Arachis hypogaea monoacylglycerol lipase AhMAGL3b participates in lipid metabolism

Authors: Yihua Zhan, Jing Wang, Xuan Zhao, Zhifu Zheng, Yi Gan

Source: BMC Plant Biology, Vol 24, Iss 1, Pp 1-11 (2024)

Subject Terms: Arachis hypogaea, MAGL, TAG metabolism, Germination, ABA, Botany, QK1-989

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2229

Access URL: https://doaj.org/article/5054f2f584fa4323946a460cf30f43da

Migraine Neuroscience

Contributors: Vécsei, László, Tuka, Bernadett, Tanaka, Masaru

Subject Terms: fremanezumab, monoclonal antibody, calcitonin gene-related peptide, glycerol trinitrate, CGRP release, meningeal blood flow, rat, migraine pain, headache, stress, biomarker, RANTES, neuroendocrine challenge, cytokine, KATP channels, provoked migraine, SUR, Kir6.x, levcromakalim, glibenclamide, human migraine model, in vivo models, migraine, inflammation, CGRP, CFA, inflammatory soup, migraine pathophysiology, nausea, osmophobia, phonophobia, vertigo, allodynia, olcegepant, chronic migraine, Src family kinases, interleukin-1β, C-C motif ligand 2, C-X-C motif ligand 1, protein kinase A, trigeminal ganglion, primary headaches, tryptophan, serotonin pathway, kynurenic pathway, serotonin, melatonin, kynurenic acid, PACAP, real-world, erenumab, galcanezumab, eptinezumab, pharmacoepidemiology, effectiveness, tolerability, safety, treatment pause, switching, migraine disorders, headache disorders, nociceptive pain, analgesics, pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal peptide, adrenomedullin, neuropeptides, drug development, CGRP concentration, endocannabinoids, FAAH, MAGL, pain, Medicine and Nursing, Neurosciences

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/152658
https://mdpi.com/books/pdfview/book/9953

Impacts of maternal separation stress on ethanol intake and endocannabinoid system in adolescent mice

Authors: Favoretto, C.A. ^{a, b, ⁎}, Bertagna, N.B. ^a, Anjos-Santos, A. ^a, Loss, C.M. ^{a, c, d, ⁎}, Rodolpho, B.T. ^a, Righi, T. ^a, Bezerra, F.R. ^{a, e}, Bianchi, P.C. ^a, Cruz, F.C. ^{a, ⁎}

Source: In Neuroscience 26 January 2025 565:124-137

Discovery of new covalent inhibitors of monoacylglycerol lipase with the nitrile warhead via SCARdock

Authors: Wang, Juanping ^{a, b, 1}, Shi, Xiaoyu ^{a, b, 1}, Wang, Junlai ^{a, b}, Zheng, Qiang ^{a, b}, Shao, Peipei ^{a, b}, Liu, Sen ^{a, b, ⁎}

Source: In Bioorganic Chemistry 1 June 2025 159

Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs

Authors: Zhao H, Liu Y, Cai N, Liao X, Tang L, Wang Y

Source: Drug Design, Development and Therapy, Vol Volume 18, Pp 2143-2167 (2024)

Subject Terms: endocannabinoid hydrolase inhibitors, endocannabinoid system, anxiety disorders, anxiolytic, magl, faah, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/endocannabinoid-hydrolase-inhibitors-potential-novel-anxiolytic-drugs-peer-reviewed-fulltext-article-DDDT; https://doaj.org/toc/1177-8881

Access URL: https://doaj.org/article/1fc5f01ea3c946d9b6a6921f4163274d

Genome-wide identification and mining elite allele variation of the Monoacylglycerol lipase (MAGL) gene family in upland cotton (Gossypium hirsutum L.)

