Pharmacological inhibition of CDK4/6 impairs diffuse pleural mesothelioma 3D spheroid growth and reduces viability of cisplatin-resistant cells

Authors: Aurora Costa, Iris Maria Forte, Francesca Pentimalli, Carmelina Antonella Iannuzzi, Luigi Alfano, Francesca Capone, Rosa Camerlingo, Alessandra Calabrese, Claudia von Arx, Reyes Benot Dominguez, Massimiliano Quintiliani, Michelino De Laurentiis, Andrea Morrione, Antonio Giordano

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: diffuse pleural mesothelioma (DPM), cyclin-dependent kinases inhibitors (CDKi), cell cycle, precision medicine, cisplatin, synergism, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1418951/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/b853fb46d9b3462d81cf3795b07f7ee6

The hydrophilic extract from a new tomato genotype (named DHO) kills cancer cell lines through the modulation of the DNA damage response induced by Campthotecin treatment

Authors: Daniela Barone, Carmelina Antonella Iannuzzi, Iris Maria Forte, Maria Carmen Ragosta, Maria Cuomo, Milena Dell’Aquila, Angela Altieri, Antonella Caporaso, Rosa Camerlingo, Maria Manuela Rigano, Daria Maria Monti, Amalia Barone, Paola Imbimbo, Luigi Frusciante, Marcellino Monda, Margherita D’Angelo, Michelino De Laurentiis, Antonio Giordano, Luigi Alfano

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: DNA damage response, Solanum lycopersicum, homologous recombination, DNA repair, single strand annealing, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1117262/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/d8120edf9fa24bd2b25af9a7fb9d0a19

HSP90 identified by a proteomic approach as druggable target to reverse platinum resistance in ovarian cancer

Authors: Rita Lombardi, Maura Sonego, Biagio Pucci, Laura Addi, Federica Iannelli, Francesca Capone, Luigi Alfano, Maria Serena Roca, Maria Rita Milone, Tania Moccia, Alice Costa, Elena Di Gennaro, Francesca Bruzzese, Gustavo Baldassarre, Alfredo Budillon

Source: Molecular Oncology, Vol 15, Iss 4, Pp 1005-1023 (2021)

Subject Terms: cisplatin, drug resistance, HSP90, ovarian cancer, proteomics, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/b460b33c2f544783a77170d47c26337c

CDK9 inhibitors in acute myeloid leukemia

Authors: Silvia Boffo, Angela Damato, Luigi Alfano, Antonio Giordano

Source: Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-10 (2018)

Subject Terms: Acute myeloid leukemia, CDK9 inhibitor, Positive transcription elongation factor b, P-TEFb, MCL-1, MYC, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13046-018-0704-8; https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/f4ba7ae22b094ca89d4f67a1d853376c