The impact of highly effective modulator therapy on sinusitis and dysosmia in young children with cystic fibrosis: a prospective study protocol

Authors: Christine M. Liu, Jakob L. Fischer, Edith T. Zemanick, Jason C. Woods, Karolin K. Markarian, Sean B. Fain, Deborah Froh, Sonya L. Heltshe, Lucas R. Hoffman, Stephen M. Humphries, Elizabeth L. Kramer, Katie Larson Ode, Michael Lewis, Douglas A. Li, Jaime Mata, Sarah S. Milla, Peter J. Niedbalski, Benjamin D. Sawatzky, Myung-Shin Sim, Jillian S. Sullivan, Andrew T. Trout, Christopher H. Goss, Jennifer L. Taylor-Cousar, Daniel M. Beswick

Source: ERJ Open Research, Vol 11, Iss 1 (2025)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://openres.ersjournals.com/content/11/1/00137-2024.full; https://doaj.org/toc/2312-0541

Access URL: https://doaj.org/article/13ece56839174cbca6340602165b2d72

Mechanisms of Staphylococcus aureus survival of trimethoprim-sulfamethoxazole-induced thymineless death

Authors: Lauren J. Gonsalves, Allyson Tran, Tessa Gardiner, Tiia Freeman, Angshita Dutta, Carson J. Miller, Sharon McNamara, Adam Waalkes, Dustin R. Long, Stephen J. Salipante, Lucas R. Hoffman, Daniel J. Wolter

Source: mBio, Vol 15, Iss 11 (2024)

Subject Terms: Staphylococcus aureus, thymineless death, antibiotic resistance, antifolate drugs, persistence, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/448c71145f6a4c8bb0d64a890bcaa067

The end of the reign of a 'master regulator’’? A defect in function of the LasR quorum sensing regulator is a common feature of Pseudomonas aeruginosa isolates

Authors: Mylène C. Trottier, Thays de Oliveira Pereira, Marie-Christine Groleau, Lucas R. Hoffman, Ajai A. Dandekar, Eric Déziel

Source: mBio, Vol 15, Iss 3 (2024)

Subject Terms: quorum sensing, Pseudomonas aeruginosa, virulence regulation, ecology, adaptive mutations, opportunistic infections, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/6edfb6c216cc4837b0609d1cfccc41f6

Pseudomonas aeruginosa aggregation and Psl expression in sputum is associated with antibiotic eradication failure in children with cystic fibrosis

Authors: Amanda J. Morris, Yvonne C. W. Yau, Subin Park, Shafinaz Eisha, Nancy McDonald, Matthew R. Parsek, P. Lynne Howell, Lucas R. Hoffman, Dao Nguyen, Antonio DiGiandomenico, Ashley M. Rooney, Bryan Coburn, Lucia Grana-Miraglia, Pauline Wang, David S. Guttman, Daniel J. Wozniak, Valerie J. Waters

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/706a1afb22bf43bb9e078f30fcaadf98

A Refined, Controlled 16S rRNA Gene Sequencing Approach Reveals Limited Detection of Cerebrospinal Fluid Microbiota in Children with Bacterial Meningitis

Authors: Christopher E. Pope, Kathryn B. Whitlock, Paul Hodor, David D. Limbrick, Patrick J. McDonald, Jason Hauptman, Lucas R. Hoffman, Tamara D. Simon

Source: Microbiology Spectrum, Vol 11, Iss 3 (2023)

Subject Terms: bacterial meningitis, cerebrospinal fluid, high-throughput sequencing, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/cc7c1954506b4d81bf04ecd1719f38a1

Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist

Authors: David P. Nichols, Sarah J. Morgan, Michelle Skalland, Anh T. Vo, Jill M. Van Dalfsen, Sachinkumar B.P. Singh, Wendy Ni, Lucas R. Hoffman, Kailee McGeer, Sonya L. Heltshe, John P. Clancy, Steven M. Rowe, Peter Jorth, Pradeep K. Singh, the PROMISE-Micro Study Group

Source: The Journal of Clinical Investigation, Vol 133, Iss 10 (2023)

Subject Terms: Microbiology, Pulmonology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/f38c402d2a6340749497b7d56e6094d6

Characterization of cerebrospinal fluid (CSF) microbiota at the time of initial surgical intervention for children with hydrocephalus

Authors: Shailly Pandey, Kathryn B. Whitlock, Matthew R. Test, Paul Hodor, Christopher E. Pope, David D. Limbrick, Patrick J. McDonald, Jason S. Hauptman, Lucas R. Hoffman, Tamara D. Simon

Source: PLoS ONE, Vol 18, Iss 6 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284395/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/eee734ba8ea3434ea393f971399638d2

