Immunogenicity and safety following a homologous booster dose of a SARS-CoV-2 recombinant spike protein vaccine with Matrix-MTM adjuvant (NVX-CoV2373) versus a primary series in people living with and without HIV-1 infection in South Africa: A randomized crossover phase 2a/2b trial

Authors: Vivek Shinde, Anthonet Lombard Koen, Zaheer Hoosain, Moherndran Archary, Qasim Bhorat, Lee Fairlie, Umesh Lalloo, Mduduzi S. L. Masilela, Dhayendre Moodley, Sherika Hanley, Leon Frederik Fouche, Cheryl Louw, Michele Tameris, Nishanta Singh, Ameena Goga, Keertan Dheda, Coert Grobbelaar, Natasha Joseph, Johan J. Lombaard, Rosie Mngqibisa, As’ad Ebrahim Bhorat, Gabriella Benadé, Natasha Lalloo, Anna Pitsi, Pieter-Louis Vollgraaff, Angelique Luabeya, Aliasgar Esmail, Friedrich G. Petrick, Aylin Oommen Jose, Sharne Foulkes, Khatija Ahmed, Asha Thombrayil, Dishiki Kalonji, Shane Cloney-Clark, Mingzhu Zhu, Chijioke Bennett, Gary Albert, Alex Marcheschi, Joyce S. Plested, Susan Neal, Gordon Chau, Iksung Cho, Louis Fries, Greg M. Glenn, Shabir A. Madhi

Source: Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)

Subject Terms: Novavax, Inc., the Bill & Melinda Gates Foundation, and the Coalition for Epidemic Preparedness Innovations, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2164-5515; https://doaj.org/toc/2164-554X

Access URL: https://doaj.org/article/90d0e4a6be6e439a95268e85ec023ca2

A Modified Novel Validated High-Throughput Hemagglutinin Inhibition Assay Using Recombinant Virus-like Particles and Human Red Blood Cells for the Objective Evaluation of Recombinant Hemagglutinin Nanoparticle Seasonal Influenza Vaccine

Authors: Timothy S. Vincent, Mingzhu Zhu, Anand Parekh, Urvashi Patel, Shane Cloney-Clark, Andrew Klindworth, David Silva, Andrew Gorinson, Karlee Miranda, Mi Wang, Zachary Longacre, Bin Zhou, Iksung Cho, Rongman Cai, Raj Kalkeri, Louis Fries, Vivek Shinde, Joyce S. Plested

Source: Microorganisms, Vol 12, Iss 11, p 2358 (2024)

Subject Terms: hemagglutination inhibition, immunogenicity, influenza vaccine, influenza virus, singleton, validation, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2607/12/11/2358; https://doaj.org/toc/2076-2607

Access URL: https://doaj.org/article/5cb3b7d14c4c4c02aa3aed68d6492e2e

Safety, efficacy, and immunogenicity of the NVX-CoV2373 vaccine

Authors: Eddie Underwood, Lisa M. Dunkle, Shabir A. Madhi, Cynthia L. Gay, Paul T. Heath, Karen L. Kotloff, Katherine Smith, Gordon Chau, Shirley Galbiati, Alice McGarry, Wayne Woo, Iksung Cho, Katia Alves, Germán Áñez, Chijioke Bennett, Vivek Shinde, Louis Fries, Raburn M. Mallory, Gregory M. Glenn, Seth Toback

Source: Expert Review of Vaccines, Vol 22, Iss 1, Pp 501-517 (2023)

Subject Terms: clinical trial, coronavirus, covid-19, matrix-m adjuvant, prevention, protein-based vaccine, sars-cov-2, vaccination, nvx-cov2373, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://doaj.org/toc/1476-0584; https://doaj.org/toc/1744-8395

Access URL: https://doaj.org/article/63a46f7f41f7419791219c14242672d7

Biodistribution of the saponin-based adjuvant Matrix-M™ following intramuscular injection in mice

Authors: Cecilia Carnrot, Berit Carow, Anna-Karin E. Palm, Eray Akpinar, Per-Henrik Helgesson, Ingrid Lekberg Osterman, Emelie Bringeland, Bryant Foreman, Nita Patel, Johan Bankefors, Louis Fries, Linda Stertman

Source: Frontiers in Drug Delivery, Vol 3 (2023)

Subject Terms: vaccine, NVX-CoV2373, draining lymph node, vaccine safety, COVID-19, mechanism of action, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fddev.2023.1279710/full; https://doaj.org/toc/2674-0850

Access URL: https://doaj.org/article/4481fd86955545dfac2655cb03706e44

The Matrix-M™ adjuvant: A critical component of vaccines for the 21st century

Authors: Linda Stertman, Anna-Karin E. Palm, Behdad Zarnegar, Berit Carow, Carolina Lunderius Andersson, Sofia E. Magnusson, Cecilia Carnrot, Vivek Shinde, Gale Smith, Gregory Glenn, Louis Fries, Karin Lövgren Bengtsson

Source: Human Vaccines & Immunotherapeutics, Vol 19, Iss 1 (2023)

