Metabolic regulation of the mitochondrial immune checkpoint

Authors: David C. Montrose, Suchandrima Saha, Lorenzo Galluzzi

Source: OncoImmunology, Vol 13, Iss 1 (2024)

Subject Terms: Apoptotic caspases, BCL2, immune checkpoint inhibition, MOMP, senescence, type I interferon, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/c995b12760714975a41da1f30fab3e05

A mitochondrial checkpoint to NF-κB signaling

Authors: Emma Guilbaud, Lorenzo Galluzzi

Source: Cell Death and Disease, Vol 15, Iss 7, Pp 1-3 (2024)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/de2542d1cb674ff794e1a58f3d96a334

Immunological aspects of central neurodegeneration

Authors: Mireia Niso-Santano, José M. Fuentes, Lorenzo Galluzzi

Source: Cell Discovery, Vol 10, Iss 1, Pp 1-14 (2024)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2056-5968

Access URL: https://doaj.org/article/0340e9507e65438ca80393877d5bae28

Inflammation and mitophagy are mitochondrial checkpoints to aging

Authors: Emma Guilbaud, Kristopher A. Sarosiek, Lorenzo Galluzzi

Source: Nature Communications, Vol 15, Iss 1, Pp 1-3 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/fc179bd8f28f4dd99248eccc115c6d20

Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer

Authors: Lenka Kasikova, Jana Rakova, Michal Hensler, Tereza Lanickova, Jana Tomankova, Josef Pasulka, Jana Drozenova, Katerina Mojzisova, Anna Fialova, Sarka Vosahlikova, Jan Laco, Ales Ryska, Pavel Dundr, Roman Kocian, Tomas Brtnicky, Petr Skapa, Linda Capkova, Marek Kovar, Jan Prochazka, Ivan Praznovec, Vladimir Koblizek, Alice Taskova, Hisashi Tanaka, Robert Lischke, Fernando Casas Mendez, Jiri Vachtenheim, Viola Heinzelmann-Schwarz, Francis Jacob, Iain A. McNeish, Michal J. Halaska, Lukas Rob, David Cibula, Sandra Orsulic, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova

Source: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/51ecc26da57243349eb37f9d6e8d150d

LTX-315 triggers anticancer immunity by inducing MyD88-dependent maturation of dendritic cells

Authors: Xiao-Qing Li, Takahiro Yamazaki, Tianzhen He, Md Masud Alam, Jia Liu, Anna L. Trivett, Baldur Sveinbjørnsson, Øystein Rekdal, Lorenzo Galluzzi, Joost J. Oppenheim, De Yang

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: antitumor immunity, dendritic cells, LTX-315, toll-like receptors, MyD88, melanoma, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1332922/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/38be6eb6a7bf4036a60a9ac668042e62

Radiation therapy improves CAR T cell activity in acute lymphoblastic leukemia

Authors: Mayumi Sugita, Takahiro Yamazaki, Mohammad Alhomoud, Jérémie Martinet, Jean-Baptiste Latouche, Encouse Golden, Olivier Boyer, Koen Van Besien, Silvia C. Formenti, Lorenzo Galluzzi, Monica L. Guzman

Source: Cell Death and Disease, Vol 14, Iss 5, Pp 1-8 (2023)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/aa1f1d202091484a98064e5028973f74

Cancer stem cell immunoediting by IFNγ

Authors: Claudia Galassi, Lorenzo Galluzzi

Source: Cell Death and Disease, Vol 14, Iss 8, Pp 1-3 (2023)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/886d04fb1e92484abd687286a47b3907

Immunogenic cell death in cancer: concept and therapeutic implications

Authors: Lorenzo Galluzzi, Oliver Kepp, Erik Hett, Guido Kroemer, Francesco M. Marincola

Source: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-8 (2023)

Subject Terms: Antigenicity, CAR T cells, DAMPs, Immune checkpoint inhibitors, Pattern recognition receptors, Tumor microenvironment, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/1bdf2d76a71049afbbebc52709f9750f

Type I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients

Authors: Peter Holicek, Iva Truxova, Jana Rakova, Cyril Salek, Michal Hensler, Marek Kovar, Milan Reinis, Romana Mikyskova, Josef Pasulka, Sarka Vosahlikova, Hana Remesova, Iva Valentova, Daniel Lysak, Monika Holubova, Petr Kaspar, Jan Prochazka, Lenka Kasikova, Radek Spisek, Lorenzo Galluzzi, Jitka Fucikova

Source: Cell Death and Disease, Vol 14, Iss 3, Pp 1-12 (2023)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/f8edc52886a84c80a88c6cee32d03c15

Cellular senescence in the response of HR+ breast cancer to radiotherapy and CDK4/6 inhibitors

Authors: Vanessa Klapp, Aitziber Buqué, Norma Bloy, Ai Sato, Takahiro Yamazaki, Xi Kathy Zhou, Silvia C. Formenti, Lorenzo Galluzzi, Giulia Petroni

Source: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-10 (2023)

Subject Terms: β-galactosidase, INK-ATTAC mice, MCF7 cells, MDA-MB-231 cells, MPA/DMBA-driven mammary carcinogenesis, TS/A cells, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/2b53eb703bf9446c8d4b1b0cd0e30b9f

Updates on radiotherapy-immunotherapy combinations: Proceedings of 6th annual ImmunoRad conference