Infants with cystic fibrosis have altered fecal functional capacities with potential clinical and metabolic consequences

Authors: Alexander Eng, Hillary S. Hayden, Christopher E. Pope, Mitchell J. Brittnacher, Anh T. Vo, Eli J. Weiss, Kyle R. Hager, Daniel H. Leung, Sonya L. Heltshe, Daniel Raftery, Samuel I. Miller, Lucas R. Hoffman, Elhanan Borenstein

Source: BMC Microbiology, Vol 21, Iss 1, Pp 1-17 (2021)

Subject Terms: Cystic fibrosis, Fecal microbiome, Metagenomics, Metabolomics, Infants, Nutrition, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2180

Access URL: https://doaj.org/article/69900369972c4aafab8be30c1ed91e63

The role of Psl in the failure to eradicate Pseudomonas aeruginosa biofilms in children with cystic fibrosis

Authors: Amanda J. Morris, Lindsay Jackson, Yvonne CW Yau, Courtney Reichhardt, Trevor Beaudoin, Stephanie Uwumarenogie, Kevin M. Guttman, P. Lynne Howell, Matthew R. Parsek, Lucas R. Hoffman, Dao Nguyen, Antonio DiGiandomenico, David S. Guttman, Daniel J. Wozniak, Valerie J. Waters

Source: npj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-8 (2021)

Subject Terms: Microbial ecology, QR100-130

File Description: electronic resource

Relation: https://doaj.org/toc/2055-5008

Access URL: https://doaj.org/article/e854128294d24e40bec501038888f54b

Impairment in inflammasome signaling by the chronic Pseudomonas aeruginosa isolates from cystic fibrosis patients results in an increase in inflammatory response

Authors: Melissa S. Phuong, Rafael E. Hernandez, Daniel J. Wolter, Lucas R. Hoffman, Subash Sad

Source: Cell Death and Disease, Vol 12, Iss 3, Pp 1-14 (2021)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/5a0cb35cbf96485cb605b9abdac30acb

Lung function and microbiota diversity in cystic fibrosis

Authors: Leah Cuthbertson, Alan W. Walker, Anna E. Oliver, Geraint B. Rogers, Damian W. Rivett, Thomas H. Hampton, Alix Ashare, J. Stuart Elborn, Anthony De Soyza, Mary P. Carroll, Lucas R. Hoffman, Clare Lanyon, Samuel M. Moskowitz, George A. O’Toole, Julian Parkhill, Paul J. Planet, Charlotte C. Teneback, Michael M. Tunney, Jonathan B. Zuckerman, Kenneth D. Bruce, Christopher J. van der Gast

Source: Microbiome, Vol 8, Iss 1, Pp 1-13 (2020)

Subject Terms: Cystic fibrosis, Lung function, Lung microbiota, Lung microbiome, Disease severity, Ecological patterns, Microbial ecology, QR100-130

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40168-020-00810-3; https://doaj.org/toc/2049-2618

Access URL: https://doaj.org/article/9cf945cb5ee8440d8a2afcecf4936353

Bacterial Signatures of Paediatric Respiratory Disease: An Individual Participant Data Meta-Analysis

Authors: David T. J. Broderick, David W. Waite, Robyn L. Marsh, Carlos A. Camargo, Paul Cardenas, Anne B. Chang, William O. C. Cookson, Leah Cuthbertson, Wenkui Dai, Mark L. Everard, Alain Gervaix, J. Kirk Harris, Kohei Hasegawa, Lucas R. Hoffman, Soo-Jong Hong, Laurence Josset, Matthew S. Kelly, Bong-Soo Kim, Yong Kong, Shuai C. Li, Jonathan M. Mansbach, Asuncion Mejias, George A. O’Toole, Laura Paalanen, Marcos Pérez-Losada, Melinda M. Pettigrew, Maxime Pichon, Octavio Ramilo, Lasse Ruokolainen, Olga Sakwinska, Patrick C. Seed, Christopher J. van der Gast, Brandie D. Wagner, Hana Yi, Edith T. Zemanick, Yuejie Zheng, Naveen Pillarisetti, Michael W. Taylor

Source: Frontiers in Microbiology, Vol 12 (2021)

Subject Terms: microbiota (16S), respiratory tract, respiratory infection, paediatrics, meta-analysis, individual participant data (IPD) meta-analysis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2021.711134/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/c272f2281790452aa37d24bfbb50f88d

Molecular Characterization of Microbiota in Cerebrospinal Fluid From Patients With CSF Shunt Infections Using Whole Genome Amplification Followed by Shotgun Sequencing

