Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate

Authors: Joanna L. Fox, Michelle A. Hughes, Xin Meng, Nikola A. Sarnowska, Ian R. Powley, Rebekah Jukes-Jones, David Dinsdale, Timothy J. Ragan, Louise Fairall, John W. R. Schwabe, Nobuhiro Morone, Kelvin Cain, Marion MacFarlane

Source: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/cbf43a167d5c47dbbf9efdc46a691fd7

The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure

Authors: Robert E. Turnbull, Louise Fairall, Almutasem Saleh, Emma Kelsall, Kyle L. Morris, T. J. Ragan, Christos G. Savva, Aditya Chandru, Christopher J. Millard, Olga V. Makarova, Corinne J. Smith, Alan M. Roseman, Andrew M. Fry, Shaun M. Cowley, John W. R. Schwabe

Source: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6a71d260306a424c936ce21edc133482

Diverse nucleosome Site-Selectivity among histone deacetylase complexes

Authors: Zhipeng A Wang, Christopher J Millard, Chia-Liang Lin, Jennifer E Gurnett, Mingxuan Wu, Kwangwoon Lee, Louise Fairall, John WR Schwabe, Philip A Cole

Source: eLife, Vol 9 (2020)

Subject Terms: enzyme, histone, HDAC, CoREST, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/57663; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/1b9752d5c4ac41d38b02862542d44d42

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

Authors: Jay H. Kalin, Muzhou Wu, Andrea V. Gomez, Yun Song, Jayanta Das, Dawn Hayward, Nkosi Adejola, Mingxuan Wu, Izabela Panova, Hye Jin Chung, Edward Kim, Holly J. Roberts, Justin M. Roberts, Polina Prusevich, Jeliazko R. Jeliazkov, Shourya S. Roy Burman, Louise Fairall, Charles Milano, Abdulkerim Eroglu, Charlotte M. Proby, Albena T. Dinkova-Kostova, Wayne W. Hancock, Jeffrey J. Gray, James E. Bradner, Sergio Valente, Antonello Mai, Nicole M. Anders, Michelle A. Rudek, Yong Hu, Byungwoo Ryu, John W. R. Schwabe, Andrea Mattevi, Rhoda M. Alani, Philip A. Cole

Source: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/879832a39de54eeeb00cc6a12113408e

Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex

Authors: Yun Song, Lisbeth Dagil, Louise Fairall, Naomi Robertson, Mingxuan Wu, T.J. Ragan, Christos G. Savva, Almutasem Saleh, Nobuhiro Morone, Micha B.A. Kunze, Andrew G. Jamieson, Philip A. Cole, D. Flemming Hansen, John W.R. Schwabe

Source: Cell Reports, Vol 30, Iss 8, Pp 2699-2711.e8 (2020)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221112472030125X; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/b39317101c204556877f028be0770bfa

The structure of the core NuRD repression complex provides insights into its interaction with chromatin

Authors: Christopher J Millard, Niranjan Varma, Almutasem Saleh, Kyle Morris, Peter J Watson, Andrew R Bottrill, Louise Fairall, Corinne J Smith, John WR Schwabe

Source: eLife, Vol 5 (2016)

Subject Terms: transcription regulation, histone deacetylase, repression complex, chromatin, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/13941; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/4ec4f0e5e4d146ce9e4fdf503a7b8149

The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain.

Authors: Sian E Evans, Benjamin T Goult, Louise Fairall, Andrew G Jamieson, Paul Ko Ferrigno, Robert Ford, John W R Schwabe, Simon D Wagner

Source: PLoS ONE, Vol 9, Iss 3, p e90889 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090889&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/fe23d50d068949fe973cb08ce7f2fb15

Structural insights into the complex of oncogenic KRas4BG12V and Rgl2, a RalA/B activator.

Authors: Mishal Tariq, Teppei Ikeya, Naoyuki Togashi, Louise Fairall, Shun Kamei, Sannojah Mayooramurugan, Abbott, Lauren R., Anab Hasan, Bueno-Alejo, Carlos, Sakura Sukegawa, omartinez-Alonso, Beatriz R, Miguel Angel Muro Campillo, Hudson, Andrew J., Yutaka Ito, Schwabe, John W. R., Dominguez, Cyril, Kayoko Tanaka

Source: Life Science Alliance; Jan2024, Vol. 7 Issue 1, p1-18, 18p

Recombinant Protein Expression for Structural Biology in HEK 293F Suspension Cells: A Novel and Accessible Approach

Authors: Nicola Portolano, author¹, Peter J. Watson, author¹, Louise Fairall, author¹, Christopher J. Millard, author¹, Charles P. Milano, author¹, Yun Song, author¹, Shaun M. Cowley, author¹, John W.R. Schwabe, author¹

Source: Journal of Visualized Experiments. (92)

Availability: http://www.jove.com/video/51897