subject Terms: Intervertebral disc degeneration, Mitophagy, MANF, MFN2, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/17503faea07446ce90e2d4775179a636

Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer’s disease

Authors: Yiran Zhang, Xiusheng Chen, Laiqiang Chen, Mingting Shao, Wenzhen Zhu, Tingting Xing, Tingting Guo, Qingqing Jia, Huiming Yang, Peng Yin, Xiao-Xin Yan, Jiandong Yu, Shihua Li, Xiao-Jiang Li, Su Yang

Source: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-22 (2024)

Subject Terms: Alzheimer’s disease, MANF, Synapse, ER stress, ELAVL2, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/20c6378e6c59460e8cba23c7081061d4

Key subdomains of mesencephalic astrocyte-derived neurotrophic factor attenuate myocardial ischemia/reperfusion injury by JAK1/STAT1/NF-κB signaling pathway

Authors: Haibin Dong, Wenjuan Jia, Chunxiao Wang, Da Teng, Bowen Xu, Xiaoning Ding, Jun Yang, Lin Zhong, Lei Gong

Source: Molecular Medicine, Vol 30, Iss 1, Pp 1-17 (2024)

Subject Terms: I/R, MANF, Apoptosis, ER stress, JAK1/STAT1/NF-κB pathway, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/5395fee3b91e4b62a385e3bbcb75be52

Oral colon-targeted delivery of recombinant human MANF for alleviation of ulcerative colitis

Authors: Jie Zhou, Tian-Le Li, Bo Wei, Yue-Feng Ruan, Ye-Qin Wang, Jiao-Yan Liu, Meng-Meng Song, Yu-Xian Shen

Source: International Journal of Pharmaceutics: X, Vol 9, Iss , Pp 100320- (2025)

Subject Terms: MANF, Oral delivery, Colon targeted, Hydrogel, Ulcerative colitis, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590156725000052; https://doaj.org/toc/2590-1567

Access URL: https://doaj.org/article/906d8d8793a84813bc974be33fd3e3e2

MANF inhibits NLRP3 inflammasome activation by competitively binding to DDX3X in paraquat-stimulated alveolar macrophages

Authors: Yi Pu, Siying Han, Jie Chen, Zhenning Liu

Source: Ecotoxicology and Environmental Safety, Vol 287, Iss , Pp 117331- (2024)

Subject Terms: Paraquat, Acute lung injury, MANF, DDX3X, NLRP3 inflammasome, Macrophage, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0147651324014076; https://doaj.org/toc/0147-6513

Access URL: https://doaj.org/article/445b156016f942d5af7e2b5bf7b67b23

Sex-specific effects of alcohol on neurobehavioral performance and endoplasmic reticulum stress: an analysis using neuron-specific MANF deficient mice

Authors: Wen Wen, Hui Li, Marisol Lauffer, Di Hu, Zuohui Zhang, Hong Lin, Yongchao Wang, Mariah Leidinger, Jia Luo

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: excessive alcohol exposure, MANF, neurobehavioral deficits, ER stress, neuroinflammation, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1407576/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/946dcdc98bf44a4a80d8debac3b95baa

Serum levels of interleukin-33 and mesencephalic astrocyte derived neurotrophic factors in patients with major depressive disorder: a cross-sectional comparative design

Authors: Zabun Nahar, Delruba Tabassum Nowshin, A. S. M. Roknuzzaman, Md. Sohan, Salsabil Islam, M. M. A. Shalahuddin Qusar, Md. Rabiul Islam

Source: BMC Psychiatry, Vol 24, Iss 1, Pp 1-8 (2024)

Subject Terms: Major depressive disorder, Interleukin-33, IL-33, Mesencephalic astrocyte derived neurotrophic factor, MANF, ELISA, Psychiatry, RC435-571

File Description: electronic resource

Relation: https://doaj.org/toc/1471-244X

Access URL: https://doaj.org/article/f43bb6b2c2294e12ace59b9b49a9d744

Mesencephalic Astrocyte-derived Neurotrophic Factor Supports Hepatitis B Virus-induced ImmunotoleranceSummary

Authors: Huiyuan Xie, Haiyan Deng, Xiaoping Yang, Xianxian Gao, Shanru Yang, Weiyi Chen, Yixuan Wang, Naibin Yang, Liang Yong, Xin Hou

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 3, Pp 101360- (2024)

Subject Terms: HBV, MANF, MDSC, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X24001140; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/c22f1c30883a4761b15e51701a3fa5e8

MANF inhibits Sjögren's syndrome salivary gland epithelial cell apoptosis and antigen expression of Ro52/SSA through endoplasmic reticulum stress/autophagy pathway

Authors: Cheng, Danqian ^a, Zhou, Tongtong ^a, Liu, Hui ^a, Li, Lijun ^a, Xuan, Yuhao ^a, Huang, Lijun ^a, Liu, Yuqi ^a, Zhang, Xiao ^a, Wei, Wei ^{a, b, ⁎}, Wu, Huaxun ^{a, b, ⁎}

Source: In International Immunopharmacology September 2023 122

CDNF and MANF in the brain dopamine system and their potential as treatment for Parkinson’s disease

Authors: Emmi Pakarinen, Päivi Lindholm

Source: Frontiers in Psychiatry, Vol 14 (2023)

Subject Terms: CDNF, MANF, dopamine, Parkinson’s disease, unfolded protein response, Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1188697/full; https://doaj.org/toc/1664-0640

