Entinostat in combination with nivolumab in metastatic pancreatic ductal adenocarcinoma: a phase 2 clinical trial

Authors: Marina Baretti, Ludmila Danilova, Jennifer N. Durham, Courtney B. Betts, Leslie Cope, Dimitrios N. Sidiropoulos, Joseph A. Tandurella, Soren Charmsaz, Nicole Gross, Alexei Hernandez, Won Jin Ho, Chris Thoburn, Rosalind Walker, James Leatherman, Sarah Mitchell, Brian Christmas, Ali Saeed, Daria A. Gaykalova, Srinivasan Yegnasubramanian, Elana J. Fertig, Lisa M. Coussens, Mark Yarchoan, Elizabeth Jaffee, Nilofer S. Azad

Source: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/da588e36b348473cb1c930008d58747b

Pan-tumor analysis to investigate the obesity paradox in immune checkpoint blockade

Authors: Evan J Lipson, Ludmila Danilova, Elizabeth M Jaffee, Won Jin Ho, Mark Yarchoan, Yasser Ged, Jean Hoffman-Censits, Jennifer Durham, Sanjay Bansal, Chester Kao, Rajat Mohindra, Stephanie L Alden, Tanguy Y Seiwert, Soren Charmsaz, Howard L Li, Kabeer Munjal, Hua-Ling Tsai, Alexei Hernandez, Erin M Coyne, Rachel Garonce-Hediger, Laura Tang, Marina Baretti, Kathryn Howe, G Scott Chandler, Madelena Brancati, Aanika Warner, Ervin Griffin, Mari Nakazawa, Chris Thoburn, Jennifer Gizzi, Nicole E Gross, Elsa Hallab, Sarah S Shin, Aditi Guha

Source: Journal for ImmunoTherapy of Cancer, Vol 13, Iss 1 (2025)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/13/1/e009734.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/8ab53f7c952740e698a3b24ac7e22152

Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence

Authors: Shuming Zhang, Long Yuan, Ludmila Danilova, Guanglan Mo, Qingfeng Zhu, Atul Deshpande, Alexander T. F. Bell, Jennifer Elisseeff, Aleksander S. Popel, Robert A. Anders, Elizabeth M. Jaffee, Mark Yarchoan, Elana J. Fertig, Luciane T. Kagohara

Source: Genome Medicine, Vol 15, Iss 1, Pp 1-14 (2023)

Subject Terms: Hepatocellular carcinoma, Spatial transcriptomics, Therapeutic resistance, Neoadjuvant therapy, Immunotherapy, Tumor recurrence, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/098a7d924d184c9b829632f226e3bd36

Myo1e overexpression in lung adenocarcinoma is associated with increased risk of mortality

Authors: Ignacio Jusue-Torres, Richies Tiv, Julio C. Ricarte-Filho, Apurva Mallisetty, Leglys Contreras-Vargas, Maria Jose Godoy-Calderon, Karam Khaddour, Kathleen Kennedy, Klara Valyi-Nagy, Odile David, Martha Menchaca, Anastasia Kottorou, Angelos Koutras, Foteinos Dimitrakopoulos, Khaled M. Abdelhady, Malek Massad, Israel Rubinstein, Lawrence Feldman, John Stewart, Takeshi Shimamura, Ludmila Danilova, Alicia Hulbert

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/bf62664e03204d8c9dafc226379352b8

1245 Th17 and Type 2 CD8+ cytokine signatures predict irAEs in solid tumors

Authors: Evan J Lipson, Jarushka Naidoo, Julie Brahmer, Ludmila Danilova, Elizabeth M Jaffee, Won Jin Ho, Mark Yarchoan, Maximilian F Konig, Yasser Ged, Jean Hoffman-Censits, Jennifer Durham, Laura Cappelli, Sanjay Bansal, Aanika Balaji, Rajat Mohindra, Stephanie L Alden, Tanguy Y Seiwert, Chester J Kao, Soren Charmsaz, Madalena Brancati, Howard L Li, Kabeer Munjal, Hua-Ling Tsai, Alexei Hernandez, Nicole Gross, Erin M Coyne, Sarah M Shin, Brian Christmas, Christopher Thoburn, Marina Barretti, Rachel Garonce-Hediger, Laura Tang, G Scott Chandler

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/9ecf458f7da7428ea7c6e82123a0c044

1484 An interplay between innate/adaptive/humoral immunity leads to increased immunogenicity of melanoma vs. non-melanoma derived brain metastases

Authors: Kim Margolin, Ludmila Danilova, Maria L Ascierto, Russell C Rockne, Alberto Mendoza Valderrey, Daria M Kessler, Douglas A Hanes, Ethan Dettmann, Kai Rau, Yueqin Quan, Stacey Stern, Daniel F Kelly, Garni Barkhoudarian, Steven E Kolker

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/af0d3217472749ba8d69e85e7db44f50

222-N Analysis of pathologic features and efficacy outcomes with neoadjuvant nivolumab plus platinum-doublet chemotherapy for resectable non-small cell lung cancer in CheckMate 816