Authors: Zhibin Zhou, Yao Chen, Mengyuan Yan, Shuqi Zhao, Feifei Li, Shuxun Yu, Zhen Feng, Libei Li

Source: BMC Plant Biology, Vol 24, Iss 1, Pp 1-15 (2024)

Subject Terms: Upland cotton, MAGL, Bioinformatics analysis, GWAS, Seed oil content, Botany, QK1-989

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2229

Access URL: https://doaj.org/article/d5b7d143a06e49ea8962dc552796de4a

Identification of a Possible Endocannabinoid-Mediated Mechanism of Action of Cetylated Fatty Acids

Authors: Giulia Bononi, Carlotta Granchi, Tiziano Tuccinardi, Filippo Minutolo

Source: Biomolecules, Vol 15, Iss 3, p 363 (2025)

Subject Terms: endocannabinoid system, cetylated fatty acids, monoacylglycerol lipase, MAGL inhibitors, analgesic agents, anti-inflammatory agents, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/15/3/363; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/9db7654bcfc54eb3a5c31273803dba3b

Analgesic Properties of Next-Generation Modulators of Endocannabinoid Signaling: Leveraging Modern Tools for the Development of Novel Therapeutics

Authors: Singh, Simar, Ellioff, Kaylin J., Bruchas, Michael R., Land, Benjamin B. ¹, Stella, Nephi ^{1, *}

Source: In The Journal of Pharmacology and Experimental Therapeutics November 2024 391(2):162-173

A helping HAND: therapeutic potential of MAGL inhibition against HIV-1-associated neuroinflammation

Authors: Alexis F. League, Barkha J. Yadav-Samudrala, Ramya Kolagani, Calista A. Cline, Ian R. Jacobs, Jonathan Manke, Micah J. Niphakis, Benjamin F. Cravatt, Aron H. Lichtman, Bogna M. Ignatowska-Jankowska, Sylvia Fitting

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: HIV-1, inflammation, transactivator of transcription (Tat), endocannabinoids, HETE, monoacylglycerol lipase (MAGL), Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1374301/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8c79ef5970b94294a9b7f4e26a0627ff

Effects of the Dual FAAH/MAGL Inhibitor AKU-005 on Trigeminal Hyperalgesia in Male Rats

Authors: Rosaria Greco, Chiara Demartini, Miriam Francavilla, Anna Maria Zanaboni, Sara Facchetti, Michela Palmisani, Valentina Franco, Cristina Tassorelli

Source: Cells, Vol 13, Iss 10, p 830 (2024)

Subject Terms: endocannabinoids, FAAH, MAGL, migraine, pain, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/13/10/830; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/a456cb7e44b14148aada90eee6b60749

Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration

Authors: Manon Allaire, Rola Al Sayegh, Morgane Mabire, Adel Hammoutene, Matthieu Siebert, Charles Caër, Mathilde Cadoux, JingHong Wan, Aida Habib, Maude Le Gall, Pierre de la Grange, Hervé Guillou, Catherine Postic, Valérie Paradis, Sophie Lotersztajn, Hélène Gilgenkrantz

Source: JHEP Reports, Vol 5, Iss 8, Pp 100794- (2023)

Subject Terms: Wound healing, Injury, MAGL, Proliferation, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555923001258; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/346571883a5f4eb1b52cd8a45a9591b1

Attenuation of allodynia and microglial reactivity by inhibiting the degradation of 2-arachidonoylglycerol following injury to the trigeminal nerve in mice

Authors: Kamimura, Rantaro ^{a, ∗}, Hossain, Mohammad Zakir ^b, Takahashi, Kojiro ^a, Saito, Isao ^a, Kitagawa, Junichi ^b

Source: In Heliyon August 2022 8(8)

ABHD6 and MAGL control 2-AG levels in the PAG and allodynia in a CSD-induced periorbital model of headache

Authors: Erika Liktor-Busa, Aidan A. Levine, Seph M. Palomino, Simar Singh, Jared Wahl, Todd W. Vanderah, Nephi Stella, Tally M. Largent-Milnes

Source: Frontiers in Pain Research, Vol 4 (2023)

Subject Terms: 2-AG, endocannabinoid, migraine, MAGL, ABHD6, PAG, Neurology. Diseases of the nervous system, RC346-429

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Relation: https://www.frontiersin.org/articles/10.3389/fpain.2023.1171188/full; https://doaj.org/toc/2673-561X

Access URL: https://doaj.org/article/d4532d8037154f8e87e75dc035f497b3

Target occupancy study and whole-body dosimetry with a MAGL PET ligand [11C]PF-06809247 in non-human primates

