Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit

Authors: Yong, Xuan Ling Hilary, Zhang, Lingrui, Yang, Liming, Chen, Xiumin, Tan, Jing Zhi Anson, Yu, Xiaojun, Chandra, Mintu, Livingstone, Emma, Widagdo, Jocelyn, Vieira, Marta M., Roche, Katherine W., Lynch, Joseph W., Keramidas, Angelo, Collins, Brett M., Anggono, Victor

Source: In Cell Reports 6 July 2021 36(1)

Proteostasis Regulators Restore Function of Epilepsy-Associated GABAA Receptors

Authors: Di, Xiao-Jing, Wang, Ya-Juan, Cotter, Edmund, Wang, Meng, Whittsette, Angela L., Han, Dong-Yun, Sangwung, Panjamaporn, Brown, Renae, Lynch, Joseph W., Keramidas, Angelo, Mu, Ting-Wei

Source: In Cell Chemical Biology 21 January 2021 28(1):46-59

Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors

Authors: Chen, Xiumin, Keramidas, Angelo, Harvey, Robert J., Lynch, Joseph W.

Source: In Neurobiology of Disease July 2020 140

Shisa7 is a GABA A receptor auxiliary subunit controlling benzodiazepine actions

Authors: Han, Wenyan, Li, Jun, Pelkey, Kenneth A., Pandey, Saurabh, Chen, Xiumin, Wang, Ya-Xian, Wu, Kunwei, Ge, Lihao, Li, Tianming, Castellano, David, Liu, Chengyu, Wu, Ling-Gang, Petralia, Ronald S., Lynch, Joseph W., McBain, Chris J., Lu, Wei

Source: Science, 2019 Oct 01. 366(6462), 246-250.

Access URL: https://www.jstor.org/stable/26843635

Inhibitory synapse deficits caused by familial α1 GABAA receptor mutations in epilepsy

Authors: Chen, Xiumin, Durisic, Nela, Lynch, Joseph W., Keramidas, Angelo

Source: In Neurobiology of Disease December 2017 108:213-224

Physiological and pharmacological properties of inhibitory postsynaptic currents mediated by α5β1γ2, α5β2γ2 and α5β3γ2 GABAA receptors

Authors: Chen, Xiumin, Keramidas, Angelo, Lynch, Joseph W.

Source: In Neuropharmacology October 2017 125:243-253

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Authors: Chassagnon, Irène R., McCarthy, Claudia A., Chin, Yanni K.-Y., Pineda, Sandy S., Keramidas, Angelo, Mobli, Mehdi, Pham, Vi, De Silva, T. Michael, Lynch, Joseph W., Widdop, Robert E., Rash, Lachlan D., King, Glenn F.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Apr 01. 114(14), 3750-3755.

Access URL: https://www.jstor.org/stable/26480693

Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia

Authors: Zhang, Yan, Bode, Anna, Nguyen, Bindi, Keramidas, Angelo, Lynch, Joseph W.

Source: In Journal of Biological Chemistry 15 July 2016 291(29):15332-15341

Investigating ion channel conformational changes using voltage clamp fluorometry

Authors: Talwar, Sahil, Lynch, Joseph W.

Source: In Neuropharmacology November 2015 98:3-12

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models

Authors: Benson, Melissa J., Thomas, Nicola K., Talwar, Sahil, Hodson, Mark P., Lynch, Joseph W., Woodruff, Trent M., Borges, Karin

Source: In Neurobiology of Disease April 2015 76:87-97

Correlating Structural and Energetic Changes in Glycine Receptor Activation

Authors: Scott, Suzanne, Lynch, Joseph W., Keramidas, Angelo

Source: In Journal of Biological Chemistry 27 February 2015 290(9):5621-5634

Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations

Authors: Zhang, Yan, Dixon, Christine L., Keramidas, Angelo, Lynch, Joseph W.

Source: In Neuropharmacology February 2015 89:391-397

The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer’s Disease Drug Memantine

Authors: Ulens, Chris, Spurny, Radovan, Thompson, Andrew J., Alqazzaz, Mona, Debaveye, Sarah, Han, Lu, Price, Kerry, Villalgordo, Jose M., Tresadern, Gary, Lynch, Joseph W., Lummis, Sarah C.R.

Source: In Structure 7 October 2014 22(10):1399-1407

Phosphorylation mediated structural and functional changes in pentameric ligand-gated ion channels: Implications for drug discovery

Authors: Talwar, Sahil, Lynch, Joseph W.

Source: In International Journal of Biochemistry and Cell Biology August 2014 53:218-223

GABAA Receptor α and γ Subunits Shape Synaptic Currents via Different Mechanisms

Authors: Dixon, Christine, Sah, Pankaj, Lynch, Joseph W., Keramidas, Angelo

Source: In Journal of Biological Chemistry 28 February 2014 289(9):5399-5411

New Hyperekplexia Mutations Provide Insight into Glycine Receptor Assembly, Trafficking, and Activation Mechanisms

Authors: Bode, Anna, Wood, Sian-Elin, Mullins, Jonathan G.L., Keramidas, Angelo, Cushion, Thomas D., Thomas, Rhys H., Pickrell, William O., Drew, Cheney J.G., Masri, Amira, Jones, Elizabeth A., Vassallo, Grace, Born, Alfred P., Alehan, Fusun, Aharoni, Sharon, Bannasch, Gerald, Bartsch, Marius, Kara, Bulent, Krause, Amanda, Karam, Elie G., Matta, Stephanie, Jain, Vivek, Mandel, Hanna, Freilinger, Michael, Graham, Gail E., Hobson, Emma, Chatfield, Sue, Vincent-Delorme, Catherine, Rahme, Jubran E., Afawi, Zaid, Berkovic, Samuel F., Howell, Owain W., Vanbellinghen, Jean-François, Rees, Mark I., Chung, Seo-Kyung, Lynch, Joseph W.

Source: In Journal of Biological Chemistry 22 November 2013 288(47):33745-33759

Analysis of Hyperekplexia Mutations Identifies Transmembrane Domain Rearrangements That Mediate Glycine Receptor Activation

Authors: Bode, Anna, Lynch, Joseph W.

Source: In Journal of Biological Chemistry 22 November 2013 288(47):33760-33771

Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator

Authors: Balansa, Walter, Islam, Robiul, Gilbert, Daniel F., Fontaine, Frank, Xiao, Xue, Zhang, Hua, Piggott, Andrew M., Lynch, Joseph W., Capon, Robert J.

Source: In Bioorganic & Medicinal Chemistry 15 July 2013 21(14):4420-4425

Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease

Authors: James, Victoria M., Bode, Anna, Chung, Seo-Kyung, Gill, Jennifer L., Nielsen, Maartje, Cowan, Frances M., Vujic, Mihailo, Thomas, Rhys H., Rees, Mark I., Harvey, Kirsten, Keramidas, Angelo, Topf, Maya, Ginjaar, Ieke, Lynch, Joseph W., Harvey, Robert J.

Source: In Neurobiology of Disease April 2013 52:137-149

Ivermectin binding sites in human and invertebrate Cys-loop receptors

Authors: Lynagh, Timothy, Lynch, Joseph W.

Source: In Trends in Pharmacological Sciences August 2012 33(8):432-441