Autoimmune Hemolytic Anemias: Classifications, Pathophysiology, Diagnoses and Management.

Authors: Loriamini, Melika^1,2 (AUTHOR) melika.loriamini@mail.utoronto.ca, Cserti-Gazdewich, Christine^1,3,4 (AUTHOR) christine.cserti@uhn.ca, Branch, Donald R.^1,2,5 (AUTHOR) don.branch@utoronto.ca

Source: International Journal of Molecular Sciences. Apr2024, Vol. 25 Issue 8, p4296. 18p.

Subject Terms: *AUTOIMMUNE hemolytic anemia, *PAROXYSMAL hemoglobinuria, *PATHOLOGICAL physiology, *BLOOD groups, *DIAGNOSIS, *MONOCLONAL antibodies

A novel small molecule phagocytosis inhibitor, KB‐208, ameliorates ITP in mouse models with similar efficacy as IVIG.

Authors: Loriamini, Melika^1,2 (AUTHOR), Lewis‐Bakker, Melissa M.³ (AUTHOR), Binnington, Beth² (AUTHOR), Kotra, Lakshmi P.^3,4 (AUTHOR) lakshmi.kotra@uhn.ca, Branch, Donald R.^1,2,5 (AUTHOR) don.branch@utoronto.ca

Source: Transfusion. Dec2024, Vol. 64 Issue 12, p2233-2240. 8p.

Subject Terms: *DRUG discovery, *DRUG efficacy, *IDIOPATHIC thrombocytopenic purpura, *SMALL molecules, *BLOOD transfusion

Small Molecule Drugs That Inhibit Phagocytosis.

Authors: Loriamini, Melika^1,2 (AUTHOR), Lewis-Bakker, Melissa M.³ (AUTHOR), Frias Boligan, Kayluz¹ (AUTHOR), Wang, Siming³ (AUTHOR), Holton, Mairead B.¹ (AUTHOR), Kotra, Lakshmi P.^3,4 (AUTHOR) p.kotra@utoronto.ca, Branch, Donald R.^1,2,5,6 (AUTHOR) p.kotra@utoronto.ca

Source: Molecules. Jan2023, Vol. 28 Issue 2, p757. 15p.

Subject Terms: *SMALL molecules, *PHAGOCYTOSIS, *CHEMICAL libraries, *PHAGOCYTIC function tests, *DRUG discovery

Oncolytic Virus Senecavirus A Inhibits Hepatocellular Carcinoma Proliferation and Growth by Inducing Cell Cycle Arrest and Apoptosis.

Authors: Tao Gong, Xiao Liu, Qingyuan Li, Branch, Donald R., Loriamini, Melika, Wenxian Wen, Yaoqiang Shi, Qi Tan, Bin Fan, Zhonghui Zhou, Yujia Li, Chunhui Yang, Shilin Li, Xiaoqiong Duan, Limin Chen

Source: Journal of Clinical & Translational Hepatology; Aug2024, Vol. 12 Issue 8, p713-725, 13p

Subject Terms: MEDICAL sciences, PORCINE epidemic diarrhea virus, VIROTHERAPY, ONCOLYTIC virotherapy, CELL cycle, CANCER cell growth

The high prevalence of occult hepatitis B infections among the partners of chronically infected HBV blood donors emphasizes the potential residual risk to blood safety.

Authors: Ye, Xianlin, Li, Tong, Yu, Binghuan, Zeng, Jinfeng, Shi, Yaoqiang, Xie, He, Branch, Donald R., Loriamini, Melika, Li, Bin, Chen, Limin

Source: Journal of Medical Virology; Aug2023, Vol. 95 Issue 8, p1-11, 11p

Subject Terms: DISEASE prevalence, HEPATITIS B virus, HEPATITIS B, SEXUAL partners, BLOOD testing

Geographic Terms: CHINA

(NZW × BXSB) F1 male mice: An unusual, severe and fatal mouse model of lupus erythematosus.

Authors: Almizraq, Ruqayyah J., Boligan, Kayluz Frias, Loriamini, Melika, McKerlie, Colin, Branch, Donald R.

Source: Frontiers in Immunology; 9/23/2022, Vol. 13, p1-13, 13p

Subject Terms: LUPUS erythematosus, LABORATORY mice, ANIMAL disease models, SYSTEMIC lupus erythematosus, EXPERIMENTAL arthritis, IDIOPATHIC thrombocytopenic purpura, LUPUS nephritis

3040 – DRUG DISCOVERY FOR INHIBITORS OF PHAGOCYTOSIS FOR USE IN IMMUNE CYTOPENIAS

Authors: Branch, Donald, Loriamini, Melika, Lewis-Bakker, Melissa, Boligan, Kayluz Frias, Kotra, Lakshmi

Source: In Experimental Hematology 2022 111 Supplement:S64-S65