Authors: Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P. Maresca, Lei Zhang, Edmund J. Keliher, Christopher R. Butler, Justin R. Piro, Tarek A. Samad, Deborah Smith, Deane Nason, Steve O’Neil, Patrick Trapa, Kari R. Fonseca, John Litchfield, Timothy McCarthy, Richard E. Carson, Christer Halldin

Source: EJNMMI Research, Vol 12, Iss 1, Pp 1-9 (2022)

Subject Terms: MAGL, Non-human primate, Occupancy, PET, Radiation dose, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://doaj.org/toc/2191-219X

Access URL: https://doaj.org/article/0b2d2f0ac72047df80a3f5d00a8935c1

[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models

Authors: Tuo Shao, Zhen Chen, Jian Rong, Vasily Belov, Jiahui Chen, Andre Jeyarajan, Xiaoyun Deng, Hualong Fu, Qingzhen Yu, Steve H. Rwema, Wenyu Lin, Mikhail Papisov, Lee Josephson, Raymond T. Chung, Steven H. Liang

Source: Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 308-315 (2022)

Subject Terms: [18F]MAGL-4-11, PET imaging, Liver fibrosis, MAGL, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383521002562; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/8eeb1fa8620445a3995e56ae5f3595fe

Cetirizine and Levetiracetam as Inhibitors of Monoacylglycerol Lipase: Investigating Their Repurposing Potential as Novel Osteoarthritic Pain Therapies

Authors: Corina Andrei, Dragos Paul Mihai, Georgiana Nitulescu, Anca Ungurianu, Denisa Marilena Margina, George Mihai Nitulescu, Octavian Tudorel Olaru, Radu Mihai Busca, Anca Zanfirescu

Source: Pharmaceuticals, Vol 16, Iss 11, p 1563 (2023)

Subject Terms: MAGL inhibitors, cetirizine, levetiracetam, osteoarthritis, analgesia, complete Freund’s adjuvant, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/11/1563; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/5294a96fb3a6425c9ae54eb18d75cc87

Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping

Authors: Zhen Chen, Wakana Mori, Jian Rong, Michael A. Schafroth, Tuo Shao, Richard S. Van, Daisuke Ogasawara, Tomoteru Yamasaki, Atsuto Hiraishi, Akiko Hatori, Jiahui Chen, Yiding Zhang, Kuan Hu, Masayuki Fujinaga, Jiyun Sun, Qingzhen Yu, Thomas L. Collier, Yihan Shao, Benjamin F. Cravatt, Lee Josephson, Ming-Rong Zhang, Steven H. Liang

Source: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1686-1695 (2021)

Subject Terms: Monoacylglycerol lipase (MAGL), Central nervous system (CNS), 2-Arachidonylglycerol (2-AG), Arachidonic acid (AA), Positron emission tomography (PET), Fluorine-18, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383521000381; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/6647b3af1e7f460aab63220f173d99be

Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice

Authors: Marino, Silvia ^{a, b}, de Ridder, Daniëlle ^a, Bishop, Ryan T. ^a, Renema, Nathalie ^c, Ponzetti, Marco ^d, Sophocleous, Antonia ^{e, f}, Capulli, Mattia ^d, Aljeffery, Abdullah ^a, Carrasco, Giovana ^a, Gens, Marianela Dalghi ^g, Khogeer, Asim ^{a, b}, Ralston, Stuart H. ^e, Gertsch, Jürg ^g, Lamoureux, Francois ^c, Heymann, Dominique ^{a, h, 1}, Rucci, Nadia ^{a, d, 1}, Idris, Aymen I. ^{a, b, ⁎}

Source: In eBioMedicine June 2019 44:452-466

Cannabis and Cannabinoid Signaling: Research Gaps and Opportunities

Authors: Valentino, Rita J. ^*, Volkow, Nora D.

Source: In The Journal of Pharmacology and Experimental Therapeutics November 2024 391(2):154-158

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

Authors: Giulio Poli, Margherita Lapillo, Vibhu Jha, Nayla Mouawad, Isabella Caligiuri, Marco Macchia, Filippo Minutolo, Flavio Rizzolio, Tiziano Tuccinardi, Carlotta Granchi

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 589-596 (2019)

Subject Terms: magl inhibitors, virtual screening, molecular modelling, drug design, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/85653fbdcc7c4cae9ce97ddfbaf2d6de