Clinical characteristics, comorbidities, and correlation with advanced lipedema stages: A retrospective study from a Swiss referral centre.

Authors: Xhyljeta Luta, Giacomo Buso, Enrica Porceddu, Roxani Psychogyiou, Sanjiv Keller, Lucia Mazzolai

Source: PLoS ONE, Vol 20, Iss 3, p e0319099 (2025)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/9f5a74d7bd0143d6b72da10b0fb9a66b

Assessment of bleeding events in patients receiving DOACs with or without statins to treat venous thromboembolism: insights from the RIETE registry

Authors: Dominique Farge-bancel, R Marqués, M Ortiz, Paolo Prandoni, J Roa, Manuel Monreal, F Couturaud, J Gutierrez, J Pagan, Peter Verhamme, A Aujayeb, Laurent Bertoletti, P Verhamme, M Monreal, S Fonseca, S Pinto, S Soler, A Lorenzo, R Lecumberri, R Otero, P DI MICCO, F Rivera-Cívico, A Molino, P Suchon, C Grange, JA Caprini, J Osorio, Henri Bounameaux, R Valle, F Negro, A Tufano, Remedios Otero, Aitor Ballaz, G Kenet, I Francisco, F Uresandi, G Barillari, Marijan Bosevski, F García-Bragado, E Grau, D Jiménez, A Maestre, A Visonà, J Criado, R Chopard, I Weinberg, M Lumbierres, B Leclercq, H Bounameaux, Farid Rashidi, Abílio Reis, Lucia Mazzolai, P Llamas, MJ Núñez-Fernández, F Dentali, O Espitia, C Siniscalchi, Rosaria Del Giorno, Sanjiv Keller, Carmine Siniscalchi, Luciano Lopez-Jimenez, Ana Cristina Montenegro, Benjamin Brenner, Raquel Barb, Pierpaolo Di Micco, Sebastian Schellong, Inna Tzoran, Radovan Malý, Joseph A. Caprini, Hanh My Bui, MD Adarraga, A Alberich-Conesa, J Aibar, A Alda-Lozano, J Alfonso, C Amado, M Angelina-García, JI Arcelus, A Ballaz, R Barba, C Barbagelata, M Barrón, B Barrón-Andrés, F Beddar-Chaib, A Blanco-Molina, JC Caballero, J Carrillo-Alonso, G Castellanos, L Chasco, C De Ancos, J Del Toro, P Demelo-Rodríguez, C De Juana-Izquierdo, MC Díaz-Pedroche, JA Díaz-Peromingo, A Dubois-Silva, JC Escribano, C Falgá, AI Farfán-Sedano, C Fernández-Aracil, C Fernández-Capitán, B Fernández-Jiménez, JL Fernández-Reyes, MA Fidalgo, C Gabara, F Galeano-Valle, C García-González, A García-Ortega, O Gavín-Sebastián, MA Gil-De Gómez, A Gil-Díaz, C Gómez-Cuervo, A González-Munera, L Guirado, L Hernández-Blasco, L Jara-Palomares, MJ Jaras, I Jou, MD Joya, JL Lobo, L López-Jiménez, P López-Miguel, H López-Brull, JJ López-Núñez, A López-Ruiz, JB LópezSáez, O Madridano, PJ Marchena, M Marcos, M Martín del Pozo, F Martín-Martos, R Martínez-Prado, JM Maza, E Mena, MI Mercado, J Moisés, MV Morales, MS Navas, JA Nieto, M Olid, L Ordieres-Ortega, S Otálora, N Pacheco-Gómez, AC Palomeque, E Paredes, P Parra-Caballero, P Parra-Rosado, JM Pedrajas, C Pérez-Ductor, M Pérez-Pinar, MA Pérez-Jacoiste, ML Peris, ML Pesce, JA Porras, R Puchades, A Rodríguez-Cobo, M Romero-Brugera, P Ruiz-Artacho, N Ruiz-Giménez, J Ruiz-Ruiz, G Salgueiro, T Sancho, V Sendín, P Sigüenza, A Steinherr, S Suárez-Fernández, R Tirado, A TorrentsVilar, MI Torres, J Trujillo-Santos, JF Varona, A Villalobos, P Villares, C Ay, S Nopp, I Pabinger, C Van Edom, A Verstraete, Yoo HHB, AC Montenegro, SN Morales, J Hirmerova, R Malý, L Bertoletti, A BuraRiviere, J Catella, R Le Mao, I Mahé, F Moustafa, L Plaisance, G Sarlon-Bartoli, E Versini, S Schellong, B Brenner, I Tzoran, P Sadeghipour, F Rashidi, A Abenante, M Basaglia, M Bertoni, F Bilora, B Brandolin, M Ciammaichella, D Colaizzo, E Grandone, E Imbalzano, R Pesavento, A Poz, P Prandoni, B Taflaj, B Zalunardo, A Skride, D Kigitovica, J Meireles, M Bosevski, M Zdraveska, L Mazzolai, HM Bui

