Reverse mutational scanning of SARS-CoV-2 spike BA.2.86 identifies epitopes contributing to immune escape from polyclonal sera

Authors: Najat Bdeir, Tatjana Lüddecke, Henrike Maaß, Stefan Schmelz, Ulfert Rand, Henning Jacobsen, Kristin Metzdorf, Upasana Kulkarni, Anne Cossmann, Metodi V. Stankov, Markus Hoffmann, Stefan Pöhlmann, Wulf Blankenfeldt, Alexandra Dopfer-Jablonka, Georg M. N. Behrens, Luka Čičin-Šain

Source: Nature Communications, Vol 16, Iss 1, Pp 1-13 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3d3104dd41e146c385b0310f75f97917

Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants

Authors: Henrike Maaß, Mario Ynga-Durand, Marko Milošević, Fran Krstanović, Marina Pribanić Matešić, Iva Žuža, Stipan Jonjić, Ilija Brizić, Alan Šustić, Frank Bloos, SepNet Critical Care Trials Group, Alen Protić, Luka Čičin-Šain

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: COVID-19, SARS-CoV-2, Cytokines, Biomarker, Variant of concern, Mortality, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/2bf62f4f5341406d88242e2d97a7f80d

A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants

Authors: Kristin Metzdorf, Henning Jacobsen, Yeonsu Kim, Luiz Gustavo Teixeira Alves, Upasana Kulkarni, Maja Cokarić Brdovčak, Jelena Materljan, Kathrin Eschke, M. Zeeshan Chaudhry, Markus Hoffmann, Federico Bertoglio, Maximilian Ruschig, Michael Hust, Marko Šustić, Astrid Krmpotić, Stipan Jonjić, Marek Widera, Sandra Ciesek, Stefan Pöhlmann, Markus Landthaler, Luka Čičin-Šain

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: SARS-CoV-2, COVID-19, MCMV, vaccination, single-dose, long-lasting protection, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1383086/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/ff2f6e1930ef4cf194f3fd3eb6aefaa4

Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cells

Authors: Bibiana Costa, Jennifer Becker, Tobias Krammer, Felix Mulenge, Verónica Durán, Andreas Pavlou, Olivia Luise Gern, Xiaojing Chu, Yang Li, Luka Čičin-Šain, Britta Eiz-Vesper, Martin Messerle, Lars Dölken, Antoine-Emmanuel Saliba, Florian Erhard, Ulrich Kalinke

Source: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7e57f2fc99c0427a90c6d097bb173ff7

Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo

Authors: Katarzyna M. Sitnik, Fran Krstanović, Natascha Gödecke, Ulfert Rand, Tobias Kubsch, Henrike Maaß, Yeonsu Kim, Ilija Brizić, Luka Čičin-Šain

Source: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/420af61a8cd44f1fa7f5b9f132fd1f4a

Učinci i sigurnosni profil dječjih cjepiva u svijetlu bioloških temelja imunološke reakcije

Authors: Luka Čičin-Šain

Source: Liječnički vjesnik, Vol 145, Iss Supp 5, Pp 7-10 (2023)

Subject Terms: CIJEPLJENJE, CJEPIVO, KALENDAR CIJEPLJENJA, IMUNI ODGOVOR, IMUNOLOŠKA ZAŠTITA, INFEKCIJA, Medicine (General), R5-920

File Description: electronic resource

Relation: https://hrcak.srce.hr/file/445808; https://doaj.org/toc/0024-3477; https://doaj.org/toc/1849-2177

Access URL: https://doaj.org/article/37d0f003f99a433f98f6ce2fb7c826c2

Systematical assessment of the impact of single spike mutations of SARS-CoV-2 Omicron sub-variants on the neutralization capacity of post-vaccination sera

Authors: Maeva Katzmarzyk, Denise Christine Clesle, Joop van den Heuvel, Markus Hoffmann, Henk Garritsen, Stefan Pöhlmann, Henning Jacobsen, Luka Čičin-Šain

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: SARS-CoV-2, antibody, omicron, COVID-19, neutralizing antibodies, spike protein, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1288794/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0d555094971546a5b1a66768eead924e

Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant

Authors: Maren Schubert, Federico Bertoglio, Stephan Steinke, Philip Alexander Heine, Mario Alberto Ynga-Durand, Henrike Maass, Josè Camilla Sammartino, Irene Cassaniti, Fanglei Zuo, Likun Du, Janin Korn, Marko Milošević, Esther Veronika Wenzel, Fran Krstanović, Saskia Polten, Marina Pribanić-Matešić, Ilija Brizić, Fausto Baldanti, Lennart Hammarström, Stefan Dübel, Alan Šustić, Harold Marcotte, Monika Strengert, Alen Protić, Antonio Piralla, Qiang Pan-Hammarström, Luka Čičin-Šain, Michael Hust

Source: BMC Medicine, Vol 20, Iss 1, Pp 1-11 (2022)

Subject Terms: SARS-CoV-2, Omicron variant (B.1.1.529), Delta variant (B.1.617.2), Beta variant (B.1.351), Vaccination, Antibody titer, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7015

Access URL: https://doaj.org/article/17cb75193cfc490592a6d9de927249e9

Evaluation of the Neutralizing Antibody STE90-C11 against SARS-CoV-2 Delta Infection and Its Recognition of Other Variants of Concerns

Authors: Leila Abassi, Federico Bertoglio, Željka Mačak Šafranko, Thomas Schirrmann, Marina Greweling-Pils, Oliver Seifert, Fawad Khan, Maeva Katzmarzyk, Henning Jacobsen, Natascha Gödecke, Philip Alexander Heine, André Frenzel, Helena Nowack, Stefan Dübel, Ivan-Christian Kurolt, Roland E. Kontermann, Alemka Markotić, Maren Schubert, Michael Hust, Luka Čičin-Šain

Source: Viruses, Vol 15, Iss 11, p 2153 (2023)

Subject Terms: SARS-CoV-2, monoclonal antibody, Delta variant, mice experiments, intravenous administration, intranasal administration, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/15/11/2153; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/077b33dc2676465b9909db3b22cbe422

Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection

Authors: Joern Pezoldt, Carolin Wiechers, Florian Erhard, Ulfert Rand, Tanja Bulat, Michael Beckstette, Andrea Brendolan, Jochen Huehn, Ulrich Kalinke, Mathias Mueller, Birgit Strobl, Bart Deplancke, Luka Čičin-Šain, Katarzyna M. Sitnik

Source: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/a39bfb883b614159a6fc0d605a03133d

Post-vaccination T cell immunity to omicron

Authors: Henning Jacobsen, Viviana Cobos Jiménez, Ioannis Sitaras, Naor Bar-Zeev, Luka Čičin-Šain, Melissa M. Higdon, Maria Deloria-Knoll

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: SARS-CoV-2, omicron, T cell, COVID-19, vaccine, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.944713/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/162c600843eb43e282bea3fe78c7698c

SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface

Authors: Federico Bertoglio, Doris Meier, Nora Langreder, Stephan Steinke, Ulfert Rand, Luca Simonelli, Philip Alexander Heine, Rico Ballmann, Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Maximilian Ruschig, Peggy Riese, Kathrin Eschke, Yeonsu Kim, Dorina Schäckermann, Mattia Pedotti, Philipp Kuhn, Susanne Zock-Emmenthal, Johannes Wöhrle, Normann Kilb, Tobias Herz, Marlies Becker, Martina Grasshoff, Esther Veronika Wenzel, Giulio Russo, Andrea Kröger, Linda Brunotte, Stephan Ludwig, Viola Fühner, Stefan Daniel Krämer, Stefan Dübel, Luca Varani, Günter Roth, Luka Čičin-Šain, Maren Schubert, Michael Hust

Source: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0dc5d5dbf361487e9f729846cf72c808

TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection

Authors: Kristin Metzdorf, Henning Jacobsen, Marina C. Greweling-Pils, Markus Hoffmann, Tatjana Lüddecke, Felicitas Miller, Lars Melcher, Amy M. Kempf, Inga Nehlmeier, Dunja Bruder, Marek Widera, Sandra Ciesek, Stefan Pöhlmann, Luka Čičin-Šain

Source: Viruses, Vol 15, Iss 2, p 271 (2023)

Subject Terms: SARS-CoV-2, COVID-19, Omicron variant (B.1.1.529), Beta variant (B.1.351), transmembrane serine protease TMPRSS2, mouse, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/15/2/271; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/4f1096b942ec4b998af992c93448d0a4

Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo

Authors: Johannes Schwerk, Lucas Kemper, Kendra A. Bussey, Stefan Lienenklaus, Siegfried Weiss, Luka Čičin-Šain, Andrea Kröger, Ulrich Kalinke, Christopher M. Collins, Samuel H. Speck, Martin Messerle, Dagmar Wirth, Melanie M. Brinkmann, Hansjörg Hauser, Mario Köster

Source: Pathogens, Vol 11, Iss 12, p 1554 (2022)

Subject Terms: murine gammaherpesvirus 68, latency, chronic infection, type I interferon, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-0817/11/12/1554; https://doaj.org/toc/2076-0817

Access URL: https://doaj.org/article/2db1caf9db6a4ebcb475422ae96a09da

A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2-RBD interface and is tolerant to most known RBD mutations

Authors: Federico Bertoglio, Viola Fühner, Maximilian Ruschig, Philip Alexander Heine, Leila Abassi, Thomas Klünemann, Ulfert Rand, Doris Meier, Nora Langreder, Stephan Steinke, Rico Ballmann, Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Philipp Kuhn, Peggy Riese, Dorina Schäckermann, Janin Korn, Allan Koch, M. Zeeshan Chaudhry, Kathrin Eschke, Yeonsu Kim, Susanne Zock-Emmenthal, Marlies Becker, Margitta Scholz, Gustavo Marçal Schmidt Garcia Moreira, Esther Veronika Wenzel, Giulio Russo, Hendrikus S.P. Garritsen, Sebastian Casu, Andreas Gerstner, Günter Roth, Julia Adler, Jakob Trimpert, Andreas Hermann, Thomas Schirrmann, Stefan Dübel, André Frenzel, Joop Van den Heuvel, Luka Čičin-Šain, Maren Schubert, Michael Hust

Source: Cell Reports, Vol 36, Iss 4, Pp 109433- (2021)

Subject Terms: SARS-CoV-2, RBD, spike protein, neutralizing antibody, recombinant antibody, phage display, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124721008500; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/9c2876f60a3849cc9e53afa0c2d3362e

SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes

Authors: Mario Ynga-Durand, Henrike Maaß, Marko Milošević, Fran Krstanović, Marina Pribanić Matešić, Stipan Jonjić, Alen Protić, Ilija Brizić, Alan Šustić, Luka Čičin-Šain

Source: Viruses, Vol 14, Iss 6, p 1292 (2022)

Subject Terms: SARS-CoV-2, COVID-19, bronchoalveolar lavage, qPCR, critical care, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/14/6/1292; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/16ca6a6146fd479e981652605999713e

ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike Protein

Authors: Rico Ballmann, Sven-Kevin Hotop, Federico Bertoglio, Stephan Steinke, Philip Alexander Heine, M. Zeeshan Chaudhry, Dieter Jahn, Boas Pucker, Fausto Baldanti, Antonio Piralla, Maren Schubert, Luka Čičin-Šain, Mark Brönstrup, Michael Hust, Stefan Dübel

Source: Viruses, Vol 14, Iss 6, p 1326 (2022)

Subject Terms: phage display, epitope mapping, COVID-19, genomic library, NGS, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/14/6/1326; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/aadd3be5d75441b3b13f8e9dfa31b510

Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge.

Authors: Xiaoyan Zheng, Jennifer D Oduro, Julia D Boehme, Lisa Borkner, Thomas Ebensen, Ulrike Heise, Marcus Gereke, Marina C Pils, Astrid Krmpotic, Carlos A Guzmán, Dunja Bruder, Luka Čičin-Šain

Source: PLoS Pathogens, Vol 15, Iss 9, p e1008036 (2019)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/bbbbac79bb5e46d5b4bf390c64deb093

Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia.

Authors: Nico A Contreras, Katarzyna M Sitnik, Ilija Jeftic, Christopher Patrick Coplen, Luka Čičin-Šain, Janko Nikolich-Žugich

Source: PLoS Pathogens, Vol 15, Iss 6, p e1007890 (2019)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/5eef8eb7552d4b8aa5703a3be1ffbb5f

The viral context instructs the redundancy of costimulatory pathways in driving CD8+ T cell expansion

Authors: Suzanne PM Welten, Anke Redeker, Kees LMC Franken, Jennifer D Oduro, Ferry Ossendorp, Luka Čičin-Šain, Cornelis JM Melief, Peter Aichele, Ramon Arens

Source: eLife, Vol 4 (2015)

Subject Terms: t cell, costimulation, viral infection, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/07486; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/5ca7fa33603a4397bda0b3f5c14a5774