EDENT1FI Master Protocol for screening of presymptomatic early-stage type 1 diabetes in children and adolescents

Authors: Melanie Gündert, Anette-Gabriele Ziegler, Peter Achenbach, Olga Kordonouri, Agnieszka Szypowska, Ezio Bonifacio, Parth Narendran, Christiane Winkler, R Ribeiro, Sandra Hummel, Przemysława Jarosz-Chobot, Emanuele Bosi, R Lahesmaa, K Casteels, M Peakman, P Jarosz-Chobot, O Kordonouri, Chantal Mathieu, Vito Lampasona, J F Raposo, H Hyöty, F Pociot, João Filipe Raposo, R Berner, R Bergholdt, E Bonifacio, Flemming Pociot, B Petersen, J Van Rampelbergh, L Overbergh, B Van der Schueren, V Lampasona, C Winkler, R Coelho, O Cohen, C Mathieu, E Bosi, Stefanie Arnolds, Lut Overbergh, Zdenek Sumnik, A Koralova, G Sebastiani, Luisa Hoffmann, Mirjam Kohls, Regine Bergholdt, Bianca K Hoefelschweiger, Jurgen Vercauteren, P Gillard, J Vercauteren, A G Ziegler, P Achenbach, F Haupt, S Hummel, T Pieber, J Mader, S Moitzi, S Del Prato, B Torbeyns, Z Sumnik, O Cinek, V Neuman, B Berka, J Antvorskov, J H Klaebel, J E Laiho, F Reschke, T von dem Berge, A Hommel, A Loff, G Gemulla, N Zubizarreta, L Piemonti, F Dotta, A Szypowska, K Karczewski, E Niemoeller, M Baccara-Dinet, K Fogh, M I Buompensiere, C Hurtado del Pozo, E Latres, G Agiostratidou

Source: BMJ Open, Vol 15, Iss 1 (2025)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/15/1/e088522.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/b1ceae6df10c4486ab1728759728e122

Citrullination of glucokinase is linked to autoimmune diabetes

Authors: Mei-Ling Yang, Sheryl Horstman, Renelle Gee, Perrin Guyer, TuKiet T. Lam, Jean Kanyo, Ana L. Perdigoto, Cate Speake, Carla J. Greenbaum, Aïsha Callebaut, Lut Overbergh, Richard G. Kibbey, Kevan C. Herold, Eddie A. James, Mark J. Mamula

Source: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/05c25682e0244aef9cf1385fd566a122

Gene expression signature predicts rate of type 1 diabetes progressionResearch in context

Authors: Tomi Suomi, Inna Starskaia, Ubaid Ullah Kalim, Omid Rasool, Maria K. Jaakkola, Toni Grönroos, Tommi Välikangas, Caroline Brorsson, Gianluca Mazzoni, Sylvaine Bruggraber, Lut Overbergh, David Dunger, Mark Peakman, Piotr Chmura, Søren Brunak, Anke M. Schulte, Chantal Mathieu, Mikael Knip, Riitta Lahesmaa, Laura L. Elo, Pieter Gillard, Kristina Casteels, Lutgart Overbergh, Chris Wallace, Mark Evans, Ajay Thankamony, Emile Hendriks, Loredana Marcoveccchio, Timothy Tree, Noel G. Morgan, Sarah Richardson, John A. Todd, Linda Wicker, Adrian Mander, Colin Dayan, Mohammad Alhadj Ali, Thomas Pieber, Decio L. Eizirik, Myriam Cnop, Flemming Pociot, Jesper Johannesen, Peter Rossing, Cristina Legido Quigley, Roberto Mallone, Raphael Scharfmann, Christian Boitard, Timo Otonkoski, Riitta Veijola, Matej Oresic, Jorma Toppari, Thomas Danne, Anette G. Ziegler, Peter Achenbach, Teresa Rodriguez-Calvo, Michele Solimena, Ezio E. Bonifacio, Stephan Speier, Reinhard Holl, Francesco Dotta, Francesco Chiarelli, Piero Marchetti, Emanuele Bosi, Stefano Cianfarani, Paolo Ciampalini, Carine De Beaufort, Knut Dahl-Jørgensen, Torild Skrivarhaug, Geir Joner, Lars Krogvold, Przemka Jarosz-Chobot, Tadej Battelino, Bernard Thorens, Martin Gotthardt, Bart O. Roep, Tanja Nikolic, Arnaud Zaldumbide, Ake Lernmark, Marcus Lundgren, Guillaume Costacalde, Thorsten Strube, Almut Nitsche, Jose Vela, Matthias Von Herrath, Johnna Wesley, Antonella Napolitano-Rosen, Melissa Thomas, Nanette Schloot, Allison Goldfine, Frank Waldron-Lynch, Jill Kompa, Aruna Vedala, Nicole Hartmann, Gwenaelle Nicolas, Jean van Rampelbergh, Nicolas Bovy, Sanjoy Dutta, Jeannette Soderberg, Simi Ahmed, Frank Martin, Esther Latres, Gina Agiostratidou, Anne Koralova, Ruben Willemsen, Anne Smith, Binu Anand, Vipan Datta, Vijith Puthi, Sagen Zac-Varghese, Renuka Dias, Premkumar Sundaram, Bijay Vaidya, Catherine Patterson, Katharine Owen, Barbara Piel, Simon Heller, Tabitha Randell, Tasso Gazis, Elise Bismuth Reismen, Jean-Claude Carel, Jean-Pierre Riveline, Jean-Francoise Gautier, Fabrizion Andreelli, Florence Travert, Emmanuel Cosson, Alfred Penfornis, Catherine Petit, Bruno Feve, Nadine Lucidarme, Jean-Paul Beressi, Catherina Ajzenman, Alina Radu, Stephanie Greteau-Hamoumou, Cecile Bibal, Thomas Meissner, Bettina Heidtmann, Sonia Toni, Birgit Rami-Merhar, Bart Eeckhout, Bernard Peene, N. Vantongerloo, Toon Maes, Leen Gommers