Authors: Keith M Kerr, Elizabeth Thompson, Mariano Provencio, Patrick M Forde, Jaclyn Neely, Ashley Cimino-Mathews, Ludmila Danilova, Daphne Wang, Robert A Anders, Tricia R Cottrell, Nicolas Girard, Janis Taube, Peter Illei, Junliang Cai, Joel Sunshine, Julie Stein Deutsch, Jonathan Spicer, Edward Gabrielson, Jaroslaw Jedrych, Mia Tran, Judy Bushong, Vipul Devas, David Balli, Alex S Baras

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/b726db52c75b450c81413c801ce2dbf2

DNA-methylation for the detection and distinction of 19 human malignancies

Authors: Ludmila Danilova, John Wrangle, James G. Herman, Leslie Cope

Source: Epigenetics, Vol 17, Iss 2, Pp 191-201 (2022)

Subject Terms: dna methylation, random forest, tcga, cancer diagnosis, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308

Access URL: https://doaj.org/article/58daba9259c643ea8da3f38b15c66f5d

Integrated T cell cytometry metrics for immune-monitoring applications in immunotherapy clinical trials

Authors: Dimitrios N. Sidiropoulos, Genevieve L. Stein-O’Brien, Ludmila Danilova, Nicole E. Gross, Soren Charmsaz, Stephanie Xavier, James Leatherman, Hao Wang, Mark Yarchoan, Elizabeth M. Jaffee, Elana J. Fertig, Won Jin Ho

Source: JCI Insight, Vol 7, Iss 19 (2022)

Subject Terms: Immunology, Oncology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/16cb3e58e1f7450682ee64a8668cb44a

Transfer learning between preclinical models and human tumors identifies a conserved NK cell activation signature in anti-CTLA-4 responsive tumors

Authors: Emily F. Davis-Marcisak, Allison A. Fitzgerald, Michael D. Kessler, Ludmila Danilova, Elizabeth M. Jaffee, Neeha Zaidi, Louis M. Weiner, Elana J. Fertig

Source: Genome Medicine, Vol 13, Iss 1, Pp 1-22 (2021)

Subject Terms: Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/80075777f0424f8d9407c33875af4fe0

Multi-omic profiling of lung and liver tumor microenvironments of metastatic pancreatic cancer reveals site-specific immune regulatory pathways

Authors: Won Jin Ho, Rossin Erbe, Ludmila Danilova, Zaw Phyo, Emma Bigelow, Genevieve Stein-O’Brien, Dwayne L. Thomas, Soren Charmsaz, Nicole Gross, Skylar Woolman, Kayla Cruz, Rebecca M. Munday, Neeha Zaidi, Todd D. Armstrong, Marcelo B. Sztein, Mark Yarchoan, Elizabeth D. Thompson, Elizabeth M. Jaffee, Elana J. Fertig

Source: Genome Biology, Vol 22, Iss 1, Pp 1-23 (2021)

Subject Terms: Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/4cd9bd7ed8eb40259c3e0e809f852646

Chromatin structure regulates cancer-specific alternative splicing events in primary HPV-related oropharyngeal squamous cell carcinoma

Authors: Theresa Guo, Kristina Diana A. Zambo, Fernando T. Zamuner, Tingting Ou, Christopher Hopkins, Dylan Z. Kelley, Hildegard A. Wulf, Eli Winkler, Rossin Erbe, Ludmila Danilova, Michael Considine, David Sidransky, Alexander Favorov, Liliana Florea, Elana J. Fertig, Daria A. Gaykalova

Source: Epigenetics, Vol 15, Iss 9, Pp 959-971 (2020)

Subject Terms: human papillomavirus, oropharyngeal cancer, alternative splicing, super-enhancers, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308

Access URL: https://doaj.org/article/79cc2062bbdf4787af9bc92b175c4901

PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies

Authors: Malabika Sen, Audrey Kindsfather, Ludmila Danilova, Feng Zhang, Raffaele Colombo, Matthew G. LaPorte, Brenda F. Kurland, Donna M. Huryn, Peter Wipf, James G. Herman

Source: Epigenetics, Vol 15, Iss 6-7, Pp 604-617 (2020)

Subject Terms: ptprt methylation, stat3, non-small cell lung cancer, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308

Access URL: https://doaj.org/article/333860db35804967959dcc5164891d1b

Supervised mutational signatures for obesity and other tissue-specific etiological factors in cancer

Authors: Bahman Afsari, Albert Kuo, YiFan Zhang, Lu Li, Kamel Lahouel, Ludmila Danilova, Alexander Favorov, Thomas A Rosenquist, Arthur P Grollman, Ken W Kinzler, Leslie Cope, Bert Vogelstein, Cristian Tomasetti

Source: eLife, Vol 10 (2021)

Subject Terms: mutational signature, somatic mutations, obesity, environmental exposures, carcinogens, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/61082; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/eb75fd97d7114fa0ba902af179400db3

Extracellular Vesicles Released by Tumor Endothelial Cells Spread Immunosuppressive and Transforming Signals Through Various Recipient Cells

