Combination of spatial transcriptomics analysis and retrospective study reveals liver infection of SARS-COV-2 is associated with clinical outcomes of COVID-19Research in context

Authors: Shiqi Chen, Yi Zhang, Asha Ashuo, Shu Song, Lunzhi Yuan, Weixia Wang, Cong Wang, Zunguo Du, Yangtao Wu, Dan Tan, Chenlu Huang, Jingna Chen, Yaming Li, Jinjin Bai, Huilin Guo, Zehong Huang, Yi Guan, Ningshao Xia, Zhenghong Yuan, Jiming Zhang, Quan Yuan, Zhong Fang

Source: EBioMedicine, Vol 111, Iss , Pp 105517- (2025)

Subject Terms: SARS-COV-2, COVID-19, Liver, Spatial transcriptome, ALB, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S235239642400553X; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/c1ed28ef232b4306a989814691f17f65

Decisive reversal of lethal coronavirus disease 2019 in senescent hamster by synchronic antiviral and immunoregulatory intervention

Authors: Xuan Liu, Ming Zhou, Mujing Fang, Ying Xie, Peiwen Chen, Rirong Chen, Kun Wu, Jianghui Ye, Che Liu, Huachen Zhu, Tong Cheng, Lunzhi Yuan, Hui Zhao, Yi Guan, Ningshao Xia

Source: MedComm, Vol 5, Iss 8, Pp n/a-n/a (2024)

Subject Terms: antiviral therapy, bio‐mimic decoy, immunoregulation, SARS‐CoV‐2, senesce associated disease deterioration, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2688-2663

Access URL: https://doaj.org/article/2fff7c5c7494459f921f393a88f116be

A cryptic site in class 5 epitope of SARS-CoV-2 RBD maintains highly conservation across natural isolates

Authors: Lingyan Cui, Tingting Li, Miaolin Lan, Ming Zhou, Wenhui Xue, Sibo Zhang, Hong Wang, Minqing Hong, Yali Zhang, Lunzhi Yuan, Hui Sun, Jianghui Ye, Qingbing Zheng, Yi Guan, Ying Gu, Ningshao Xia, Shaowei Li

Source: iScience, Vol 27, Iss 7, Pp 110208- (2024)

Subject Terms: Virology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224014330; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/37b7c53b72da4f90bcacb95b2bf39a1d

Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters

Authors: Liang Zhang, Yao Jiang, Jinhang He, Junyu Chen, Ruoyao Qi, Lunzhi Yuan, Tiange Shao, Hui Zhao, Congjie Chen, Yaode Chen, Xijing Wang, Xing Lei, Qingxiang Gao, Chunlan Zhuang, Ming Zhou, Jian Ma, Wei Liu, Man Yang, Rao Fu, Yangtao Wu, Feng Chen, Hualong Xiong, Meifeng Nie, Yiyi Chen, Kun Wu, Mujin Fang, Yingbin Wang, Zizheng Zheng, Shoujie Huang, Shengxiang Ge, Shih Chin Cheng, Huachen Zhu, Tong Cheng, Quan Yuan, Ting Wu, Jun Zhang, Yixin Chen, Tianying Zhang, Changgui Li, Hai Qi, Yi Guan, Ningshao Xia

Source: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e3960e4523224e0888469ff72727bae6

Efficacy of small molecules against the severe acute respiratory syndrome coronavirus 2 XBB1.16 and XBB1.9.2.1

Authors: Lunzhi Yuan, Xuan Liu, Song Li, Wu Zhong, Ningshao Xia

Source: MedComm, Vol 5, Iss 3, Pp n/a-n/a (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2688-2663

Access URL: https://doaj.org/article/76d3f590bf8a4717a624fac47fce0633

Chronic hepatitis B virus infection deteriorates disease outcome of coronavirus disease 2019 in hamster

Authors: Lunzhi Yuan, Xuan Liu, Yi Guan, Tong Cheng, Ningshao Xia

Source: MedComm, Vol 5, Iss 3, Pp n/a-n/a (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2688-2663

Access URL: https://doaj.org/article/627063fa2c424cd8a142af2eb9de3ced

Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus

Authors: Xuan Liu, Lunzhi Yuan, Jijing Chen, Yali Zhang, Peiwen Chen, Ming Zhou, Jiaxuan Xie, Jian Ma, Jianzhong Zhang, Kun Wu, Qiyi Tang, Quan Yuan, Huachen Zhu, Tong Cheng, Yi Guan, Gang Liu, Ningshao Xia

