Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer

Authors: Yu, Liqun ^{1, 2, 3}, Liebenberg, Keziah ⁴, Shen, Yichao ^{1, 2, 3, 5}, Liu, Fengshuo ^{1, 2, 3, 6}, Xu, Zhan ^{1, 2, 3}, Hao, Xiaoxin ^{1, 2, 3, 11}, Wu, Ling ^{1, 2, 3}, Zhang, Weijie ^{1, 2, 3, 12}, Chan, Hilda L. ^{1, 2, 3, 7}, Wei, Bo ⁸, Lorenzi, Philip L. ⁸, Gao, Yang ^{1, 2, 3}, Bado, Igor ^{1, 2, 3}, Becerra-Dominguez, Luis ^{1, 2, 3, 9}, Rivas, Charlotte Helena ^{1, 2, 3, 6}, Aguirre, Sergio ^{1, 2, 3, 5}, Pingel, Bradley C. ^{1, 2, 3, 9}, Wu, Yi-Hsuan ^{1, 2, 3, 6}, Ding, Yunfeng ^{1, 2, 3}, Liu, Jun ^{1, 2, 3}, Edwards, David G. ^{1, 2, 3}, Eberlin, Livia S. ^{2, 4}, Zhang, Xiang H.-F. ^{1, 2, 3, 10, 13, ∗}

Source: In Immunity 8 April 2025 58(4):909-925

Blood-based proteomic profiling identifies OSMR as a novel biomarker of AML outcomes

Authors: Reville, Patrick K. ¹, Wang, Bofei ¹, Marvin-Peek, Jennifer ¹, Yuan, Bin ¹, Kuo, Yu-An ¹, Garza, Araceli ¹, Root, Jessica ¹, Qiao, Wei ², Arruda, Andrea ³, Veletic, Ivo ¹, Liu, Yiwei ⁴, Short, Nicholas J. ¹, DiNardo, Courtney D. ¹, Kadia, Tapan M. ¹, Daver, Naval G. ¹, Lorenzi, Philip L. ⁴, Sasaki, Koji ¹, Kornblau, Steven ¹, Minden, Mark D. ³, Ravandi, Farhad ¹, Kantarjian, Hagop M. ¹, Abbas, Hussein A. ^{1, 5, ∗}

Source: In Blood March 2025

Targeting caseinolytic mitochondrial matrix peptidase, a novel contributor to the pathobiology of high-risk multiple myeloma

Authors: Qin, Li ¹, Moreno Rueda, Luz Yurany ¹, Ray, Upasana ¹, Mahmud, Iqbal ², Tan, Lin ², Lorenzi, Philip L. ², Liu, Suyu ³, Lin, Heather ³, Mery, David E. ⁴, Zhan, Fenghuang ⁴, Shaughnessy, John D., Jr. ⁴, Yi, Qing ⁵, Acevedo Calado, Maria Jose ¹, Wang, Hua ¹, Manasanch, Elisabet E. ¹, Lee, Hans C. ¹, Patel, Krina K. ¹, Kuiatse, Isere ¹, Symer, David E. ⁶, Orlowski, Robert Z. ^{1, 7, ∗}

Source: In Blood January 2025

Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage

Authors: Yang, Bosco Seong Kyu ^a, Blackburn, Spiros L. ^a, Lorenzi, Philip L. ^b, Choi, Huimahn A. ^a, Gusdon, Aaron M. ^{a, ⁎, 1}

Source: In Neurotherapeutics January 2025 22(1)

Mechanistic insights into metabolic function of dynamin-related protein 1

Authors: Li, Xin, Pham, Katherine, Ysaguirre, Jazmin, Mahmud, Iqbal, Tan, Lin, Wei, Bo, Shao, Long J., Elizondo, Maryam, Habib, Rabie, Elizondo, Fathima, Sesaki, Hiromi, Lorenzi, Philip L., Sun, Kai

Source: In Journal of Lipid Research September 2024 65(9)

Autophagic signaling promotes systems-wide remodeling in skeletal muscle upon oncometabolic stress by D2-HG

Authors: Gao, Yaqi, Kim, Kyoungmin, Vitrac, Heidi, Salazar, Rebecca L., Gould, Benjamin D., Soedkamp, Daniel, Spivia, Weston, Raedschelders, Koen, Dinh, An Q., Guzman, Anna G., Tan, Lin, Azinas, Stavros, Taylor, David J.R., Schiffer, Walter, McNavish, Daniel, Burks, Helen B., Gottlieb, Roberta A., Lorenzi, Philip L., Hanson, Blake M., Van Eyk, Jennifer E., Taegtmeyer, Heinrich, Karlstaedt, Anja

