Establishment of a bat lung organoid culture model for studying bat-derived infectious diseases

Authors: Mohamed Elbadawy, Nagisa Saito, Yuki Kato, Kimika Hayashi, Amira Abugomaa, Mio Kobayashi, Toshinori Yoshida, Makoto Shibutani, Masahiro Kaneda, Hideyuki Yamawaki, Kazuaki Sasaki, Tatsuya Usui, Tsutomu Omatsu

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-13 (2025)

Subject Terms: Bat, Rousettus leschenaultii, Lung organoid, ACE2, TMPRSS2, Alveolar type 2 cells, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/a0f0cc285a3b461abc94430a80f092c6

Regenerative Capacity of Alveolar Type 2 Cells Is Proportionally Reduced Following Disease Progression in Idiopathic Pulmonary Fibrosis-Derived Organoid Cultures

Authors: Hyeon Kyu Choi, Gaeul Bang, Ju Hye Shin, Mi Hwa Shin, Ala Woo, Song Yee Kim, Sang Hoon Lee, Eun Young Kim, Hyo Sup Shim, Young Joo Suh, Ha Eun Kim, Jin Gu Lee, Jinwook Choi, Ju Hyeon Lee, Chul Hoon Kim, Moo Suk Park

Source: Tuberculosis and Respiratory Diseases, Vol 88, Iss 1, Pp 130-137 (2025)

Subject Terms: idiopathic pulomonary fibrosis, alveolar type 2 cells, patient-derived lung organoid, lung regeneration, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://e-trd.org/upload/pdf/trd-2024-0094.pdf; https://doaj.org/toc/1738-3536; https://doaj.org/toc/2005-6184

Access URL: https://doaj.org/article/567cd3e89cc342e5893ccf31865fce93

Matrix-free human lung organoids derived from induced pluripotent stem cells to model lung injury

Authors: Bettina Budeus, Chiara Kroepel, Lisa Marie Stasch, Diana Klein

Source: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)

Subject Terms: Lung organoid, iPSC, Lung injury, Disease modeling, Genotoxic stress, Single cell RNAseq, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/4a0df2f477d24733a3b739af66ec2fdd

Recent advances and applications of human lung alveolar organoids

Authors: Kim, Sun Kyung ^†, Sung, Eunho ^†, Lim, Kyungtae ^⁎

Source: In Molecules and Cells December 2024 47(12)

Bioinspired Hyaluronic Acid‐Based Hydrogel Fuels Bi‐Directional Lung Organoid Maturation via PIEZO1 and ITGB1 Mediated Mechanosensation

Authors: Junyao Zhang, Daniele Marciano, Lei Wang, Weiwei Wang, Manfred Gossen, Mengting Yang, Tingying Peng, Julien Gautrot, Xun Xu, Nan Ma

Source: Advanced Materials Interfaces, Vol 11, Iss 28, Pp n/a-n/a (2024)

Subject Terms: biomechanics, hyaluronic acid (HA), hydrogel, lung organoid, piezo1, Physics, QC1-999, Technology

File Description: electronic resource

Relation: https://doaj.org/toc/2196-7350

Access URL: https://doaj.org/article/311b5d6aaad34c4fbc188054f9169acd

The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy

Authors: Toka A. Ahmed, Bassant Eldaly, Shadwa Eldosuky, Hoda Elkhenany, Azza M. El-Derby, Muhamed F. Elshazly, Nagwa El-Badri

Source: Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-20 (2023)

Subject Terms: COVID-19, Lung organoid, Synthetic polymers, Lung spheroid, Natural polymers, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/3daf7c1f360a4bcd9526f64369598709

Development of a screening platform to discover natural products active against SARS-CoV-2 infection using lung organoid models

Authors: Joo-Eun Lee, Se Yun Jeong, Zijun Li, Hyun-Yi Kim, Hyun-Woo Kim, Min Jeong Yoo, Hee Joo Jang, Do-Kyun Kim, Namki Cho, Hee Min Yoo, Ki Hyun Kim

Source: Biomaterials Research, Vol 27, Iss 1, Pp 1-17 (2023)

Subject Terms: Natural products, Screening platform, SARS-CoV-2, Antiviral activity, Lung organoid models, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/2055-7124

Access URL: https://doaj.org/article/eea6a5aaf1354d9b99f59cc88dcb80a1

Advanced lung organoids and lung-on-a-chip for cancer research and drug evaluation: a review

Authors: Leqing Zhu, Jianhua Zhang, Quanwei Guo, Jun Kuang, Dongfang Li, Mengxi Wu, Yijun Mo, Tao Zhang, Xinghua Gao, Jianfeng Tan

Source: Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)

Subject Terms: 3D culture system, lung organoid, lung-on-a-chip, lung cancer, drug evaluation, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fbioe.2023.1299033/full; https://doaj.org/toc/2296-4185

Access URL: https://doaj.org/article/caa451f752ad4e7a9ca5bc46c155b552

Identification of cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants

Authors: Chao Hu, Meiying Shen, Xiaojian Han, Qian Chen, Luo Li, Siyin Chen, Jing Zhang, Fengxia Gao, Wang Wang, Yingming Wang, Tingting Li, Shenglong Li, Jingjing Huang, Jianwei Wang, Ju Zhu, Dan Chen, Qingchen Wu, Kun Tao, Da Pang, Aishun Jin

Source: Genes and Diseases, Vol 9, Iss 1, Pp 216-229 (2022)

Subject Terms: CD8+T cell, HLA class I, Lung organoid, SARS-CoV-2, T cell epitope, TCR, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352304221000842; https://doaj.org/toc/2352-3042

