In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans

Authors: Fahad Almutairi, Jaber Alyami, Susan Pritchard, Wala Alsharef, Robin C. Spiller, Penny A. Gowland, Moira A. Taylor, Luca Marciani, Caroline L. Hoad

Source: Clinical Nutrition Open Science, Vol 51, Iss , Pp 35-43 (2023)

Subject Terms: MRI, Tagging, Gastric contents, Motion, Intragastric handling, Breakfast, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667268523000360; https://doaj.org/toc/2667-2685

Access URL: https://doaj.org/article/f98d9193e65041188205539a1800d1a3

Development of Resorbable Phosphate-Based Glass Microspheres as MRI Contrast Media Agents

Authors: Jesús Molinar-Díaz, Andi Arjuna, Nichola Abrehart, Alison McLellan, Roy Harris, Md Towhidul Islam, Ahlam Alzaidi, Chris R. Bradley, Charlotte Gidman, Malcolm J. W. Prior, Jeremy Titman, Nicholas P. Blockley, Peter Harvey, Luca Marciani, Ifty Ahmed

Source: Molecules, Vol 29, Iss 18, p 4296 (2024)

Subject Terms: Magnetic Resonance Imaging, phosphate-based glasses, oral contrast agents, porous microspheres, resorbable materials, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/29/18/4296; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/546ea4a30ba348fcb47f1a9f7a04a58a

Experimental Measurements of the Length of the Human Colon: A Systematic Review and Meta-Analysis

Authors: Faiz Alqarni, Tejal Akbar, Hala Fatani, Soma Kumasaka, Caroline L. Hoad, Robin C. Spiller, Moira A. Taylor, Luca Marciani

Source: Diagnostics, Vol 14, Iss 19, p 2190 (2024)

Subject Terms: colon length, large intestine length, large bowel morphology, colon measurements, colon anatomy, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/2075-4418/14/19/2190; https://doaj.org/toc/2075-4418

Access URL: https://doaj.org/article/4ffd25e0aac54d2582f70a950286606b

A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study. [version 2; peer review: 2 approved]

Authors: Christabella Ng, Helen Barr, Caroline Hoad, Neele S Dellschaft, Robin Spiller, Luca Marciani, Alan R Smyth, Trevor Hill, Colin Crooks, Jochen G Mainz, Alex Menys, Giles Major, Penny A. Gowland

Source: NIHR Open Research, Vol 3 (2024)

Subject Terms: cystic fibrosis, gastrointestinal symptoms, CFTR modulators, magnetic resonance imaging., eng, Medicine

File Description: electronic resource

Relation: https://openresearch.nihr.ac.uk/articles/3-65/v2; https://doaj.org/toc/2633-4402

Access URL: https://doaj.org/article/5c1c3656d9e84dffb5b38374c1d6241e

Colon length in pediatric health and constipation measured using magnetic resonance imaging and three dimensional skeletonization

Authors: Hayfa Sharif, Caroline L. Hoad, Nichola Abrehart, Penny A. Gowland, Robin C. Spiller, Sian Kirkham, Sabarinathan Loganathan, Michalis Papadopoulos, Marc A. Benninga, David Devadason, Luca Marciani

Source: PLoS ONE, Vol 19, Iss 1 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10760671/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/639480a865f9413bb01271d29b17784f

'A little (PPI) MAGIC can take you a long way' : involving children and young people in research from inception of a novel medical device to multi-centre clinical trial Roald Dahl, James and the Giant Peach (1961)

Authors: Nichola Abrehart, Kate Frost, the Young Persons Advisory Group, Roy Harris, Andrew Wragg, Derek Stewart, Hayfa Sharif, Rachel Matthews, Luca Marciani

Source: Research Involvement and Engagement, Vol 7, Iss 1, Pp 1-15 (2021)

Subject Terms: Patient and public involvement (PPI), Involvement, Young persons advisory group (YPAG), Children and young people (CYP), Children and young people in research, GenerationR, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2056-7529

Access URL: https://doaj.org/article/b78fe5f8202949359707778ee5cd9f37

Heat Treatment of Bovine Milk Impacts Gastric Emptying and Nutrient Appearance

Authors: Amber M. Milan, Matthew P. G. Barnett, Warren C. McNabb, Nicole C. Roy, Schynell Coutinho, Caroline L. Hoad, Luca Marciani, Samson Nivins, Hayfa Sharif, Timothy R. Angeli-Gordon, Peng Du, Armen A. Gharibans, Greg O’Grady, Pankaja Sharma, Aahana Shrestha, Richard F. Mithen

