Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

Authors: Frank, Daria, Patnana, Pradeep Kumar, Vorwerk, Jan, Mao, Lianghao, Gopal, Lavanya Mokada, Jung, Noelle, Hennig, Thorben, Ruhnke, Leo, Frenz, Joris Maximillian, Kuppusamy, Maithreyan, Autry, Robert, Wei, Lanying, Sun, Kaiyan, Mohammed Ahmed, Helal Mohammed, Künstner, Axel, Busch, Hauke, Müller, Heiko, Hutter, Stephan, Hoermann, Gregor, Liu, Longlong, Xie, Xiaoqing, Al-Matary, Yahya, Nimmagadda, Subbaiah Chary, Cano, Fiorella Charles, Heuser, Michael, Thol, Felicitas, Göhring, Gudrun, Steinemann, Doris, Thomale, Jürgen, Leitner, Theo, Fischer, Anja, Rad, Roland, Röllig, Christoph, Altmann, Heidi, Kunadt, Desiree, Berdel, Wolfgang E., Hüve, Jana, Neumann, Felix, Klingauf, Jürgen, Calderon, Virginie, Opalka, Bertram, Dührsen, Ulrich, Rosenbauer, Frank, Dugas, Martin, Varghese, Julian, Reinhardt, Hans Christian, von Bubnoff, Nikolas, Möröy, Tarik, Lenz, Georg, Batcha, Aarif M. N., Giorgi, Marianna, Selvam, Murugan, Wang, Eunice, McWeeney, Shannon K., Tyner, Jeffrey W., Stölzel, Friedrich, Mann, Matthias, Jayavelu, Ashok Kumar, Khandanpour, Cyrus

Source: In Blood 21 December 2023 142(25):2175-2191

DDX3: a relevant therapeutic target for lymphoma?

Authors: Lacroix, Marion, Beauchemin, Hugues, Möröy, Tarik

Source: Expert opinion on therapeutic targets. 26(12):1037-1040

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173009104.0x000001&indx=1&recIds=ETOCvdc_100173009104.0x000001

Targeting MYC: From understanding its biology to drug discovery

Authors: Ross, Julie, Miron, Caitlin E., Plescia, Jessica, Laplante, Patricia, McBride, Kevin, Moitessier, Nicolas, Möröy, Tarik

Source: In European Journal of Medicinal Chemistry 5 March 2021 213

Severe Inflammatory Reactions in Mice Expressing a GFI1^P^2^A Mutant Defective in Binding to the Histone Demethylase KDM1A (LSD1)

Authors: Fraszczak, Jennifer, Arman, Kaifee Mohammad, Lacroix, Marion, Vadnais, Charles, Gaboury, Louis, Möröy, Tarik

Source: Journal of immunology. 207(6):1599-1615

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627465050&indx=1&recIds=ETOCRN627465050

The transcription factors GFI1 and GFI1B as modulators of the innate and acquired immune response

Authors: Fraszczak, Jennifer, Möröy, Tarik

Source: Advances in immunology. 149:35-94

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626529927&indx=1&recIds=ETOCRN626529927

A novel regulatory circuit between p53 and GFI1 controls induction of apoptosis in T cells

Authors: Vadnais, Charles, Chen, Riyan, Fraszczak, Jennifer, Hamard, Pierre-Jacques, Manfredi, James, Möröy, Tarik

Source: Scientific reports. 9(1):1-9

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133337060.0x000001&indx=1&recIds=ETOCvdc_100133337060.0x000001

Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice

Authors: Fraszczak, Jennifer, Vadnais, Charles, Rashkovan, Marissa, Ross, Julie, Beauchemin, Hugues, Chen, Riyan, Grapton, Damien, Khandanpour, Cyrus, Möröy, Tarik

Source: Leukemia. 33(1):110-121

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103847512.0x000001&indx=1&recIds=ETOCvdc_100103847512.0x000001

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

Authors: Shooshtarizadeh, Peiman, Helness, Anne, Vadnais, Charles, Brouwer, Nelleke, Beauchemin, Hugues, Chen, Riyan, Bagci, Halil, Staal, Frank, Coté, Jean-François, Möröy, Tarik

Source: Nature communications. 10(1):1-16

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128921673.0x000001&indx=1&recIds=ETOCvdc_100128921673.0x000001

Conserved role of hnRNPL in alternative splicing of epigenetic modifiers enables B cell activation.

Authors: Subramani, Poorani Ganesh, Fraszczak, Jennifer, Helness, Anne, Estall, Jennifer L, Möröy, Tarik, Di Noia, Javier M

Source: EMBO Reports; Jun2024, Vol. 25 Issue 6, p2662-2697, 36p

GFI1B specifies developmental potential of innate lymphoid cell progenitors in the lungs.

Authors: Huang, Qiutong, H. J. Cao, Wang, Curio, Sophie, Yu, Huiyang, Denman, Renae, Chen, Evelyn, Schreuder, Jaring, Dight, James, Chaudhry, Zeeshan, Jacquelot, Nicolas, Wimmer, Verena C., Seillet, Cyril, Möröy, Tarik, Belz, Gabrielle T.