Subject Terms: matrix-m™ adjuvant, quillaja saponin, vaccine, immunogenicity, safety, mechanism of action, innate immune response, adaptive immune response, sars-cov-2, covid-19, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2164-5515; https://doaj.org/toc/2164-554X

Access URL: https://doaj.org/article/f73e86e78de8490f9c7688c046ee0852

NVX-CoV2373 vaccination induces functional SARS-CoV-2–specific CD4+ and CD8+ T cell responses

Authors: Carolyn Rydyznski Moderbacher, Christina Kim, Jose Mateus, Joyce Plested, Mingzhu Zhu, Shane Cloney-Clark, Daniela Weiskopf, Alessandro Sette, Louis Fries, Gregory Glenn, Shane Crotty

Source: The Journal of Clinical Investigation, Vol 132, Iss 19 (2022)

Subject Terms: Immunology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/d1bcb00519ff408b99a843d3d67b9a38

A Severe Acute Respiratory Syndrome Coronavirus 2 Anti-Spike Immunoglobulin G Assay: A Robust Method for Evaluation of Vaccine Immunogenicity Using an Established Correlate of Protection

Authors: Mingzhu Zhu, Shane Cloney-Clark, Sheau-line Feng, Anand Parekh, Drew Gorinson, David Silva, Paul Skonieczny, Adjele Wilson, Raj Kalkeri, Wayne Woo, Miranda R. Cai, Louis Fries, Greg Glenn, Joyce S. Plested

Source: Microorganisms, Vol 11, Iss 7, p 1789 (2023)

Subject Terms: Binding antibodies, correlate of protection, IgG, ELISA, COVID-19, antibodies, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2607/11/7/1789; https://doaj.org/toc/2076-2607

Access URL: https://doaj.org/article/7031ad406929446f93365e8f5df4cb5a

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice

Authors: Jing-Hui Tian, Nita Patel, Robert Haupt, Haixia Zhou, Stuart Weston, Holly Hammond, James Logue, Alyse D. Portnoff, James Norton, Mimi Guebre-Xabier, Bin Zhou, Kelsey Jacobson, Sonia Maciejewski, Rafia Khatoon, Malgorzata Wisniewska, Will Moffitt, Stefanie Kluepfel-Stahl, Betty Ekechukwu, James Papin, Sarathi Boddapati, C. Jason Wong, Pedro A. Piedra, Matthew B. Frieman, Michael J. Massare, Louis Fries, Karin Lövgren Bengtsson, Linda Stertman, Larry Ellingsworth, Gregory Glenn, Gale Smith

Source: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4a4e382fc93a4e5c84f3c4b94fc40a65

Severe Acute Respiratory Syndrome Coronavirus 2 Receptor (Human Angiotensin-Converting Enzyme 2) Binding Inhibition Assay: A Rapid, High-Throughput Assay Useful for Vaccine Immunogenicity Evaluation

Authors: Joyce S. Plested, Mingzhu Zhu, Shane Cloney-Clark, Edmond Massuda, Urvashi Patel, Andrew Klindworth, Michael J. Massare, Rongman Cai, Louis Fries, Greg Glenn, Raj Kalkeri

Source: Microorganisms, Vol 11, Iss 2, p 368 (2023)

Subject Terms: COVID-19, human angiotensin-converting enzyme 2 (hACE2), immunogenicity, SARS-CoV-2, assay validation, neutralizing antibody titers, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2607/11/2/368; https://doaj.org/toc/2076-2607

Access URL: https://doaj.org/article/eccebede663c4ad0a28cb35070d10ef6

Influenza A(H7N9) Pandemic Preparedness: Assessment of the Breadth of Heterologous Antibody Responses to Emerging Viruses from Multiple Pre-Pandemic Vaccines and Population Immunity

Authors: Min Z. Levine, Crystal Holiday, Yaohui Bai, Weimin Zhong, Feng Liu, Stacie Jefferson, F. Liaini Gross, Wen-pin Tzeng, Louis Fries, Gale Smith, Philippe Boutet, Damien Friel, Bruce L. Innis, Corey P. Mallett, C. Todd Davis, David E. Wentworth, Ian A. York, James Stevens, Jacqueline M. Katz, Terrence Tumpey

Source: Vaccines, Vol 10, Iss 11, p 1856 (2022)

Subject Terms: A(H7N9) viruses, influenza vaccine, pandemic preparedness, population immunity, heterologous cross-reactivity, hemagglutination inhibition, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/10/11/1856; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/68771ddb6ca74390957381a38314d5b0

Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adults

Authors: Louis Fries, Vivek Shinde, Jeffrey J. Stoddard, D. Nigel Thomas, Eloi Kpamegan, Hanxin Lu, Gale Smith, Somia P. Hickman, Pedro Piedra, Gregory M. Glenn

Source: Immunity & Ageing, Vol 14, Iss 1, Pp 1-14 (2017)

Subject Terms: Anti-F IgG, F or fusion protein, Microneutralization, Nanoparticle vaccine, Palivizumab-competitive antibody (PCA), Recombinant, Immunologic diseases. Allergy, RC581-607, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12979-017-0090-7; https://doaj.org/toc/1742-4933

Access URL: https://doaj.org/article/ede5a421c05f45379e58ee05f42f78c7