Source: EBioMedicine, Vol 92, Iss , Pp 104625- (2023)

Subject Terms: Type 1 diabetes, Autoantibodies, RNA-seq, Gene expression signature, Predictive model, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423001901; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/2c41bdea112542e1901b5cf0742fc2e4

Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation

Authors: Aїsha Callebaut, Ylke Bruggeman, Cloé Zamit, Fernanda Marques Câmara Sodré, Magali Irla, Chantal Mathieu, Mijke Buitinga, Lut Overbergh

Source: Frontiers in Endocrinology, Vol 13 (2022)

Subject Terms: diabetes, neoepitopes, deamidation, post-translational modification, NOD mouse, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2022.908248/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/2d1b545b8d42415fad5446261cee44bf

NET Proteome in Established Type 1 Diabetes Is Enriched in Metabolic Proteins

Authors: Samal Bissenova, Darcy Ellis, Aïsha Callebaut, Guy Eelen, Rita Derua, Mijke Buitinga, Chantal Mathieu, Conny Gysemans, Lut Overbergh

Source: Cells, Vol 12, Iss 9, p 1319 (2023)

Subject Terms: neutrophils, NETosis, NET proteome, type 1 diabetes, metabolism, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/9/1319; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/05c8ee2e79e64818bd2a2509db291283

Study protocol: Minimum effective low dose: anti-human thymocyte globulin (MELD-ATG): phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes

Authors: Simon Bond, David Dunger, Mark Wilson, Adrian Mander, Mikael Knip, Anita Chhabra, M Loredana Marcovecchio, Charlotte S Wilhelm-Benartzi, Michael J Haller, Timothy Tree, Hilde Morobé, Sarah E Miller, Sylvaine Bruggraber, Diane Picton, Katrina Gatley, A Emile J Hendriks, Bärbel Aschemeier-Fuchs, Lut Overbergh, Jaivier Pall, Olivier Arnaud, Almut Nitsche, Anke M Schulte

Source: BMJ Open, Vol 11, Iss 12 (2021)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/11/12/e053669.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/3be62c3bfb884f7a8feae2f2becbd435

Citrullination and PAD Enzyme Biology in Type 1 Diabetes – Regulators of Inflammation, Autoimmunity, and Pathology

Authors: Mei-Ling Yang, Fernanda M. C. Sodré, Mark J. Mamula, Lut Overbergh

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: type 1 diabetes, neoepitopes, post-translational modification, citrullination, peptidylarginine deiminase, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.678953/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/af18f2608aeb4fdb9357fb71b7c20c62

Neoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets

Authors: Teresa Rodriguez-Calvo, James D. Johnson, Lut Overbergh, Jessica L. Dunne

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: type 1 diabetes, neoepitopes, autoantigens, pathogenesis, beta-cell, biomarker, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.667989/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4c1aa0729138418aba969598f0ed92f5

SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature

Authors: Daniela Fignani, Giada Licata, Noemi Brusco, Laura Nigi, Giuseppina E. Grieco, Lorella Marselli, Lut Overbergh, Conny Gysemans, Maikel L. Colli, Piero Marchetti, Chantal Mathieu, Decio L. Eizirik, Guido Sebastiani, Francesco Dotta

Source: Frontiers in Endocrinology, Vol 11 (2020)

Subject Terms: diabetes, COVID-19, angiotensin I-converting enzyme type 2 (ACE2), beta-cell, human pancreatic islets, SARS-CoV-2, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2020.596898/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/05d99993f96f49f999863eb96b71f66c