Source: Advanced Science, Vol 10, Iss 17, Pp n/a-n/a (2023)

Subject Terms: ARDS, biomimetic nanocarrier, cell membrane vesicles, endogenous type I interferon, highly pathogenic coronavirus, imbalanced innate immune responses, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/d6954536acd14b80925f857e77e5bec4

Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model

Authors: Lunzhi Yuan, Huachen Zhu, Ming Zhou, Jian Ma, Xuan Liu, Kun Wu, Jianghui Ye, Huan Yu, Peiwen Chen, Rirong Chen, Jia Wang, Yali Zhang, Shengxiang Ge, Quan Yuan, Tong Cheng, Yi Guan, Ningshao Xia

Source: iScience, Vol 25, Iss 12, Pp 105475- (2022)

Subject Terms: Immunology, Virology, Immune response, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222017473; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/29a3ac494e524612b855de178baef72d

Female sex hormone, progesterone, ameliorates the severity of SARS-CoV-2-caused pneumonia in the Syrian hamster model

Authors: Lunzhi Yuan, Huachen Zhu, Kun Wu, Ming Zhou, Jian Ma, Rirong Chen, Qiyi Tang, Tong Cheng, Yi Guan, Ningshao Xia

Source: Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-3 (2022)

Subject Terms: Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2059-3635

Access URL: https://doaj.org/article/19f627868f344721b578c97c33779c54

Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster

Authors: Lunzhi Yuan, Huachen Zhu, Ming Zhou, Jian Ma, Rirong Chen, Yao Chen, Liqiang Chen, Kun Wu, Minping Cai, Junping Hong, Lifeng Li, Che Liu, Huan Yu, Yali Zhang, Jia Wang, Tianying Zhang, Shengxiang Ge, Jun Zhang, Quan Yuan, Yixin Chen, Qiyi Tang, Honglin Chen, Tong Cheng, Yi Guan, Ningshao Xia

Source: Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-8 (2021)

Subject Terms: Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2059-3635

Access URL: https://doaj.org/article/8477bcc6cc3d4872b00f5fba217f2910

SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications

Authors: Lunzhi Yuan, Qiyi Tang, Huachen Zhu, Yi Guan, Tong Cheng, Ningshao Xia

Source: Emerging Microbes and Infections, Vol 10, Iss 1, Pp 1881-1889 (2021)

Subject Terms: SARS-CoV-2, non-human primates, severe acute respiratory syndrome, immunopathogenesis, vaccine and drug discovery, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/bc48129502fb4389a514bf643f589ec5

Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants

Authors: Yali Zhang, Min Wei, Yangtao Wu, Juan Wang, Yuting Hong, Yang Huang, Lunzhi Yuan, Jian Ma, Kai Wang, Shaojuan Wang, Yang Shi, Zikang Wang, Huilin Guo, Jin Xiao, Chuanlai Yang, Jianghui Ye, Jijing Chen, Yuxi Liu, Baorong Fu, Miaolin Lan, Peixuan Gong, Zehong Huang, Yingying Su, Yixin Chen, Tianying Zhang, Jun Zhang, Huachen Zhu, Hai Yu, Quan Yuan, Tong Cheng, Yi Guan, Ningshao Xia

Source: Cell Reports, Vol 38, Iss 12, Pp 110558- (2022)

Subject Terms: CP: Microbiology, CP: Immunology, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2211124722003023; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/e14a0f7a6d9e484ba5254157cfb7430c

Animal models for emerging coronavirus: progress and new insights

Authors: Lunzhi Yuan, Qiyi Tang, Tong Cheng, Ningshao Xia

Source: Emerging Microbes and Infections, Vol 9, Iss 1, Pp 949-961 (2020)

Subject Terms: Coronavirus, infectious disease, respiratory syndrome, animal model, vaccine and drug discovery, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/6366ccfd2e3249f0afb975da8b9736fa

Liver chimeric mice with tupaia hepatocyte transplantation as an animal model for hepatitis B virus infection and antiviral therapy

Authors: Lunzhi Yuan, Yao Chen, Xuan Liu, Yali Zhang, Ming Zhou, Kun Wu, Quan Yuan, Tong Cheng, Ningshao Xia

Source: Biosafety and Health, Vol 1, Iss 2, Pp 76-83 (2019)

Subject Terms: Tupaia, Hepatitis B, Liver chimeric mice, Infectious animal model, Antiviral therapy, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590053619300242; https://doaj.org/toc/2590-0536