Access URL: https://doaj.org/article/dbbc61accec0439f8144016538c03889

Emerging toolset of three-dimensional pulmonary cell culture models for simulating lung pathophysiology towards mechanistic elucidation and therapeutic treatment of SARS-COV-2 infection

Authors: Kai Ni, Bo Che, Chongxin Yang, Youyuan Qin, Rong Gu, Chunhong Wang, Mingzhi Luo, Linhong Deng

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: COVID-19, lung organoid, lung-on-a-chip, 3D bioprinting, drug discovery, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.1033043/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/6a8ccacd54de4d90adf83b814034149b

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Authors: Dora Barbosa Rabago, author^{1, 2, 3}, Collin M. Blakely, author^{1, 2}, Franziska Haderk, author^{1, 2, 3}, Trever G. Bivona, author^{1, 2, 3}

Source: Journal of Visualized Experiments. (177)

Availability: http://www.jove.com/video/63039

Lung organoid simulations for modelling and predicting the effect of mutations on SARS-CoV-2 infectivity

Authors: Sally Esmail, Wayne R. Danter

Source: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 1701-1712 (2021)

Subject Terms: SARS-CoV2 evolution, Infectivity, Viral mutations, Lung organoid, Machine learning, Simulations of COVID-19, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037021000921; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/7bad5ea5da0a4af18eb7317790ee8bcb

Lung organoids, useful tools for investigating epithelial repair after lung injury

Authors: Jing Kong, Shiyuan Wen, Wenjing Cao, Peng Yue, Xin Xu, Yu Zhang, Lisha Luo, Taigui Chen, Lianbao Li, Feng Wang, Jian Tao, Guozhong Zhou, Suyi Luo, Aihua Liu, Fukai Bao

Source: Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2021)

Subject Terms: Stem cell, Lung organoid, Lung injury, Epithelial repair, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/fc7c1d1a1329460a828140981262a596

Disease modeling in organoid cultures: a new tool for studying viruses

Authors: Jaewon Cho, Eun-Hye Hong, Hyun-Jeong Ko

Source: Organoid, Vol 2 (2022)

Subject Terms: intestinal organoid, lung organoid, tonsil organoid, disease modeling, viruses, Biotechnology, TP248.13-248.65, Miscellaneous systems and treatments, RZ409.7-999

File Description: electronic resource

Relation: http://j-organoid.org/upload/pdf/organoid-2022-2-e15.pdf; https://doaj.org/toc/2765-205X

Access URL: https://doaj.org/article/6b49d95f750747c78a8c550e33e1e812

Human Organotypic Airway and Lung Organoid Cells of Bronchiolar and Alveolar Differentiation Are Permissive to Infection by Influenza and SARS-CoV-2 Respiratory Virus

Authors: Camilla Tvedt Ekanger, Fan Zhou, Dana Bohan, Maria Lie Lotsberg, Maria Ramnefjell, Laurence Hoareau, Gro Vatne Røsland, Ning Lu, Marianne Aanerud, Fabian Gärtner, Pirjo Riitta Salminen, Mariann Bentsen, Thomas Halvorsen, Helge Ræder, Lars A. Akslen, Nina Langeland, Rebecca Cox, Wendy Maury, Linda Elin Birkhaug Stuhr, James B. Lorens, Agnete S. T. Engelsen

Source: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Subject Terms: human airway and lung organoid model, respiratory epithelium, regional differences, histopathology, viral infection and replication, influenza virus, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2022.841447/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/06230d8f61374086afc8f77f85184e25

Single-cell transcriptomics of lung organoids

Authors: Ye Na Song, Man Ryul Lee

Source: Organoid, Vol 1 (2021)

Subject Terms: single cell mrna sequencing, organoid, lung organoid, Biotechnology, TP248.13-248.65, Miscellaneous systems and treatments, RZ409.7-999

File Description: electronic resource

Relation: http://j-organoid.org/upload/pdf/organoid-2021-1-e9.pdf; https://doaj.org/toc/2765-205X

Access URL: https://doaj.org/article/94deaf8be726408293b6c9fd4d146e5c

Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

Authors: Courtney Tindle, MacKenzie Fuller, Ayden Fonseca, Sahar Taheri, Stella-Rita Ibeawuchi, Nathan Beutler, Gajanan Dattatray Katkar, Amanraj Claire, Vanessa Castillo, Moises Hernandez, Hana Russo, Jason Duran, Laura E Crotty Alexander, Ann Tipps, Grace Lin, Patricia A Thistlethwaite, Ranajoy Chattopadhyay, Thomas F Rogers, Debashis Sahoo, Pradipta Ghosh, Soumita Das

Source: eLife, Vol 10 (2021)

Subject Terms: lung organoid, SARS-CoV2, disease modeling, computational, immune response, AT2 differentiation, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/66417; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/a2f6ea2e6df643eab8feb143e8860634

Rho-Kinase 1/2 Inhibition Prevents Transforming Growth Factor-β-Induced Effects on Pulmonary Remodeling and Repair

Authors: Xinhui Wu, Vicky Verschut, Manon E. Woest, John-Poul Ng-Blichfeldt, Ana Matias, Gino Villetti, Alessandro Accetta, Fabrizio Facchinetti, Reinoud Gosens, Loes E. M. Kistemaker

Source: Frontiers in Pharmacology, Vol 11 (2021)

Subject Terms: pulmonary remodeling, lung repair, rock inhibition, lung organoid, TGFβ signaling, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2020.609509/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/f521fbe6701e4e26ac42b4ff7c85f16c

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