Development of Machine Learning Classifiers for Blood-based Diagnosis and Prognosis of Suspected Acute Infections and Sepsis

Authors: Buturovic, Ljubomir, Mayhew, Michael, Luethy, Roland, Choi, Kirindi, Midic, Uros, Damaraju, Nandita, Hasin-Brumshtein, Yehudit, Pratap, Amitesh, Adams, Rhys M., Fonseca, Joao, Srinath, Ambika, Fleming, Paul, Pereira, Claudia, Liesenfeld, Oliver, Khatri, Purvesh, Sweeney, Timothy

Subject Terms: Quantitative Biology - Quantitative Methods, Computer Science - Machine Learning

Access URL: http://arxiv.org/abs/2407.02737

Optimization of Genomic Classifiers for Clinical Deployment: Evaluation of Bayesian Optimization to Select Predictive Models of Acute Infection and In-Hospital Mortality

Authors: Mayhew, Michael B., Tran, Elizabeth, Choi, Kirindi, Midic, Uros, Luethy, Roland, Damaraju, Nandita, Buturovic, Ljubomir

Subject Terms: Computer Science - Machine Learning, Quantitative Biology - Quantitative Methods, Statistics - Machine Learning, J.3, I.2.6, I.2.1

Access URL: http://arxiv.org/abs/2003.12310

Prospective validation of a transcriptomic severity classifier among patients with suspected acute infection and sepsis in the emergency department

Authors: Galtung, Noa, Diehl-Wiesenecker, Eva, Lehmann, Dana, Markmann, Natallia, Bergström, Wilma H., Wacker, James, Liesenfeld, Oliver, Mayhew, Michael, Buturovic, Ljubomir, Luethy, Roland, Sweeney, Timothy E., Tauber, Rudolf, Kappert, Kai, Somasundaram, Rajan, Bauer, Wolfgang

Source: European journal of emergency medicine. 29(5):357-365

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179825833.0x000001&indx=1&recIds=ETOCvdc_100179825833.0x000001

A Novel 29-Messenger RNA Host-Response Assay From Whole Blood Accurately Identifies Bacterial and Viral Infections in Patients Presenting to the Emergency Department With Suspected Infections: A Prospective Observational Study*

Authors: Bauer, Wolfgang, Kappert, Kai, Galtung, Noa, Lehmann, Dana, Wacker, James, Cheng, Henry K., Liesenfeld, Oliver, Buturovic, Ljubomir, Luethy, Roland, Sweeney, Timothy E., Tauber, Rudolf, Somasundaram, Rajan

Source: Critical care medicine. 49(10):1664-1673

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188857659.0x000001&indx=1&recIds=ETOCvdc_100188857659.0x000001

A generalizable 29-mRNA neural-network classifier for acute bacterial and viral infections

Authors: Mayhew, Michael B., Buturovic, Ljubomir, Luethy, Roland, Midic, Uros, Moore, Andrew R., Roque, Jonasel A., Shaller, Brian D., Asuni, Tola, Rawling, David, Remmel, Melissa, Choi, Kirindi, Wacker, James, Khatri, Purvesh, Rogers, Angela J., Sweeney, Timothy E.

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164270726.0x000001&indx=1&recIds=ETOCvdc_100164270726.0x000001

A Method to Identify Protein Sequences that Fold into a Known Three- Dimensional Structure

Authors: Bowie, James U., Lüthy, Roland, Eisenberg, David

Source: Science, 1991 Jul 01. 253(5016), 164-170.

Access URL: https://www.jstor.org/stable/2878692

Stochastic Response of Human Blood Platelets to Stimulation of Shape Changes and Secretion

Authors: Deranleau, David A., Lüthy, Roland, Lüscher, Ernst F.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1986 Apr 01. 83(7), 2076-2080.