Source: BMJ Open, Vol 14, Iss 10 (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/14/10/e085401.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/783c0993cd8248e8891454a53ddc48b0

Tortuosity in non-atherosclerotic vascular diseases is associated with age, arterial aneurysms, and hypertension

Authors: Xhyljeta Luta, Fabio Zanchi, Marco Fresa, Enrica Porccedu, Sanjiv Keller, Judith Bouchardy, Sébastien Déglise, Salah Dine Qanadli, Matthias Kirsch, Grégoire Wuerzner, Andrea Superti-Furga, Giacomo Buso, Lucia Mazzolai

Source: Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-10 (2024)

Subject Terms: Rare vascular diseases, Non-atherosclerotic vascular diseases, Arterial tortuosity, Tortuosity index, Computed tomography angiography, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/cda633fcc2b648b99366f74622844090

Risk of recurrence after discontinuing anticoagulation in patients with COVID-19- associated venous thromboembolism: a prospective multicentre cohort studyResearch in context

Authors: Luis Jara-Palomares, Behnood Bikdeli, David Jiménez, Alfonso Muriel, Pablo Demelo-Rodríguez, Farès Moustafa, Aurora Villalobos, Patricia López-Miguel, Luciano López-Jiménez, Sonia Otálora, María Luisa Peris, Cristina Amado, Romain Chopard, Francisco Rivera-Cívico, Manuel Monreal, María Dolores Adarraga, Ana Alberich Conesa, Jesús Aibar, Alicia Alda Lozano, Joaquín Alfonso, Jesús Alonso Carrillo, María Angelina García, Juan Ignacio Arcelus, Aitor Ballaz, Raquel Barba, María Barca Hernando, Cristina Barbagelata, Manuel Barrón, Belén Barrón Andrés, Fahd Beddar Chaib, María Ángeles Blanco Molina, Juan Carlos Caballero, Gonzalo Castellanos, Leyre Chasco, Juan Criado, Cristina de Ancos, Jorge del Toro, Pablo Demelo Rodríguez, Cristina de Juana Izquierdo, Ana María Díaz Brasero, José Antonio Díaz Peromingo, Álvaro Dubois Silva, Juan Carlos Escribano, Concepción Falgá, Ana Isabel Farfán Sedano, Cleofe Fernández Aracil, Carmen Fernández Capitán, Begoña Fernández Jiménez, José Luis Fernández Reyes, María Ángeles Fidalgo, Iria Francisco, Cristina Gabara, Francisco Galeano Valle, Francisco García Bragado, Alberto García Ortega, Olga Gavín Sebastián, María Allende Gil de Gómez, Aída Gil Díaz, Covadonga Gómez Cuervo, Adriana González Munera, Enric Grau, Leticia Guirado, Javier Gutiérrez, Luis Hernández Blasco, Luis Jara Palomares, María Jesús Jaras, Rafael Jiménez, Inés Jou, María Dolores Joya, Sara Lainez Justo, Antonio Lalueza, Ramón Lecumberri, José Manuel León Ramírez, Pilar Llamas, José Luis Lobo, Luciano López Jiménez, Patricia López Miguel, Juan José López Núñez, Antonio López Ruiz, Juan Bosco López Sáez, Alicia Lorenzo, Marina Lumbierres, Olga Madridano, Ana Maestre, Pablo Javier Marchena, María Marcos, Mar Martín del Pozo, Francisco Martín Martos, Jorge Manuel Maza, Elisabeth Mena, Maria Isabel Mercado, Jorge Moisés, María del Valle Morales, Maria Sierra Navas, José Antonio Nieto, Manuel Jesús Núñez Fernández, Mónica Olid, Lucía Ordieres Ortega, María Ortiz, Jeisson Osorio, Remedios Otero, Nazaret Pacheco Gómez, Javier Pagán, Andrea Catalina Palomeque, Ezequiel Paredes, Pedro Parra Caballero, José María Pedrajas, Cristina Pérez Ductor, Montserrat Pérez Pinar, María Lourdes Pesce, José Antonio Porras, Ramón Puchades, Francisco Rivera Cívico, Ana Rodríguez Cobo, Vladimir Rosa, Marta Romero Brugera, Pedro Ruiz Artacho, Nuria Ruiz Giménez, Justo Ruiz Ruiz, Georgina Salgueiro, Teresa Sancho, Vanesa Sendín, Patricia Sigüenza, Silvia Soler, Susana Suárez Fernández, Raimundo Tirado, Ana Torrents Vilar, María Isabel Torres, Javier Trujillo Santos, Fernando Uresandi, Reina Valle, José Felipe Varona, Paula Villares, Cihan Ay, Stephan Nopp, Ingrid Pabinger, Matthias Engelen, Thomas Vanassche, Peter Verhamme, Hugo Hyung Bok Yoo, Ana Cristina Montenegro, Silvia Natalia Morales, Jairo Roa, Jana Hirmerova, Radovan Malý, Laurent Bertoletti, Alessandra Bura-Riviere, Judith Catella, Francis Couturaud, Olivier Espitia, Claire Grange, Barbara Leclercq, Raphael Le Mao, Isabelle Mahé, Ludovic Plaisance, Gabrielle Sarlon Bartoli, Pierre Suchon, Edouard Versini, Sebastian Schellong, Benjamin Brenner, Najib Dally, Inna Tzoran, Parham Sadeghipour, Fahrid Rashidi, Alessia Abenante, Giovanni Barillari, Manuela Basaglia, Franca Bilora, Daniele Bissacco, Cristiano Bortoluzzi, Barbara Brandolin, Renato Casana, Maurizio Ciammaichella, Donatella Colaizzo, Francesco Dentali, Pierpaolo Di Micco, Elvira Grandone, Egidio Imbalzano, Daniela Lambertenghi Deliliers, Federica Negro, Raffaele Pesavento, Alessandra Poz, Paolo Prandoni, Paolo Scarinzi, Carmine Siniscalchi, Beldisa Taflaj, Antonella Tufano, Adriana Visonà, Ngoc Vo Hong, Beniamino Zalunardo, Andris Skride, Dana Kigitovica, Samuel Fonseca, Rafael Marques, José Meireles, Sara Barbosa Pinto, Marijan Bosevsky, Aleksandra Eftimova, Marijan Zdraveska, Henri Bounameaux, Lucia Mazzolai, Avinash Aujayeb, Joseph Caprini, Ido Weinberg, Hanh My Bui

