Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infection

Authors: Kristina Zec, Stephanie Thiebes, Jenny Bottek, Devon Siemes, Philippa Spangenberg, Duc Viet Trieu, Nils Kirstein, Nirojah Subramaniam, Robin Christ, Diana Klein, Verena Jendrossek, Maria Loose, Florian Wagenlehner, Jadwiga Jablonska, Thilo Bracht, Barbara Sitek, Bettina Budeus, Ludger Klein-Hitpass, Dirk Theegarten, Olga Shevchuk, Daniel R. Engel

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: alveolar macrophage, proteomics, bioinformatics, transcriptomics, infection, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1227191/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/23d3fe4f1c024fdb82b614f980d5c4d4

TLR2-induced CD8+ T-cell deactivation shapes dendritic cell differentiation in the bone marrow during sepsis

Authors: Anne-Charlotte Antoni, Ekaterina Pylaeva, Bettina Budeus, Jadwiga Jablonska, Ludger Klein-Hitpaß, Marcel Dudda, Stefanie B. Flohé

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: dendritic cells, differentiation, sepsis, bone marrow, T cells, immunosuppression, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.945409/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/ea97a97caf654e0795a48ce4cafce52c

Improved risk-stratification for posterior fossa ependymoma of childhood considering clinical, histological and genetic features – a retrospective analysis of the HIT ependymoma trial cohort

Authors: Stephanie T. Jünger, Martin Mynarek, Inken Wohlers, Evelyn Dörner, Anja zur Mühlen, Natalia Velez-Char, Katja von Hoff, Stefan Rutkowski, Monika Warmuth-Metz, Rolf-Dieter Kortmann, Beate Timmermann, Sven Rahmann, Ludger Klein-Hitpass, Andre O. von Bueren, Torsten Pietsch

Source: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-12 (2019)

Subject Terms: Ependymoma, Risk stratification, Posterior fossa, Genetics, Neuropathology, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40478-019-0820-5; https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/b6f10fd32cfe498ea52b2120536a0527

A Comparative Transcriptome Analysis of Human and Porcine Choroid Plexus Cells in Response to Streptococcus suis Serotype 2 Infection Points to a Role of Hypoxia

Authors: Alexa N. Lauer, Rene Scholtysik, Andreas Beineke, Christoph Georg Baums, Kristin Klose, Peter Valentin-Weigand, Hiroshi Ishikawa, Horst Schroten, Ludger Klein-Hitpass, Christian Schwerk

Source: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

Subject Terms: next generation sequencing, Streptococcus suis, meningitis, choroid plexus, host-pathogen interaction, blood-cerebrospinal fluid barrier, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2021.639620/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/1f15b0cd66be487c981aeb7ca9990747

Anti-leukemic effect of CDK9 inhibition in T-cell prolymphocytic leukemia

Authors: Patricia Johansson, Laura Dierichs, Ludger Klein-Hitpass, Anke K. Bergmann, Michael Möllmann, Sascha Menninger, Peter Habenberger, Bert Klebl, Jens T. Siveke, Ulrich Dührsen, Axel Choidas, Jan Dürig

Source: Therapeutic Advances in Hematology, Vol 11 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2040-6215

Access URL: https://doaj.org/article/dbaad95c53fa476da2bd0fedf8b2e735

Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia

Authors: Maurizio Mangolini, Frederik Götte, Andrew Moore, Tim Ammon, Madlen Oelsner, Gloria Lutzny-Geier, Ludger Klein-Hitpass, James C. Williamson, Paul J. Lehner, Jan Dürig, Michael Möllmann, Lívia Rásó-Barnett, Katherine Hughes, Antonella Santoro, Simón Méndez-Ferrer, Robert A. J. Oostendorp, Ursula Zimber-Strobl, Christian Peschel, Daniel J. Hodson, Marc Schmidt-Supprian, Ingo Ringshausen

Source: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c4f9c099f3104cabbf026773512a17d1

Regions of common inter-individual DNA methylation differences in human monocytes: genetic basis and potential function

Authors: Christopher Schröder, Elsa Leitão, Stefan Wallner, Gerd Schmitz, Ludger Klein-Hitpass, Anupam Sinha, Karl-Heinz Jöckel, Stefanie Heilmann-Heimbach, Per Hoffmann, Markus M. Nöthen, Michael Steffens, Peter Ebert, Sven Rahmann, Bernhard Horsthemke

Source: Epigenetics & Chromatin, Vol 10, Iss 1, Pp 1-18 (2017)

Subject Terms: DNA methylation, Haplotype, Genome-wide association study, Differentially methylated regions, Inter-individual variability, Allele-specific methylation, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13072-017-0144-2; https://doaj.org/toc/1756-8935

Access URL: https://doaj.org/article/b29c717003854f678a6bbf2253c68dc6

Comparison of clinical and immunological findings in gnotobiotic piglets infected with Escherichia coli O104:H4 outbreak strain and EHEC O157:H7