Access URL: https://doaj.org/article/ab1e912e62f74c58aa680c30a2f99210

Identification of ER/SR resident proteins as biomarkers for ER/SR calcium depletion in skeletal muscle cells

Authors: Lacey K. Greer, Katherine G. Meilleur, Brandon K. Harvey, Emily S. Wires

Source: Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-11 (2022)

Subject Terms: Exodosis, Ryanodine receptor isoform-1, Myopathy, Skeletal muscle, Bromocriptine, MANF, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/fd93747235684bd5a467c03348f87f42

Mesencephalic astrocyte-derived neurotrophic factor (MANF) prevents the neuroinflammation induced dopaminergic neurodegeneration

Authors: Jing-Xing Zhang, Kai-Ge Zhou, Yan-Xin Yin, Ling-Jing Jin, Wei-Fang Tong, Jia Guo, Li-Hua Yu, Xian-Cheng Ye, Ming Jiang

Source: Experimental Gerontology, Vol 171, Iss , Pp 112037- (2023)

Subject Terms: Parkinson's disease (PD), Mesencephalic astrocyte-derived neurotrophic factor (MANF), Dopaminergic neurodegeneration, Neuroinflammation, Nrf-2, Microglia activation, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0531556522003461; https://doaj.org/toc/1873-6815

Access URL: https://doaj.org/article/bfbe207de8294bfe9151f9bdfae69d72

DLC1 inhibits colon adenocarcinoma cell migration by promoting secretion of the neurotrophic factor MANF

Authors: Yi-Min Chu, Ying Xu, Xiu-Qun Zou, Feng-Li Zhou, Yu-Liang Deng, Yu-Tong Han, Ji Li, Da-Ming Yang, Hai-Xia Peng

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: colorectal cancer (CRC), deleted in liver cancer-1 (DLC1), conditioned medium (CM), mesencephalic astrocyte-derived neurotrophic factor (MANF), migration, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.900166/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/0cb8e327faa244b88557493567627791

Novel Flux Linkage Estimation Algorithm for a Variable Flux PMSM

Authors: Aljehaimi, A.M., Pillay, P.

Source: IEEE Transactions on Industry Applications IEEE Trans. on Ind. Applicat. Industry Applications, IEEE Transactions on. 54(3):2319-2335 Jun, 2018

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF): An Emerging Therapeutic Target for Neurodegenerative Disorders

Authors: Bhadrapriya Sivakumar, Anand Krishnan

Source: Cells, Vol 12, Iss 7, p 1032 (2023)

Subject Terms: MANF, ER stress, UPR, neuroprotection, nerve regeneration, apoptosis, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/7/1032; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/0882dd853f014554ba36fc9cb335f332

Gene Delivery of Manf to Beta-Cells of the Pancreatic Islets Protects NOD Mice from Type 1 Diabetes Development

Authors: Kailash Singh, Orian Bricard, Jeason Haughton, Mikaela Björkqvist, Moa Thorstensson, Zhengkang Luo, Loriana Mascali, Emanuela Pasciuto, Chantal Mathieu, James Dooley, Adrian Liston

Source: Biomolecules, Vol 12, Iss 10, p 1493 (2022)

Subject Terms: type 1 diabetes, AAV, Manf, gene delivery, NOD mice, beta-cells, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/12/10/1493; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/d7b0e48976b34253a68535f580cbf024

MANF Is Neuroprotective in Early Stages of EAE, and Elevated in Spinal White Matter by Treatment With Dexamethasone

Authors: Jinhan Nam, Tapani K. Koppinen, Merja H. Voutilainen

Source: Frontiers in Cellular Neuroscience, Vol 15 (2021)

Subject Terms: MS, EAE, MANF, dexamethasone, neuroinflammation, UPR, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fncel.2021.640084/full; https://doaj.org/toc/1662-5102

Access URL: https://doaj.org/article/2f346f82558d4a35bdb2ce12542147d3

Increased MANF Expression in the Inferior Temporal Gyrus in Patients With Alzheimer Disease

Authors: Xue-Chun Liu, Xiu-Hong Qi, Hui Fang, Ke-Qing Zhou, Qing-Song Wang, Gui-Hai Chen

Source: Frontiers in Aging Neuroscience, Vol 13 (2021)

Subject Terms: Alzheimer disease, cerebral cortex, endoplasmic reticulum stress, MANF, hyperphosphorylated tau, senile plaque, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnagi.2021.639318/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/df8dd473d6b9474db5f60650f74bf0e3

MANF Produced by MRL Mouse-Derived Mesenchymal Stem Cells Is Pro-regenerative and Protects From Osteoarthritis

Authors: Gautier Tejedor, Patricia Luz-Crawford, Audrey Barthelaix, Karine Toupet, Sébastien Roudières, François Autelitano, Christian Jorgensen, Farida Djouad

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: MRL mouse, regeneration, mesenchymal stem cells, MANF, chondroprotection, osteoarthritis, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.579951/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/70ea9f6fd5974dcf817aa954be4b1a66

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Regulates Neurite Outgrowth Through the Activation of Akt/mTOR and Erk/mTOR Signaling Pathways

Authors: Wen Wen, Yongchao Wang, Hui Li, Hong Xu, Mei Xu, Jacqueline A. Frank, Murong Ma, Jia Luo

Source: Frontiers in Molecular Neuroscience, Vol 13 (2020)

Subject Terms: MANF, neurotrophic factor, neurite outgrowth, neuronal differentiation, Erk/mTOR, Akt/mTOR, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnmol.2020.560020/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/d530da340c8242349b5276cfc86cd628