Source: EClinicalMedicine, Vol 73, Iss , Pp 102659- (2024)

Subject Terms: Pulmonary embolism, Venous thromboembolism, Anticoagulation, COVID-19, SARS-CoV-2, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537024002384; https://doaj.org/toc/2589-5370

Access URL: https://doaj.org/article/548cf0001e7246a9a5b684b961b5a842

The MD-PhD program: a key investment for academic medical centres

Authors: Ivan Stamenkovic, Lucia Mazzolai

Source: Swiss Medical Weekly, Vol 154, Iss 7 (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://smw.ch/index.php/smw/article/view/3738; https://doaj.org/toc/1424-3997

Access URL: https://doaj.org/article/ba4e9fade79d4ed79207977d4ffe8372

Systematic review of the use of ultrasound for venous assessment and venous thrombosis screening in spaceflight

Authors: Antoine Elias, Tobias Weber, David A. Green, Katie M. Harris, Jonathan M. Laws, Danielle K. Greaves, David S. Kim, Lucia Mazzolai-Duchosal, Lara Roberts, Lonnie G. Petersen, Ulrich Limper, Andrej Bergauer, Michael Elias, Andrew Winnard, Nandu Goswami

Source: npj Microgravity, Vol 10, Iss 1, Pp 1-17 (2024)

Subject Terms: Biotechnology, TP248.13-248.65, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2373-8065

Access URL: https://doaj.org/article/3d30e8afb945477d87a308f93e0cd8d1

New Paradigms for Thoracic Outlet Compression and Thoracic Outlet Syndrome, with or without Complications or Sequelae: A Trans-Continental and Trans-Disciplinary Opinion Paper

Authors: Pierre Abraham, Paul W. Wennberg, Pascal Bauer, Yongquan Gu, Nafi Ouedraogo, Lianrui Guo, Garry Tew, Lucia Mazzolai, Romeo Martini, Samir Henni

Source: Journal of Vascular Diseases, Vol 2, Iss 4, Pp 413-418 (2023)

Subject Terms: thoracic outlet syndrome, upper limb, peripheral artery disease, classification, diagnosis, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.mdpi.com/2813-2475/2/4/32; https://doaj.org/toc/2813-2475

Access URL: https://doaj.org/article/33949f10e9ab4007a6cd1ba6288af4a3

Short-duration aerobic high-intensity intervals versus moderate exercise training intensity in patients with peripheral artery disease: study protocol for a randomised controlled trial (the Angiof-HIIT Study)

