Maraviroc enhances Bortezomib sensitivity in multiple myeloma by inhibiting M2 macrophage polarization via PI3K/AKT/RhoA signaling pathway in macrophages

Authors: Huiye Yang, Yuchan He, Fujun Qu, Jie Zhu, Liyuan Deng, Fang Jiang, Xianyi Wu, Yixuan Chen, Ali Kashif, Xiaotao Wang

Source: Cell Division, Vol 20, Iss 1, Pp 1-13 (2025)

Subject Terms: Multiple myeloma, CCL3/CCR5, PI3K/AKT/RhoA, M2 polarization, Tumor microenvironment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1747-1028

Access URL: https://doaj.org/article/56168ffeecc447c981dfa4ab6339bec7

STC1 encapsulated in small extracellular vesicles from laryngeal squamous cell carcinoma cells induces CD8+ T cell dysfunction by reprogramming tumor-associated macrophages into M2-like macrophages

Authors: Xiaoxue Chen, Zhigang Zhao, Rui Zhao, Wenjing Li, Xinyu Liu, Linli Tian, Ming Liu

Source: Cancer Immunology, Immunotherapy, Vol 74, Iss 2, Pp 1-15 (2025)

Subject Terms: Laryngeal squamous cell carcinoma, Small extracellular vesicles, Metabolic reprogramming, M2 polarization, Tumor-associated macrophages, STC1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1432-0851

Access URL: https://doaj.org/article/b52c22b11dfe41c193002316f6e1590e

Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression

Authors: Zhenzhen Ye, Jianfeng Yi, Xiangyan Jiang, Wengui Shi, Hao Xu, Hongtai Cao, Long Qin, Lixin Liu, Tianming Wang, Zhijian Ma, Zuoyi Jiao

Source: Journal of Experimental & Clinical Cancer Research, Vol 44, Iss 1, Pp 1-21 (2025)

Subject Terms: Gastric cancer, SERPINE1/PAI-1, let-7 g-5p, Cancer-derived exosome, M2 polarization, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/39029d9005354e81ab647c6edc40694f

Inhibition of Kv1.3 channel restrains macrophage M2 polarization and ameliorates renal fibrosis via regulating STAT6 phosphorylation

Authors: Yanshan Chen, Yuanxing Zhi, Hailin Zhong, Liang Ma, Xinpei Gu, Yijing Cai, Jingjing Huang, Xin Yi, Xiaoyan Wu, Ken Kin Lam Yung, Pingzheng Zhou

Source: Pharmacological Research, Vol 213, Iss , Pp 107623- (2025)

Subject Terms: Kv1.3, Potassium channel, Macrophage, M2 polarization, STAT6, Renal fibrosis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661825000489; https://doaj.org/toc/1096-1186

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A375 melanoma-derived lactate controls A375 melanoma phenotypes by inducing macrophage M2 polarization via TCA cycle and TGF-β signaling

Authors: Qifei Wang, Yurui Shi, Zelian Qin, Mengli Xu, Jingyi Wang, Yuhao Lu, Zhenmin Zhao, Hongsen Bi

Source: PeerJ, Vol 13, p e18887 (2025)

Subject Terms: Lactate, Macrophage, Melanoma, M2 polarization, TCA cycle, TGF-β, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://peerj.com/articles/18887.pdf; https://peerj.com/articles/18887/; https://doaj.org/toc/2167-8359

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Polystyrene nanoplastics of different particle sizes regulate the polarization of pro-inflammatory macrophages

Authors: Wanlan Jiang, Yilin Liu, Yuqi Wu, Lu Zhang, Biqing Zhang, Shiliang Zhou, Peng Zhang, Ting Xu, Min Wu, Songwei Lv

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Subject Terms: Nanoplastics, Macrophage, M1&M2 polarization, Polystyrene, iNOS, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/4cf928c680f743d682b32e19c4179ab2

Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization

Authors: Huijun Qiu, Jiang Liu, Jingyi You, Ou Zhou, Chang Hao, Yi Shu, Deyu Ma, Wenjing Zou, Linghuan Zhang, Enmei Liu, Zhengxiu Luo, Luo Ren, Gang Geng, Lin Zou, Danyi Peng, Zhou Fu

Source: Genes and Diseases, Vol 12, Iss 3, Pp 101244- (2025)

Subject Terms: Bleomycin, IL-4, M2 polarization, Macrophage, Pulmonary fibrosis, S1pr3, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352304224000412; https://doaj.org/toc/2352-3042

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Kushenol O Regulates GALNT7/NF-κB axis-Mediated Macrophage M2 Polarization and Efferocytosis in Papillary Thyroid Carcinoma

Authors: Li, Yutong ^{a, b}, Miao, Jianhang ^b, Liu, Chizhuai ^b, Tao, Jiahua ^a, Zhou, Sifan ^a, Song, Xingyu ^a, Zou, Yecheng ^a, Huang, Yuyang ^a, Zhong, Linkun ^{b, ⁎}

Source: In Phytomedicine March 2025 138

m6A demethylation of NNMT in CAFs promotes gastric cancer progression by enhancing macrophage M2 polarization

Authors: Mak, Tsz Kin ^{a, c, 1}, Li, Kuan ^{a, 1}, Zhao, Zidan ^{a, 1}, Wang, Kexin ^{a, b}, Zeng, Leli ^{a, b}, He, Qilang ^b, Lu, Weiqun ^c, Chen, Wei ^a, He, Yulong ^{a, ⁎⁎}, Li, Jia ^{a, ⁎⁎⁎}, Zhang, Changhua ^{a, ⁎}