Authors: Paul Hodor, Christopher E. Pope, Kathryn B. Whitlock, Lucas R. Hoffman, David L. Limbrick, Patrick J. McDonald, Jason S. Hauptman, Jeffrey G. Ojemann, Tamara D. Simon

Source: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

Subject Terms: cerebrospinal fluid, CSF shunt infection, microbiota, Staphylococcus epidermidis CLIMB1, high throughput DNA sequencing, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2021.699506/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/d45480b2b6c840b28770adce8deac8d7

How low can we go? The implications of low bacterial load in respiratory microbiota studies

Authors: Robyn L. Marsh, Maria T. Nelson, Chris E. Pope, Amanda J. Leach, Lucas R. Hoffman, Anne B. Chang, Heidi C. Smith-Vaughan

Source: Pneumonia, Vol 10, Iss 1, Pp 1-9 (2018)

Subject Terms: Microbiota, 16S rRNA gene sequencing, Bacterial load, Low bacterial load, Background contamination, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s41479-018-0051-8; https://doaj.org/toc/2200-6133

Access URL: https://doaj.org/article/7e129652960543699ca20a7df458f6f4

Human and Extracellular DNA Depletion for Metagenomic Analysis of Complex Clinical Infection Samples Yields Optimized Viable Microbiome Profiles

Authors: Maria T. Nelson, Christopher E. Pope, Robyn L. Marsh, Daniel J. Wolter, Eli J. Weiss, Kyle R. Hager, Anh T. Vo, Mitchell J. Brittnacher, Matthew C. Radey, Hillary S. Hayden, Alexander Eng, Samuel I. Miller, Elhanan Borenstein, Lucas R. Hoffman

Source: Cell Reports, Vol 26, Iss 8, Pp 2227-2240.e5 (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124719301287; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/aa353231eef24d6ba4bb9100acd19923

LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa

Authors: John B. Feltner, Daniel J. Wolter, Christopher E. Pope, Marie-Christine Groleau, Nicole E. Smalley, E. Peter Greenberg, Nicole Mayer-Hamblett, Jane Burns, Eric Déziel, Lucas R. Hoffman, Ajai A. Dandekar

Source: mBio, Vol 7, Iss 5 (2016)

Subject Terms: Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/97a6eb5631c8429c9f56c029c1d8ea3c

Staphylococcus aureus Protein A Mediates Interspecies Interactions at the Cell Surface of Pseudomonas aeruginosa

Authors: Catherine R. Armbruster, Daniel J. Wolter, Meenu Mishra, Hillary S. Hayden, Matthew C. Radey, Gennifer Merrihew, Michael J. MacCoss, Jane Burns, Daniel J. Wozniak, Matthew R. Parsek, Lucas R. Hoffman

Source: mBio, Vol 7, Iss 3 (2016)

Subject Terms: Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/cf5f148f17ca47f3bc5b80d2746e50f9

Characterization of cerebrospinal fluid (CSF) microbiota at the time of initial surgical intervention for children with hydrocephalus.

Authors: Shailly Pandey, Kathryn B Whitlock, Matthew R Test, Paul Hodor, Christopher E Pope, David D Limbrick, Patrick J McDonald, Jason S Hauptman, Lucas R Hoffman, Tamara D Simon, Cerebrospinal FLuId MicroBiota in Shunts (CLIMB) Study Group

Source: PLoS ONE, Vol 18, Iss 6, p e0280682 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/9ae7add615f145ae94046a35321de8aa

Characterization of cerebrospinal fluid (CSF) microbiota from patients with CSF shunt infection and reinfection using high throughput sequencing of 16S ribosomal RNAgenes.

Authors: Kathryn B Whitlock, Christopher E Pope, Paul Hodor, Lucas R Hoffman, David L Limbrick, Patrick J McDonald, Jason S Hauptman, Jeffrey G Ojemann, Tamara D Simon, Cerebrospinal FLuId MicroBiota in Shunts Study (CLIMB) Group

Source: PLoS ONE, Vol 16, Iss 1, p e0244643 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/925348d470b6468f869e48db54759b07

Elevated exopolysaccharide levels in Pseudomonas aeruginosa flagellar mutants have implications for biofilm growth and chronic infections.

Authors: Joe J Harrison, Henrik Almblad, Yasuhiko Irie, Daniel J Wolter, Heather C Eggleston, Trevor E Randall, Jacob O Kitzman, Bethany Stackhouse, Julia C Emerson, Sharon Mcnamara, Tyler J Larsen, Jay Shendure, Lucas R Hoffman, Daniel J Wozniak, Matthew R Parsek

Source: PLoS Genetics, Vol 16, Iss 6, p e1008848 (2020)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/acbec44d4bbb4dbeb96f2b9bdc39b2fa