Authors: Benoît Desgraz, Stefano Lanzi, Anina Pousaz, Marco Fresa, Cyril Besson, Vincent Gremeaux-Bader, Lucia Mazzolai

Source: BMJ Open, Vol 14, Iss 4 (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/14/4/e081883.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/0cf2742c57c14a73832f5ae19d55ca7c

Comparison effect of high-intensity interval training and moderate intensity continuous training on vascular function in a mouse model of lower extremity peripheral artery disease

Authors: Slobodan Kojic, Steeve Menetrey, Karima Bouzourène, Lucia Mazzolai, Anne-Christine Peyter, Nathalie Rosenblatt-Velin, Grégoire P. Millet, Maxime Pellegrin

Source: Current Issues in Sport Science, Vol 9, Iss 2 (2024)

Subject Terms: lower extremity peripheral artery disease, exercise training intensity, vascular reactivity, nitric oxide bioavailability, Sports, GV557-1198.995, Sports medicine, RC1200-1245

File Description: electronic resource

Relation: https://ciss-journal.org/article/view/10894; https://doaj.org/toc/2414-6641

Access URL: https://doaj.org/article/4a2b20ad76854a1e856d2f3f9fcbe8ef

Pathophysiology, risk, diagnosis, and management of venous thrombosis in space: where are we now?

Authors: Katie M. Harris, Roopen Arya, Antoine Elias, Tobias Weber, David A. Green, Danielle K. Greaves, Lonnie G. Petersen, Lara Roberts, Tovy Haber Kamine, Lucia Mazzolai, Andrej Bergauer, David S. Kim, Rik H. Olde Engberink, Peter zu Eulenberg, Bruno Grassi, Lucrezia Zuccarelli, Giovanni Baldassarre, Kevin Tabury, Sarah Baatout, Jens Jordan, Andrew P. Blaber, Alexander Choukér, Thais Russomano, Nandu Goswami

Source: npj Microgravity, Vol 9, Iss 1, Pp 1-7 (2023)

Subject Terms: Biotechnology, TP248.13-248.65, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2373-8065

Access URL: https://doaj.org/article/f2babbd6901c464c8cabbd2d1d60f0de

Body Composition Assessment by Dual-Energy X-Ray Absorptiometry: A Useful Tool for the Diagnosis of Lipedema

Authors: Giacomo Buso, Lucie Favre, Nathalie Vionnet, Elena Gonzalez-Rodriguez, Didier Hans, Jardena Jacqueline Puder, Céline Dubath, Chin-Bin Eap, Wassim Raffoul, Tinh-Hai Collet, Lucia Mazzolai

Source: Obesity Facts, Vol 15, Iss 6, Pp 762-773 (2022)

Subject Terms: lipedema, body composition, dual-energy x-ray absorptiometry, diagnostic test, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627

File Description: electronic resource

Relation: https://www.karger.com/Article/FullText/527138; https://doaj.org/toc/1662-4025; https://doaj.org/toc/1662-4033

Access URL: https://doaj.org/article/b20338335f8b404fa5eb1ccc2d71bc12

Author Correction: Systematic review of the use of ultrasound for venous assessment and venous thrombosis screening in spaceflight

Authors: Antoine Elias, Tobias Weber, David A. Green, Katie M. Harris, Jonathan M. Laws, Danielle K. Greaves, David S. Kim, Lucia Mazzolai-Duchosal, Lara Roberts, Lonnie G. Petersen, Ulrich Limper, Andrej Bergauer, Michael Elias, Andrew Winnard, Nandu Goswami

Source: npj Microgravity, Vol 10, Iss 1, Pp 1-1 (2024)

Subject Terms: Biotechnology, TP248.13-248.65, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2373-8065

Access URL: https://doaj.org/article/c683916be08048d8bee73a4f45b42deb

Type I IFNs link skin-associated dysbiotic commensal bacteria to pathogenic inflammation and angiogenesis in rosacea

Authors: Alessio Mylonas, Heike C. Hawerkamp, Yichen Wang, Jiaqi Chen, Francesco Messina, Olivier Demaria, Stephan Meller, Bernhard Homey, Jeremy Di Domizio, Lucia Mazzolai, Alain Hovnanian, Michel Gilliet, Curdin Conrad

Source: JCI Insight, Vol 8, Iss 4 (2023)

Subject Terms: Dermatology, Inflammation, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/d033bfd462684a7e9f4fe0c374da5b1b

Moderate Effects of Hypoxic Training at Low and Supramaximal Intensities on Skeletal Muscle Metabolic Gene Expression in Mice