Source: In Molecular Metabolism August 2024 86

Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells

Authors: Ramalho, Theresa, Assis, Patricia A., Ojelabi, Ogooluwa, Tan, Lin, Carvalho, Brener, Gardinassi, Luiz, Campos, Osvaldo, Lorenzi, Philip L., Fitzgerald, Katherine A., Haynes, Cole, Golenbock, Douglas T., Gazzinelli, Ricardo T.

Source: In Cell Metabolism 5 March 2024 36(3):484-497

Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD

Authors: Ghrayeb, Alia, Finney, Alexandra C., Agranovich, Bella, Peled, Daniel, Anand, Sumit Kumar, McKinney, M. Peyton, Sarji, Mahasen, Yang, Dongshan, Weissman, Natan, Drucker, Shani, Fernandes, Sara Isabel, Fernández-García, Jonatan, Mahan, Kyle, Abassi, Zaid, Tan, Lin, Lorenzi, Philip L., Traylor, James, Zhang, Jifeng, Abramovich, Ifat, Chen, Y. Eugene, Rom, Oren, Mor, Inbal, Gottlieb, Eyal

Source: In Cell Metabolism 2 January 2024 36(1):116-129

Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring

Authors: Colbert, Lauren E., El Alam, Molly B., Wang, Rui, Karpinets, Tatiana, Lo, David, Lynn, Erica J., Harris, Timothy A., Elnaggar, Jacob H., Yoshida-Court, Kyoko, Tomasic, Katarina, Bronk, Julianna K., Sammouri, Julie, Yanamandra, Ananta V., Olvera, Adilene V., Carlin, Lily G., Sims, Travis, Delgado Medrano, Andrea Y., Napravnik, Tatiana Cisneros, O’Hara, Madison, Lin, Daniel, Abana, Chike O., Li, Hannah X., Eifel, Patricia J., Jhingran, Anuja, Joyner, Melissa, Lin, Lilie, Ramondetta, Lois M., Futreal, Andrew M., Schmeler, Kathleen M., Mathew, Geena, Dorta-Estremera, Stephanie, Zhang, Jianhua, Wu, Xiaogang, Ajami, Nadim J., Wong, Matthew, Taniguchi, Cullen, Petrosino, Joseph F., Sastry, K. Jagannadha, Okhuysen, Pablo C., Martinez, Sara A., Tan, Lin, Mahmud, Iqbal, Lorenzi, Philip L., Wargo, Jennifer A., Klopp, Ann H.

Source: In Cancer Cell 13 November 2023 41(11):1945-1962

The transcription factor ChREBP links mitochondrial lipidomes to mitochondrial morphology and progression of diabetic kidney disease

Authors: Li, Li, Long, Jianyin, Mise, Koki, Poungavrin, Naravat, Lorenzi, Philip L., Mahmud, Iqbal, Tan, Lin, Saha, Pradip K., Kanwar, Yashpal S., Chang, Benny H., Danesh, Farhad R.

Source: In Journal of Biological Chemistry September 2023 299(9)

Integrated systems approach identifies pathways from the genome to triglycerides through a metabolomic causal network

Authors: Yazdani, Azam, Yazdani, Akram, Lorenzi, Philip L., Samiei, Ahmad

Subject Terms: Quantitative Biology - Genomics

Access URL: http://arxiv.org/abs/1809.05024

Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease

Authors: Hayase, Eiko, Hayase, Tomo, Jamal, Mohamed A., Miyama, Takahiko, Chang, Chia-Chi, Ortega, Miriam R., Ahmed, Saira S., Karmouch, Jennifer L., Sanchez, Christopher A., Brown, Alexandria N., El-Himri, Rawan K., Flores, Ivonne I., McDaniel, Lauren K., Pham, Dung, Halsey, Taylor, Frenk, Annette C., Chapa, Valerie A., Heckel, Brooke E., Jin, Yimei, Tsai, Wen-Bin, Prasad, Rishika, Tan, Lin, Veillon, Lucas, Ajami, Nadim J., Wargo, Jennifer A., Galloway-Peña, Jessica, Shelburne, Samuel, Chemaly, Roy F., Davey, Lauren, Glowacki, Robert W.P., Liu, Chen, Rondon, Gabriela, Alousi, Amin M., Molldrem, Jeffrey J., Champlin, Richard E., Shpall, Elizabeth J., Valdivia, Raphael H., Martens, Eric C., Lorenzi, Philip L., Jenq, Robert R.