Source: Science Immunology; 2024, Vol. 9 Issue 95, p1-17, 17p

Subject Terms: INNATE lymphoid cells, LUNGS, PROGENITOR cells, LUNG development, BONE marrow

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1

Authors: Vadnais, Charles, Chen, Riyan, Fraszczak, Jennifer, Yu, Zhenbao, Boulais, Jonathan, Pinder, Jordan, Frank, Daria, Khandanpour, Cyrus, Hébert, Josée, Dellaire, Graham, Côté, Jean-François, Richard, Stéphane, Orthwein, Alexandre, Drobetsky, Elliot, Möröy, Tarik

Source: Nature communications. 9(1):1-14

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132423204.0x000001&indx=1&recIds=ETOCvdc_100132423204.0x000001

Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML

Authors: Botezatu, Lacramioara, Michel, Lars C., Helness, Anne, Vadnais, Charles, Makishima, Hideki, Hönes, Judith M., Robert, François, Vassen, Lothar, Thivakaran, Aniththa, Al-Matary, Yahya, Lams, Robert F., Schütte, Judith, Giebel, Bernd, Görgens, André, Heuser, Michael, Medyouf, Hind, Maciejewski, Jaroslaw, Dührsen, Ulrich, Möröy, Tarik ^∗∗, Khandanpour, Cyrus

Source: In Experimental Hematology August 2016 44(8):713-726

GFI136N as a therapeutic and prognostic marker for myelodysplastic syndrome

Authors: Botezatu, Lacramioara, Michel, Lars C., Makishima, Hideki, Schroeder, Thomas, Germing, Ulrich, Haas, Rainer, van der Reijden, Bert, Marneth, Anne E., Bergevoet, Saskia M., Jansen, Joop H., Przychodzen, Bartlomiej, Wlodarski, Marcin, Niemeyer, Charlotte, Platzbecker, Uwe, Ehninger, Gerhard, Unnikrishnan, Ashwin, Beck, Dominik, Pimanda, John, Hellström-Lindberg, Eva, Malcovati, Luca, Boultwood, Jacqueline, Pellagatti, Andrea, Papaemmanuil, Elli, Le Coutre, Philipp, Kaeda, Jaspal, Opalka, Bertram, Möröy, Tarik, Dührsen, Ulrich, Maciejewski, Jaroslaw, Khandanpour, Cyrus

Source: In Experimental Hematology July 2016 44(7):590-595

From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation

Authors: Möröy, Tarik ^*, Vassen, Lothar, Wilkes, Brian, Khandanpour, Cyrus

Source: In Blood 10 December 2015 126(24):2561-2569

The role of the transcriptional repressor growth factor independent 1 in the formation of myeloid cells

Authors: Fraszczak, Jennifer, Möröy, Tarik

Source: Current opinion in hematology. 24(1):32-37

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100042280142.0x000001&indx=1&recIds=ETOCvdc_100042280142.0x000001

Rhythmic U2af26 Alternative Splicing Controls PERIOD1 Stability and the Circadian Clock in Mice

Authors: Preußner, Marco, Wilhelmi, Ilka, Schultz, Astrid-Solveig, Finkernagel, Florian, Michel, Monika, Möröy, Tarik, Heyd, Florian

Source: In Molecular Cell 22 May 2014 54(4):651-662

Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination

Authors: Rashkovan, Marissa, Vadnais, Charles, Ross, Julie, Gigoux, Mathieu, Suh, Woong-Kyung, Gu, Wei, Kosan, Christian, Möröy, Tarik

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Dec . 111(50), 17707-17707.

Access URL: https://www.jstor.org/stable/43278764

Growth Factor Independence 1 Antagonizes a p53-Induced DNA Damage Response Pathway in Lymphoblastic Leukemia

Authors: Khandanpour, Cyrus, Phelan, James D., Vassen, Lothar, Schütte, Judith, Chen, Riyan, Horman, Shane R., Gaudreau, Marie-Claude, Krongold, Joseph, Zhu, Jinfang, Paul, William E., Dührsen, Ulrich, Göttgens, Bertie, Grimes, H. Leighton, Möröy, Tarik

Source: In Cancer Cell 11 February 2013 23(2):200-214

The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice

Authors: Khandanpour, Cyrus, Krongold, Joseph ^*, Schɒtte, Judith ^*, Bouwman, Frederique, Vassen, Lothar, Gaudreau, Marie-Claude, Chen, Riyan, Calero-Nieto, Fernando J., Diamanti, Evangelia, Hannah, Rebecca, Meyer, Sara E., Grimes, H. Leighton, van der Reijden, Bert A., Jansen, Joop H., Patel, Chandrashekhar V., Peeters, Justine K., Löwenberg, Bob, Dɒhrsen, Ulrich, Göttgens, Bertie ^*, Möröy, Tarik ^*

Source: In Blood 8 November 2012 120(19):4006-4017

CD8 Lineage-specific Regulation of Interleukin-7 Receptor Expression by the Transcriptional Repressor Gfi1

Authors: Ligons, Davinna L., Tuncer, Ceren, Linowes, Brett A., Akcay, Izzet Mehmet, Kurtulus, Sema, Deniz, Emre, Atasever Arslan, Belkis, Cevik, Safak Isil, Keller, Hilary R., Luckey, Megan A., Feigenbaum, Lionel, Möröy, Tarik, Ersahin, Tulin ^**, Atalay, Rengul ^**, Erman, Batu, Park, Jung-Hyun

Source: In Journal of Biological Chemistry 5 October 2012 287(41):34386-34399