Access URL: https://doaj.org/article/8250498c14c24d118bc352f3b48468a4

DLL4 restores damaged liver by enhancing hBMSC differentiation into cholangiocytes

Authors: Suwan Sun, Lunzhi Yuan, Zhanglu An, Dongyan Shi, Jiaojiao Xin, Jing Jiang, Keke Ren, Jiaxian Chen, Beibei Guo, Xingping Zhou, Qian Zhou, Xiaojun Jin, Sihan Ruan, Tong Cheng, Ningshao Xia, Jun Li

Source: Stem Cell Research, Vol 47, Iss , Pp 101900- (2020)

Subject Terms: Biliary restoration, hBMSC, DLL4, Cholangiocyte differentiation, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506120302014; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/b96ca7ee47d64bddb0592e188184937d

A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection

Authors: Lunzhi Yuan, Xuan Liu, Liang Zhang, Xiaoling Li, Yali Zhang, Kun Wu, Yao Chen, Jiali Cao, Wangheng Hou, Jun Zhang, Hua Zhu, Quan Yuan, Qiyi Tang, Tong Cheng, Ningshao Xia

Source: Frontiers in Microbiology, Vol 9 (2018)

Subject Terms: stem cells, hepatocyte-like cells, liver humanized mouse, hepatitis B virus, infectious animal model, hHLC-FRGS, Microbiology, QR1-502

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fmicb.2018.00908/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/225da9be6b334ee9aecc362a35d6a966

The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2.

Authors: Hualong Xiong, Hui Sun, Siling Wang, Lunzhi Yuan, Liqin Liu, Yuhe Zhu, Jinlei Zhang, Yang Huang, Ruoyao Qi, Yao Jiang, Jian Ma, Ming Zhou, Yue Ma, Rao Fu, Siping Yan, Mingxi Yue, Yangtao Wu, Min Wei, Yizhen Wang, Tingting Li

Source: Proceedings of the National Academy of Sciences of the United States of America; 8/23/2022, Vol. 119 Issue 34, p1-12, 33p

Subject Terms: SARS-CoV-2 Omicron variant, SARS-CoV-2 Delta variant, SARS virus, SARS-CoV-2, EPITOPES, TAX evasion

A SCID mouse-human lung xenograft model of SARS-CoV-2 infection.

Authors: Wenkun Fu, Wei Wang, Lunzhi Yuan, Yanzhen Lin, Xiumin Huang, Rirong Chen, Minping Cai, Che Liu, Liqiang Chen, Ming Zhou, Kun Wu, Huan Zhao, Dequan Pan, Jian Ma, Junping Hong, Bingke Zhai, Yali Zhang, Zhibo Kong, Yingbin Wang, Yixin Chen

Source: Theranostics; 2021, Vol. 11 Issue 13, p6607-6615, 9p

HBV infection-induced liver cirrhosis development in dual-humanised mice with human bone mesenchymal stem cell transplantation.

Authors: Lunzhi Yuan, Jing Jiang, Xuan Liu, Yali Zhang, Liang Zhang, Jiaojiao Xin, Kun Wu, Xiaoling Li, Jiali Cao, Xueran Guo, Dongyan Shi, Jun Li, Longyan Jiang, Suwan Sun, Tengyun Wang, Wangheng Hou, Tianying Zhang, Hua Zhu, Jun Zhang, Quan Yuan

Source: Gut; Nov2019, Vol. 68 Issue 11, p2044-2056, 13p, 1 Diagram, 6 Graphs

Subject Terms: PLURIPOTENT stem cells, LIVER cells, MESENCHYMAL stem cells, STEM cell transplantation, CIRRHOSIS of the liver, STEM cell niches, MICE

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration.

Authors: Fuqin Fan, Zhixiang He, Lu-Lu Kong, Qinghua Chen, Quan Yuan, Shihao Zhang, Jinjin Ye, Hao Liu, Xiufeng Sun, Jing Geng, Lunzhi Yuan, Lixin Hong, Chen Xiao, Weiji Zhang, Xihuan Sun, Yunzhan Li, Ping Wang, Lihong Huang, Xinrui Wu, Zhiliang Ji

Source: Science Translational Medicine; 8/17/2016, Vol. 8 Issue 352, p1-14, 14p, 7 Graphs

Subject Terms: PROTEIN kinases, REGENERATIVE medicine, TISSUE engineering, PHARMACEUTICAL research, ENZYME-linked immunosorbent assay