Authors: Tatiana Lopatina, Enrica Favaro, Ludmila Danilova, Elana J. Fertig, Alexander V. Favorov, Luciane T. Kagohara, Tiziana Martone, Benedetta Bussolati, Renato Romagnoli, Roberto Albera, Giancarlo Pecorari, Maria Felice Brizzi, Giovanni Camussi, Daria A. Gaykalova

Source: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Subject Terms: extracellular vesicles, tumor endothelial cells, tumor immune editing, T regulatory (T reg) cells, head and neck cancer, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcell.2020.00698/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/3f57d57f6592444bb1d03d52e863e046

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

Authors: Kellie N. Smith, Nicolas J. Llosa, Tricia R. Cottrell, Nicholas Siegel, Hongni Fan, Prerna Suri, Hok Yee Chan, Haidan Guo, Teniola Oke, Anas H. Awan, Franco Verde, Ludmila Danilova, Valsamo Anagnostou, Ada J. Tam, Brandon S. Luber, Bjarne R. Bartlett, Laveet K. Aulakh, John-William Sidhom, Qingfeng Zhu, Cynthia L. Sears, Leslie Cope, William H. Sharfman, Elizabeth D. Thompson, Joanne Riemer, Kristen A. Marrone, Jarushka Naidoo, Victor E. Velculescu, Patrick M. Forde, Bert Vogelstein, Kenneth W. Kinzler, Nickolas Papadopoulos, Jennifer N. Durham, Hao Wang, Dung T. Le, Sune Justesen, Janis M. Taube, Luis A. Diaz, Julie R. Brahmer, Drew M. Pardoll, Robert A. Anders, Franck Housseau

Source: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-8 (2019)

Subject Terms: Checkpoint blockade, Predictive biomarkers, Oncogene, Neoantigens, T cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40425-018-0492-x; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/1bbf8602f6f8428183fdc7d49f984cca

Viral status, immune microenvironment and immunological response to checkpoint inhibitors in hepatocellular carcinoma

Authors: Hao Wang, Elizabeth Jaffee, Ludmila Danilova, James M Leatherman, Won Jin Ho, Mark Yarchoan, Su Jin Lim, Rohan Verma, Stephanie Xavier, Marcelo B Sztein, Elana J Fertig

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/8/1/e000394.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/9037bcadd9db4dd9b7f4a8059d5a8348

Multidimensional, quantitative assessment of PD-1/PD-L1 expression in patients with Merkel cell carcinoma and association with response to pembrolizumab

Authors: Nicolas A. Giraldo, Peter Nguyen, Elizabeth L. Engle, Genevieve J. Kaunitz, Tricia R. Cottrell, Sneha Berry, Benjamin Green, Abha Soni, Jonathan D. Cuda, Julie E. Stein, Joel C. Sunshine, Farah Succaria, Haiying Xu, Aleksandra Ogurtsova, Ludmila Danilova, Candice D. Church, Natalie J. Miller, Steve Fling, Lisa Lundgren, Nirasha Ramchurren, Jennifer H. Yearley, Evan J. Lipson, Mac Cheever, Robert A. Anders, Paul T. Nghiem, Suzanne L. Topalian, Janis M. Taube

Source: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-11 (2018)

Subject Terms: PD-1, PD-L1, Merkel cell, Multispectral immunofluorescence, Pembrolizumab, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40425-018-0404-0; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/76e43af2693646548cca3682365754c1

GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer

Authors: Lorraine Pelosof, Sashidhar Yerram, Todd Armstrong, Nina Chu, Ludmila Danilova, Breann Yanagisawa, Manuel Hidalgo, Nilofer Azad, James G. Herman

Source: Epigenetics, Vol 12, Iss 7, Pp 540-550 (2017)

Subject Terms: cisplatin, colorectal cancer, gpx3, methylation, oxaliplatin, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308

Access URL: https://doaj.org/article/ef0106233e1b4f0ead57cee02a0bc36a

Correction: Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

Authors: Simeon U Springer, Chung-Hsin Chen, Maria Del Carmen Rodriguez Pena, Lu Li, Christopher Douville, Yuxuan Wang, Joshua David Cohen, Diana Taheri, Natalie Silliman, Joy Schaefer, Janine Ptak, Lisa Dobbyn, Maria Papoli, Isaac Kinde, Bahman Afsari, Aline C Tregnago, Stephania M Bezerra, Christopher VandenBussche, Kazutoshi Fujita, Dilek Ertoy, Isabela W Cunha, Lijia Yu, Trinity J Bivalacqua, Arthur P Grollman, Luis A Diaz, Rachel Karchin, Ludmila Danilova, Chao-Yuan Huang, Chia-Tung Shun, Robert J Turesky, Byeong Hwa Yun, Thomas A Rosenquist, Yeong-Shiau Pu, Ralph H Hruban, Cristian Tomasetti, Nickolas Papadopoulos, Ken W Kinzler, Bert Vogelstein, Kathleen G Dickman, George J Netto

Source: eLife, Vol 7 (2018)

Subject Terms: Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/43237; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/2a64088993e947c28fb98bda8c6de228