Access URL: https://www.jstor.org/stable/27141

Community Assessment of the Predictability of Cancer Protein and Phosphoprotein Levels from Genomics and Transcriptomics

Authors: Aderinwale, Tunde, Afyounian, Ebrahim, Agrawal, Piyush, Ali, Mehreen, Amadoz, Alicia, Azuaje, Francisco, Bachman, John, Bae, Seohui, Bhalla, Sherry, Carbonell-Caballero, José, Chakraborty, Priyanka, Chaudhary, Kumardeep, Choi, Yonghwa, Choi, Yoonjung, Çubuk, Cankut, Dhanda, Sandeep Kumar, Dopazo, Joaquín, Elo, Laura L., Fóthi, Ábel, Gevaert, Olivier, Granberg, Kirsi, Greiner, Russell, Heo, Eunji, Hidalgo, Marta R., Jayaswal, Vivek, Jeon, Hwisang, Jeon, Minji, Kalmady, Sunil V., Kambara, Yasuhiro, Kang, Jaewoo, Kang, Keunsoo, Kaoma, Tony, Kaur, Harpreet, Kazan, Hilal, Kesar, Devishi, Kesseli, Juha, Kim, Daehan, Kim, Keonwoo, Kim, Sang-Yoon, Kim, Sunkyu, Kumar, Sajal, Lee, Bora, Lee, Heewon, Liu, Yunpeng, Luethy, Roland, Mahajan, Swapnil, Mahmoudian, Mehrad, Muller, Arnaud, Nazarov, Petr V., Nguyen, Hien, Nykter, Matti, Okuda, Shujiro, Park, Sungsoo, Pal Singh Raghava, Gajendra, Rajapakse, Jagath C., Rantapero, Tommi, Ryu, Hobin, Salavert, Francisco, Saraei, Sohrab, Sharma, Ruby, Siitonen, Ari, Sokolov, Artem, Subramanian, Kartik, Suni, Veronika, Suomi, Tomi, Tranchevent, Léon-Charles, Usmani, Salman Sadullah, Välikangas, Tommi, Vega, Roberto, Zhong, Hua, Yang, Mi, Petralia, Francesca, Li, Zhi, Li, Hongyang, Ma, Weiping, Song, Xiaoyu, Yu, Han, Kaczmarczyk, Jan, Stępniak, Piotr, Warchoł, Michał, Yu, Thomas, Calinawan, Anna P., Boutros, Paul C., Payne, Samuel H., Reva, Boris, Boja, Emily, Rodriguez, Henry, Stolovitzky, Gustavo, Guan, Yuanfang, Wang, Pei, Fenyö, David, Saez-Rodriguez, Julio

Source: In Cell Systems 26 August 2020 11(2):186-195

Secreted Epithelial Stromal-1 Molecules and Uses Thereof

Secreted epithelial colon stromal-1 molecules and uses thereof

Secreted epithelial colon stromal-1 molecules and uses thereof

Secreted epithelial colon stromal-1 molecules and uses thereof

Fibroblast Growth Factor-23 molecules and uses thereof

TNFr/OPG-like molecules and uses thereof

Nucleic encoding interleukin-1 receptor antagonist-like proteins and uses thereof

Agouti-related proteins

Hardware and software systems for accelerating common bioinformatics sequence analysis algorithms

Authors: Luethy, Roland, Hoover, Christopher

Source: In Drug Discovery Today: Biosilico 2004 2(1):12-17

A 6-mRNA host response classifier in whole blood predicts outcomes in COVID-19 and other acute viral infections.

Authors: Buturovic, Ljubomir, Zheng, Hong, Tang, Benjamin, Lai, Kevin, Kuan, Win Sen, Gillett, Mark, Santram, Rahul, Shojaei, Maryam, Almansa, Raquel, Nieto, Jose Ángel, Muñoz, Sonsoles, Herrero, Carmen, Antonakos, Nikolaos, Koufargyris, Panayiotis, Kontogiorgi, Marina, Damoraki, Georgia, Liesenfeld, Oliver, Wacker, James, Midic, Uros, Luethy, Roland

Source: Scientific Reports; 1/18/2022, Vol. 12 Issue 1, p1-16, 16p

Subject Terms: COVID-19, MESSENGER RNA, GENE amplification, RESPIRATORY insufficiency, VIRUS diseases, INFLUENZA, LOGISTIC regression analysis, GENE expression

Genes encoding art, an agouti-related transcript

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