Authors: Fabiana Gregucci, Sheila Spada, Mary Helen Barcellos-Hoff, Nina Bhardwaj, Charleen Chan Wah Hak, Alba Fiorentino, Chandan Guha, Monica L. Guzman, Kevin Harrington, Fernanda G. Herrera, Jamie Honeychurch, Theodore Hong, Lorea Iturri, Elisabeth Jaffee, Sana D. Karam, Simon R.V. Knott, Constantinos Koumenis, David Lyden, Ariel E. Marciscano, Alan Melcher, Michele Mondini, Anna Mondino, Zachary S. Morris, Sean Pitroda, Sergio A. Quezada, Laura Santambrogio, Stephen Shiao, John Stagg, Irma Telarovic, Robert Timmerman, Marie-Catherine Vozenin, Ralph Weichselbaum, James Welsh, Anna Wilkins, Chris Xu, Roberta Zappasodi, Weiping Zou, Alexandre Bobard, Sandra Demaria, Lorenzo Galluzzi, Eric Deutsch, Silvia C. Formenti

Source: OncoImmunology, Vol 12, Iss 1 (2023)

Subject Terms: dose and fractionation, FLASH radiotherapy, immune checkpoint inhibitors, immunomodulators, lymph node sparing, tumor-associated macrophages, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/420f3d04260044b482062ca48125b481

A mitochondrial checkpoint to adaptive anticancer immunity

Authors: Oliver Kepp, Peng Liu, Guido Kroemer, Lorenzo Galluzzi

Source: OncoImmunology, Vol 12, Iss 1 (2023)

Subject Terms: Antigen presentation, CGAS, immune checkpoint inhibitors, immunogenic cell death, mtDNA, type I interferon, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/ebf92ae9bf2145f581500c4a7fe90ecb

1106 Molecular mechanisms of immunogenic cell death driven by PT-112

Authors: Lorenzo Galluzzi, Takahiro Yamazaki, Christina Yim, Tyler Ames, Emma Guilbaud, Maria Congenie

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/1ff7aeb8e41f4a2ba6dd6e552de37618

858 Breaking through the resistance of breast cancer to immune checkpoint blockers in a unique mouse model of HR+ disease

Authors: Silvia Formenti, Lorenzo Galluzzi, Takahiro Yamazaki, Giulia Petroni, Claudia Galassi, Ai Sato, Norma Bloy, Aitziber Buqué, Cristina Iribarren

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/3d3f84d7348f4d4d80a965348b3e23ad

Cell death and senescence

Authors: Lorenzo Galluzzi, Melissa Myint

Source: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-3 (2023)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/5243b154e51342b49006016c00752274

NK cells and solid tumors: therapeutic potential and persisting obstacles

Authors: Le Tong, Carlos Jiménez-Cortegana, Apple H.M. Tay, Stina Wickström, Lorenzo Galluzzi, Andreas Lundqvist

Source: Molecular Cancer, Vol 21, Iss 1, Pp 1-18 (2022)

Subject Terms: Adoptive cell therapy, CAR T cells, CGAS/STING1 signaling, Immune checkpoint inhibitors, PD-L1, TREG cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/79fefdad892946759dec98503965999f

A biologic-device combination product delivering tumor-derived antigens elicits immunogenic cell death-associated immune responses against glioblastoma

Authors: Lorenzo Galluzzi, Jenny Zilberberg, Amelia Zellander, Kenneth Kirby, Christopher Uhl, Christopher Cultrara, Essam Abed Elrazaq, David W Andrews, Charles B Scott, Mark A Exley

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/11/8/e006880.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/4dcff276a1bf4922837be3e5877e9195

Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models

Authors: Luis A. Williams, David J. Gerber, Amy Elder, Wei Chou Tseng, Valeriya Baru, Nathaniel Delaney-Busch, Christina Ambrosi, Gauri Mahimkar, Vaibhav Joshi, Himali Shah, Karthiayani Harikrishnan, Hansini Upadhyay, Sakthi H. Rajendran, Aishwarya Dhandapani, Joshua Meier, Steven J. Ryan, Caitlin Lewarch, Lauren Black, Julie Douville, Stefania Cinquino, Helen Legakis, Karsten Nalbach, Christian Behrends, Ai Sato, Lorenzo Galluzzi, Timothy W. Yu, Duncan Brown, Sudhir Agrawal, David Margulies, Alan Kopin, Graham T. Dempsey

Source: Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 189-203 (2022)

Subject Terms: Oligonucleotides: Therapies and Applications, antisense oligonucleotide, TECPR2, human induced pluripotent stem cells, SPG49, HSAN9, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253122001676; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/555fd4156baf47509e8e7211947eb238

A loss-of-function polymorphism in ATG16L1 compromises therapeutic outcome in head and neck carcinoma patients

Authors: Julie Le Naour, Zsofia Sztupinszki, Vincent Carbonnier, Odile Casiraghi, Virginie Marty, Lorenzo Galluzzi, Zoltan Szallasi, Guido Kroemer, Erika Vacchelli

Source: OncoImmunology, Vol 11, Iss 1 (2022)

Subject Terms: Immunogenic cell death, toll-like receptor, FPR1, P2RX7, radiotherapy, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/64bfee1a1598400ba81d0e705f40fabf