Authors: Bettina Wöchtl, Florian Gunzer, Wilhelm Gerner, Hagen Gasse, Michaela Koch, Zoltán Bagó, Martin Ganter, Herbert Weissenböck, Nora Dinhopl, Sina M. Coldewey, Alexandra von Altrock, Karl-Heinz Waldmann, Armin Saalmüller, Kurt Zimmermann, Jörg Steinmann, Jan Kehrmann, Ludger Klein-Hitpass, Jochen Blom, Ralf Ehricht, Ines Engelmann, Isabel Hennig-Pauka

Source: Gut Pathogens, Vol 9, Iss 1, Pp 1-18 (2017)

Subject Terms: Swine, Gnotobiotic piglets, Enteroaggregative E. coli, Enterohaemmorrhagic E. coli, Shiga toxin, Haemolytic uraemic syndrome (HUS), Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13099-017-0179-8; https://doaj.org/toc/1757-4749

Access URL: https://doaj.org/article/031960d9048645ac86ac1874ea9f1037

Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions

Authors: Antje Sucker, Fang Zhao, Natalia Pieper, Christina Heeke, Raffaela Maltaner, Nadine Stadtler, Birgit Real, Nicola Bielefeld, Sebastian Howe, Benjamin Weide, Ralf Gutzmer, Jochen Utikal, Carmen Loquai, Helen Gogas, Ludger Klein-Hitpass, Michael Zeschnigk, Astrid M. Westendorf, Mirko Trilling, Susanne Horn, Bastian Schilling, Dirk Schadendorf, Klaus G. Griewank, Annette Paschen

Source: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7dba103f7a864f4c8cb9130aa2e816d2

Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression.

Authors: Stefanie Jeruschke, Kay Jeruschke, Andrew DiStasio, Sinem Karaterzi, Anja K Büscher, Perihan Nalbant, Ludger Klein-Hitpass, Peter F Hoyer, Jürgen Weiss, Rolf W Stottmann, Stefanie Weber

Source: PLoS ONE, Vol 10, Iss 9, p e0137043 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4557973?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/a717350a9c5046bfa105ee797e497590

Osteoblast-specific Krm2 overexpression and Lrp5 deficiency have different effects on fracture healing in mice.

Authors: Astrid Liedert, Viktoria Röntgen, Thorsten Schinke, Peggy Benisch, Regina Ebert, Franz Jakob, Ludger Klein-Hitpass, Jochen K Lennerz, Michael Amling, Anita Ignatius

Source: PLoS ONE, Vol 9, Iss 7, p e103250 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4111586?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/d07ae21fecbd41798f58a7610da764ba

Progranulin is a novel independent predictor of disease progression and overall survival in chronic lymphocytic leukemia.

Authors: Maria Göbel, Lewin Eisele, Michael Möllmann, Andreas Hüttmann, Patricia Johansson, René Scholtysik, Manuela Bergmann, Raymonde Busch, Hartmut Döhner, Michael Hallek, Till Seiler, Stephan Stilgenbauer, Ludger Klein-Hitpass, Ulrich Dührsen, Jan Dürig

Source: PLoS ONE, Vol 8, Iss 8, p e72107 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3751910?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/9703eff2c92f44caa45af17aed231c40

The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors.

Authors: Peggy Benisch, Tatjana Schilling, Ludger Klein-Hitpass, Sönke P Frey, Lothar Seefried, Nadja Raaijmakers, Melanie Krug, Martina Regensburger, Sabine Zeck, Thorsten Schinke, Michael Amling, Regina Ebert, Franz Jakob

Source: PLoS ONE, Vol 7, Iss 9, p e45142 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3454401?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/204867a6e02c4dc898c79644a332f348

Epigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia.

Authors: Maher Hanoun, Lewin Eisele, Masako Suzuki, John M Greally, Andreas Hüttmann, Semra Aydin, René Scholtysik, Ludger Klein-Hitpass, Ulrich Dührsen, Jan Dürig

Source: PLoS ONE, Vol 7, Iss 3, p e34347 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22470559/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/90463603a82440d4a52cfa3953def144

A systematic analysis of the 3'UTR of HNF4A mRNA reveals an interplay of regulatory elements including miRNA target sites.

Authors: Andrea Wirsing, Sabine Senkel, Ludger Klein-Hitpass, Gerhart U Ryffel

Source: PLoS ONE, Vol 6, Iss 11, p e27438 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3227676?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/9e86a2207ac04202a17762a70d0450e2

Aging of Xenopus tropicalis eggs leads to deadenylation of a specific set of maternal mRNAs and loss of developmental potential.

Authors: Anna Kosubek, Ludger Klein-Hitpass, Katrin Rademacher, Bernhard Horsthemke, Gerhart U Ryffel

Source: PLoS ONE, Vol 5, Iss 10, p e13532 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2962626?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/df3875ffa48747ee91bcd48feefa641e

Heterogeneous in vitro effects of doxorubicin on gene expression in primary human liposarcoma cultures

Authors: Hans-Ulrich Steinau, Heinz-Herbert Homann, Jörg Hauser, Michael Chromik, Oliver Müller, Ludger Klein-Hitpass, Adrien Daigeler, Marcus Lehnhardt

Source: BMC Cancer, Vol 8, Iss 1, p 313 (2008)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.biomedcentral.com/1471-2407/8/313; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/985efda1480b4cc0acd2989d102bd939

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