Source: Medical Sciences Forum, Vol 18, Iss 1, p 8 (2023)

Subject Terms: milk, ultra-high temperature milk, pasteurised milk, food structure, digestion, gastric emptying, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2673-9992/18/1/8; https://doaj.org/toc/2673-9992

Access URL: https://doaj.org/article/d450a4aa11194b28bacb48adc286390f

Correction: Schütt et al. Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model. Pharmaceutics 2022, 14, 184

Authors: Michael Schütt, Connor O’Farrell, Konstantinos Stamatopoulos, Caroline L. Hoad, Luca Marciani, Sarah Sulaiman, Mark J. H. Simmons, Hannah K. Batchelor, Alessio Alexiadis

Source: Pharmaceutics, Vol 14, Iss 7, p 1402 (2022)

Subject Terms: n/a, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/7/1402; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/a147ba1016604bc4b9fe7911f6d82691

Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research

Authors: Stefan Senekowitsch, Philipp Schick, Bertil Abrahamsson, Patrick Augustijns, Thomas Gießmann, Hans Lennernäs, Christophe Matthys, Luca Marciani, Xavier Pepin, Alan Perkins, Maximilian Feldmüller, Sarah Sulaiman, Werner Weitschies, Clive G. Wilson, Maura Corsetti, Mirko Koziolek

Source: Pharmaceutics, Vol 14, Iss 4, p 801 (2022)

Subject Terms: biopharmaceutics, imaging tools, in vivo, pharmacokinetics, aspiration, salivary tracer technique, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/4/801; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/066006c0c1c1439380a8f6bc23b79db6

Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model

Authors: Michael Schütt, Connor O’Farrell, Konstantinos Stamatopoulos, Caroline L. Hoad, Luca Marciani, Sarah Sulaiman, Mark J. H. Simmons, Hannah K. Batchelor, Alessio Alexiadis

Source: Pharmaceutics, Vol 14, Iss 1, p 184 (2022)

Subject Terms: Dynamic Colon Model (DCM), digital twin, discrete multiphysics, Smoothed Particle Hydrodynamics (SPH), large intestine, colon, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/1/184; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/7613cdd0ba5543b0814e9a526b2a501f

Application of In Vivo MRI Imaging to Track a Coated Capsule and Its Disintegration in the Gastrointestinal Tract in Human Volunteers

Authors: Sarah Sulaiman, Pavel Gershkovich, Caroline L. Hoad, Matthew Calladine, Robin C. Spiller, Snow Stolnik, Luca Marciani

Source: Pharmaceutics, Vol 14, Iss 2, p 270 (2022)

Subject Terms: targeted drug delivery, delayed-release formulations, magnetic resonance imaging, fat imaging, large intestine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/2/270; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/f68c840370fa4199bda136de72ef4c95

Medical Device Development for Children and Young People—Reviewing the Challenges and Opportunities

Authors: Paul Dimitri, Valeria Pignataro, Mariangela Lupo, Donato Bonifazi, Maria Henke, Umberto M. Musazzi, Floris Ernst, Paola Minghetti, Davide F. Redaelli, Sophia G. Antimisiaris, Giovanni Migliaccio, Fedele Bonifazi, Luca Marciani, Aaron J. Courtenay, Nunzio Denora, Angela Lopedota

Source: Pharmaceutics, Vol 13, Iss 12, p 2178 (2021)

Subject Terms: medical devices, pediatrics, 3D printing, diagnostic imaging, delivery device, patient involvement, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/13/12/2178; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/f31aedb629d6404a9d8584176e80d34f

Diagnostic Accuracy of Non-Invasive Imaging for Detection of Colonic Inflammation in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Authors: Meshari T. Alshammari, Rebecca Stevenson, Buraq Abdul-Aema, Guangyong Zou, Vipul Jairath, Shellie Radford, Luca Marciani, Gordon W. Moran

Source: Diagnostics, Vol 11, Iss 10, p 1926 (2021)

Subject Terms: inflammatory bowel disease, Crohn’s disease, ulcerative colitis, colon, endoscopy, ultrasonography, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/2075-4418/11/10/1926; https://doaj.org/toc/2075-4418

Access URL: https://doaj.org/article/f1ade62c5dd1437fbe8673a43a51f525

Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants.