Authors: Svitlana Drozdovska, Nadège Zanou, Jessica Lavier, Lucia Mazzolai, Grégoire P. Millet, Maxime Pellegrin

Source: Metabolites, Vol 13, Iss 10, p 1103 (2023)

Subject Terms: exercise intensity, normobaric hypoxia, gene expression, metabolic pathways, mice, skeletal muscle, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/13/10/1103; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/23e389e485b8445592faeaf155aa1af1

Predictors of use of direct oral anticoagulants in patients with venous thromboembolism: Findings from the Registro Informatizado Enfermedad Tromboembólica registry

Authors: Alicia Lorenzo, Patricia Beroiz, Salvador Ortiz, Jorge del Toro, Lucia Mazzolai, Alessandra Bura-Riviere, Adriana Visonà, Peter Verhamme, Pierpaolo Di Micco, Giuseppe Camporese, Teresa Sancho Bueso, Manuel Monreal, the RIETE Investigators

Source: Frontiers in Medicine, Vol 9 (2022)

Subject Terms: venous thromboembolism, direct oral anticoagulants, anticoagulant therapy, predictors, RIETE, different countries, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2022.991376/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/503704dd0433413aa731f1e45069d323

Venous malformation of the penis treated with a combined Nd:YAG laser and sclerotherapy technique

Authors: Marco Fresa, Lucia Mazzolai

Source: Skin Health and Disease, Vol 2, Iss 3, Pp n/a-n/a (2022)

Subject Terms: Dermatology, RL1-803

File Description: electronic resource

Relation: https://doaj.org/toc/2690-442X

Access URL: https://doaj.org/article/5432d2eb9c0841c3b83b7ab007185851

Therapeutic anticoagulation to prevent thrombosis, coagulopathy, and mortality in severe COVID‐19: The Swiss COVID‐HEP randomized clinical trial

Authors: Marc Blondon, Sara Cereghetti, Jérôme Pugin, Christophe Marti, Pauline Darbellay Farhoumand, Jean‐Luc Reny, Alexandra Calmy, Christophe Combescure, Lucia Mazzolai, Olivier Pantet, Zied Ltaief, Marie Méan, Sara Manzocchi Besson, Séverin Jeanneret, Hans Stricker, Helia Robert‐Ebadi, Pierre Fontana, Marc Righini, Alessandro Casini

Source: Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 4, Pp n/a-n/a (2022)

Subject Terms: anticoagulants, COVID‐19, heparin, randomized controlled trial, thrombosis, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2475-0379

Access URL: https://doaj.org/article/0b7ac534371343c3bb2a965f1d443a36

Search for Venous Endothelial Biomarkers Heralding Venous Thromboembolism in Space: A Qualitative Systematic Review of Terrestrial Studies

Authors: Katie Harris, Jonathan Michael Laws, Antoine Elias, David Andrew Green, Nandu Goswami, Jens Jordan, Tovy Haber Kamine, Lucia Mazzolai, Lonnie G. Petersen, Andrew James Winnard, Tobias Weber

Source: Frontiers in Physiology, Vol 13 (2022)

Subject Terms: venous thrombosis, biomarker, Virchow’s triad, venous thromboembolism, VTE, DVT, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2022.885183/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/da7b8b66f1744471ab26aa87711cb113

Physical Performance and Skeletal Muscle Transcriptional Adaptations Are Not Impacted by Exercise Training Frequency in Mice with Lower Extremity Peripheral Artery Disease

Authors: Jessica Lavier, Karima Bouzourène, Grégoire P. Millet, Lucia Mazzolai, Maxime Pellegrin

Source: Metabolites, Vol 13, Iss 4, p 562 (2023)

Subject Terms: exercise training frequency, lower extremity peripheral artery disease, skeletal muscle, gene expression, physical performance, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/13/4/562; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/469724664c5542a7bd0a6d3325c80ec9

Biomarkers of Neutrophil Activation in Patients with Symptomatic Chronic Peripheral Artery Disease Predict Worse Cardiovascular Outcome

Authors: Giacomo Buso, Elisabetta Faggin, Alessandro Bressan, Silvia Galliazzo, Francesco Cinetto, Carla Felice, Michele Fusaro, Andreas Erdmann, Paolo Pauletto, Marcello Rattazzi, Lucia Mazzolai

Source: Biomedicines, Vol 11, Iss 3, p 866 (2023)

Subject Terms: peripheral artery disease, biomarkers, neutrophil degranulation, myeloperoxidase, neutrophil extracellular traps, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/11/3/866; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/350fc48a23924ecd9ed5e208b45c2194