Source: In Cancer Letters 28 February 2025 611

Melatonin induces white-to-beige adipocyte transdifferentiation through melatonin receptor 1-mediated direct browning and indirect M2 polarization

Authors: Ji, Seong Mi ^{a, 1}, Yoo, Hana ^{a, 1}, Kim, Jea Il ^b, Choi, Mi Jin ^a, Cheon, Hyae Gyeong ^{a, b, ⁎}

Source: In Molecular and Cellular Endocrinology 1 February 2025 597

Metformin alleviates colitis-associated colorectal cancer via inhibition of the TLR4/MyD88/NFκB/MAPK pathway and macrophage M2 polarization

Authors: Lai, Xueying ^{a, b, 1}, Liu, Bin ^{c, 1}, Wan, Yu ^b, Zhou, Ping ^a, Li, Wanjun ^a, Hu, Wei ^a, Gong, Wei ^{a, ⁎}

Source: In International Immunopharmacology 10 January 2025 144

RNA-seq shows Angiopoietin-like 4 promotes hepatocellular carcinoma progression by inducing M2 polarization of tumor-associated macrophages

Authors: Cui, Guanghua ^a, Liu, Wei ^{b, c}, Sun, Xiaoke ^a, Bai, Yun ^a, Ding, Meijuan ^a, Zhao, Ning ^a, Guo, Jialu ^a, Qu, Di ^a, Wang, Song ^d, Qin, Luyao ^e, Yang, Yu ^{a, ⁎}

Source: In International Journal of Biological Macromolecules January 2025 287

Ginsenoside RK3 inhibits glioblastoma by modulating macrophage M2 polarization via the PPARG/CCL2 axis

Authors: Zhang, Haiying ^{a, 1}, Hu, Jinpeng ^{b, 1}, Zhao, Xiang ^{c, 1}, Zheng, Bohao ^a, Han, Ying ^a, Luo, Gang ^{d, ⁎}, Dou, Deqiang ^{e, ⁎}

Source: In Phytomedicine January 2025 136

M2 macrophages promote subconjunctival fibrosis through YAP/TAZ signalling

Authors: Yiwei Wang, Xingchen Geng, Zhihua Guo, Dandan Chu, Ruixing Liu, Boyuan Cheng, Haohao Cui, Chengcheng Li, Jingguo Li, Zhanrong Li

Source: Annals of Medicine, Vol 56, Iss 1 (2024)

Subject Terms: Subconjunctival fibrosis, macrophage, M2 polarization, YAP, fibroblast, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/0785-3890; https://doaj.org/toc/1365-2060

Access URL: https://doaj.org/article/f5a94fa0884c436da4ff97ceaa3746a1

Global lncRNA expression signature in pre-metastatic lung and their regulatory effects in pulmonary metastasis

Authors: Huifang Shi, Peng Wang, Jiaan Wang, Lei Chen, Yan Qin, Jie Lv

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: pre-metastatic niche, lncRNAs, alveolar macrophage, M2 polarization, metastasis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1506561/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/624571c9479b4d1b809348a23d4b6f4f

Gastrointestinal stromal tumors regulate macrophage M2 polarization through the MIF/CXCR4 axis to immune escape

Authors: Shuo-meng Xiao, Rui Xu, Ying-xin Yang, Rui Zhao, Yuan Xie, Xu-dan Lei, Xiao-ting Wu

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: gastrointestinal stromal tumor, macrophage, single-cell RNA sequencing, tumor microenvironment, M2 polarization, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1431535/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f3e95196969e44f4a856c6a4ece2d827

Gelatin methacryloyl @MP196/exos hydrogel induced neutrophil apoptosis and macrophage M2 polarization to inhibit periodontal bone loss

Authors: Zhuo, Haiwei ^{a, b}, Zhang, Shuting ^{a, b}, Wang, Hongbo ^{a, b}, Deng, Jiayin ^{a, b, ⁎}, Zhang, Xi ^{a, b, ⁎}

Source: In Colloids and Surfaces B: Biointerfaces April 2025 248

PPARA ameliorates sepsis-induced myocardial injury via promoting macrophage M2 polarization by interacting with DUSP1

Authors: Li Cheng, Dezhi Liu, Shanglan Gao

Source: Regenerative Therapy, Vol 26, Iss , Pp 33-41 (2024)

Subject Terms: Sepsis, Myocardial injury, PPARA, DUSP1, M2 polarization, Medicine (General), R5-920, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352320424000798; https://doaj.org/toc/2352-3204

Access URL: https://doaj.org/article/e161e882e85e4ac2848a88ba91c8a87c

Hsa_circ_0000092 up-regulates IL24 by SMC1A to induce macrophages M2 polarization

Authors: Rihai Ma, Anmin Wang, Meng Yang, Zihua Huang, Guoman Liu, Qing Wei, Yuan Lu, Huamei Wei, Jianchu Wang, Qianli Tang, Jian Pu

Source: Heliyon, Vol 10, Iss 17, Pp e36517- (2024)

Subject Terms: HCC, hsa_circ_0000092, SMC1A, IL24, Macrophages M2 polarization, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024125480; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/06e309b159244599a6384c583df7245e

Exosomal NAT10 from esophageal squamous cell carcinoma cells modulates macrophage lipid metabolism and polarization through ac4C modification of FASN

Authors: Chun Jin, Jian Gao, Ji Zhu, Yongqiang Ao, Bowen Shi, Xin Li

Source: Translational Oncology, Vol 45, Iss , Pp 101934- (2024)

Subject Terms: NAT10, FASN, Macrophage M2 polarization, ESCC, m6A modification, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1936523324000615; https://doaj.org/toc/1936-5233

Access URL: https://doaj.org/article/b2327ae71ecb483db84402c15cbd6918