Source: In Cell 29 September 2022 185(20):3705-3719

Regulation of growth, invasion and metabolism of breast ductal carcinoma through CCL2/CCR2 signaling interactions with MET receptor tyrosine kinases

Authors: Acevedo, Diana Sofía, Fang, Wei Bin, Rao, Vinamratha, Penmetcha, Vedha, Leyva, Hannah, Acosta, Gabriela, Cote, Paige, Brodine, Rebecca, Swerdlow, Russell, Tan, Lin, Lorenzi, Philip L, Cheng, Nikki

Source: In Neoplasia June 2022 28

The bacterial microbiota regulates normal hematopoiesis via metabolite-induced type 1 interferon signaling

Authors: Yan, Hannah ^*, Walker, Forrest C. ^*, Ali, Arushana, Han, Hyojeong, Tan, Lin, Veillon, Lucas, Lorenzi, Philip L., Baldridge, Megan T. ^*, King, Katherine Y. ^*

Source: In Blood Advances 22 March 2022 6(6):1754-1765

Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets

Authors: Liu, Rui, Lee, Jong-Ho, Li, Jingyi, Yu, Rilei, Tan, Lin, Xia, Yan, Zheng, Yanhua, Bian, Xue-Li, Lorenzi, Philip L., Chen, Qianming, Lu, Zhimin

Source: In Molecular Cell 1 July 2021 81(13):2722-2735

Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma.

Authors: Chattopadhyay, Chandrani, Roszik, Janos, Bhattacharya, Rajat, Alauddin, Md, Mahmud, Iqbal, Yadugiri, Sirisha, Ali, Mir Mustafa, Khan, Fatima S., Prabhu, Varun Vijay, Lorenzi, Philip L., Wei, Bo, Burton, Elizabeth, Morey, Rohini R., Lazcano, Rossana, Davies, Michael A., Patel, Sapna P., Grimm, Elizabeth A.

Source: British Journal of Cancer; Dec2024, Vol. 131 Issue 11, p1846-1857, 12p

Suppression of Membranous LRP5 Recycling, Wnt/β-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P

Authors: Liu, Fuyao, Zuo, Xiangsheng, Liu, Yi, Deguchi, Yasunori, Moussalli, Micheline J., Chen, Weidong, Yang, Peiying, Wei, Bo, Tan, Lin, Lorenzi, Philip L., Gao, Shen, Jaoude, Jonathan C., Mehdizadeh, Amir, Valentin, Lovie Ann, Wei, Daoyan, Shureiqi, Imad

Source: In Cell Reports 18 August 2020 32(7)

Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer

Authors: Becker, Lisa M., O’Connell, Joyce T., Vo, Annie P., Cain, Margo P., Tampe, Desiree, Bizarro, Lauren, Sugimoto, Hikaru, McGow, Anna K., Asara, John M., Lovisa, Sara, McAndrews, Kathleen M., Zielinski, Rafal, Lorenzi, Philip L., Zeisberg, Michael, Raza, Sughra, LeBleu, Valerie S., Kalluri, Raghu

Source: In Cell Reports 2 June 2020 31(9)

Mass spectrometry-based stable-isotope tracing uncovers metabolic alterations in pyruvate kinase-deficient Aedes aegypti mosquitoes

Authors: Petchampai, Natthida, Isoe, Jun, Horvath, Thomas D., Dagan, Shai, Tan, Lin, Lorenzi, Philip L., Hawke, David H., Scaraffia, Patricia Y.

Source: In Insect Biochemistry and Molecular Biology June 2020 121

PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1

Authors: Qian, Xu, Li, Xinjian, Shi, Zhumei, Xia, Yan, Cai, Qingsong, Xu, Daqian, Tan, Lin, Du, Linyong, Zheng, Yanhua, Zhao, Dan, Zhang, Chuanbao, Lorenzi, Philip L., You, Yongping, Jiang, Bing-Hua, Jiang, Tao, Li, Haitao, Lu, Zhimin

Source: In Molecular Cell 7 November 2019 76(3):516-527