Authors: Khaled Heissam, Nichola Abrehart, Caroline L Hoad, Jeff Wright, Alex Menys, Kathryn Murray, Paul M Glover, Geoffrey Hebbard, Penny A Gowland, Jason Baker, William L Hasler, Robin C Spiller, Maura Corsetti, James G Brasseur, Bart Hens, Kerby Shedden, Joseph Dickens, Deanna M Mudie, Greg E Amidon, Gordon L Amidon, Luca Marciani

Source: PLoS ONE, Vol 15, Iss 11, p e0241441 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/8b870100c3494f05b33becca50d1d77a

Luminal Fluid Motion Inside an In Vitro Dissolution Model of the Human Ascending Colon Assessed Using Magnetic Resonance Imaging

Authors: Connor O’Farrell, Caroline L. Hoad, Konstantinos Stamatopoulos, Luca Marciani, Sarah Sulaiman, Mark J. H. Simmons, Hannah K. Batchelor

Source: Pharmaceutics, Vol 13, Iss 10, p 1545 (2021)

Subject Terms: dynamic colon model (DCM), large intestine, colon, colon-specific drug formulations, colonic flow, phase contrast cine-MRI, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/13/10/1545; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/68d9ca066dec4482b4222dd190fd60e2

Assessing Lymphatic Uptake of Lipids Using Magnetic Resonance Imaging: A Feasibility Study in Healthy Human Volunteers with Potential Application for Tracking Lymph Node Delivery of Drugs and Formulation Excipients

Authors: Adelaide Jewell, Hannah Williams, Caroline L. Hoad, Paul R. Gellert, Marianne B. Ashford, James Butler, Snow Stolnik, David Scurr, Michael J. Stocks, Luca Marciani, Penny A. Gowland, Pavel Gershkovich

Source: Pharmaceutics, Vol 13, Iss 9, p 1343 (2021)

Subject Terms: intestinal lymphatic transport, lymph nodes, MRI, lipids, lipid-based formulations, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/13/9/1343; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/eda50324022943f1bc792c23864ae969

Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI

Authors: Hayfa Sharif, Caroline L. Hoad, Nichola Abrehart, Penny A. Gowland, Robin C. Spiller, Sian Kirkham, Sabarinathan Loganathan, Michalis Papadopoulos, Marc A. Benninga, David Devadason, Luca Marciani

Source: Diagnostics, Vol 11, Iss 6, p 974 (2021)

Subject Terms: colon, children, constipation, MRI, volume, transit, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/2075-4418/11/6/974; https://doaj.org/toc/2075-4418

Access URL: https://doaj.org/article/a1b1c2fde78342589c01584937040938

Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques

Authors: Konstantinos Stamatopoulos, Sharad Karandikar, Mark Goldstein, Connor O’Farrell, Luca Marciani, Sarah Sulaiman, Caroline L. Hoad, Mark J. H. Simmons, Hannah K. Batchelor

Source: Pharmaceutics, Vol 12, Iss 7, p 659 (2020)

Subject Terms: dynamic colon model (DCM), colon-specific drug formulations, magnetic resonance imaging (MRI), positron emission tomography (PET), in vitro models, dissolution, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/12/7/659; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/b84b4d5fab48443d81b7f955d4d3103c

A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis.

Authors: Kathryn A Murray, Caroline L Hoad, Jill Garratt, Mehri Kaviani, Luca Marciani, Jan K Smith, Britta Siegmund, Penny A Gowland, David J Humes, Robin C Spiller

Source: PLoS ONE, Vol 14, Iss 5, p e0216528 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f618c143a9824553bb0ae4fb1992d402

A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects.

Authors: Tim J Sloan, Jonna Jalanka, Giles A D Major, Shanthi Krishnasamy, Sue Pritchard, Salah Abdelrazig, Katri Korpela, Gulzar Singh, Claire Mulvenna, Caroline L Hoad, Luca Marciani, David A Barrett, Miranda C E Lomer, Willem M de Vos, Penny A Gowland, Robin C Spiller

Source: PLoS ONE, Vol 13, Iss 7, p e0201410 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0201410&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/baf301fd890543c188f98ec62f70859a