Pancreatic Alpha-Cells Contribute Together With Beta-Cells to CXCL10 Expression in Type 1 Diabetes

Authors: Laura Nigi, Noemi Brusco, Giuseppina E. Grieco, Giada Licata, Lars Krogvold, Lorella Marselli, Conny Gysemans, Lut Overbergh, Piero Marchetti, Chantal Mathieu, Knut Dahl Jørgensen, Guido Sebastiani, Francesco Dotta

Source: Frontiers in Endocrinology, Vol 11 (2020)

Subject Terms: type 1 diabetes, pancreas, alpha-cells, chemokines, CXCL10, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fendo.2020.00630/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/6e0149b28c6944afbe9510cf087f784b

At similar weight loss, dietary composition determines the degree of glycemic improvement in diet-induced obese C57BL/6 mice.

Authors: Roman Vangoitsenhoven, Miranda van der Ende, Katrien Corbeels, João Paulo Monteiro Carvalho Mori Cunha, Matthias Lannoo, Pierre Bedossa, Schalk van der Merwe, Ann Mertens, Ina Gesquiere, Ann Meulemans, Christophe Matthys, Chantal Mathieu, Lut Overbergh, Bart Van der Schueren

Source: PLoS ONE, Vol 13, Iss 7, p e0200779 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6056053?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/2263f545f7e34761862be91c366a4946

Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways

Authors: Gabriela Bomfim Ferreira, An-Sofie Vanherwegen, Guy Eelen, Ana Carolina Fierro Gutiérrez, Leentje Van Lommel, Kathleen Marchal, Lieve Verlinden, Annemieke Verstuyf, Tatiane Nogueira, Maria Georgiadou, Frans Schuit, Décio L. Eizirik, Conny Gysemans, Peter Carmeliet, Lut Overbergh, Chantal Mathieu

Source: Cell Reports, Vol 10, Iss 5, Pp 711-725 (2015)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124715000261; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/1cebc382a3f9483389844b884a3cbeb4

Foodborne cereulide causes beta-cell dysfunction and apoptosis.

Authors: Roman Vangoitsenhoven, Dieter Rondas, Inne Crèvecoeur, Wannes D'Hertog, Pieter Baatsen, Matilde Masini, Mirjana Andjelkovic, Joris Van Loco, Christophe Matthys, Chantal Mathieu, Lut Overbergh, Bart Van der Schueren

Source: PLoS ONE, Vol 9, Iss 8, p e104866 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4132018?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/36bae51bce2247fb9e1945d4b7d58da4

Oleate-Induced Beta Cell Dysfunction and Apoptosis: A Proteomic Approach to Glucolipotoxicity by an Unsaturated Fatty Acid.

Authors: Michael Maris, Etienne Waelkens, Miriam Cnop, Wannes D’Hertog, Daniel A. Cunha, Hannelie Korf, Tatsuro Koike, Lut Overbergh, Chantal Mathieu

Source: Journal of Proteome Research; Aug2011, Vol. 10 Issue 8, p3372-3385, 14p

High Glucose Induces Dysfunction in Insulin Secretory Cells by Different Pathways: A Proteomic Approach.

Authors: Michael Maris, Gabriela B. Ferreira, Wannes D’Hertog, Miriam Cnop, Etienne Waelkens, Lut Overbergh, Chantal Mathieu

Source: Journal of Proteome Research; Dec2010, Vol. 9 Issue 12, p6274-6287, 14p

Vitamin D3and the immune system: maintaining the balance in health and disease.

Authors: Femke Baeke, Evelyne Van Etten, Lut Overbergh, Chantal Mathieu

Source: Nutrition Research Reviews; Jun2007, Vol. 20 Issue 1, p106-118, 13p

Subject Terms: IMMUNE system, CHOLECALCIFEROL, HEALTH, DISEASES

UVB‐induced 1,25(OH)2D3 production and vitamin D activity in intestinal CaCo‐2 cells and in THP‐1 macrophages pretreated with a sterol Δ7‐reductase inhibitor.

Authors: Katleen Vantieghem, Lut Overbergh, Geert Carmeliet, Petra De Haes, Roger Bouillon, Siegfried Segaert

Source: Journal of Cellular Biochemistry; Sep2006, Vol. 99 Issue 1, p229-240, 12p

Early Accumulation of Interferon-? in Grafts Tolerized by Donor-Specific Blood Transfusion: Friend or Enemy?

Authors: Hiroaki Kitade, Masaru Kawai, Takaaki Koshiba, Annapaula Giulietti, Lut Overbergh, Omer Rutgeerts, Dirk Valckx, Mark Waer, Chantal Mathieu, Jacques Pirenne

Source: Transplantation; Dec2004, Vol. 78 Issue 12, p1747-1755, 9p

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